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  2. Assessing and Managing Chemicals under TSCA

Supporting Documents for Manufacturer Requested Risk Evaluation for Octamethylcyclotetra- siloxane (D4)

Documents supporting the Section 6 manufacturer’s request for risk evaluation submitted by the American Chemistry Council’s Silicones Environmental, Health, and Safety Center (SEHSC) are provided below. EPA received a complete request on March 19, 2020 and granted the request on October 6, 2020. A revised version of "EPA’s Possible Additional Conditions of Use for D4" was posted here and in the docket on October 8, 2020. The June 2020 version of "EPA’s Possible Additional Conditions of Use for D4" released for public comment is available in docket EPA-HQ-OPPT-2018-0443.

EPA published for public comment the draft scope of the risk evaluation for D4 on September 8, 2021 and accepted comments in docket EPA-HQ-OPPT-2018-0443. EPA published the final scope of the risk evaluation for D4 on March 7, 2022.

Additional information will be updated periodically as required under the risk evaluation rule.

Back to the list of manufacturer-requested risk evaluations.

  • Final Scope of the Risk Evaluation for D4 (pdf) (2.81 MB)
  • Final Scope of the Risk Evaluation for D4 Supplemental File: Data Extraction and Data Evaluation Tables for Physical and Chemical Property Studies (pdf) (1.9 MB)
  • Final Scope of the Risk Evaluation for D4 Supplemental File: Data Extraction and Data Evaluation Tables for Physical and Chemical Studies for D4 Degradants (pdf) (843.88 KB)
  • Response to Comments Received for Draft Scope of the Risk Evaluation for D4 (pdf) (494.15 KB)
  • Response to Comments Received for D4 (pdf) (174.5 KB)
  • Letter Granting Request for Risk Evaluation of D4 (pdf) (207.98 KB)
  • EPA’s Possible Additional Conditions of Use for D4 (Revised) (pdf) (147.93 KB)
  • Letter Acknowledging Receipt of Request for D4 Risk Evaluation (pdf) (143.88 KB) ​
  • Addendum to Request for Risk Evaluation of D4 (pdf) (317.48 KB)
  • Request for Risk Evaluation of D4 (pdf) (10.99 MB)

Assessing and Managing Chemicals under TSCA

  • How EPA Evaluates the Safety of Existing Chemicals
  • Prioritizing Existing Chemicals for Risk Evaluation
  • Risk Evaluations for Existing Chemicals under TSCA
  • Risk Management for Existing Chemicals under TSCA
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Last updated on January 16, 2025
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