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Safer Chemicals Research

  • NOW AVAILABLE: NAMs Conference Report

    Read a summary report of EPA's 2024 New Approach Methods Conference. 

    Access Conference Materials
  • Toxicity Forecaster (ToxCast) Update

    The database containing ToxCast data (invitroDB) has recently been updated!

    ToxCast webpage

What is Safer Chemicals Research?

EPA’s Safer Chemicals Research is addressing the lack of sufficient information on chemicals needed to make informed, risk-based decisions. This high-quality, innovative research supports Agency, local, state, regional, and tribal decision-making and actions to protect human health and the environment. 

Hot Topics

  • EPA Transcriptomics Assessment Product (ETAP)
  • New Approach Methods (NAMs)Training
  • Per- and Polyfluoroalkyl (PFAS) Chemicals
  • 6PPD-quinone
  • Chemical Evaluation & Characterization

    Safer Chemicals researcher working in a laboratory in RTP, North Carolina.

    Learn how our researchers evaluate chemicals for health effects and develop predictive approaches for chemical safety evaluations.

    Chemical Evaluation & Characterization Research
  • Complex Systems Science

    Virtual Tissue Model Laboratory System Simulation

    Learn how our researchers study complex chemical interactions in biological systems.

    Complex Systems Science Research
  • Translation, Training, & Online Applications

    Team sitting around a table collaborating with a person virtually on a large screen in front of them.

    Learn about how we translate our research for decision making and develop training materials for computational toxicology tools and data.

    Research Translation, Training, & Tools
  • New Approach Methodologies Research

    Researchers look at computer images of painted cells

    Learn about EPA's commitment to reduce vertebrate animal testing via the New Approach Methods (NAMs) Work Plan and how Safer Chemicals researchers are contributing. 

    NAMs Research
  • Chemical Research to Inform Decision Making

    Child wearing a mask

    Learn about the chemicals and materials we are researching to inform decision making, such as PFAS and other contaminants of emerging concern.

    Chemical Research for Decision Making
  • Collaborative Agreements & Funding Opportunities

    Different hands coming together in the middle

    Access information on research funding opportunities, collaborative agreements, and more.

    Collaborations & Funding

Meet Our Researchers!

Ryan Lepak holding a trout.
Meet Safer Chemicals Researcher Ryan Lepak! 
Other Chemical Safety Researchers

Additional Resources

  • Chemical Safety for Sustainability National Research Program
  • Publications, Presentations, and Other Research Products
  • Chemical Regulation and Enforcement 
  • About the Office of Research and Development
  • Other EPA Research Topics

Safer Chemicals on Social Media

Contact Us to ask a question, provide feedback, or report a problem.
Last updated on March 24, 2025
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