Science & Technology

Benchmark Dose Technical Guidance

This document provides guidance on the application of the benchmark dose approach for determining the point of departure for health effects data.

Regional Issue's Paper for PCB Characterization

US EPA Region 4 Technical Services Section Issue Paper for PCBs.

Framework for Application of the Toxicity Equivalence Methodology for Polychlorinated Dioxins, Furans, and Biphenyls in Ecological Risk Assessment

This framework is intended to assist EPA scientists in using the toxicity equivalence methodology in ecological risk assessments that involve dioxins and dioxin-like chemicals.

Generic Ecological Assessment Endpoints (GEAE) for Ecological Risk Assessment

The purpose of this document is to build on existing EPA guidance and experience in ecological risk assessment and provide guidance to risk assessors involved in conducting an ecological assessment.

Guidance for Applying Quantitative Data to Develop Data-Derived Extrapolation Factors for Interspecies and Intraspecies Extrapolation

This document was developed to outline approaches to compensate for these uncertainties and to provide guidance for EPA staff in evaluating interspecies and intraspecies data.

Guidance for Evaluating and Documenting the Quality of Existing Scientific and Technical Information

Guidance for assessing and accepting existing scientific and technical information, and documenting the review and analysis of existing scientific and technical
information.

Methods for Derivation of Inhalation Reference Concentrations and Application of Inhalation Dosimetry

EPA's methodology for estimation of inhalation reference concentrations (RfCs) as benchmark estimates of the quantitative dose-response assessment of chronic noncancer toxicity for individual inhaled chemicals.

Supplemental Guidance for Assessing Susceptibility from Early-Life Exposure to Carcinogens

This Supplemental Guidance does not establish any substantive “rules” under the Administrative Procedure Act or any other law and has no binding effect on EPA or any regulated entity, but instead represents a non-binding statement of policy.

National Grants: 2008-2011 RFPs & Documents

These documents are the 2008-2011 requests for proposals (RFPs )and supporting documents.

Nutrient Pollution Module

Watershed Academy module: When Nutrients Pollute Our Waterways

Efficacy Requirements for Antimicrobial Pesticides

Pesticides designed to control microbial pests such as viruses and bacteria must have data proving their ability to kill these pests (known as efficacy). The guidance documents on this page describe current efficacy-related requirements.

Equipment Certifications at the Laboratory Services and Applied Science Division

Field Branches Quality System and Technical Procedures

Emissions Estimation Tools

EPA Reaches Settlement with Alabama Power Company to Address Compliance with Certain Coal Ash Regulations

Case is part of EPA’s larger initiative to protect communities from coal ash contamination

EPA News Release: EPA Reaches Settlement with Alabama Power Company to Address Compliance with Certain Coal Ash Regulations

Release Date: October 9, 2024