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Significant New Alternatives Policy (SNAP)

Substitutes in Industrial Process Refrigeration

You may need a PDF reader to view some of the files on this page. See EPA’s About PDF page to learn more.Substitutes are reviewed on the basis of environmental and health risks, including factors such as ozone depletion potential, global warming potential, toxicity, flammability, and exposure potential. Lists of acceptableHelpacceptableThis designation means that a substitute may be used, without restriction, to replace the relevant ODS within the end-use specified. For example, HCFC-22 is an acceptable substitute for R-502 in industrial process refrigeration. Note that all SNAP determinations apply to the use of a specific product as a substitute for a specific ODS in a specific end-use. and unacceptableHelpUnacceptableThis designation means that it is illegal to use a product as a substitute for an ODS in a specific end-use. For example, HCFC-141b is an unacceptable substitute for CFC-11 in building chillers. Note that all SNAP determinations apply to the use of a specific product as a substitute for a specific ODS in a specific end-use. substitutes are updated several times each year. The list of substitutes is shown below.

Note: SNAP-related information published in the Federal Register takes precedence over all information on this page.

               
Substitute Trade Name(s) Retrofit/New ODPHelpODPA number that refers to the amount of ozone depletion caused by a substance. The ODP is the ratio of the impact on ozone of a chemical compared to the impact of a similar mass of CFC-11. Thus, the ODP of CFC-11 is defined to be 1.0. Other CFCs and HCFCs have ODPs that range from 0.01 to 1.0. The halons have ODPs ranging up to 10. Carbon tetrachloride has an ODP of 1.2, and methyl chloroform's ODP is 0.11. HFCs have zero ODP because they do not contain chlorine. A table of all ozone-depleting substances (https://www3.epa.gov/ozone/science/ods/index.html) shows their ODPs, GWPs, and CAS numbers. GWPHelpGWPThe index used to translate the level of emissions of various gases into a common measure in order to compare the relative radiative forcing of different gases without directly calculating the changes in atmospheric concentrations. GWPs are calculated as the ratio of the radiative forcing that would result from the emissions of one kilogram of a greenhouse gas to that from the emission of one kilogram of carbon dioxide over a period of time (usually 100 years). Gases involved in complex atmospheric chemical processes have not been assigned GWPs. See lifetime. ASHRAEHelpASHRAEASHRAE is an international organization that establishes standards for the uniform testing and rating of heating, ventilation, air conditioning, and refrigeration equipment. It also conducts related research, disseminates publications, and provides continuing education to its members.
Designation
(Safety
Classification)
SNAP Listing Date Listing Status
Ammonia Absorption   N 0 0 B2 September 5, 1996;
June 16, 2010
Acceptable
Ammonia Vapor Compression   N 0 0 B2 March 18, 1994;
September 5, 1996;
June 16, 2010
Acceptable
Chlorine   R/N N/A N/A A1 March 18, 1994 Acceptable
Desiccant Cooling   N 0 N/A N/A March 18, 1994;
