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[]
["Final Risk Evaluation for 1,4-Dioxane"]
[]
[]
[]
[]
["Supplemental Information File on"]
["Occupational Risk Calculations"]
["1,4-Dioxane"]
["CASRN: 123-91-1"]
[]
["December 2020"]

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["Risk Evaluation for 1,4-Dioxane"]
["Supplemental File on 1,4-Dioxane Risk Calculations, December 2020"]
["Description of this workbook:"]
["The risk calculator for 1,4-dioxane contains the following spreadsheets: 1) Dashboard, 2) Bridge Table, 3) Risk Results (RR), 4) Health Data, 5) Dermal Exposure, 6) Dermal Crosswalk, 7) Inhalation Exposure, 8) List Values, and 9) Exposure Factors. The workbook is designed so that the user need only to use/change inputs the first three spreadsheets (i.e. the Dashboard, the Bridge Table, and the RR), which have tabs colored green and contain the results of the risk calculator. The remaining spreadsheets contain data storage and calculation spreadsheets. "]
[]
["Key Worksheets","Description"]
["Dashboard","This Dashboard is an interactive spreadsheet that allows a user to view exposure results for a selected conditions of use (COU) and with a single personal protective equipment (PPE) option of their choosing (i.e. respirator assignmed protection factor [APF] or Glove Protection Factor [PF]). The user can select a) the desired conditions of use (COU), b) PPE options, and c) dermal exposures for the worker type (either an average adult or a woman of childbearing age) from a drop-down menu. The exposure estimates are shown in the “Exposure Outputs” section for both inhalation and dermal routes and for high-end and central tendency exposures. For inhalation exposures the columns show results for both worker and occupational non-user (ONU) exposures. The “Risk Estimation” sections are separated into acute, chronic non-cancer and cancer sections. For each section there is a brief description of the hazard endpoint and the hazard value i.e. human equivalent concentration (HEC) for non-cancer effects from inhalation exposure, human equivalent dose (HED) for non-cancer effects from dermal exposure or a slope factor for cancer and the benchmark margins of exposure (MOEs) or benchmark values for cancer risk are provided to the right of the hazard value. The risk estimations show two columns of risk estimates: one column for exposures without PPE and one column for the results of the user-selected PPE option. These two columns allow the user to compare with and without PPE results side-by-side."]
["Bridge Table","The table provides summary of the risk estimates for inhalation and dermal exposures for all occupational exposure scenarios.  Risk estimates that exceed the benchmark (i.e., MOEs less than the benchmark MOE or cancer risks greater than the cancer risk benchmark) are highlighted by bolding the number and shading the cell. "]
["RR","The RR spreadsheet is an expanded version of the Dashboard. Similar to the Dashboard the RR allows the user to select a COU. However, the user also selected to see results for a worker or ONU and instead of requiring a user to select a single exposure reduction option, the Heat Map displays all the PPE options. The RR spreadsheet has a column each for no PPE and each PPE option (i.e. APF or PF). The RR spreadsheet has a row for each toxicity endpoint, and each row shows the cancer risk or MOE values. Similar to the Dashboard, the RR spreadsheet shades results if the MOE or cancer risk exceeds the benchmark MOE or cancer benchmark."]
["Health Data, \nDermal Exposure, \nDermal Crosswalk, \nInhalation Exposure, \nList Values and \nExposure Factors","As described above the remaining spreadsheets are data storage and calculation spreadsheets. These worksheets store the exposure estimates, health values and store some of the risk calculations. The user does not need to access these worksheets to use the Dashboard and RR spreadsheets as described above; all results are automatically loaded into the Dashboard and RR spreadsheets."]

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[]
[]
[null,null,"Condition of Use",null,null,null,"Personal Protective Equipment (PPE)",null,null,null,null,null,"Dermal"]
[null,null,"Select the Condition of Use (select)",null,null,null,"Respirator Protection Factor (Select)","Glove Protection Factor (Select)",null,null,null,null,"Worker Type\n(select)"]
[null,null,"Repackaging (Bottle)",null,null,null,10,5,null,null,null,null,"Average Adult Worker"]
[]
[null,null,"8-hr TWA Exposures",null,null,null,null,null,null,null,null,null,"Dermal"]
[null,null,"Exposure Outputs",null,null,null,null,null,null,null,null,null,"Exposure Outputs"]
[null,null,"Category","Exposure Level","Full-Shift (Eight-Hour) TWA Exposure","Chronic, Non-Cancer Exposures","Chronic, Cancer Exposures",null,null,null,null,null,"Category","Exposure Level","Potential Dose Rate","Acute Retained Dose","Chronic Retained Dose, Non-Cancer","Chronic Retained Dose, Cancer"]
[null,null,null,null,"C1,4-Dioxane, 8-hr TWA (mg/m3)","ADC1,4-Dioxane, 8-hr TWA (mg/m3)","LADC1,4-Dioxane, 8-hr TWA (mg/m3)",null,null,null,null,null,null,null,"APDRexp (mg/day)","ADD1,4-Dioxane (mg/kg-day)","CRD1,4-Dioxane (mg/kg-day)","CRD1,4-Dioxane (mg/kg-day)"]
[null,null,"Worker","High End",{"$f":"SUMIFS('Inhalation Exposure'!$H:$H,'Inhalation Exposure'!$C:$C,$C$5,'Inhalation Exposure'!$D:$D,$C11)","v":33.110907137861894},{"$f":"SUMIFS('Inhalation Exposure'!$L:$L,'Inhalation Exposure'!$C:$C,$C$5,'Inhalation Exposure'!$D:$D,$C11)","v":3.3945543040684436},{"$f":"SUMIFS('Inhalation Exposure'!$N:$N,'Inhalation Exposure'!$C:$C,$C$5,'Inhalation Exposure'!$D:$D,$C11)","v":1.319318871042662},null,null,null,null,null,"Worker, No Gloves","High End",{"$f":"'Dermal Exposure'!N7","v":1759.0507689983178},{"$f":"'Dermal Exposure'!O7","v":21.988134612478973},{"$f":"'Dermal Exposure'!P7","v":2.7062319523051044},{"$f":"'Dermal Exposure'!Q7","v":1.3878112575923611}]
[null,null,"ONU",null,{"$f":"SUMIFS('Inhalation Exposure'!$H:$H,'Inhalation Exposure'!$C:$C,$C$5,'Inhalation Exposure'!$D:$D,$C12)","v":0},{"$f":"SUMIFS('Inhalation Exposure'!$L:$L,'Inhalation Exposure'!$C:$C,$C$5,'Inhalation Exposure'!$D:$D,$C12)","v":0},{"$f":"SUMIFS('Inhalation Exposure'!$N:$N,'Inhalation Exposure'!$C:$C,$C$5,'Inhalation Exposure'!$D:$D,$C12)","v":0},null,null,null,null,null,null,"Central Tendency",{"$f":"'Dermal Exposure'!N8","v":586.35025633277257},{"$f":"'Dermal Exposure'!O8","v":7.3293782041596574},{"$f":"'Dermal Exposure'!P8","v":8.4569748509534512E-2},{"$f":"'Dermal Exposure'!Q8","v":3.3611053894815002E-2}]
[null,null,"Worker","Central Tendency",{"$f":"SUMIFS('Inhalation Exposure'!$I:$I,'Inhalation Exposure'!$C:$C,$C$5,'Inhalation Exposure'!$D:$D,$C13)","v":9.2841377990776905},{"$f":"SUMIFS('Inhalation Exposure'!$M:$M,'Inhalation Exposure'!$C:$C,$C$5,'Inhalation Exposure'!$D:$D,$C13)","v":0.46327653032639138},{"$f":"SUMIFS('Inhalation Exposure'!$O:$O,'Inhalation Exposure'!$C:$C,$C$5,'Inhalation Exposure'!$D:$D,$C13)","v":0.17541188791086573},null,null,null,null,null,{"$f":"_xlfn.CONCAT(\"Worker with Gloves; \nPF of \",H5)","v":"Worker with Gloves; \nPF of 5"},"High End",{"$f":"O11/$H$5","v":351.81015379966357},{"$f":"P11/$H$5","v":4.3976269224957942},0.54124639046102085,0.27756225151847225]
[null,null,"ONU",null,{"$f":"SUMIFS('Inhalation Exposure'!$I:$I,'Inhalation Exposure'!$C:$C,$C$5,'Inhalation Exposure'!$D:$D,$C14)","v":0},{"$f":"SUMIFS('Inhalation Exposure'!$M:$M,'Inhalation Exposure'!$C:$C,$C$5,'Inhalation Exposure'!$D:$D,$C14)","v":0},{"$f":"SUMIFS('Inhalation Exposure'!$O:$O,'Inhalation Exposure'!$C:$C,$C$5,'Inhalation Exposure'!$D:$D,$C14)","v":0},null,null,null,null,null,null,"Central Tendency",{"$f":"O12/$H$5","v":117.27005126655452},{"$f":"P12/$H$5","v":1.4658756408319316},1.6913949701906902E-2,6.7222107789630002E-3]
[]
[null,null,"Risk Estimation for Acute Inhalation Exposures",null,null,null,null,null,null,null,null,null,"Risk Estimation for Acute, Non-Cancer Dermal Exposures"]
[null,null,"Health Effect, Endpoint and Study","HEC (mg/m3)","Exposure Level","Benchmark MOE \n(= Total UF)","Acute Exposure Estimates",null,{"$f":"_xlfn.CONCAT(\"Respirator Scenario: APF of \",$G$5)","v":"Respirator Scenario: APF of 10"},null,null,null,"Health Effect, Endpoint and Study","HED (mg/kg)","Exposure Level","Benchmark MOE \n(= Total UF)","Chronic Exposure Estimates","Gloved Scenarios"]
