An official website of the United States government.

Due to a lapse in appropriations, EPA websites will not be regularly updated. In the event of an environmental emergency imminently threatening the safety of human life or where necessary to protect certain property, the EPA website will be updated with appropriate information. Please note that all information on the EPA website may not be up to date, and transactions and inquiries submitted to the EPA website may not be processed or responded to until appropriations are enacted.

We've made some changes to If the information you are looking for is not here, you may be able to find it on the EPA Web Archive or the January 19, 2017 Web Snapshot.

Guidance on Procedures Used To Develop Acute Exposure Guideline Levels (AEGLs)

In 2001, the National Academies published guidance to develop AEGLs. These "standing operating procedures" were intended to make development of the guidelines systematic, consistent, documented and transparent to the public.

Read the Standing Operating Procedures (SOP) To Develop Acute Exposure Guideline Levels for Hazardous Substances 

Physiologically-based Pharmacokinetic Modeling White Paper 

Another key document in the creation of AEGLs is the Physiologically-Based Pharmacokinetic Modeling White Paper, which describes the methods for integrating physiologically-based pharmacokinetic (PBPK) modeling in the development of AEGLs.

Read the Physiologically-Based Pharmacokinetic Modeling White Paper.