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Assessments for TSCA Work Plan Chemicals

N-Methylpyrrolidone (NMP)

March 23, 2015 - EPA released the final TSCA Work Plan Chemical Risk Assessment for N-Methylpyrrolidone (NMP). The NMP assessment identified acute and chronic health risks to people, particularly pregnant women and women of childbearing age, who who are exposed to paint and coating removal products containing high concentrations of NMP, but those risks could be minimized by using NMP-resistant gloves in well ventilated work areas to reduce exposure.

EPA is continuing its efforts to develop assessments for chemicals in the Toxic Substances Control Act (TSCA) Work Plan (PDF) (28 pp, 258 kb, About PDF).

See the TSCA Work Plan Chemicals webpage for background information.

This page explains the assessment process and provides the status of EPA’s ongoing assessments of chemicals on the TSCA Work Plan and assessment-related activities and documents.


EPA develops TSCA Work Plan Chemical assessments using the best available information and approaches. Assessments focus on those TSCA uses of the chemical with significant potential for exposure to humans and/or the environment. In some cases, EPA’s TSCA Work Plan Chemical assessments will address chemicals that are not on the TSCA Work Plan when it is advantageous to group and review related/similar chemicals together. For example, EPA may assess groups of structurally similar chemicals in order to support more informed decisions about alternative substances with similar properties and potential uses.

TSCA Work Plan Chemical Assessment Process

As a first step in evaluating TSCA Work Plan Chemicals, EPA performs problem formulation to determine if available data and current assessment approaches and tools will support the assessments. When a TSCA Work Plan Chemical has an existing EPA Hazard Characterization developed through the High Production Volume Challenge Program, it is supplemented as necessary and used in problem formulation along with other data and information available to EPA. If problem formulation indicates risks are not likely or that data are insufficient to conduct a risk assessment, the Agency may conclude its work on the chemical and post the analysis performed to make such a conclusion.

If problem formulation indicates the need to conduct a risk assessment, and there are enough data to do so, EPA will initiate a risk assessment which is the process to estimate the nature and probability of adverse health and environmental effects in humans and ecological receptors from chemical contaminants and other stressors that may be present in the environment.

Opportunities for Public Input

EPA issues draft risk assessments for public review and comment followed by independent peer review in accordance with Agency peer review guidelines. The Agency considers all public and peer review comments as it revises and finalizes the risk assessment. There are multiple opportunities for public input on peer review plans, chemical assessments, and opportunities to submit relevant data on assessments to the EPA docket. These opportunities for public input on chemicals may include:

Completed Chemical Assessments

To date, EPA has completed assessments for the TSCA Work Plan Chemicals listed below.

Ongoing Chemical Assessments

To date, EPA has initiated assessments for the TSCA Work Plan Chemicals listed below.

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