[null,null,null,null,null,null,"Worker MOE","ONU MOE","Worker MOE","ONU MOE",null,null,null,null,null,null,"Worker MOE, No Gloves",{"$f":"_xlfn.CONCAT(\"Worker MOE with Gloves: \nPF of \",$H$5)","v":"Worker MOE with Gloves: \nPF of 5"}]
[null,"Tox1","Short-term Liver Effects\nMattie et al., 2012",{"$f":"VLOOKUP($B19,'Health Data'!$F$7:$K$12,2,FALSE)","v":284},"High End",{"$f":"VLOOKUP($B$19,'Health Data'!$F$7:$I$12,4,FALSE)","v":300},{"$f":"IFERROR(D19/$E$11, \"\")","v":8.5772340460962386},{"$f":"IFERROR(D19/$E$12, \"\")","v":""},{"$f":"IFERROR(G19*$G$5,\"\")","v":85.772340460962383},{"$f":"IFERROR(H19*$G$5,\"\")","v":""},null,"Tox1","Short-term Liver Effects\nMattie et al., 2012",{"$f":"VLOOKUP($L$19,'Health Data'!$F$7:$K$13,3,FALSE)","v":35.4},"High End",{"$f":"VLOOKUP($L$19,'Health Data'!$F$7:$I$12,4,FALSE)","v":300},{"$f":"IFERROR(N19/$P$11, \"\")","v":1.6099592177277904},{"$f":"IFERROR(N19/$P$13, \"\")","v":8.0497960886389528}]
[null,null,null,null,"Central Tendency",{"$f":"VLOOKUP($B$19,'Health Data'!$F$7:$I$12,4,FALSE)","v":300},{"$f":"IFERROR(D19/$E$13, \"\")","v":30.589808784205385},{"$f":"IFERROR(D19/$E$14, \"\")","v":""},{"$f":"IFERROR(G20*$G$5,\"\")","v":305.89808784205383},{"$f":"IFERROR(H20*$G$5,\"\")","v":""},null,null,null,null,"Central Tendency",{"$f":"VLOOKUP($L$19,'Health Data'!$F$7:$I$12,4,FALSE)","v":300},{"$f":"IFERROR(N19/$P$12,\"\")","v":4.8298776531833711},{"$f":"IFERROR(N19/$P$14,\"\")","v":24.149388265916855}]
[]
[null,null,"Risk Estimation for Chronic, Non-Cancer Inhalation Exposures",null,null,null,null,null,null,null,null,null,"Risk Estimation for Chronic, Non-Cancer Dermal Exposures"]
[null,null,"Health Effect, Endpoint and Study","HEC (mg/m3)","Exposure Level","Benchmark MOE \n(= Total UF)","Chronic Exposure Estimates",null,{"$f":"_xlfn.CONCAT(\"Respirator Scenario: APF of \",$G$5)","v":"Respirator Scenario: APF of 10"},null,null,null,"Health Effect, Endpoint and Study","HED (mg/kg)","Exposure Level","Benchmark MOE \n(= Total UF)","Chronic Exposure Estimates","Gloved Scenarios"]
[null,null,null,null,null,null,"Worker MOE","ONU MOE","Worker MOE","ONU MOE",null,null,null,null,null,null,"Worker MOE, No Gloves",{"$f":"_xlfn.CONCAT(\"Worker MOE with Gloves: \nPF of \",$H$5)","v":"Worker MOE with Gloves: \nPF of 5"}]
[null,"Tox3","Olfactory epithelium effects (i.e., metaplasia and atrophy)\nKasai et al., 2009",{"$f":"VLOOKUP($B25,'Health Data'!$F$7:$K$12,2,FALSE)","v":12.8},"High End",{"$f":"VLOOKUP($B$25,'Health Data'!$F$7:$I$12,4,FALSE)","v":30},{"$f":"IFERROR(D25/$F$11, \"\")","v":3.7707453920118277},{"$f":"IFERROR(D25/$F$12, \"\")","v":""},{"$f":"IFERROR(G25*$G$5,\"\")","v":37.707453920118276},{"$f":"IFERROR(H25*$G$5,\"\")","v":""},null,"Tox4","Liver\nKociba et al., 1974",{"$f":"VLOOKUP($L$25,'Health Data'!$F$7:$K$12,3,FALSE)","v":2.56},"High End",{"$f":"VLOOKUP($L$25,'Health Data'!$F$7:$I$12,4,FALSE)","v":30},{"$f":"IFERROR(N25/$Q$11, \"\")","v":0.94596473809994464},{"$f":"IFERROR(N25/$Q$13, \"\")","v":4.7298236904997237}]
[null,null,null,null,"Central Tendency",{"$f":"VLOOKUP($B$25,'Health Data'!$F$7:$I$12,4,FALSE)","v":30},{"$f":"IFERROR(D25/$F$13, \"\")","v":27.629286532132419},{"$f":"IFERROR(D25/$F$14, \"\")","v":""},{"$f":"IFERROR(G26*$G$5,\"\")","v":276.2928653213242},{"$f":"IFERROR(H26*$G$5,\"\")","v":""},null,null,null,null,"Central Tendency",{"$f":"VLOOKUP($L$25,'Health Data'!$F$7:$I$12,4,FALSE)","v":30},{"$f":"IFERROR(N25/$Q$12,\"\")","v":30.270871619198228},{"$f":"IFERROR(N25/$Q$14,\"\")","v":151.35435809599116}]
[]
[]
[]
[null,null,"Cancer Risks",null,null,null,"Chronic Cancer Exposure Estimates",null,{"$f":"_xlfn.CONCAT(\"Respirator Scenario: APF of \",$G$5)","v":"Respirator Scenario: APF of 10"},null,null,null,"Cancer Risks",null,null,null,"Chronic Cancer Exposure Estimates","Gloved Scenarios"]
[null,null,"Risk Estimate","IUR (mg/m3)-1","Exposure Level","Benchmark","Worker ","ONU ","Worker ","ONU ",null,null,"Risk Estimate","CSF (mg/kg-d)-1","Exposure Level","Benchmark","Worker, No Gloves",{"$f":"_xlfn.CONCAT(\"Worker with Gloves: \nPF of \",$H$5)","v":"Worker with Gloves: \nPF of 5"}]
[null,"Tox5","Cancer\nResult of combined cancer modeling (including liver)",{"$f":"VLOOKUP($B32,'Health Data'!$F$7:$K$12,5,FALSE)","v":1E-3},"High End","10-4, 10-5, 10-6",{"$f":"IFERROR(G11*D32, \"\")","v":1.3193188710426619E-3},{"$f":"IFERROR(G12*D32, \"\")","v":0},{"$f":"IFERROR(G32/$G$5,\"\")","v":1.3193188710426619E-4},{"$f":"IFERROR(H32/$G$5,\"\")","v":0},null,"Tox6","Cancer\nLiver cancer in female mice (Kano 2009)",{"$f":"VLOOKUP($L$32,'Health Data'!$F$7:$K$12,6,FALSE)","v":0.123},"High End","10-4, 10-5, 10-6",{"$f":"IFERROR($R$11*N32, \"\")","v":0.17070078468386041},{"$f":"IFERROR($R$13*N32, \"\")","v":3.4140156936772088E-2}]
[null,null,null,null,"Central Tendency","10-4, 10-5, 10-6",{"$f":"IFERROR(G13*D32, \"\")","v":1.7541188791086573E-4},{"$f":"IFERROR(G14*D32, \"\")","v":0},{"$f":"IFERROR(G33/$G$5,\"\")","v":1.7541188791086571E-5},{"$f":"IFERROR(H33/$G$5,\"\")","v":0},null,null,null,null,"Central Tendency",null,{"$f":"IFERROR($R$12*N32, \"\")","v":4.1341596290622451E-3},{"$f":"IFERROR($R$14*N32, \"\")","v":8.2683192581244904E-4}]
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[null,null,"Inhalation Cancer Risk Estimates","Cancer Risk",{"$f":"_xlfn.CONCAT(\"Cancer Risk with APF of \",$G$5)","v":"Cancer Risk with APF of 10"},null,null,null,null,null,null,null,"Dermal Cancer Risk Estimates"]
[null,null,"ONU: 50th Percentile",{"$f":"H33","v":0},{"$f":"J33","v":0},null,null,null,null,null,null,null,{"$f":"Q31","v":"Worker, No Gloves"},{"$f":"Q32","v":0.17070078468386041}]
[null,null,"ONU: 95th Percentile",{"$f":"H32","v":0},{"$f":"J32","v":0},null,null,null,null,null,null,null,{"$f":"R31","v":"Worker with Gloves: \nPF of 5"},{"$f":"R32","v":3.4140156936772088E-2}]
[null,null,"Worker: 50th Percentile",{"$f":"G33","v":1.7541188791086573E-4},{"$f":"I33","v":1.7541188791086571E-5}]
[null,null,"Worker: 95th Percentile",{"$f":"G32","v":1.3193188710426619E-3},{"$f":"I32","v":1.3193188710426619E-4}]

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[]
[null,"Summary of Risk Estimates for Inhalation and Dermal Exposures to Workers by Condition of Use"]
[null,null,null,null,null,null,null,null,null,null,"Benchmarks"]
[null,null,null,null,null,null,null,null,null,null,{"$f":"'Health Data'!I7","v":300},{"$f":"'Health Data'!I9","v":30},{"$f":"'Health Data'!P10","v":1E-4},{"$f":"K4","v":300},{"$f":"L4","v":30},{"$f":"M4","v":1E-4},null,null,null,"Respirator APF =",10]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Glove PF =",5]
[null,"OES Group","Population","Exposure Route","Life Cycle Stage/ Category","Subcategory","Occupational Exposure Scenario","Population","Exposure Route and Duration","Exposure Level","Risk Estimates for No PPE",null,null,"Risk Estimates with PPE",null,null,null,"Select the PPE APF or PF for Each OES, Receptor, and Endpoint"]
[null,null,null,null,null,null,null,null,null,null,"Acute Non-cancer (bench­mark MOE = 300)","Chronic Non-cancer (bench­mark MOE = 30)","Cancer (bench­mark = 10-4)","Acute Non-cancer (bench­mark MOE = 300)","Chronic Non-cancer (bench­mark MOE = 30)","Cancer (bench­mark = 10‑4)",null,"Acute Non-cancer","Chronic Non-cancer","Cancer",null,null,"Acute Non-cancer HEC (mg/m3) and HED (mg/kg-d)","Chronic Non-cancer HEC (mg/m3) and HED (mg/kg-d)","Cancer CSF (mg/m3)-1 and (mg/kg-d)-1"]
