EPA’s Office of Pesticide Programs (OPP) has developed a strategic vision for implementing the 2007 NRC report on Toxicity Testing in the 21st Century. This strategic vision has multiple components involving a combination of computational and predictive modeling approaches, in vitro techniques, and limited, targeted in vivo testing, to supplement or replace the existing toxicity tests required in 40 CFR part 158 in support of pesticide registration. 

• Process for Evaluating & Implementing Alternative Approaches to Traditional in Vivo Acute Toxicity Studies for FIFRA Regulatory Use (PDF)(9 pp, 54 K, February 4, 2016)