Science & Technology

Chemical Safety for Sustainability Subcommittee Meeting Documents (November 16-18, 2016)

Meeting documents for the Chemical Safety for Sustainability (CSS) Subcommittee meeting on November 16-18, 2016.

Papers Addressing Scientific Issues in the Risk Assessment of Metals

To inform the consideration of metals properties, and to engage the external scientific community, the Agency commissioned external experts to lead the development of a series of issue papers.

Methods for Identifying a Default Cross-Species Scaling Factor (Rhomsberg, 2004)

Provides a rationale for selecting default cross-species extrapolation factors with which to scale oral doses across species for non-carcinogenic endpoints.

Antimicrobial Exposure Assessment Task Force II (AEATF II) Volume 5: Governing Document for a Multi-Year Antimicrobial Chemical Exposure Monitoring Program (interim draft document with changes)

This document describes the overall scope of the AEATF II program, demonstrates the need for additional human exposure monitoring data and explains the proposed methodology for the exposure monitoring studies proposed for conduct by the AEATF II.

Memorandum on Cumulative Risk Assessment Guidance - Phase I Planning and Scoping

This guidance directs each EPA office to take into account cumulative risk issues in scoping and planning major risk assessments.

External Review Draft: Harmonization in Interspecies Extrapolation: Use of BW 3/4 as Default Method in Derivation of the Oral RfD

Recommends procedures, inclusive of default procedures, that will be used to estimate oral exposures in terms of human equivalents for all toxicologic endpoints.

Issue Paper on the Human Health Effects of Metals

This paper discusses issues important to consider in developing a framework for performing human health assessments for exposure to metals and metal compounds

Antimicrobial Exposure Assessment Task Force II (AEATF II) Volume 5: Governing Document for a Multi-Year Antimicrobial Chemical Exposure Monitoring Program (interim draft document)

Describes the overall scope of the AEATF II program, demonstrates the need for additional human exposure monitoring data and explains the proposed methodology for the exposure monitoring studies proposed for conduct by the AEATF II.

Background Material for the Human Studies Review Board's Review of Spak 1989

Journal article and details of EPA's science and ethics reviews of the study by Spak et al. from 1989.

Antimicrobial Exposure Assessment Task Force II (AEATF II) Volume 6: Standard Operating Procedures for a Multi-Year Antimicrobial Chemical Exposure Monitoring Program

This document presents key AEATF II Standard Operating Procedures that support the submitted study protocols.

Charge Questions for the October 1, 2013, Meeting of the Human Studies Review Board

Supporting material for the October 1, 2013, Meeting of the Human Studies Review Board

Issue Paper on the Ecological Effects of Metals

A summary of biological and ecological responses to metals, and discuss the role of descriptive and predictive methods used to characterize effects of metals in risk assessment.

Issue Paper on the Environmental Chemistry of Metals

EPA has identified three types of regulatory risk assessments where information regarding speciation of metals is useful and desirable: national hazard/risk ranking and characterization, site-specific assessments, and National Regulatory Assessments.

Issue Paper on the Bioavailability and Bioaccumulation of Metals

The goal of this paper is to summarize the current and emerging state of the science supporting assessments of metal bioavailability and bioaccumulation in aquatic and terrestrial organisms.

WhAEM BBM Files - Iowa

WhAEM2000 (Wellhead Analytic Element Model) binary base map browser for quadrangles in Iowa. Files serve as geographic basis for groundwater modeling.

WhAEM2000 BBM Files - West Frankfort, Indiana

WhAEM2000 (Wellhead Analytic Element Model) binary base map browser for West Frankfort Quadrangle, Indiana. Files serve as geographic basis for groundwater modeling.

WhAEM2000 BBM Files - Watseka, Indiana

WhAEM2000 (Wellhead Analytic Element Model) binary base map browser for Watseka Quadrangle, Indiana. Files serve as geographic basis for groundwater modeling.

WhAEM2000 BBM Files - Wabash, Indiana

WhAEM2000 (Wellhead Analytic Element Model) binary base map browser for Wabash Quadrangle, Indiana. Files serve as geographic basis for groundwater modeling.

WhAEM2000 BBM Files - Vincenne, Indiana

WhAEM2000 (Wellhead Analytic Element Model) binary base map browser for Vincennes Quadrangle, Indiana. Files serve as geographic basis for groundwater modeling.

WhAEM2000 BBM Files - Terre Haute, Indiana

WhAEM2000 (Wellhead Analytic Element Model) binary base map browser for Terre Haute Quadrangle, Indiana. Files serve as geographic basis for groundwater modeling.