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[null,1,"Worker","Dermal",null,null,null,"Worker","Dermal","Central Tendency",{"$f":"IFERROR(VLOOKUP($D12,$V$8:$Y$9,2,FALSE)/IF($D12=\"Inhalation\",IF($J12=\"Central Tendency\",SUMIFS('Inhalation Exposure'!$I$6:$I$19,'Inhalation Exposure'!$B$6:$B$19,$B12,'Inhalation Exposure'!$D$6:$D$19,$C12),SUMIFS('Inhalation Exposure'!$H$6:$H$19,'Inhalation Exposure'!$B$6:$B$19,$B12,'Inhalation Exposure'!$D$6:$D$19,$C12)),IF($J12=\"Central Tendency\",VLOOKUP($B12,'Dermal Crosswalk'!$A$6:$R$16,16,FALSE),VLOOKUP($B12,'Dermal Crosswalk'!$A$6:$R$16,12,FALSE))),\"--\")","v":4.8298776531833711},{"$f":"IFERROR(VLOOKUP($D12,$V$8:$Y$9,3,FALSE)/IF($D12=\"Inhalation\",IF($J12=\"Central Tendency\",SUMIFS('Inhalation Exposure'!$M$6:$M$19,'Inhalation Exposure'!$B$6:$B$19,$B12,'Inhalation Exposure'!$D$6:$D$19,$C12),SUMIFS('Inhalation Exposure'!$L$6:$L$19,'Inhalation Exposure'!$B$6:$B$19,$B12,'Inhalation Exposure'!$D$6:$D$19,$C12)),IF($J12=\"Central Tendency\",VLOOKUP($B12,'Dermal Crosswalk'!$A$6:$R$16,17,FALSE),VLOOKUP($B12,'Dermal Crosswalk'!$A$6:$R$16,13,FALSE))),\"--\")","v":0.22703153714398674},{"$f":"IFERROR(VLOOKUP(D12,$V$8:$Y$9,4,FALSE)*IF($D12=\"Inhalation\",IF($J12=\"Central Tendency\",SUMIFS('Inhalation Exposure'!$O$6:$O$19,'Inhalation Exposure'!$B$6:$B$19,$B12,'Inhalation Exposure'!$D$6:$D$19,$C12),SUMIFS('Inhalation Exposure'!$N$6:$N$19,'Inhalation Exposure'!$B$6:$B$19,$B12,'Inhalation Exposure'!$D$6:$D$19,$C12)),IF($J12=\"Central Tendency\",VLOOKUP($B12,'Dermal Crosswalk'!$A$6:$R$16,18,FALSE),VLOOKUP($B12,'Dermal Crosswalk'!$A$6:$R$16,14,FALSE))),\"--\")","v":0.34451330242185368},{"$f":"K12*R12","v":96.597553063667419},{"$f":"L12*S12","v":4.5406307428797348},{"$f":"M12/T12","v":1.7225665121092686E-2},null,20,20,20]
[null,1,"Worker","Dermal",null,null,null,null,null,null,null,null,null,{"$f":"CONCATENATE(\"(PF \",R12,\")\")","v":"(PF 20)"},{"$f":"CONCATENATE(\"(PF \",S12,\")\")","v":"(PF 20)"},{"$f":"CONCATENATE(\"(PF \",T12,\")\")","v":"(PF 20)"},null,"PF","PF","PF"]
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[null,10,"Worker","Dermal",null,null,null,null,null,null,null,null,null,{"$f":"CONCATENATE(\"(PF \",R154,\")\")","v":"(PF 20)"},{"$f":"CONCATENATE(\"(PF \",S154,\")\")","v":"(PF 20)"},{"$f":"CONCATENATE(\"(PF \",T154,\")\")","v":"(PF 20)"},null,"PF","PF","PF"]
[null,10,"ONU","Inhalation",null,"Recycling",null,"ONU","Inhalation\n8-hr TWA","Central Tendency",{"$f":"IFERROR(VLOOKUP($D156,$V$8:$Y$9,2,FALSE)/IF($D156=\"Inhalation\",IF($J156=\"Central Tendency\",SUMIFS('Inhalation Exposure'!$I$6:$I$19,'Inhalation Exposure'!$B$6:$B$19,$B156,'Inhalation Exposure'!$D$6:$D$19,$C156),SUMIFS('Inhalation Exposure'!$H$6:$H$19,'Inhalation Exposure'!$B$6:$B$19,$B156,'Inhalation Exposure'!$D$6:$D$19,$C156)),IF($J156=\"Central Tendency\",VLOOKUP($B156,'Dermal Crosswalk'!$A$6:$R$16,16,FALSE),VLOOKUP($B156,'Dermal Crosswalk'!$A$6:$R$16,12,FALSE))),\"--\")","v":"--"},{"$f":"IFERROR(VLOOKUP($D156,$V$8:$Y$9,3,FALSE)/IF($D156=\"Inhalation\",IF($J156=\"Central Tendency\",SUMIFS('Inhalation Exposure'!$M$6:$M$19,'Inhalation Exposure'!$B$6:$B$19,$B156,'Inhalation Exposure'!$D$6:$D$19,$C156),SUMIFS('Inhalation Exposure'!$L$6:$L$19,'Inhalation Exposure'!$B$6:$B$19,$B156,'Inhalation Exposure'!$D$6:$D$19,$C156)),IF($J156=\"Central Tendency\",VLOOKUP($B156,'Dermal Crosswalk'!$A$6:$R$16,17,FALSE),VLOOKUP($B156,'Dermal Crosswalk'!$A$6:$R$16,13,FALSE))),\"--\")","v":"--"},"--","N/A","N/A","N/A",null,"N/A","N/A","N/A"]
[null,10,"ONU","Inhalation",null,"Incineration",null,null,null,"High-End",{"$f":"IFERROR(VLOOKUP($D157,$V$8:$Y$9,2,FALSE)/IF($D157=\"Inhalation\",IF($J157=\"Central Tendency\",SUMIFS('Inhalation Exposure'!$I$6:$I$19,'Inhalation Exposure'!$B$6:$B$19,$B157,'Inhalation Exposure'!$D$6:$D$19,$C157),SUMIFS('Inhalation Exposure'!$H$6:$H$19,'Inhalation Exposure'!$B$6:$B$19,$B157,'Inhalation Exposure'!$D$6:$D$19,$C157)),IF($J157=\"Central Tendency\",VLOOKUP($B157,'Dermal Crosswalk'!$A$6:$R$16,16,FALSE),VLOOKUP($B157,'Dermal Crosswalk'!$A$6:$R$16,12,FALSE))),\"--\")","v":"--"},{"$f":"IFERROR(VLOOKUP($D157,$V$8:$Y$9,3,FALSE)/IF($D157=\"Inhalation\",IF($J157=\"Central Tendency\",SUMIFS('Inhalation Exposure'!$M$6:$M$19,'Inhalation Exposure'!$B$6:$B$19,$B157,'Inhalation Exposure'!$D$6:$D$19,$C157),SUMIFS('Inhalation Exposure'!$L$6:$L$19,'Inhalation Exposure'!$B$6:$B$19,$B157,'Inhalation Exposure'!$D$6:$D$19,$C157)),IF($J157=\"Central Tendency\",VLOOKUP($B157,'Dermal Crosswalk'!$A$6:$R$16,17,FALSE),VLOOKUP($B157,'Dermal Crosswalk'!$A$6:$R$16,13,FALSE))),\"--\")","v":"--"},"--","N/A","N/A","N/A",null,"N/A","N/A","N/A"]
[]
[null,null,null,null,"N/A = not assessed because ONUs are not assumed to be wearing PPE"]
[null,null,null,null,"NR = not reported"]
[null,null,null,null,"- - = exposure data for ONUs were not available"]
[null,null,null,null,"– = not included because calculated risk was below benchmark MOE for high-end exposures without PPE"]
[null,null,null,null,"*EPA cannot separately determine a central tendency and high-end estimate and/or EPA cannot determine statistical representativeness of the values given the small sample size."]
[null,null,null,null,"** The risk assessment did not provide details about how these values were calculated, therefore, it is unclear what percentile is represented when an exposure is described as “reasonable worst case.”"]
[null,null,null,null,"***For this scenario, the high-end was the 90th percentile."]
[null,null,null,null,"****For this scenario, the high-end was the maximum value. "]

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[]
[]
[null,null,null,null,null,null,null,"Condition of Use","Inhalation Exposure",null,null,null,null,null,null,null,null,"Dermal"]
[null,null,null,null,null,null,null,"Select the Condition of Use (select)","Exposure Type \n(select)",null,null,null,null,null,null,null,null,"Worker Type\n(select)"]
[null,null,null,null,null,null,null,"Manufacturing","Worker",null,null,null,null,null,null,null,null,"Average Adult Worker"]
[]
[null,null,null,null,null,null,null,"8-hr TWA Exposures",null,null,null,null,null,null,null,null,null,"Dermal"]
[null,null,null,null,null,null,null,"Exposure Outputs",null,null,null,null,null,null,null,null,null,"Exposure Outputs"]
[null,null,null,null,null,null,null,"Category","Exposure Level","Full-Shift (Eight-Hour) TWA Exposure","Chronic, Non-Cancer Exposures","Chronic, Cancer Exposures",null,null,null,null,null,"Category","Exposure Level","Potential Dose Rate","Acute Retained Dose","Chronic Retained Dose, Non-Cancer","Chronic Retained Dose, Cancer"]
[null,null,null,null,null,null,null,null,null,"C1,4-Dioxane, 8-hr TWA (ppm)","ADC1,4-Dioxane, 8-hr TWA (ppm)","LADC1,4-Dioxane, 8-hr TWA (ppm)",null,null,null,null,null,null,null,"APDRexp (mg/day)","ADD1,4-Dioxane (mg/kg-day)","CRD1,4-Dioxane (mg/kg-day)","CRD1,4-Dioxane (mg/kg-day)"]
[null,null,null,null,null,null,null,"Worker","High End",{"$f":"SUMIFS('Inhalation Exposure'!$H:$H,'Inhalation Exposure'!$C:$C,$H$5,'Inhalation Exposure'!$D:$D,$H11)","v":7.7344999999999988},{"$f":"SUMIFS('Inhalation Exposure'!$L:$L,'Inhalation Exposure'!$C:$C,$H$5,'Inhalation Exposure'!$D:$D,$H11)","v":7.4370192307692298},{"$f":"SUMIFS('Inhalation Exposure'!$N:$N,'Inhalation Exposure'!$C:$C,$H$5,'Inhalation Exposure'!$D:$D,$H11)","v":3.8138560157790922},null,null,null,null,null,"Worker, No Gloves","High End",{"$f":"'Dermal Exposure'!N10","v":1759.0507689983178},{"$f":"'Dermal Exposure'!O10","v":21.988134612478973},{"$f":"'Dermal Exposure'!P10","v":21.14243712738363},{"$f":"'Dermal Exposure'!Q10","v":10.842275449940322}]
[null,null,null,null,null,null,null,"ONU",null,{"$f":"SUMIFS('Inhalation Exposure'!$H:$H,'Inhalation Exposure'!$C:$C,$H$5,'Inhalation Exposure'!$D:$D,$H12)","v":0},{"$f":"SUMIFS('Inhalation Exposure'!$L:$L,'Inhalation Exposure'!$C:$C,$H$5,'Inhalation Exposure'!$D:$D,$H12)","v":0},{"$f":"SUMIFS('Inhalation Exposure'!$N:$N,'Inhalation Exposure'!$C:$C,$H$5,'Inhalation Exposure'!$D:$D,$H12)","v":0},null,null,null,null,null,null,"Central Tendency",{"$f":"'Dermal Exposure'!N11","v":586.35025633277257},{"$f":"'Dermal Exposure'!O11","v":7.3293782041596574},{"$f":"'Dermal Exposure'!P11","v":7.0474790424612088},{"$f":"'Dermal Exposure'!Q11","v":2.8009211579012496}]
[null,null,null,null,null,null,null,"Worker","Central Tendency",{"$f":"SUMIFS('Inhalation Exposure'!$I:$I,'Inhalation Exposure'!$C:$C,$H$5,'Inhalation Exposure'!$D:$D,$H13)","v":0.41500000000000004},{"$f":"SUMIFS('Inhalation Exposure'!$M:$M,'Inhalation Exposure'!$C:$C,$H$5,'Inhalation Exposure'!$D:$D,$H13)","v":0.39903846153846162},{"$f":"SUMIFS('Inhalation Exposure'!$O:$O,'Inhalation Exposure'!$C:$C,$H$5,'Inhalation Exposure'!$D:$D,$H13)","v":0.15859220907297833},null,null,null,null,null,{"$f":"_xlfn.CONCAT(\"Worker with Gloves; \nPF of \",'List Values'!H4)","v":"Worker with Gloves; \nPF of 5"},"High End",{"$f":"T11/'List Values'!$H$4","v":351.81015379966357},{"$f":"U11/'List Values'!$H$4","v":4.3976269224957942},{"$f":"V11/'List Values'!$H$4","v":4.2284874254767262},{"$f":"W11/'List Values'!$H$4","v":2.1684550899880644}]
