Integrated Risk Information System (IRIS)

The Integrated Risk Information System (IRIS) is a human health assessment program that evaluates quantitative and qualitative risk information on effects that may result from exposure to environmental contaminants. IRIS was initially developed for EPA staff in response to a growing demand for consistent information on substances for use in risk assessments, decision-making, and regulatory activities. The information in IRIS is intended for those without extensive training in toxicology, but with some knowledge of health sciences.

Getting Started with IRIS

An overview of the web site What is IRIS? How does EPA decide which substances to add or update? More frequent questions >>

Using the IRIS Database

IRIS Process (2009 Update) Advanced Search in IRIS Compare IRIS Values Download IRIS

New Assessments and Reviews

The following documents are new assessments or under external Peer-Review at this time: More Recent Additions >> Substance Milestone Meeting/Release date Methanol External Peer-Review Draft Interagency Science Consultation Draft Listening Session 01/12/2010 01/12/2010 02/23/2010 Trichloroethylene External Peer-Review Draft Interagency Science Consultation Draft Listening Session 11/03/2009 11/03/2009 01/26/2010 Chloroprene External Peer-Review Draft Listening Session External Peer-Review Workshop 09/29/2009 11/23/2009 01/06/2010 Trichloroacetic Acid External Peer-Review Draft Interagency Science Consultation Draft Listening Session External Peer-Review Workshop 09/24/2009 10/14/2009 11/04/2009 12/10/2009 Cis-and Trans-1,2-Dichloroethylene External Peer-Review Draft Interagency Science Consultation Draft Listening Session External Peer-Review Workshop 09/24/2009 10/14/2009 10/19/2009 12/17/2009 1,1,2,2-Tetrachloroethane External Peer-Review Draft Listening Session External Peer-Review Workshop 09/24/2009 10/14/2009 01/27/2010 Hydrogen Cyanide and Cyanide Salts External Peer-Review Draft Listening Session External Peer-Review Workshop 09/23/2009 10/27/2009 12/14/2009 Ethyl Tertiary Butyl Ether External Peer-Review Draft Listening Session External Peer-Review Workshop 08/20/2009 10/07/2009 01/26/2010