Laws & Regulations

TSCA Section 5(a)(3)(C) Determination for Premanufacture Number (PMN) P-18-0321

This document describes EPA's pre-manufacture notice review determination under amended TSCA for P-18-0321.

Policy Statement on a New Chemicals Category for Persistent, Bioaccumulative, and Toxic (PBT) Chemicals

On November 4, 1999, EPA issued its policy statement on a category for Persistent Bioaccumulative and Toxic (PBT) new chemicals. The statement provides guidance criteria for persistence, bioaccumulation, and toxicity for new chemicals.

TSCA Section 5(a)(3)(C) Determination for Premanufacture Number (PMN) P-18-0270

This document describes EPA's pre-manufacture notice review determination under amended TSCA for P-18-0270.

TSCA Section 5(a)(3)(C) Determination for Premanufacture Number (PMN) P-16-0429

This document describes EPA's pre-manufacture notice review determination under amended TSCA for P-16-0429.

TSCA Section 5(a)(3)(C) Determination for Premanufacture Number (PMN) P-16-0314

This document describes EPA's pre-manufacture notice review determination under amended TSCA for P-16-0314.

TSCA Section 5(a)(3)(C) Determination for Microbial Commercial Activity Notice (MCAN) J-19-0018

This document describes EPA's Microbial Commercial Activity Notice (MCAN) review determination under amended TSCA for J-19-0018.

TSCA Section 5(a)(3)(C) Determination for Microbial Commercial Activity Notice (MCAN) J-19-0019, J-19-0020

This document describes EPA's Microbial Commercial Activity Notice (MCAN) review determination under amended TSCA for J-19-0019, J-19-0020.

TSCA Section 5(a)(3)(C) Determination for Premanufacture Number (PMN) P-17-0108

This document describes EPA's pre-manufacture notice review determination under amended TSCA for P-17-0108.

Joint Statement on Insect Repellents by EPA and CDC

The EPA and the CDC are recommending the public to use insect repellents and take other precautions to avoid biting insects that carry serious diseases. This statement discusses diseases of concern, government roles, and repellent selection and use.

Physiologically-Based Pharmacokinetic (PBPK) Modeling White Paper

PBPK whitepaper Final AEGL Document

Legislative and Regulatory Authority for Reviewing New Chemicals under TSCA

Section 5 of the Toxic Substances Control Act (TSCA) gives EPA the authority to require anyone who plans to manufacture a new chemical substance for a non-exempt commercial purpose to provide EPA with notice 90 days before initiating the activity.

TSCA Section 5(a)(3)(C) Determination for Premanufacture Number (PMN) P-19-0059

This document describes EPA's pre-manufacture notice review determination under amended TSCA for P-19-0059.

TSCA Section 5(a)(3)(C) Determination for Premanufacture Number (PMN) P-19-0120

This document describes EPA's pre-manufacture notice review determination under amended TSCA for P-19-0120.

TSCA Section 5(a)(3)(C) Determination for Premanufacture Number (PMN) P-19-0047

This document describes EPA's pre-manufacture notice review determination under amended TSCA for P-19-0047.

TSCA Section 5(a)(3)(C) Determination for Premanufacture Number (PMN) P-18-0276

This document describes EPA's pre-manufacture notice review determination under amended TSCA for P-18-0276.

TSCA Section 5(a)(3)(C) Determination for Premanufacture Number (PMN) P-16-0581

This document describes EPA's pre-manufacture notice review determination under amended TSCA for P-16-0581.

TSCA Section 5(a)(3)(C) Determination for Premanufacture Number (PMN) P-17-0190

This document describes EPA's pre-manufacture notice review determination under amended TSCA for P-17-0190.

TSCA Section 5(a)(3)(C) Determination for Premanufacture Number (PMN) P-17-0390

This document describes EPA's pre-manufacture notice review determination under amended TSCA for P-17-0390.

TSCA Section 5(a)(3)(C) Determination for Premanufacture Number (PMN) P-16-0313

This document describes EPA's pre-manufacture notice review determination under amended TSCA for P-16-0313.

TSCA Section 5(a)(3)(C) Determination for Premanufacture Number (PMN) P-18-0363

This document describes EPA's pre-manufacture notice review determination under amended TSCA for P-18-0363.