[null,null,null,null,null,null,null,"ONU",null,{"$f":"SUMIFS('Inhalation Exposure'!$I:$I,'Inhalation Exposure'!$C:$C,$H$5,'Inhalation Exposure'!$D:$D,$H14)","v":0},{"$f":"SUMIFS('Inhalation Exposure'!$M:$M,'Inhalation Exposure'!$C:$C,$H$5,'Inhalation Exposure'!$D:$D,$H14)","v":0},{"$f":"SUMIFS('Inhalation Exposure'!$O:$O,'Inhalation Exposure'!$C:$C,$H$5,'Inhalation Exposure'!$D:$D,$H14)","v":0},null,null,null,null,null,null,"Central Tendency",{"$f":"T12/'List Values'!$H$4","v":117.27005126655452},{"$f":"U12/'List Values'!$H$4","v":1.4658756408319316},{"$f":"V12/'List Values'!$H$4","v":1.4094958084922418},{"$f":"W12/'List Values'!$H$4","v":0.56018423158024988}]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"_xlfn.CONCAT(\"Worker with Gloves; \nPF of \",'List Values'!H5)","v":"Worker with Gloves; \nPF of 10"},"High End",{"$f":"T11/'List Values'!$H$5","v":175.90507689983178},{"$f":"U11/'List Values'!$H$5","v":2.1988134612478971},{"$f":"V11/'List Values'!$H$5","v":2.1142437127383631},{"$f":"W11/'List Values'!$H$5","v":1.0842275449940322}]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Central Tendency",{"$f":"T12/'List Values'!$H$5","v":58.635025633277259},{"$f":"U12/'List Values'!$H$5","v":0.73293782041596578},{"$f":"V12/'List Values'!$H$5","v":0.70474790424612088},{"$f":"W12/'List Values'!$H$5","v":0.28009211579012494}]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"_xlfn.CONCAT(\"Worker with Gloves; \nPF of \",'List Values'!H6)","v":"Worker with Gloves; \nPF of 20"},"High End",{"$f":"T11/'List Values'!$H$6","v":87.952538449915892},{"$f":"U11/'List Values'!$H$6","v":1.0994067306239486},{"$f":"V11/'List Values'!$H$6","v":1.0571218563691815},{"$f":"W11/'List Values'!$H$6","v":0.54211377249701609}]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Central Tendency",{"$f":"T12/'List Values'!$H$6","v":29.317512816638629},{"$f":"U12/'List Values'!$H$6","v":0.36646891020798289},{"$f":"V12/'List Values'!$H$6","v":0.35237395212306044},{"$f":"W12/'List Values'!$H$6","v":0.14004605789506247}]
[]
[null,null,null,null,null,null,null,"Risk Estimation for Inhalation Exposures",null,null,null,null,null,null,null,null,null,"Risk Estimation for Dermal Exposures"]
[null,null,"Risk Type","Toxicity Endpoint",null,"Study",null,"HEC (mg/m3)","Exposure Level","Benchmark MOE \n(= Total UF)",{"$f":"_xlfn.CONCAT(\"Exposure Estimates: \",$I$5,\" MOE\")","v":"Exposure Estimates: Worker MOE"},null,null,null,null,null,null,"HED (mg/kg)","Exposure Level","Benchmark MOE \n(= Total UF)",{"$f":"_xlfn.CONCAT(\"Exposure Estimates: \",$I$5,\" MOE\")","v":"Exposure Estimates: Worker MOE"}]
[null,null,null,null,null,null,null,null,null,null,"No Respirator","APF = 10","APF = 25","APF = 50","APF = 1,000","APF = 10,000",null,null,null,null,"No Gloves","PF = 5","PF = 10","PF = 20"]
[null,"Tox1","Acute, Non-Cancer","Liver","Short-term Liver Effects","Mattie et al., 2012",null,{"$f":"VLOOKUP($B23,'Health Data'!$F$7:$K$12,2,FALSE)","v":284},"High End",300,{"$f":"IFERROR($H23/IF($I$5=\"Worker\",$J$11,$J$12), \"\")","v":36.718598487297179},{"$f":"IFERROR($K23*'List Values'!$E$19, \"\")","v":367.1859848729718},{"$f":"IFERROR($K23*'List Values'!$E$20, \"\")","v":917.96496218242942},{"$f":"IFERROR($K23*'List Values'!$E$21, \"\")","v":1835.9299243648588},{"$f":"IFERROR($K23*'List Values'!$E$22, \"\")","v":36718.598487297182},{"$f":"IFERROR($K23*'List Values'!$E$23, \"\")","v":367185.98487297178},null,{"$f":"VLOOKUP($B23,'Health Data'!$F$7:$K$13,3,FALSE)","v":35.4},"High End",300,{"$f":"IFERROR($R23/U$11, \"\")","v":1.6099592177277904},{"$f":"IFERROR($R23/U$13, \"\")","v":8.0497960886389528},{"$f":"IFERROR($R23/U$15, \"\")","v":16.099592177277906},{"$f":"IFERROR($R23/U$17, \"\")","v":32.199184354555811}]
[null,null,null,null,null,null,null,null,"Central Tendency",300,{"$f":"IFERROR($H23/IF($I$5=\"Worker\",$J$13,$J$14), \"\")","v":684.33734939759029},{"$f":"IFERROR($K24*'List Values'!$E$19, \"\")","v":6843.3734939759033},{"$f":"IFERROR($K24*'List Values'!$E$20, \"\")","v":17108.433734939757},{"$f":"IFERROR($K24*'List Values'!$E$21, \"\")","v":34216.867469879515},{"$f":"IFERROR($K24*'List Values'!$E$22, \"\")","v":684337.34939759027},{"$f":"IFERROR($K24*'List Values'!$E$23, \"\")","v":6843373.4939759029},null,null,"Central Tendency",300,{"$f":"IFERROR($R23/U$12, \"\")","v":4.8298776531833711},{"$f":"IFERROR($R23/U$14, \"\")","v":24.149388265916855},{"$f":"IFERROR($R23/U$16, \"\")","v":48.29877653183371},{"$f":"IFERROR($R23/U$18, \"\")","v":96.597553063667419}]
[null,"Tox3","Chronic, Non-Cancer","Liver","olfactory epithelium effects (i.e., metaplasia and atrophy)","Kasai et al., 2009",null,{"$f":"VLOOKUP($B25,'Health Data'!$F$7:$K$12,2,FALSE)","v":12.8},"High End",30,{"$f":"IFERROR($H25/IF($I$5=\"Worker\",$K$11,$K$12), \"\")","v":1.7211196586721833},{"$f":"IFERROR($K25*'List Values'!$E$19, \"\")","v":17.211196586721833},{"$f":"IFERROR($K25*'List Values'!$E$20, \"\")","v":43.027991466804579},{"$f":"IFERROR($K25*'List Values'!$E$21, \"\")","v":86.055982933609158},{"$f":"IFERROR($K25*'List Values'!$E$22, \"\")","v":1721.1196586721833},{"$f":"IFERROR($K25*'List Values'!$E$23, \"\")","v":17211.196586721831},null,{"$f":"VLOOKUP($B25,'Health Data'!$F$7:$K$13,3,FALSE)","v":1.6},"High End",30,{"$f":"IFERROR($R25/V$11, \"\")","v":7.5677179047995563E-2},{"$f":"IFERROR($R25/V$13, \"\")","v":0.37838589523997784},{"$f":"IFERROR($R25/V$15, \"\")","v":0.75677179047995569},{"$f":"IFERROR($R25/V$17, \"\")","v":1.5135435809599114}]
[null,null,null,null,null,null,null,null,"Central Tendency",30,{"$f":"IFERROR($H25/IF($I$5=\"Worker\",$K$13,$K$14), \"\")","v":32.077108433734935},{"$f":"IFERROR($K26*'List Values'!$E$19, \"\")","v":320.77108433734935},{"$f":"IFERROR($K26*'List Values'!$E$20, \"\")","v":801.92771084337335},{"$f":"IFERROR($K26*'List Values'!$E$21, \"\")","v":1603.8554216867467},{"$f":"IFERROR($K26*'List Values'!$E$22, \"\")","v":32077.108433734935},{"$f":"IFERROR($K26*'List Values'!$E$23, \"\")","v":320771.08433734934},null,null,"Central Tendency",30,{"$f":"IFERROR($R25/V$12, \"\")","v":0.22703153714398674},{"$f":"IFERROR($R25/V$14, \"\")","v":1.1351576857199337},{"$f":"IFERROR($R25/V$16, \"\")","v":2.2703153714398674},{"$f":"IFERROR($R25/V$18, \"\")","v":4.5406307428797348}]
[null,"Tox4",null,null,"Liver effects","Kociba et al., 1974",null,{"$f":"VLOOKUP($B27,'Health Data'!$F$7:$K$12,2,FALSE)","v":"--"},"High End",30,{"$f":"IFERROR($H27/IF($I$5=\"Worker\",$K$11,$K$12), \"\")","v":""},{"$f":"IFERROR($K27*'List Values'!$E$19, \"\")","v":""},{"$f":"IFERROR($K27*'List Values'!$E$20, \"\")","v":""},{"$f":"IFERROR($K27*'List Values'!$E$21, \"\")","v":""},{"$f":"IFERROR($K27*'List Values'!$E$22, \"\")","v":""},{"$f":"IFERROR($K27*'List Values'!$E$23, \"\")","v":""},null,{"$f":"VLOOKUP($B27,'Health Data'!$F$7:$K$13,3,FALSE)","v":2.56},"High End",30,{"$f":"IFERROR($R27/V$11, \"\")","v":0.1210834864767929},{"$f":"IFERROR($R27/V$13, \"\")","v":0.6054174323839645},{"$f":"IFERROR($R27/V$15, \"\")","v":1.210834864767929},{"$f":"IFERROR($R27/V$17, \"\")","v":2.421669729535858}]
[null,null,null,null,null,null,null,null,"Central Tendency",30,{"$f":"IFERROR($H27/IF($I$5=\"Worker\",$K$13,$K$14), \"\")","v":""},{"$f":"IFERROR($K28*'List Values'!$E$19, \"\")","v":""},{"$f":"IFERROR($K28*'List Values'!$E$20, \"\")","v":""},{"$f":"IFERROR($K28*'List Values'!$E$21, \"\")","v":""},{"$f":"IFERROR($K28*'List Values'!$E$22, \"\")","v":""},{"$f":"IFERROR($K28*'List Values'!$E$23, \"\")","v":""},null,null,"Central Tendency",30,{"$f":"IFERROR($R27/V$12, \"\")","v":0.36325045943037876},{"$f":"IFERROR($R27/V$14, \"\")","v":1.816252297151894},{"$f":"IFERROR($R27/V$16, \"\")","v":3.6325045943037879},{"$f":"IFERROR($R27/V$18, \"\")","v":7.2650091886075758}]
