Learn the Issues

The Use of Data on Cholinesterase Inhibition for Risk Assessments of Organophosphorous and Carbamate Pesticides

This revised science policy emphasizes the weighing of all relevant evidence when selecting endpoints for the hazard assessment of anticholinesterase pesticides.

Developmental Neurotoxicity Study Guidance

This guidance covers review and interpretation of DNT data and was developed collaboratively by EPA and Health Canada, with the goal of more consistent reviews of DNT data.

Process for Establishing & Implementing Alternative Approaches to Traditional in Vivo Acute Toxicity Studies

EPA’s Office of Pesticide Programs (OPP) has developed a strategic vision1 for implementing the 2007 NRC report on Toxicity Testing in the 21st Century.

Guidance for Identifying Pesticide Chemicals and Other Substances that have a Common Mechanism Toxicity

Label Review Manual Chapter 10; Revised Respirator Descriptions for Public Comment

Revised Respirator Descriptions for Public Comment Documents

Retrospective Analysis of the Immunotoxicity Study

This document forms part of the basis for the immunotoxicity study data waiver criteria. It is related to OCSPP Test Guideline 870.7800.

Dinotefuran Petition and Response

Petition and response for Dinotefuran

Carfentrazone-ethyl Petition and Response

Petition(s) and Response(s) for Carfentrazone-ethyl

General Substantiation Questions to Support CBI Claims

General Questions and Answers Concerning Confidential Business Information (CBI) Provisions of the Toxic Substances Control Act (TSCA), as amended by the Frank R. Lautenberg Chemical Safety for the 21st Century Act

EPA Announces Rescheduled Meeting for Peer Review of the Draft Risk Evaluation for Asbestos

EPA is holding a rescheduled public meeting of the Toxic Substances Control Act Science Advisory Committee on Chemicals from June 8 to 11, 2020, to review the draft risk evaluation for asbestos

EPA Releases Outreach Materials for National Lead Poisoning Prevention Week

Listserv announcing the release of the 2021 National Lead Poisoning Prevention Week Outreach Materials.

Information on EPA’s Inaugural Conference on New Approach Methods for Reducing Animal Testing for Chemical Safety

Deadline Extended for Pollution Prevention Grant Applications

EPA is extending the application deadlines for two grant opportunities

January 22, 2020 Webinar on Reducing Vertebrate Animal Testing

EPA Public Webinar in Partnership with People for the Ethical Treatment of Animals (PETA) and Physicians for Responsible Medicine (PCRM)

Register for the April 27-30, 2020, Peer Review Virtual Public Meeting of the TSCA Science Advisory Committee on Chemicals

EPA will hold a virtual public meeting on April 27-30, 2020, from 10:00 a.m. to approximately 5:00 p.m.