In October 2023, EPA issued a Federal Register Notice (FRN) with Endocrine Disruptor Screening Program (EDSP) Near-term Strategies and supporting documents that describe how EPA is prioritizing its screening for potential impacts to the estrogen, androgen, and thyroid systems in humans, focusing initially on conventional pesticide active ingredients. EPA has committed to posting regular updates through this web page on the status of any Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) data call-in notices (DCIs) to track release of and responses to such DCIs for conventional pesticides in what EPA has referred to as Group 1 chemicals in the EDSP Near-Term Strategies. The EDSP Near-term Strategies FRN and the support documents are available on www.regulations.gov in docket number EPA-HQ-OPP-2023-0474. The supporting documents include:

• Use of Existing Mammalian Data to Address Data Needs and Decisions for Endocrine Disruptor Screening Program (EDSP) for Humans under FFDCA Section 408(p);
• List of Conventional Registration Review Chemicals for Which an FFDCA Section 408(p)(6) Determination is Needed; and
• Status of Endocrine Disruptor Screening Program (EDSP) List 1 Screening Conclusions (referred to here as List 1 Screening Conclusions).

As explained in these documents, conventional pesticides in registration review that may need additional estrogen and/or androgen data were placed into one of three priority groups. Pesticides that demonstrated potential impact to the estrogen and/or androgen pathways were placed in the high priority group, which is referred to as Group 1 in the EDSP Near-term Strategies. EPA is requiring data earlier in the registration review process and expediting DCIs for this group. 

On September 11, 2024, EPA published an update to the prioritized list of conventional registration review chemicals:

• Updated List of Conventional Pesticide Active Ingredients with Adequate Estrogen and Androgen Data for Humans to Inform FFDCA Section 408(p)(6) Determinations.

Since the release of the update, EPA has subsequently determined that DCIs would not be issued at this time for the following chemicals:

• Acetochlor: removed from Group 1; an updated two-generation reproductive study with adequate estrogen and androgen data was previously submitted and reviewed for this chemical prior to the release of the EDSP Near-term Strategies
• Fenitrothion: no FIFRA registration for this active ingredient; there are only import tolerances
• DCNA: voluntary FIFRA cancellation is in progress

The table below contains the status of DCIs for the Group 1 chemicals since the release of the EDSP Near-term Strategies as of December 13, 2024.