[null,"Tox5","Chronic, Cancer","Cancer","Result of combined cancer modeling (including liver)","Kasai et al., 2009",null,{"$f":"VLOOKUP($B29,'Health Data'!$F$7:$K$12,5,FALSE)","v":1E-3},"High End","10-4, 10-5, 10-6",{"$f":"IFERROR($H29*IF($I$5=\"Worker\",$L$11,$L$12), \"\")","v":3.8138560157790925E-3},{"$f":"IFERROR($K29/'List Values'!$E$19, \"\")","v":3.8138560157790927E-4},{"$f":"IFERROR($K29/'List Values'!$E$20, \"\")","v":1.5255424063116371E-4},{"$f":"IFERROR($K29/'List Values'!$E$21, \"\")","v":7.6277120315581854E-5},{"$f":"IFERROR($K29/'List Values'!$E$22, \"\")","v":3.8138560157790923E-6},{"$f":"IFERROR($K29/'List Values'!$E$23, \"\")","v":3.8138560157790923E-7},null,{"$f":"VLOOKUP($B29,'Health Data'!$F$7:$K$13,3,FALSE)","v":"--"},"High End","10-4, 10-5, 10-6",{"$f":"IFERROR($R29*$W11, \"\")","v":""},{"$f":"IFERROR($R29*$W13, \"\")","v":""},{"$f":"IFERROR($R29*$W15, \"\")","v":""},{"$f":"IFERROR($R29*$W17, \"\")","v":""}]
[null,null,null,null,null,null,null,null,"Central Tendency","10-4, 10-5, 10-6",{"$f":"IFERROR($H29*IF($I$5=\"Worker\",$L$13,$L$14), \"\")","v":1.5859220907297832E-4},{"$f":"IFERROR($K30/'List Values'!$E$19, \"\")","v":1.5859220907297831E-5},{"$f":"IFERROR($K30/'List Values'!$E$20, \"\")","v":6.3436883629191331E-6},{"$f":"IFERROR($K30/'List Values'!$E$21, \"\")","v":3.1718441814595665E-6},{"$f":"IFERROR($K30/'List Values'!$E$22, \"\")","v":1.5859220907297833E-7},{"$f":"IFERROR($K30/'List Values'!$E$23, \"\")","v":1.5859220907297833E-8},null,null,"Central Tendency",null,{"$f":"IFERROR($R29*$W12, \"\")","v":""},{"$f":"IFERROR($R29*$W14, \"\")","v":""},{"$f":"IFERROR($R29*$W16, \"\")","v":""},{"$f":"IFERROR($R29*$W18, \"\")","v":""}]
[null,"Tox6","Chronic, Cancer","Cancer","Result of combined cancer modeling - male rats (including liver)","Kano et al., 2009",null,{"$f":"VLOOKUP($B31,'Health Data'!$F$7:$G$12,2,FALSE)","v":"--"},"High End","10-4, 10-5, 10-6",null,null,null,null,null,null,null,{"$f":"VLOOKUP($B31,'Health Data'!$F$7:$K$12,6,FALSE)","v":0.123},"High End","10-4, 10-5, 10-6",{"$f":"IFERROR($R31*$W11, \"\")","v":1.3335998803426596},{"$f":"IFERROR($R31*$W13, \"\")","v":0.26671997606853193},{"$f":"IFERROR($R31*$W15, \"\")","v":0.13335998803426596},{"$f":"IFERROR($R31*$W17, \"\")","v":6.6679994017132982E-2}]
[null,null,null,null,null,null,null,null,"Central Tendency","10-4, 10-5, 10-6",null,null,null,null,null,null,null,null,"Central Tendency",null,{"$f":"IFERROR($R31*$W12, \"\")","v":0.34451330242185368},{"$f":"IFERROR($R31*$W14, \"\")","v":6.8902660484370729E-2},{"$f":"IFERROR($R31*$W16, \"\")","v":3.4451330242185364E-2},{"$f":"IFERROR($R31*$W18, \"\")","v":1.7225665121092682E-2}]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[null,null,null,null,null,null,null,"Inhalation Cancer Risk Estimates",{"$f":"I29","v":"High End"},{"$f":"I30","v":"Central Tendency"},null,null,null,null,null,null,null,"Dermal Cancer Risk Estimates",{"$f":"S29","v":"High End"},{"$f":"S30","v":"Central Tendency"}]
[null,null,null,null,null,null,null,"No Respirator",{"$f":"K29","v":3.8138560157790925E-3},{"$f":"K30","v":1.5859220907297832E-4},null,null,null,null,null,null,null,"No Gloves \n(PF = 1)",{"$f":"U31","v":1.3335998803426596},{"$f":"U32","v":0.34451330242185368}]
[null,null,null,null,null,null,null,"APF = 10",{"$f":"L29","v":3.8138560157790927E-4},{"$f":"L30","v":1.5859220907297831E-5},null,null,null,null,null,null,null,"Protective Gloves \n(PF = 5)",{"$f":"V31","v":0.26671997606853193},{"$f":"V32","v":6.8902660484370729E-2}]
[null,null,null,null,null,null,null,"APF = 25",{"$f":"M29","v":1.5255424063116371E-4},{"$f":"M30","v":6.3436883629191331E-6},null,null,null,null,null,null,null,"Protective Gloves \n(Commercial uses, PF = 10)",{"$f":"W31","v":0.13335998803426596},{"$f":"W32","v":3.4451330242185364E-2}]
["=",null,null,null,null,null,null,"APF = 50",{"$f":"N29","v":7.6277120315581854E-5},{"$f":"N30","v":3.1718441814595665E-6},null,null,null,null,null,null,null,"Protective Gloves \n(Industrial uses, PF = 20)",{"$f":"X31","v":6.6679994017132982E-2},{"$f":"X32","v":1.7225665121092682E-2}]
[null,null,null,null,null,null,null,"APF = 1,000",{"$f":"O29","v":3.8138560157790923E-6},{"$f":"O30","v":1.5859220907297833E-7}]
[null,null,null,null,null,null,null,"APF = 10,000",{"$f":"P29","v":3.8138560157790923E-7},{"$f":"P30","v":1.5859220907297833E-8}]

{"sheet":"Health Data","index":5,"n_rows":25,"n_cols":17,"rows_kept":25,"cut":false,"hidden":false,"merged":[[0,0,0,12],[20,13,20,15],[19,13,19,14],[18,13,18,14],[12,13,12,14],[4,5,4,8],[7,1,9,1],[10,1,11,1],[10,2,11,2],[4,13,4,15],[5,2,5,3],[4,9,4,10]]}
[]
[]
[null,"Look-up Values and Risk Parameter Values"]
[null,null,null,null,null,null,"Inhalation","Dermal",null,"Inhalation","Dermal"]
[null,null,null,null,null,"Acute and Chronic, Non-Cancer Parameters",null,null,null,"Cancer Parameters",null,null,null,"Look-up Table Values"]
[null,null,"Toxicity Endpoint",null,"Study","Code","HEC (mg/m3)","HED (mg/kg-d)","Benchmark MOE","IUR (mg/m3)-1","CSF (mg/kg-d)-1",null,null,null,"Exposure Percentiles","Target Cancer Risk Level"]
[null,"Acute, Non-Cancer",null,"Short-term liver effects","Mattie et al., 2012","Tox1",284,35.4,300,"--","--",null,null,null,"High End",{"$f":"0.000001","v":9.9999999999999995E-7}]
[null,"Chronic, Non-Cancer",null,"Centribular necrosis; Liver","Kasai et al., 2009","Tox2",{"$f":"(119000)/ug_per_mg","v":119},"--",30,"--","--",null,null,null,"Central Tendancy",{"$f":"0.00001","v":1.0000000000000001E-5}]
[null,null,null,"Olfactory epithelium effects (i.e., metaplasia and atrophy)","Kasai et al., 2009","Tox3",12.8,1.6,30,"--","--"]
[null,null,null,"Liver effects","Kociba et al., 1974","Tox4","--",2.56,30,"--","--",null,null,null,null,{"$f":"0.0001","v":1E-4}]
[null,"Chronic, Cancer","Cancer","Result of combined cancer modeling (including liver)","Kasai et al., 2009","Tox5","--","--","--",{"$f":"(0.000001)*ug_per_mg","v":1E-3},"--"]
[null,null,null,"liver cancer in female mice","Kano et al., 2009","Tox6","--","--","--","--",0.123,null,null,"HEC conversion factor"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"O15/O14","v":0.27750663972941686},null,"ppm/mg/m3"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,"1,4-Dioxane MW",88.105999999999995,"g/mol"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,"Molar Volume",24.45,"L/mol"]
[]
[]
[null,null,null,null,null,null,null,null,null,null,null,null,null,"Data for Risk Graph on Dashboard",null,"High End","Central Tendancy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,"Occupational Non-user",null,{"$f":"Dashboard!$G$32","v":1.3193188710426619E-3},{"$f":"Dashboard!$G$33","v":1.7541188791086573E-4}]
[null,null,null,null,null,null,null,null,null,null,null,null,null,"Worker",null,{"$f":"Dashboard!$E$32","v":"High End"},{"$f":"Dashboard!E33","v":"Central Tendency"}]
[null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"_xlfn.CONCAT(Dashboard!C7,\" \",Dashboard!M4,\" Exposure Estimates\")","v":"8-hr TWA Exposures Worker Type\n(select) Exposure Estimates"}]
[]
[]
[null,null,null,null,null,null,null,null,null,null,null,null,null,"Occupational Non-user",{"$f":"Dashboard!L39","v":0}]
[null,null,null,null,null,null,null,null,null,null,null,null,null,"Worker",{"$f":"Dashboard!H39","v":0}]

{"sheet":"Dermal Exposure","index":6,"n_rows":11,"n_cols":18,"rows_kept":11,"cut":false,"hidden":false,"merged":[[0,0,0,8],[3,17,5,17],[3,12,5,12],[3,8,5,8],[3,3,5,3],[3,4,5,4],[2,0,2,5],[8,0,8,5],[2,6,2,12],[3,7,5,7],[2,13,2,16],[3,14,4,14],[3,16,4,16],[3,10,5,10],[3,11,5,11],[3,6,5,6],[3,13,4,13],[3,9,5,9],[3,15,4,15]]}
[]
[]
["For Dashboard",null,null,null,null,null,"Dermal Calculation Numbers",null,null,null,null,null,null,"Calculated Doses"]
[null,null,null,"Exposure Category","Exposure Level",null,"Max Yderm","Calculated Fraction Absorbed, Fabs","Exposure Frequency (EF)\n(days/yr)","Exposure Frequency (FT)\n(event/day)","2-Hand Surface Area (cm2)","Body Weight (kg)","Quantity Remaining on Skin (Qu) \n(mg/cm2-event)","Potential Dose Rate","Acute Retained Dose","Chronic Retained Dose, Non-Cancer","Chronic Retained Dose, Cancer","Notes"]
[]
["Look-up Name","Condition of Use ","Worker Type",null,null,"Bin",null,null,null,null,null,null,null,"APDRexp (mg/day)","ADD1,4-Dioxane (mg/kg-day)","CRD1,4-Dioxane (mg/kg-day)","CRD1,4-Dioxane (mg/kg-day)"]
