RFC 21005 – Chloroprene

Chloroprene RFC Letter (pdf) (311.37 KB) Toxicological Review of Chloroprene (CAS No. 126-99-8) In Support of Summary Information on the Integrated Risk Information System (IRIS)

EPA Response to RFC 21005 Chloroprene (pdf) (379.62 KB)  EPA Response to RFC 21005 dated 3/14/2022

Exhibit A: Incorporation of In Vitro Metabolism Data in a Physiologically Based Pharmacokinetic (PBPK) Model for Chloroprene- Revised Documentation in Response to USEPA Peer Review (pdf) (1.05 MB) Report by Ramboll dated July 15, 2021.

Attachments to Exhibit A:

• Supplemental Materials A: Supplemental Tables Supplemental Materials A: Supplemental Tables (pdf) (279.73 KB)

• Supplemental Materials B: Re-estimation of Metabolism  Supplemental Materials B: Re-estimation of Metabolism Parameters (pdf) (1.03 MB)

• Supplemental Materials C: IVIVE Literature  Supplemental Materials C: IVIVE Literature Review (pdf) (415.28 KB)

• Supplemental Materials D: Metabolism Parameter Calculations  Supplemental Materials D: Metabolism Parameter Calculations (xlsx) (2.93 MB)

• Supplemental Materials E: Model Files  Supplemental Materials E: Model Files (pdf) (535.04 KB)

• Supplemental Materials F: Reactive Metabolite Modeling  Supplemental Materials F: Reactive Metabolite Modeling (pdf) (632.98 KB)

• Supplemental Materials G: Responses to Peer Reviewer Comments  Supplemental Materials G: Responses to Peer Reviewer (pdf) (385.75 KB)

Exhibit B: Epidemiological Basis for Supporting a Correction of the Chloroprene Inhalation Unit Risk (IUR) (pdf) (620.29 KB) Report by Ramboll dated July 15, 2021