Laws & Regulations

TSCA Section 5(a)(3)(C) Determination for Premanufacture Numbers (PMN) P-21-0039, P-21-0040, P-21-0041

This document describes EPA's pre-manufacture notice review determination under amended TSCA for P-21-0039, P-21-0040, P-21-0041.

TSCA Section 5(a)(3)(C) Determination for Premanufacture Number (PMN) P-21-0103

This document describes EPA's pre-manufacture notice review determination under amended TSCA for P-16-0588.

TSCA Section 5(a)(3)(C) Determination for Premanufacture Number (PMN) P-16-0425

This document describes EPA's pre-manufacture notice review determination under amended TSCA for P-16-0425.

Physiologically-Based Pharmacokinetic (PBPK) Modeling White Paper

PBPK whitepaper Final AEGL Document

Fact Sheet: Nanoscale Materials

This page provides information on how EPA treats nanoscale materials, particularily chemicals under the Toxic Substances Control Act (TSCA).

Control of Nanoscale Materials under the Toxic Substances Control Act

Many nanoscale materials are regarded as chemical substances, but they may have different properties than their larger counterparts. EPA is working to ensure that nanoscale materials are manufactured and used in ways that prevent risk to health.

TSCA Section 5(a)(3)(C) Determination for Microbial Commercial Activity Notice (MCAN) J-19-0012-0015

This document describes EPA's Microbial Commercial Activity Notice (MCAN) review determination under amended TSCA for J-19-0012-0015.

Inert Reassessment Document for Glycerol-Propylene Oxide Polymer - CAS No. 25791-96-2

Glycerol-Propylene Oxide Polymer is used in hair styling. It is also used as an ingredient (component in water-soluble film) in pesticide formulations.

Inert Reassessment Document for Glyceryl tris-12-hydroxystearate - CAS No. 139-44-6

Glyceryl tris-12-hydroxystearate is classified as a List 4B inert ingredient.

Inert Reassessment Document for Ethyl Alcohol - CAS No. 64-17-5

The main use of ethyl alcohol is in the consumption of alcoholic beverage and as a solvent in the laboratory and industry, and in the manufacture of denatured alcohol, pharmaceuticals, perfumes, and organic synthesis.

Inert Reassessment Document for FD&C Blue No. 1

FD&C Blue No. 1 and tartrazine (FD&C Yellow No.5) are currently classified as List 3 inert ingredients; FD&C Red. No. 40 is currently classified as a List 4B inert ingredient.

Inert Reassessment Document for Kerosene

The predominant use of kerosene in the U.S. is an aviation turbine fuel for civilian (Jet A or Jet A-1) and military (JP-8 or JP-5 aircraft.

Inert Reassessment Document for Ethylene Glycol

Ethylene Glycol has many uses and are also used as antifreeze and deicers, as solvents, humectants, as chemical intermediates in the synthesis of other chemicals, and as components of many products such as brake fluids, lubricants, inks,and lacquers.

Inert Reassessment Document for Ethylenediaminetetracetric acid (EDTA)

EDTA is a chelating agent. Its ability to bind heavy metal ions can be used to sequester these trace metals. However, trace amounts of various metals are necessary for the proper functioning of the body.

Inert Reassessment Document for n-Hexyl Alcohol - CAS No. 111-27-3

Commercially, n-Hexyl alcohol is used as a solvent and in the manufacture of perfume, antiseptics, and plasticizers.

Minimum Risk - Addition of an Inert Ingredient or Active Ingredient to the Exemption

Find out whether you can add an inert or active ingredient to the minimum risk pesticide exemption.

Inert Reassessment Document for Isobutylene-butene copolymers - CAS No. 9044-17-1

Isobutylene-butene copolymers are used as lubricants, adhesives, coking material, sealing material, electrical insulation material, rubber, asphalt, ink, fertilizers and dispersants.

Inert Reassessment Document for Gluconic Acid and Sodium Salt

Gluconic acid and D-gluconic acid are classified as List 3 inert ingredients, sodium gluconate is classified as a List 4B inert ingredient, and D-gluconic acid, sodium salt has not been categorized as to inert ingredient list classification status.

Inert Reassessment Document for Methyl Alcohol - CAS No. 67-56-1

Methyl Alcohol is used as an inert ingredient in agricultural and residential-use pesticides. It is also found in a wide-array of consumer products including paints, cleaning products, adhesives, and alternative fuels.

Inert Reassessment Document for N-methylpyrrolidone - CAS No. 872-50-4

NMP is used by various industries as solvent for processing of petroleum, resins, acetylene, olefins, diolefins, and gas as well as for aromatic extraction from feedstock.