[{"$f":"Dashboard!$C$5","v":"Repackaging (Bottle)"},{"$f":"VLOOKUP($A7,'Dermal Crosswalk'!$B$6:$J$16,2,FALSE)","v":"Repackaging"},{"$f":"Dashboard!$M$5","v":"Average Adult Worker"},"No Gloves","High End",{"$f":"VLOOKUP($A7,'Dermal Crosswalk'!$B$6:$J$16,3,FALSE)","v":1},{"$f":"VLOOKUP($A7,'Dermal Crosswalk'!$B$6:$J$16,4,FALSE)","v":1},{"$f":"VLOOKUP($A7,'Dermal Crosswalk'!$B$6:$J$16,9,FALSE)","v":0.78284413395563768},{"$f":"VLOOKUP($A7,'Inhalation Exposure'!$C$6:$G$19,MATCH($E7,'Inhalation Exposure'!$F$5:$G$5,0)+3,FALSE)","v":32},1,{"$f":"IF(E7=\"High End\",HLOOKUP($C7,'Exposure Factors'!$C$5:$D$11,4,FALSE),HLOOKUP($C7,'Exposure Factors'!$C$5:$D$11,3,FALSE))","v":1070},{"$f":"HLOOKUP($C7,'Exposure Factors'!$C$5:$D$11,2,FALSE)","v":80},2.1,{"$f":"IFERROR(K7*M7*H7*G7*J7,\"Not Assessed\")","v":1759.0507689983178},{"$f":"IFERROR($N7/L7,\"Not Assessed\")","v":21.988134612478973},{"$f":"IFERROR($O7*$I7*HLOOKUP($C7,'Exposure Factors'!$C$5:$D$11,MATCH($E7,'Exposure Factors'!$E$9:$E$10,0)+4,FALSE)/(260*HLOOKUP($C7,'Exposure Factors'!$C$5:$D$11,MATCH($E7,'Exposure Factors'!$E$9:$E$10,0)+4,FALSE)),\"Not Assessed\")","v":2.7062319523051044},{"$f":"IFERROR($O7*$I7*HLOOKUP($C7,'Exposure Factors'!$C$5:$D$11,MATCH($E7,'Exposure Factors'!$E$9:$E$10,0)+4,FALSE)/(260*HLOOKUP($C7,'Exposure Factors'!$C$5:$D$11,7,FALSE)),\"Not Assessed\")","v":1.3878112575923611}]
[{"$f":"Dashboard!$C$5","v":"Repackaging (Bottle)"},{"$f":"VLOOKUP($A8,'Dermal Crosswalk'!$B$6:$J$16,2,FALSE)","v":"Repackaging"},{"$f":"Dashboard!$M$5","v":"Average Adult Worker"},"No Gloves","Central Tendency",{"$f":"VLOOKUP($A8,'Dermal Crosswalk'!$B$6:$J$16,3,FALSE)","v":1},{"$f":"VLOOKUP($A8,'Dermal Crosswalk'!$B$6:$J$16,4,FALSE)","v":1},{"$f":"VLOOKUP($A8,'Dermal Crosswalk'!$B$6:$J$16,9,FALSE)","v":0.78284413395563768},{"$f":"VLOOKUP($A8,'Inhalation Exposure'!$C$6:$G$19,MATCH($E8,'Inhalation Exposure'!$F$5:$G$5,0)+3,FALSE)","v":3},1,{"$f":"IF(E8=\"High End\",HLOOKUP($C8,'Exposure Factors'!$C$5:$D$11,4,FALSE),HLOOKUP($C8,'Exposure Factors'!$C$5:$D$11,3,FALSE))","v":535},{"$f":"HLOOKUP($C8,'Exposure Factors'!$C$5:$D$11,2,FALSE)","v":80},1.4,{"$f":"IFERROR(K8*M8*H8*G8*J8,\"Not Assessed\")","v":586.35025633277257},{"$f":"IFERROR($N8/L8,\"Not Assessed\")","v":7.3293782041596574},{"$f":"IFERROR($O8*$I8*HLOOKUP($C8,'Exposure Factors'!$C$5:$D$11,MATCH($E8,'Exposure Factors'!$E$9:$E$10,0)+4,FALSE)/(260*HLOOKUP($C8,'Exposure Factors'!$C$5:$D$11,MATCH($E8,'Exposure Factors'!$E$9:$E$10,0)+4,FALSE)),\"Not Assessed\")","v":8.4569748509534512E-2},{"$f":"IFERROR($O8*$I8*HLOOKUP($C8,'Exposure Factors'!$C$5:$D$11,MATCH($E8,'Exposure Factors'!$E$9:$E$10,0)+4,FALSE)/(260*HLOOKUP($C8,'Exposure Factors'!$C$5:$D$11,7,FALSE)),\"Not Assessed\")","v":3.3611053894815002E-2}]
["For Risk Reduction (RR) Heat Map"]
[{"$f":"RR!$H$5","v":"Manufacturing"},{"$f":"VLOOKUP($A10,'Dermal Crosswalk'!$B$6:$J$16,2,FALSE)","v":"Manufacturing"},{"$f":"RR!$R$5","v":"Average Adult Worker"},"No Gloves","High End",{"$f":"VLOOKUP($A10,'Dermal Crosswalk'!$B$6:$J$16,3,FALSE)","v":1},{"$f":"VLOOKUP($A10,'Dermal Crosswalk'!$B$6:$J$16,4,FALSE)","v":1},{"$f":"VLOOKUP($A10,'Dermal Crosswalk'!$B$6:$J$16,9,FALSE)","v":0.78284413395563768},{"$f":"VLOOKUP($A10,'Inhalation Exposure'!$C$6:$G$19,MATCH($E10,'Inhalation Exposure'!$F$5:$G$5,0)+3,FALSE)","v":250},1,{"$f":"IF(E10=\"High End\",HLOOKUP($C10,'Exposure Factors'!$C$5:$D$11,4,FALSE),HLOOKUP($C10,'Exposure Factors'!$C$5:$D$11,3,FALSE))","v":1070},{"$f":"HLOOKUP($C10,'Exposure Factors'!$C$5:$D$11,2,FALSE)","v":80},2.1,{"$f":"IFERROR(K10*M10*H10*G10*J10,\"Not Assessed\")","v":1759.0507689983178},{"$f":"IFERROR($N10/L10,\"Not Assessed\")","v":21.988134612478973},{"$f":"IFERROR($O10*$I10*HLOOKUP($C10,'Exposure Factors'!$C$5:$D$11,MATCH($E10,'Exposure Factors'!$E$9:$E$10,0)+4,FALSE)/(260*HLOOKUP($C10,'Exposure Factors'!$C$5:$D$11,MATCH($E10,'Exposure Factors'!$E$9:$E$10,0)+4,FALSE)),\"Not Assessed\")","v":21.14243712738363},{"$f":"IFERROR($O10*$I10*HLOOKUP($C10,'Exposure Factors'!$C$5:$D$11,MATCH($E10,'Exposure Factors'!$E$9:$E$10,0)+4,FALSE)/(260*HLOOKUP($C10,'Exposure Factors'!$C$5:$D$11,7,FALSE)),\"Not Assessed\")","v":10.842275449940322}]
[{"$f":"RR!$H$5","v":"Manufacturing"},{"$f":"VLOOKUP($A11,'Dermal Crosswalk'!$B$6:$J$16,2,FALSE)","v":"Manufacturing"},{"$f":"RR!$R$5","v":"Average Adult Worker"},"No Gloves","Central Tendency",{"$f":"VLOOKUP($A11,'Dermal Crosswalk'!$B$6:$J$16,3,FALSE)","v":1},{"$f":"VLOOKUP($A11,'Dermal Crosswalk'!$B$6:$J$16,4,FALSE)","v":1},{"$f":"VLOOKUP($A11,'Dermal Crosswalk'!$B$6:$J$16,9,FALSE)","v":0.78284413395563768},{"$f":"VLOOKUP($A11,'Inhalation Exposure'!$C$6:$G$19,MATCH($E11,'Inhalation Exposure'!$F$5:$G$5,0)+3,FALSE)","v":250},1,{"$f":"IF(E11=\"High End\",HLOOKUP($C11,'Exposure Factors'!$C$5:$D$11,4,FALSE),HLOOKUP($C11,'Exposure Factors'!$C$5:$D$11,3,FALSE))","v":535},{"$f":"HLOOKUP($C11,'Exposure Factors'!$C$5:$D$11,2,FALSE)","v":80},1.4,{"$f":"IFERROR(K11*M11*H11*G11*J11,\"Not Assessed\")","v":586.35025633277257},{"$f":"IFERROR($N11/L11,\"Not Assessed\")","v":7.3293782041596574},{"$f":"IFERROR($O11*$I11*HLOOKUP($C11,'Exposure Factors'!$C$5:$D$11,MATCH($E11,'Exposure Factors'!$E$9:$E$10,0)+4,FALSE)/(260*HLOOKUP($C11,'Exposure Factors'!$C$5:$D$11,MATCH($E11,'Exposure Factors'!$E$9:$E$10,0)+4,FALSE)),\"Not Assessed\")","v":7.0474790424612088},{"$f":"IFERROR($O11*$I11*HLOOKUP($C11,'Exposure Factors'!$C$5:$D$11,MATCH($E11,'Exposure Factors'!$E$9:$E$10,0)+4,FALSE)/(260*HLOOKUP($C11,'Exposure Factors'!$C$5:$D$11,7,FALSE)),\"Not Assessed\")","v":2.8009211579012496}]

{"sheet":"Dermal Crosswalk","index":7,"n_rows":16,"n_cols":18,"rows_kept":16,"cut":false,"hidden":false,"merged":[[2,10,2,13],[3,7,3,8],[3,5,3,6],[2,14,2,17],[0,0,0,12]]}
[]
[]
[null,null,null,null,null,null,null,null,null,null,"Calculated High-End Doses",null,null,null,"Calculated Central Tendency Doses"]
[null,null,null,null,null,"High-End",null,"Central Tendency",null,null,"Potential Dose Rate","Acute Retained Dose","Chronic Retained Dose, Non-Cancer","Chronic Retained Dose, Cancer","Potential Dose Rate","Acute Retained Dose","Chronic Retained Dose, Non-Cancer","Chronic Retained Dose, Cancer"]
["OES","Look-up Name","Condition of Use ","Bin","Max Yderm","Qu (mg/cm2-event)","Surface Area (cm2)","Qu (mg/cm2-event)","Surface Area (cm2)","Fraction Absorbed, fabs","APDRexp (mg/day)","ARD1,4-Dioxane (mg/kg-day)","CRD1,4-Dioxane (mg/kg-day)","CRD1,4-Dioxane (mg/kg-day)","APDRexp (mg/day)","ARD1,4-Dioxane (mg/kg-day)","CRD1,4-Dioxane (mg/kg-day)","CRD1,4-Dioxane (mg/kg-day)"]
[1,"Manufacturing","Manufacturing",1,1,2.1,{"$f":"'Exposure Factors'!$C$8","v":1070},1.4,{"$f":"'Exposure Factors'!$C$7","v":535},0.78284413395563768,{"$f":"F6*G6*$E6*$J6","v":1759.0507689983178},{"$f":"K6/BW_default","v":21.988134612478973},{"$f":"(L6*VLOOKUP($A6,'Inhalation Exposure'!$B$6:$F$19,5,FALSE)*WY_HE_default)/(EF*WY_HE_default)","v":21.14243712738363},{"$f":"(L6*VLOOKUP($A6,'Inhalation Exposure'!$B$6:$F$19,5,FALSE)*WY_HE_default)/(EF*LT)","v":10.842275449940322},{"$f":"H6*I6*$E6*$J6","v":586.35025633277257},{"$f":"O6/BW_default","v":7.3293782041596574},{"$f":"(P6*VLOOKUP($A6,'Inhalation Exposure'!$B$6:$G$19,6,FALSE)*WY_CT_default)/(EF*WY_CT_default)","v":7.0474790424612088},{"$f":"(P6*VLOOKUP($A6,'Inhalation Exposure'!$B$6:$G$19,6,FALSE)*WY_CT_default)/(EF*LT)","v":2.8009211579012496}]
["2a","Repackaging (Bottle)","Repackaging",1,1,2.1,{"$f":"'Exposure Factors'!$C$8","v":1070},1.4,{"$f":"'Exposure Factors'!$C$7","v":535},0.78284413395563768,{"$f":"F7*G7*$E7*$J7","v":1759.0507689983178},21.988134612478973,{"$f":"(L7*VLOOKUP($A7,'Inhalation Exposure'!$B$6:$F$19,5,FALSE)*WY_HE_default)/(EF*WY_HE_default)","v":2.7062319523051044},{"$f":"(L7*VLOOKUP($A7,'Inhalation Exposure'!$B$6:$F$19,5,FALSE)*WY_HE_default)/(EF*LT)","v":1.3878112575923611},{"$f":"H7*I7*$E7*$J7","v":586.35025633277257},7.3293782041596574,{"$f":"(P7*VLOOKUP($A7,'Inhalation Exposure'!$B$6:$G$19,6,FALSE)*WY_CT_default)/(EF*WY_CT_default)","v":8.4569748509534512E-2},{"$f":"(P7*VLOOKUP($A7,'Inhalation Exposure'!$B$6:$G$19,6,FALSE)*WY_CT_default)/(EF*LT)","v":3.3611053894815002E-2}]
["2b","Repackaging (Drum)","Repackaging",1,1,2.1,{"$f":"'Exposure Factors'!$C$8","v":1070},1.4,{"$f":"'Exposure Factors'!$C$7","v":535},0.78284413395563768,1759.0507689983178,21.988134612478973,{"$f":"(L8*VLOOKUP($A8,'Inhalation Exposure'!$B$6:$F$19,5,FALSE)*WY_HE_default)/(EF*WY_HE_default)","v":4.9050454135530011},{"$f":"(L8*VLOOKUP($A8,'Inhalation Exposure'!$B$6:$F$19,5,FALSE)*WY_HE_default)/(EF*LT)","v":2.5154079043861541},586.35025633277257,7.3293782041596574,{"$f":"(P8*VLOOKUP($A8,'Inhalation Exposure'!$B$6:$G$19,6,FALSE)*WY_CT_default)/(EF*WY_CT_default)","v":0.16913949701906902},{"$f":"(P8*VLOOKUP($A8,'Inhalation Exposure'!$B$6:$G$19,6,FALSE)*WY_CT_default)/(EF*LT)","v":6.7222107789630003E-2}]
