Learn the Issues

EPA Celebrates National Farmworker Awareness Week by Highlighting Pesticide Safety Education Projects

The EPA is seeking public comment on the National Marine Fisheries Service’s opinion for the insecticides carbaryl and methomyl.

Exception for Limited Contact Activities and Irrigation Tasks under the Worker Protection Standard

An exception to the worker protection standard allows, under specified conditions, workers to enter pesticide treated areas during an REI to perform certain tasks. Learn about the necessary conditions.

Federal Certification Standards for Pesticide Applicators

Learn about how to comply with federal law and regulations that require any person who applies or supervises the use of restricted use pesticides (RUPs) be certified as a private or commercial applicator.

NAFTA Guidance Document on Data Requirements for Tolerances on Imported Commodities in the United States and Canada

The purpose of this document is to provide detailed guidance on data requirements that meet the North American Free Trade Agreement standards for the establishment of pesticide import tolerances or maximum residue levels in Canada and the United States.

Guidance on Cumulative Risk Assessment of Pesticide Chemicals that have a Common Mechanism of Toxicity

This document provides guidance to OPP scientists for evaluating and estimating the potential human risks associated with such multichemical and multipathway exposures to pesticides. This process is referred to as cumulative risk assessment.

Consideration of the FQPA Safety Factor and Other Uncertainty Factors in Cumulative Risk Assessment of Chemicals Sharing a Common Mechanism of Toxicity

This guidance document provides OPP's current thinking on application of the provision in FFDCA about an additional safety factor for the protection of infants and children in the context of cumulative risk assessments.

The Use of Data on Cholinesterase Inhibition for Risk Assessments of Organophosphorous and Carbamate Pesticides

This revised science policy emphasizes the weighing of all relevant evidence when selecting endpoints for the hazard assessment of anticholinesterase pesticides.

Developmental Neurotoxicity Study Guidance

This guidance covers review and interpretation of DNT data and was developed collaboratively by EPA and Health Canada, with the goal of more consistent reviews of DNT data.

Process for Establishing & Implementing Alternative Approaches to Traditional in Vivo Acute Toxicity Studies

EPA’s Office of Pesticide Programs (OPP) has developed a strategic vision1 for implementing the 2007 NRC report on Toxicity Testing in the 21st Century.

Guidance for Identifying Pesticide Chemicals and Other Substances that have a Common Mechanism Toxicity

Label Review Manual Chapter 10; Revised Respirator Descriptions for Public Comment

Revised Respirator Descriptions for Public Comment Documents

Retrospective Analysis of the Immunotoxicity Study

This document forms part of the basis for the immunotoxicity study data waiver criteria. It is related to OCSPP Test Guideline 870.7800.

Dinotefuran Petition and Response

Petition and response for Dinotefuran

Carfentrazone-ethyl Petition and Response

Petition(s) and Response(s) for Carfentrazone-ethyl

General Substantiation Questions to Support CBI Claims

General Questions and Answers Concerning Confidential Business Information (CBI) Provisions of the Toxic Substances Control Act (TSCA), as amended by the Frank R. Lautenberg Chemical Safety for the 21st Century Act

EPA Announces Rescheduled Meeting for Peer Review of the Draft Risk Evaluation for Asbestos

EPA is holding a rescheduled public meeting of the Toxic Substances Control Act Science Advisory Committee on Chemicals from June 8 to 11, 2020, to review the draft risk evaluation for asbestos

EPA Releases Outreach Materials for National Lead Poisoning Prevention Week

Listserv announcing the release of the 2021 National Lead Poisoning Prevention Week Outreach Materials.

Information on EPA’s Inaugural Conference on New Approach Methods for Reducing Animal Testing for Chemical Safety

Deadline Extended for Pollution Prevention Grant Applications

EPA is extending the application deadlines for two grant opportunities

January 22, 2020 Webinar on Reducing Vertebrate Animal Testing

EPA Public Webinar in Partnership with People for the Ethical Treatment of Animals (PETA) and Physicians for Responsible Medicine (PCRM)