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Consideration of the FQPA Safety Factor and Other Uncertainty Factors in Cumulative Risk Assessment of Chemicals Sharing a Common Mechanism of Toxicity

This guidance document provides the Office of Pesticide Programs (OPP) current thinking on application of the provision in FFDCA section 408(b)(2)(C) regarding an additional safety factor for the protection of infants and children in the context of cumulative risk assessments. In an earlier science policy paper for individual chemicals, OPP addressed how its risk assessments will consider the FQPA safety factor provision for individual chemicals. Additionally, OPP has prepared guidance on how to conduct a cumulative risk assessment for two or more pesticides sharing a common mechanism of toxicity. This document is intended to serve as a guide for OPP risk assessors to facilitate consistent implementation of the children’s FQPA safety factor provision in cumulative risk assessments and to increase the regulated entities’ and the public’s understanding of OPP cumulative risk assessments. 

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