[3,"Industrial Use","Industrial Use",1,1,2.1,{"$f":"'Exposure Factors'!$C$8","v":1070},1.4,{"$f":"'Exposure Factors'!$C$7","v":535},0.78284413395563768,1759.0507689983178,21.988134612478973,{"$f":"(L9*VLOOKUP($A9,'Inhalation Exposure'!$B$6:$F$19,5,FALSE)*WY_HE_default)/(EF*WY_HE_default)","v":21.14243712738363},{"$f":"(L9*VLOOKUP($A9,'Inhalation Exposure'!$B$6:$F$19,5,FALSE)*WY_HE_default)/(EF*LT)","v":10.842275449940322},586.35025633277257,7.3293782041596574,{"$f":"(P9*VLOOKUP($A9,'Inhalation Exposure'!$B$6:$G$19,6,FALSE)*WY_CT_default)/(EF*WY_CT_default)","v":7.0474790424612088},{"$f":"(P9*VLOOKUP($A9,'Inhalation Exposure'!$B$6:$G$19,6,FALSE)*WY_CT_default)/(EF*LT)","v":2.8009211579012496}]
[10,"Disposal","Disposal",1,1,2.1,{"$f":"'Exposure Factors'!$C$8","v":1070},1.4,{"$f":"'Exposure Factors'!$C$7","v":535},0.78284413395563768,1759.0507689983178,21.988134612478973,{"$f":"(L10*VLOOKUP($A10,'Inhalation Exposure'!$B$6:$F$19,5,FALSE)*WY_HE_default)/(EF*WY_HE_default)","v":21.14243712738363},{"$f":"(L10*VLOOKUP($A10,'Inhalation Exposure'!$B$6:$F$19,5,FALSE)*WY_HE_default)/(EF*LT)","v":10.842275449940322},586.35025633277257,7.3293782041596574,{"$f":"(P10*VLOOKUP($A10,'Inhalation Exposure'!$B$6:$G$19,6,FALSE)*WY_CT_default)/(EF*WY_CT_default)","v":7.0474790424612088},{"$f":"(P10*VLOOKUP($A10,'Inhalation Exposure'!$B$6:$G$19,6,FALSE)*WY_CT_default)/(EF*LT)","v":2.8009211579012496}]
[4,"Open System Functional Fluids","Open System Functional Fluids",2,1E-3,2.1,{"$f":"'Exposure Factors'!$C$8","v":1070},1.4,{"$f":"'Exposure Factors'!$C$7","v":535},0.78284413395563768,1.7590507689983177,2.198813461247897E-2,{"$f":"(L11*VLOOKUP($A11,'Inhalation Exposure'!$B$6:$F$19,5,FALSE)*WY_HE_default)/(EF*WY_HE_default)","v":2.1142437127383625E-2},{"$f":"(L11*VLOOKUP($A11,'Inhalation Exposure'!$B$6:$F$19,5,FALSE)*WY_HE_default)/(EF*LT)","v":1.0842275449940321E-2},0.5863502563327726,7.3293782041596572E-3,{"$f":"(P11*VLOOKUP($A11,'Inhalation Exposure'!$B$6:$G$19,6,FALSE)*WY_CT_default)/(EF*WY_CT_default)","v":7.0474790424612088E-3},{"$f":"(P11*VLOOKUP($A11,'Inhalation Exposure'!$B$6:$G$19,6,FALSE)*WY_CT_default)/(EF*LT)","v":2.8009211579012494E-3}]
[6,"Lab Chemicals","Lab Chemicals",3,1,2.1,{"$f":"'Exposure Factors'!$C$8","v":1070},1.4,{"$f":"'Exposure Factors'!$C$7","v":535},0.85639576624888991,1924.3212867612556,24.054016084515695,{"$f":"(L12*VLOOKUP($A12,'Inhalation Exposure'!$B$6:$F$19,5,FALSE)*WY_HE_default)/(EF*WY_HE_default)","v":23.128861619726628},{"$f":"(L12*VLOOKUP($A12,'Inhalation Exposure'!$B$6:$F$19,5,FALSE)*WY_HE_default)/(EF*LT)","v":11.860954676782887},641.44042892041853,8.0180053615052316,{"$f":"(P12*VLOOKUP($A12,'Inhalation Exposure'!$B$6:$G$19,6,FALSE)*WY_CT_default)/(EF*WY_CT_default)","v":7.709620539908876},{"$f":"(P12*VLOOKUP($A12,'Inhalation Exposure'!$B$6:$G$19,6,FALSE)*WY_CT_default)/(EF*LT)","v":3.0640799581689122}]
[8,"Use of Printing Inks","Use of Printing Inks",3,1,2.1,{"$f":"'Exposure Factors'!$C$8","v":1070},1.4,{"$f":"'Exposure Factors'!$C$7","v":535},0.85639576624888991,1924.3212867612556,24.054016084515695,{"$f":"(L13*VLOOKUP($A13,'Inhalation Exposure'!$B$6:$F$19,5,FALSE)*WY_HE_default)/(EF*WY_HE_default)","v":23.128861619726628},{"$f":"(L13*VLOOKUP($A13,'Inhalation Exposure'!$B$6:$F$19,5,FALSE)*WY_HE_default)/(EF*LT)","v":11.860954676782887},641.44042892041853,8.0180053615052316,{"$f":"(P13*VLOOKUP($A13,'Inhalation Exposure'!$B$6:$G$19,6,FALSE)*WY_CT_default)/(EF*WY_CT_default)","v":7.709620539908876},{"$f":"(P13*VLOOKUP($A13,'Inhalation Exposure'!$B$6:$G$19,6,FALSE)*WY_CT_default)/(EF*LT)","v":3.0640799581689122}]
[5,"Spray Foam Application","Spray Foam Application",4,1E-3,2.1,{"$f":"'Exposure Factors'!$C$8","v":1070},1.4,{"$f":"'Exposure Factors'!$C$7","v":535},0.85639576624888991,1.9243212867612556,2.4054016084515694E-2,{"$f":"(L14*VLOOKUP($A14,'Inhalation Exposure'!$B$6:$F$19,5,FALSE)*WY_HE_default)/(EF*WY_HE_default)","v":2.3128861619726628E-2},{"$f":"(L14*VLOOKUP($A14,'Inhalation Exposure'!$B$6:$F$19,5,FALSE)*WY_HE_default)/(EF*LT)","v":1.1860954676782887E-2},0.64144042892041853,8.0180053615052319E-3,{"$f":"(P14*VLOOKUP($A14,'Inhalation Exposure'!$B$6:$G$19,6,FALSE)*WY_CT_default)/(EF*WY_CT_default)","v":7.7096205399088766E-3},{"$f":"(P14*VLOOKUP($A14,'Inhalation Exposure'!$B$6:$G$19,6,FALSE)*WY_CT_default)/(EF*LT)","v":3.0640799581689126E-3}]
[7,"Film Cement","Film Cement",5,0.5,2.1,{"$f":"'Exposure Factors'!$C$8","v":1070},1.4,{"$f":"'Exposure Factors'!$C$7","v":535},0.85639576624888991,962.16064338062779,12.027008042257847,{"$f":"(L15*VLOOKUP($A15,'Inhalation Exposure'!$B$6:$F$19,5,FALSE)*WY_HE_default)/(EF*WY_HE_default)","v":11.564430809863314},{"$f":"(L15*VLOOKUP($A15,'Inhalation Exposure'!$B$6:$F$19,5,FALSE)*WY_HE_default)/(EF*LT)","v":5.9304773383914435},320.72021446020926,4.0090026807526158,{"$f":"(P15*VLOOKUP($A15,'Inhalation Exposure'!$B$6:$G$19,6,FALSE)*WY_CT_default)/(EF*WY_CT_default)","v":3.854810269954438},{"$f":"(P15*VLOOKUP($A15,'Inhalation Exposure'!$B$6:$G$19,6,FALSE)*WY_CT_default)/(EF*LT)","v":1.5320399790844561}]
[9,"Dry Film Lubricant","Dry Film Lubricant",6,1,2.1,{"$f":"'Exposure Factors'!$C$8","v":1070},1.4,{"$f":"'Exposure Factors'!$C$7","v":535},0.78284413395563768,1759.0507689983178,21.988134612478973,{"$f":"(L16*VLOOKUP($A16,'Inhalation Exposure'!$B$6:$F$19,5,FALSE)*WY_HE_default)/(EF*WY_HE_default)","v":4.735905916533933},{"$f":"(L16*VLOOKUP($A16,'Inhalation Exposure'!$B$6:$F$19,5,FALSE)*WY_HE_default)/(EF*LT)","v":2.4286697007866325},586.35025633277257,7.3293782041596574,{"$f":"(P16*VLOOKUP($A16,'Inhalation Exposure'!$B$6:$G$19,6,FALSE)*WY_CT_default)/(EF*WY_CT_default)","v":1.5786353055113107},{"$f":"(P16*VLOOKUP($A16,'Inhalation Exposure'!$B$6:$G$19,6,FALSE)*WY_CT_default)/(EF*LT)","v":0.62740633936987988}]

{"sheet":"Inhalation Exposure","index":8,"n_rows":37,"n_cols":19,"rows_kept":37,"cut":false,"hidden":false,"merged":[[13,30,16,30],[13,28,16,28],[13,29,16,29],[2,13,2,14],[3,7,3,8],[3,9,3,10],[3,11,3,12],[3,13,3,14],[2,7,2,8],[2,9,2,10],[2,11,2,12],[0,0,0,15],[3,29,5,29],[3,30,5,30],[3,28,5,28],[2,5,2,6],[3,5,3,6]]}
[]
[]
[null,null,null,null,null,"Exposure Frequency",null,"Eight Hour  TWA Exposures",null,"24-hr Acute Exposures",null,"Chronic, Non-Cancer Exposures",null,"Chronic, Cancer Exposures"]
[null,null,null,null,null,"(day/yr)",null,"C8-hr TWA (mg/m3)",null,"AEC24-hr TWA (mg/m3)",null,"ADC8-hr TWA (mg/m3)",null,"LADC8-hr TWA (mg/m3)"]
[null,"OES Group","Condition of Use","Category","Exposure Scenario","High End","Central Tendency","High End","Central Tendency","High End","Central Tendency","High End","Central Tendency","High End","Central Tendency","8 hr Data Points","Total Datapoints","Sources & Notes","Data Type"]
[null,1,"Manufacturing","Worker","8-hr",250,250,7.7344999999999988,0.41500000000000004,null,null,7.4370192307692298,0.39903846153846162,3.8138560157790922,0.15859220907297833,30,30,"BASF, 2017; BASF, 2016","Monitoring Data"]
[null,"2a","Repackaging (Bottle)","Worker","8-hr",32,3,33.110907137861894,9.2841377990776905,null,null,3.3945543040684436,0.46327653032639138,1.319318871042662,0.17541188791086573,"N/A","N/A","Monte Carlo Simulation results","Modeled Data"]
[null,"2b","Repackaging (Drum)","Worker","8-hr",58,6,38.153046974438951,10.647307074712439,null,null,3.3945543040684436,0.46327653032639138,1.319318871042662,0.17541188791086573,"N/A","N/A","Monte Carlo Simulation results","Modeled Data"]
[null,3,"Industrial Use","Worker","8-hr",250,250,20,5,null,null,{"$f":"H9*ED_8*F9*WY_high/AT_ADC_high","v":19.23076923076923},{"$f":"I9*ED_8*G9*WY_mid/AT_ADC_mid","v":4.8076923076923075},{"$f":"H9*ED_8*F9*WY_high/AT_LADC","v":9.8619329388560164},{"$f":"I9*ED_8*G9*WY_mid/AT_LADC","v":1.9107495069033531},"<293","<294","EU, 2002","Monitoring Data"]
[null,4,"Open System Functional Fluids","Worker","8-hr",250,250,3.7913941227932057E-3,1.0657646879348654E-3,null,null,3.6455712719165442E-3,1.0247737383989092E-3,1.4531958901607197E-3,3.8759291232858461E-4,"N/A","N/A","Monte Carlo Simulation results","Modeled Data"]
