- the most common route of dosing used in toxicology studies
- the route least affected by factors (e.g., differences in respiratory physiology or skin thickness) which are unlikely to follow a clear relationship across species
The oral route is not the only exposure route for which cross-species scaling is of interest but, for the reasons just given, it is considered as the base case upon which further scaling relationships can be built to account for factors specific to other exposure routes.You may need a PDF reader to view some of the files on this page. See EPA’s About PDF page to learn more.
- Methods for Identifying a Default Cross-Species Scaling Factor (Rhomsberg, 2004) (PDF)(50 pp, 442 K, April 2, 2004 )