Benchmark Dose Software User Guide (December 2025)
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Overview
With the 25.2 release of pybmds, EPA has updated the online version of the BMDS User Guide. The revised online User Guide summarizes the information in the previous PDF version of the User Guide in a more accessible, user-friendly format.
Moving to online documentation will increase accessibility, interactivity, and integration with BMDS applications. Moving to online documentation will also increase the ease of maintenance and boost search engine visibility.
The Benchmark Dose Software Online User Guide describes how to use BMDS Online for dose-response modeling. Because BMDS Desktop employs the same interface, the user guide serves as a companion to that application as well.
The guide’s step-by-step procedures and conceptual explanations have been comprehensively updated to reflect the latest changes to the underlying model code and to the BMDS Online interface.
The User Guide also provides detailed explanations of each of the models used for dose-response analysis. This information may be critical to a risk assessor seeking to understand how a specific dose-response analysis result was calculated.
This user guide provides instruction on how to use BMDS but is not intended to address or replace EPA BMD guidance. However, every attempt has been made to make the software consistent with EPA guidance, including the Risk Assessment Forum (RAF) Benchmark Dose Technical Guidance Document (U.S. EPA, 2012).
Access the User Guide
This document has been reviewed in accordance with U.S. Environmental Protection Agency policy and approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation for use.
Benchmark Dose Software Online User Guide