June 16, 2010
Acceptable
Direct Nitrogen Expansion   N 0 0 A1 March 18, 1994;
June 16, 2010
Acceptable
Evaporative Cooling   N 0 N/A N/A March 18, 1994;
June 16, 2010
Acceptable
FOR12A FOR12A R/N 0 1,100 A1 December 18, 2000 Acceptable
FOR12B FOR12B R/N 0 1,000 A1 December 18, 2000 Acceptable
RB-276 Free Zone, HCFC Blend Delta R/N 0.013 1,592 A1 September 5, 1996 Acceptable
Freeze 12 Freeze 12 R/N 0.013 1,606 A1 September 5, 1996 Acceptable
R-416A FRIGC FR-12, HCFC Blend Beta R/N 0.009 1,081 A1 February 8, 1996;
February 24, 1998
Acceptable
G2018C G2018C R/N 0.053 1,731 A1 September 5, 1996 Acceptable
GHG-HP HCFC Blend Lambda R/N 0.056 1,893 A1 February 8, 1996 Acceptable
R-414A GHG-X4, Autofrost, Chill-it, HCFC Blend Xi R/N 0.045 1,478 A1 September 5, 1996 Acceptable
GHG-X5 GHG-X5 R/N 0.032 2,377 A1 June 3, 1997 Acceptable
HC Blend B Original formulation of HC-12a R/N 0 4 A3 January 13, 1995;
June 16, 2010
Acceptable
HC Blend A OZ-12 R/N 0 3 A3 March 18, 1994;
June 16, 2010
Acceptable
HCFC-123   R/N 0.02 77 A1 August 26, 1994 Acceptable
HCFC-22   R/N 0.055 1,810 A1 March 18, 1994 Acceptable
HCFC-22/HCFC-142b   R/N 0.055-0.065 1,810-2,310 A1 June 3, 1997 Acceptable
HFC-134a   R/N 0 1,430 A1 March 18, 1994;
June 16, 2010
Acceptable
HFC-134a/HBr (92/8)   N 0.0016 N/A A1 May 23, 2001 Acceptable
HFC-227ea   N 0 3,220 A1 March 18, 1994;
June 16, 2010
Acceptable with Use Conditions: When manufactured using any process that does not convert perfluoroisobutylene (PFIB) directly to HFC-236fa in a single step.
HFC-23   R/N 0 14,800 A1 August 26, 1994 Acceptable
HFC-236fa   R/N 0 9,810 A1 March 10, 1997 Acceptable
HFC-245fa Genetron® 245fa R/N 0 1,030 A1 March 29, 2006 Acceptable
HFE-347mcc3 (heptafluoropropyl methyl ether) Novec 7000 Engineered Fluid (HFE-7000) R/N 0 575 A1 March 22, 2002;
June 16, 2010
Acceptable
HFE-449s1 (methoxynonafluorobutane, iso and normal) Novec 7100 Engineered Fluid (HFE-7100)  N 0 297 A1 December 18, 2000;
June 16, 2010
Acceptable: Only acceptable for use as a secondary heat transfer fluid in not-in-kind systems.
HFE-569sf2 (ethoxynonafluorobutane, iso and normal) Novec™ 7200 Engineered Fluid (HFE-7200) N 0 59 N/A December 18, 2000;
June 16, 2010
Acceptable: Only acceptable for use as a secondary heat transfer fluid in not-in-kind systems.
R-414B Hot Shot, Kar Kool, HCFC Blend Omicron  R/N 0.098 3,337 A1 September 5, 1996 Acceptable
R-417C Hot Shot 2 R 0 1,820 A1 October 4, 2011 Acceptable
Ikon A Ikon-12, Blend Zeta N 0 N/A A1 June 19, 2000 Acceptable
Ikon B   R/N 0 N/A A1 December 6, 1999 Acceptable
NARM-502   R/N >0 N/A A1 September 5, 1996 Acceptable
R-125/R-134a/R-600a (28.1/70.0/1.9) NU-22 old composition R/N 0 1,990 A1 June 16, 2010 Acceptable
R-125/R-290/R-134a/R-600a (55.0/1.0/42.5/1.5) ICOR AT-22 R/N 0 2,530 A1 March 29, 2006;
June 16, 2010
Acceptable
R-1270 (Propylene)   R/N 0 5 A3 March 18, 1994;
June 16, 2010
Acceptable
R-290 (Propane)   R/N 0 3 A3 March 18, 1994;
June 16, 2010
Acceptable
R-401A SUVA MP-39 N 0.037 1,182 A1 January 13, 1995 Acceptable
R-401B SUVA MP-66 N 0.040 1,288 A1 January 13, 1995 Acceptable
R-402A HP-80 R/N 0.019 2,746 A1 March 18, 1994 Acceptable
R-402B HP-81 R/N 0.03 2,379 A1 March 18, 1994 Acceptable
R-403B ISCEON 69-L R/N 0.041 3,096 A1 August 26, 1994 Acceptable
R-404A SUVA HP-62 R/N 0 3,920 A1 March 18, 1994;
