Laws & Regulations

TSCA Section 5(a)(3)(C) Determination for Microbial Commercial Activity Notice (MCAN) J-16-0006

This document describes EPA's pre-manufacture notice review TSCA Section 5(a)(3)(C) determination for Microbial Commercial Activity Notice (MCAN) J-16-0006.

TSCA Section 5(a)(3)(C) Determination for Premanufacture Number (PMN) P-16-0429

This document describes EPA's pre-manufacture notice review determination under amended TSCA for P-16-0429.

Successor Transfer Forms under TSCA Section 5

"Transfer Notice" forms authorize successor rights and liabilities of manufacture of new chemicals subject to prior TSCA section 5 notices.

Materials for the December 10, 2019 New Chemicals Meeting

This page contains documents related to the 12/10/19 public meeting on chemicals.

TSCA Section 5(a)(3)(C) Determination for Microbial Commercial Activity Notice (MCAN) J-21-0013

This document describes EPA's Microbial Commercial Activity Notice (MCAN) review determination under amended TSCA for J-21-0013.

TSCA Section 5(a)(3)(C) Determination for Premanufacture Number (PMN) P-21-0103

This document describes EPA's pre-manufacture notice review determination under amended TSCA for P-16-0588.

TSCA Section 5(a)(3)(C) Determination for Microbial Commercial Activity Notice (MCAN) J-18-002/3

This document describes EPA's Microbial Commercial Activity Notice (MCAN) review determination under amended TSCA for J-18-002/3.

TSCA Section 5(a)(3)(C) Determination for Microbial Commercial Activity Notice (MCAN) J-19-0019, J-19-0020

This document describes EPA's Microbial Commercial Activity Notice (MCAN) review determination under amended TSCA for J-19-0019, J-19-0020.

TSCA Section 5(a)(3)(C) Determination for Microbial Commercial Activity Notice (MCAN) J-20-0019, J-20-0020, J-20-0021, J-20-0022, J-20-0023, J-20-0024

This document describes EPA's Microbial Commercial Activity Notice (MCAN) review determination under amended TSCA for J-20-0019, J-20-0020, J-20-0021, J-20-0022, J-20-0023, J-20-0024.

TSCA Section 5(a)(3)(C) Determination for Premanufacture Number (PMN) P-18-0322

This document describes EPA's pre-manufacture notice review determination under amended TSCA for P-18-0322.

TSCA Section 5(a)(3)(C) Determination for Premanufacture Number (PMN) P-18-0270

This document describes EPA's pre-manufacture notice review determination under amended TSCA for P-18-0270.

TSCA Section 5(a)(3)(C) Determination for Premanufacture Number (PMN) P-16-0314

This document describes EPA's pre-manufacture notice review determination under amended TSCA for P-16-0314.

TSCA Section 5(a)(3)(C) Determination for Microbial Commercial Activity Notice (MCAN) J-18-002/3

This document describes EPA's Microbial Commercial Activity Notice (MCAN) review determination under amended TSCA for J-18-002/3.

TSCA Section 5(a)(3)(C) Determination for Premanufacture Number (PMN) P-18-0321

This document describes EPA's pre-manufacture notice review determination under amended TSCA for P-18-0321.

TSCA Section 5(a)(3)(C) Determination for Premanufacture Numbers (PMN) P-21-0039, P-21-0040, P-21-0041

This document describes EPA's pre-manufacture notice review determination under amended TSCA for P-21-0039, P-21-0040, P-21-0041.

TSCA Section 5(a)(3)(C) Determination for Premanufacture Number (PMN) P-21-0103

This document describes EPA's pre-manufacture notice review determination under amended TSCA for P-16-0588.

TSCA Section 5(a)(3)(C) Determination for Premanufacture Number (PMN) P-16-0425

This document describes EPA's pre-manufacture notice review determination under amended TSCA for P-16-0425.

Physiologically-Based Pharmacokinetic (PBPK) Modeling White Paper

PBPK whitepaper Final AEGL Document

Fact Sheet: Nanoscale Materials

This page provides information on how EPA treats nanoscale materials, particularily chemicals under the Toxic Substances Control Act (TSCA).

Control of Nanoscale Materials under the Toxic Substances Control Act

Many nanoscale materials are regarded as chemical substances, but they may have different properties than their larger counterparts. EPA is working to ensure that nanoscale materials are manufactured and used in ways that prevent risk to health.