Integrated Science Assessments (ISAs)

NOTICE: EPA is announcing the availability of the Integrated Science Assessment for Oxides of Nitrogen - Health Criteria (2016 Final Report) This report provides the EPA's evaluation and synthesis of the most policy-relevant science related to the health effects of gaseous oxides of nitrogen. It provides a critical part of the scientific foundation for the EPA's decision regarding the adequacy of the current primary (health-based) national ambient air quality standards for nitrogen dioxide.

EPA has set National Ambient Air Quality Standards (NAAQS) for six principal criteria air pollutants, which include:

Numerous sources emit these "criteria pollutants", which are considered harmful to public health and the environment. Since 2008, EPA’s Integrated Science Assessments (ISAs) have formed the scientific foundation for the review of the NAAQS standards. Prior to 2008, Air Quality Criteria Documents provided the scientific foundation for the NAAQS process; as part of a streamlining of the NAAQS process these documents were replaced by the ISAs. 

Calendar of Workshops and Meetings


Clean Air Scientific Advisory Committee (CASAC), which provides independent advice to EPA on the technical basis for the NAAQS, is the primarily reviewing authority for the ISAs.

The CASAC Calendar includes a complete list of past and future meeting details.