Laws & Regulations
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Guidance on Cumulative Risk Assessment of Pesticide Chemicals that have a Common Mechanism of Toxicity
This document provides guidance to OPP scientists for evaluating and estimating the potential human risks associated with such multichemical and multipathway exposures to pesticides. This process is referred to as cumulative risk assessment.
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Consideration of the FQPA Safety Factor and Other Uncertainty Factors in Cumulative Risk Assessment of Chemicals Sharing a Common Mechanism of Toxicity
This guidance document provides OPP's current thinking on application of the provision in FFDCA about an additional safety factor for the protection of infants and children in the context of cumulative risk assessments.
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The Use of Data on Cholinesterase Inhibition for Risk Assessments of Organophosphorous and Carbamate Pesticides
This revised science policy emphasizes the weighing of all relevant evidence when selecting endpoints for the hazard assessment of anticholinesterase pesticides.
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Guidance for Considering and Using Open Literature Toxicity Studies to Support Human Health Risk Assessment
This guidance was developed to assist OPP scientists and is intended for use in OPP’s risk assessments. It is intended to ensure consistent consideration, use, and documentation of information in the open literature by OPP scientists and risk assessors.
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Guidance for Identifying Pesticide Chemicals and Other Substances that have a Common Mechanism Toxicity
Guidance for Identifying Pesticide Chemicals and Other Substances that have a Common Mechanism Toxicity
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Retrospective Analysis of the Immunotoxicity Study
This document forms part of the basis for the immunotoxicity study data waiver criteria. It is related to OCSPP Test Guideline 870.7800.
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Dinotefuran Petition and Response
Petition and response for Dinotefuran
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Carfentrazone-ethyl Petition and Response
Petition(s) and Response(s) for Carfentrazone-ethyl
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General Substantiation Questions to Support CBI Claims
General Questions and Answers Concerning Confidential Business Information (CBI) Provisions of the Toxic Substances Control Act (TSCA), as amended by the Frank R. Lautenberg Chemical Safety for the 21st Century Act
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Updates to the EPA List of Alternative Test Methods to Animal Testing
Listserv announcing updates to the list of Alternative Test Methods to Animal Testing
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Comment Period Extended for PV29 Revised Draft Risk Evaluation
Extension of the public comment period on the revised draft risk evaluation for C.I. Pigment Violet 29 (PV29).
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EPA Issues Final Guidance to Clarify PFAS Significant New Use Rule
Listserv announcing Final Guidance to Clarify PFAS Significant New Use Rule
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EPA Releases Final Chemical Risk Evaluation for TCE
Listserv announcing the final RE for TCE
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EPA Launches Stewardship Program to Reduce PFAS in the Marketplace
Listserv announcing PFAS LVE Stewardship Program
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EPA Launches New Electronic Reporting Application for TSCA Chemical Export Notifications
Listserv announcing a new electronic reporting application for chemical export notifications under TSCA
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EPA Releases Draft Revised Risk Determination for Methylene Chloride for Public Comment
this page has info on the release of the final unreasonable risk determination for HBCD
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EPA Seeks Public Input on Draft Guidance for PFAS Significant New Use Rule
Listserv announcing draft guidance for PFAS SNUR
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EPA Reopens Comment Period for Draft Revised Risk Determination for HBCD
announcement about extending comment period for the HBCD revised risk deterination
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EPA Opens Public Comment Period on Technical Updates to the Formaldehyde Emission Standards for Composite Wood Products
Listserv announcing public comment period on proposed technical updates to the Formaldehyde Emission Standards for Composite Wood Products rule.
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EPA Regulation of Bed Bug Pesticides
All pesticides must be registered by EPA before being sold and used in the U.S., other than those that rely on a limited set of active ingredients (so-called minimum risk pesticides). EPA reviews for safety and effectiveness.