Basic Information about Human Subjects Research
Program in Human Research Ethics and Oversight (PHREO) Overview
EPA's Program in Human Research Ethics and Oversight (PHREO) supports the ethical conduct and regulatory compliance of human subjects research conducted or supported by EPA. This support is accomplished through project review, cross-agency partnership, and education and training. Lead by the Human Subjects Research Review Official (HSRRO), the PHREO reviews, supports, and guides the work of EPA conducted or supported researchers involved in human subjects research to ensure that the rights and welfare of human research subjects are protected. The PHREO is in place to ensure that all EPA employees, contractors, grant recipients, and parties to other EPA agreements adhere to the highest standards of ethical conduct and are properly informed of the regulatory aspects of research involving human subjects. All research involving human subjects proposed by EPA staff or EPA supported researchers must be approved by the EPA HSRRO before human subjects work may begin.
Human subjects research at EPA allows for the collection of valuable information necessary in our mission to protect human health and the environment. Research involving human subjects informs decision-making and the formulation of regulatory standards at the Agency. HSR is critical for EPA’s program offices to consider when making regulatory decisions under many of the programs it administers, e.g., National Ambient Air Quality Standards, water quality criteria and drinking water standards, pollution mitigation techniques, and pesticide registration. Human subjects research advances scientists’ understanding of the links between human health and the environment so that EPA is better able to carry out its mission.