[null,4,"Open System Functional Fluids","ONU","8-hr",250,250,2.51625E-4,1.4918750000000001E-4,null,null,{"$f":"H11*ED_8*F11*WY_high/AT_ADC_high","v":2.4194711538461536E-4},{"$f":"I11*ED_8*G11*WY_mid/AT_ADC_mid","v":1.4344951923076925E-4},{"$f":"H11*ED_8*F11*WY_high/AT_LADC","v":1.2407544378698225E-4},{"$f":"I11*ED_8*G11*WY_mid/AT_LADC","v":5.7011988412228807E-5},5,5,"Area monitoring data","Monitoring Data"]
[null,5,"Spray Foam Application","Worker","8-hr",250,250,1.181854675892919E-2,9.7280545033647161E-3,null,null,1.1363987268201144E-2,9.3538985609276093E-3,5.2547653957109352E-3,3.6296665110535967E-3,"N/A","N/A","Monte Carlo Simulation results","Modeled Data"]
[null,5,"Spray Foam Application","ONU","8-hr",250,250,1.8749999999999999E-3,1.8749999999999999E-3,null,null,{"$f":"H13*ED_8*F13*WY_high/AT_ADC_high","v":1.8028846153846155E-3},{"$f":"I13*ED_8*G13*WY_mid/AT_ADC_mid","v":1.8028846153846155E-3},{"$f":"H13*ED_8*F13*WY_high/AT_LADC","v":9.2455621301775143E-4},{"$f":"I13*ED_8*G13*WY_mid/AT_LADC","v":7.1653106508875737E-4},"N/A","N/A","What-if exposures based on OSHA PNOR PEL adjusted for dioxane weight fraction.","Modeled Data"]
[null,6,"Lab Chemicals","Worker","8-hr",250,250,5.7493749999999997,0.11,null,null,5.5282451923076925,0.10576923076923077,2.8349975345167655,4.2036489151873767E-2,334,335,"EU, 2002","Monitoring Data"]
[null,7,"Film Cement","Worker","8-hr",250,250,2.807291666666667,1.5218750000000001,null,null,{"$f":"H15*ED_8*F15*WY_high/AT_ADC_high","v":2.6993189102564106},{"$f":"I15*ED_8*G15*WY_mid/AT_ADC_mid","v":1.4633413461538463},{"$f":"H15*ED_8*F15*WY_high/AT_LADC","v":1.3842661078238003},{"$f":"I15*ED_8*G15*WY_mid/AT_LADC","v":0.58158438116370814},4,5,"NIOSH, 1982","Monitoring Data"]
[null,7,"Film Cement","ONU","8-hr",250,250,0.10416666666666667,0.10416666666666667,null,null,0.10016025641025642,0.10016025641025642,5.1364234056541752E-2,3.9807281393819859E-2,1,1,"NIOSH, 1982","Monitoring Data"]
[null,8,"Use of Printing Inks","Worker","8-hr",250,250,9.7200000000000009E-2,9.7200000000000009E-2,null,null,9.3461538461538457E-2,9.3461538461538471E-2,4.7928994082840237E-2,3.7144970414201187E-2,"Unknown","Unknown","Ryand and Hubbard, 2016","Monitoring Data"]
[null,9,"Dry Film Lubricant","Worker","8-hr",56,56,1.6019999999999994,0.46800000000000003,null,null,0.34504615384615372,0.10080000000000001,0.17694674556213011,4.0061538461538468E-2,7,15,"KCNSC, 2018. 15 PBZ samples, from which 7 8-hr TWAs are derived.","Monitoring Data"]
[null,10,"Disposal","Worker","8-hr",250,250,6.6429099270708836,1.8718116628854526,null,null,6.3874133914143121,1.7998189066206274,2.5401266896461454,0.67983486168931362,"N/A","N/A","Monte Carlo Simulation results","Modeled Data"]
[]
[]
[]
[null,null,null,null,null,null,null,null,null,null,null,null,1000,"CT","HE"]
[null,null,null,null,null,null,null,null,null,null,null,"Manufacturing","Worker",{"$f":"O6*$M$23","v":158.59220907297833},{"$f":"N6*$M$23","v":3813.8560157790921}]
[null,null,null,null,null,null,null,null,null,null,null,"Repackaging (Bottle)","Worker",175.41188791086574,1319.3188710426621]
[null,null,null,null,null,null,null,null,null,null,null,"Repackaging (Drum)","Worker",175.41188791086574,1319.3188710426621]
[null,null,null,null,null,null,null,null,null,null,null,"Industrial Use","Worker",1910.749506903353,9861.9329388560163]
[null,null,null,null,null,null,null,null,null,null,null,"Open System Functional Fluids","Worker",0.38759291232858462,1.4531958901607196]
[null,null,null,null,null,null,null,null,null,null,null,"Open System Functional Fluids","ONU",5.7011988412228806E-2,0.12407544378698225]
[null,null,null,null,null,null,null,null,null,null,null,"Spray Foam Application","Worker",3.6296665110535966,5.254765395710935]
[null,null,null,null,null,null,null,null,null,null,null,"Spray Foam Application","ONU",0.71653106508875741,0.92455621301775148]
[null,null,null,null,null,null,null,null,null,null,null,"Lab Chemicals","Worker",42.036489151873766,2834.9975345167654]
[null,null,null,null,null,null,null,null,null,null,null,"Film Cement","Worker",581.58438116370814,1384.2661078238004]
[null,null,null,null,null,null,null,null,null,null,null,"Film Cement","ONU",39.807281393819856,51.364234056541754]
[null,null,null,null,null,null,null,null,null,null,null,"Use of Printing Inks","Worker",37.14497041420119,47.928994082840234]
[null,null,null,null,null,null,null,null,null,null,null,"Dry Film Lubricant","Worker",40.061538461538468,176.9467455621301]
[null,null,null,null,null,null,null,null,null,null,null,"Disposal","Worker",679.83486168931358,2540.1266896461452]

{"sheet":"List Values","index":9,"n_rows":36,"n_cols":11,"rows_kept":36,"cut":false,"hidden":false,"merged":[[0,0,0,7]]}
[]
[]
[null,"Conditions of Use",null,null,"Exposure Data Types",null,null,"Dermal Exposure Scenario"]
[null,"Manufacturing",null,null,"Monitoring Data",null,null,5]
[null,"Repackaging (Bottle)",null,null,"Modeled Data",null,null,10]
[null,"Repackaging (Drum)",null,null,null,null,null,20]
[null,"Industrial Use"]
[null,"Open System Functional Fluids",null,null,"Worker Type"]
[null,"Spray Foam Application",null,null,"Average Adult Worker"]
[null,"Lab Chemicals",null,null,"Woman of Childbearing Age",null,null,"Exposure Type"]
[null,"Film Cement",null,null,null,null,null,"Worker"]
[null,"Use of Printing Inks",null,null,null,null,null,"ONU"]
[null,"Dry Film Lubricant"]
[null,"Disposal",null,null,"BMDL Percentile"]
[null,null,null,null,0.5,null,null,"1,4-Dioxane"]
[null,null,null,null,0.99]
[null,null,null,null,null,null,null,"MW",88.1,"g/mol"]
[null,null,null,null,"Assigned Protection Factor",null,null,"Molar Volume",24.45,"L/mol"]
[null,null,null,null,10]
[null,null,null,null,25,null,null,"OSHA PEL",100,"ppm"]
[null,null,null,null,50,null,null,null,{"$f":"I20/I18*MW","v":360.32719836400815},"mg/m3"]
[null,null,null,null,1000]
[null,null,null,null,10000,null,null,"Unit Conversions"]
[null,null,null,null,null,null,null,"Micrograms to milligrams",1000,"μg/mg"]
[]
[null,null,null,null,null,null,null,"Parameter Name","Symbol","Value","Unit"]
[null,null,null,null,null,null,null,"Exposure Duration (8-hr)","ED_8",8,"hr/day "]
[null,null,null,null,null,null,null,"Exposure Duration (12-hr)","ED_12",12,"hr/day "]
[null,null,null,null,null,null,null,"Acute Exposure Averaging Time","AT",24,"hr/day "]
[null,null,null,null,null,null,null,"Exposure Frequency ","EF",260,"day/yr "]
[null,null,null,null,null,null,null,"Working Years Per Lifetime (Mid)","WY_mid",31,"yr "]
[null,null,null,null,null,null,null,"Working Years Per Lifetime (High)","WY_high",40,"yr "]
[null,null,null,null,null,null,null,"Lifetime Years for LADC","LT",78,"yr "]
[null,null,null,null,null,null,null,"Averaging time For ADC (Mid)","AT_ADC_mid",{"$f":"WY_mid*EF*ED_8","v":64480},"hr "]
[null,null,null,null,null,null,null,"Averaging time For ADC (High)","AT_ADC_high",{"$f":"WY_high*EF*ED_8","v":83200},"hr "]
[null,null,null,null,null,null,null,"Averaging time For LADC","AT_LADC",{"$f":"LT*EF*ED_8","v":162240},"hr "]

{"sheet":"Exposure Factors","index":10,"n_rows":23,"n_cols":5,"rows_kept":23,"cut":false,"hidden":false,"merged":[[22,1,22,4],[11,1,11,4],[0,0,0,11]]}
[]
[]
[null,"Exposure Factors"]
[]
[null,null,"Average Adult Worker","Woman of Childbearing Age","Characterization of Value"]
[null,"Body Weight, BW (kg)",80,{"$f":"AVERAGE(65.9,71.9,74.8,77.1)","v":72.425000000000011}]
[null,"1 Hand Surface Area (cm2)",{"$f":"C8/2","v":535},{"$f":"D8/2","v":445},"Central Tendency"]
[null,"2 Hand Surface Area (cm2)",1070,890,"High End"]
[null,"Working Years - High-End (yr)",40,40,"High End"]
[null,"Working Years - Central Tendency (yr)",31,31,"Central Tendency"]
[null,"Lifetime",78,78]
[]
[]
[null,"Woman of Childbearing Age Exposure Factors:"]
[null,"Body Weight:"]
[null,"From the Exposure Factors Handbook Table 8-5: Mean and Percentile Body Weights (kg) for Females Derived from NHANES (1990-2006) (1)"]
[null,"Age 16 to <21 years: 65.9 kg (mean)"]
[null,"Age 21 to <30 years: 71.9 kg (mean)"]
[null,"Age 30 to <40 years: 74.8 kg (mean)"]
[null,"Age 40 to <50 years: 77.1 kg (mean)"]
[]
[]
[null,"(1) U.S. Environmental Protection Agency (EPA). (2011) Exposure Factors Handbook: 2011 Edition. National Center for Environmental Assessment, Washington, DC; EPA/600/R-09/052F. Available from the National Technical Information Service, Springfield, VA, and online at http://www.epa.gov/ncea/efh."]