March 22, 2002
Acceptable
R-406A GHG-12, GHG-X3, McCool, Autofrost X3 R 0.057 1,900 A2 August 26, 1994 Acceptable
R-407A Klea 60, Klea 407A R/N 0 2,110 A1 August 26, 1994;
June 16, 2010
Acceptable
R-407B Klea 61 R/N 0 2,800 A1 August 26, 1994;
June 16, 2010
Acceptable
R-407C Suva 407C, Klea 407C R/N 0 1,770 A1 February 8, 1996;
December 20, 2002;
August 21, 2003
Acceptable
R-407F  Genetron Performax LT R/N 0 1,820 A1 October 4, 2011 Acceptable
R-408A  HCFC Blend Epsilon R 0.026 55 A1 August 26, 1994 Acceptable
R-410A AZ-20, Suva 9100, Puron N 0 2,090 A1 February 8, 1996;
December 20, 2002
Acceptable
R-410B   N 0 2,230 A1 February 8, 1996;
June 16, 2010
Acceptable
R-411A   R/N 0.048 1,600 A2 February 8, 1996 Acceptable
R-411B   R/N 0.052 1,700 A2 February 8, 1996 Acceptable
R-417A ISCEON 59, NU-22 R/N 0 2,350 A1 December 6, 1999;
December 18, 2000;
December 20, 2002;
June 16, 2010
Acceptable
R-420A Choice R-420A R/N 0.008 1,536 A1 October 1, 2004 Acceptable
R-421A Choice R-421A R/N 0 2,630 A1 September 28, 2006;
June 16, 2010
Acceptable
R-421B Choice R-421B R/N 0 3,190 A1 September 28, 2006;
June 16, 2010
Acceptable
R-422A ISCEON 79 R/N 0 3,140 A1 October 1, 2004 Acceptable
R-422B ICOR XAC1, NU-22B R/N 0 2,530 A1 March 29, 2006;
June 16, 2010
Acceptable
R-422C ICOR XLT1 R/N 0 3,390 A1 March 29, 2006;
June 16, 2010
Acceptable
R-422D ISCEON MO29 R/N 0 2,730 A1 September 28, 2006;
June 16, 2010
Acceptable
R-423A ISCEON 39TC R/N 0 2,280 A1 March 22, 2002;
June 16, 2010
Acceptable
R-424A RS-44 R/N 0 2,440 A1 September 28, 2006;
June 16, 2010
Acceptable
R-426A RS-24 R/N 0 1,510 A1 September 28, 2006;
June 16, 2010
Acceptable
R-427A Forane 427A R 0 2,140 A1 June 16, 2010 Acceptable
R-428A RS-52 N 0 3,610 A1 October 4, 2007;
June 16, 2010
Acceptable
R-434A RS-45 R/N 0 3,250 A1 October 4, 2007;
June 16, 2010
Acceptable
R-437A KDD6, ISCEON MO49 Plus R/N 0 1,810 A1 January 2, 2009 Acceptable
R-438A KDD5, ISCEON MO99 R/N 0 2,270 A1 October 4, 2007;
June 16, 2010
Acceptable
R-450A Solstice® N-13 R/N 0 601 A1 October 21, 2014 Acceptable
R-507, R-507A AZ-50 R/N 0 3,990 A1 March 18, 1994;
September 5, 1996;
December 20, 2002
Acceptable
R-508A Klea 5R3,  PFC Blend Alpha R/N 0 13,214 A1 July 28, 1995 Acceptable
R-508B Suva 95 R/N 0 13,396 A1 July 28, 1995 Acceptable
R-513A Opteon® XP 10 R/N 0 630 A1 July 16, 2015 Acceptable
R-600 (Butane)   R/N 0 3 A3 March 18, 1994;
June 16, 2010
Acceptable
R-744 (Carbon Dioxide, CO2)   R/N 0 1 A1 January 13, 1995;
June 16, 2010
Acceptable
RS-24 (2002 formulation)   R/N 0 1,510 A1 December 20, 2002;
June 16, 2010
Acceptable
RS-44 (2003 formulation)   R/N 0 2,420 A1 June 16, 2010 Acceptable
SP34E SP34E R/N 0 <1,470 A1 December 18, 2000 Acceptable
Stirling Cycle   N 0 N/A N/A March 18, 1994;
June 16, 2010
Acceptable
THR-02   R/N 0 N/A A1 December 6, 1999 Acceptable
THR-03   R/N 0 N/A A1 December 6, 1999 Acceptable
THR-04   R/N >0 N/A A1 June 8, 1999 Acceptable
R-448A Solstice® N-40 R/N 0 1,387 A1 July 21, 2017 Acceptable
R-449A Opteon® XP 40 R/N 0 1,400 A1 July 21, 2017 Acceptable
R-449B Forane® 449B R/N 0 1,412 A1 July 21, 2017 Acceptable
R-453A RS-70 R/N 0 1,770 A1 July 21, 2017 Acceptable
R-458A Bluon TdX 20 R/N 0 1,650 A1 July 21, 2017 Acceptable

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