Benchmark Dose Software (BMDS) Version 3 Release History
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Released February 2019
- Now compatible with all 32- and 64-bit versions of Excel released since 2007.
- Numerous UI improvements and enhancements:
- Moved the "Load Analysis" button from result workbooks into the main analysis workbook to provide better workflow and more robust behavior.
- When changing the output directory, BMDS will prompt whether to save the new directory as the default
- Added links to the Summary table so that clicking a model's name displays the model's individual model results tab
- Redesigned the Report Options tab to make the Export and Word Report Options boxes expandable
- Added the dose-response and variance model formulas to the individual model output pages
- Fixed issue with model selection and added a more informative message when BMDL=0
- Fixed issue where the Results Workbook summary table reported inappropriate recommendations for Bayesian models
- Fixed Multistage plots so the linear extrapolation line for the slope factorslope factorAn upper bound, approximating a 95% confidence limit, on the increased cancer risk from a lifetime exposure to an agent. This estimate, usually expressed in units of proportion (of a population) affected per mg/kg-day, is generally reserved for use in the low-dose region of the dose-response relationship, that is, for exposures corresponding to risks less than 1 in 100. goes to estimated background response, not zero
- Fixed a missing link for Model Averaging results
- Fixed issue with running a nested analysis with empty rows
- Fixed issue with Excel auto-adding secondary axis to plots
- Minor tweaks and updates to the user interface to enhance clarity and usability
- Added model and option set information to the "Running selected models" message box:
- Numerous programmatic improvements and enhancements:
- Fixed an issue with Akaike Informaton Criterion (AIC) derivation for continuous response models
- Fixed issue where "Added Risk" and BMRF=0.001 caused slow performance for Dichotomous Hill and Bayesian MA models
- Fixed issue with Test 3 and Individual Response Analysis for continuous models
- Fixed issue with continuous models Likelihood of Interest reporting incorrect number of parameters
- Fixed issue with continous models Test of Interest and p-values
- Fixed a problem with running BMDS from a network drive
- Fixed the Weibull model default parameter values and priors
- Fixed miscellaneous issues with the nested logistic model
- Fixed intermittent crashes with the Polynomial, Multistage and other models
- Resolved a problem with A3 and R log-likelihood values, which are used to measure goodness-of-fit
- Minor improvements
Released September 30, 2018.
- Implemented in Microsoft Excel, with modeling computations performed in custom DLLs.
- Fast analysis of multiple datasets and options
- Enables users to see and specify modeling options in a single worksheet
- Flexible documentation and report generation
- Includes auto-selection features for identifying the “best” results in accordance with EPA recommendations or user-defined logic
- Documents all inputs and outputs in a single results workbook for each dataset modeled
- Provides flexible print options for displaying results in Microsoft Word tables formatted in a manner suitable for presentation in a risk assessment
- Backwards compatible with prior BMDS versions
- Bayesian versions of all traditional frequentist dichotomous models
- Bayesian model averaging using all or weighted dichotomous models
- Hybrid approach added to all continuous models
- Lognormal response distribution added for all continuous models
All existing models have been re-coded to facilitate their maintenance and improve their performance in terms of stability, accuracy, reliability, and speed.