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Acute-to-Chronic Estimation (ACE) with Time-Concentration-Effect Models Software

This model is distributed by EPA as a legacy model, but no user support is available from EPA.

ICE and ACE were developed by the U.S. EPA in collaboration with other federal agencies, industry, and universities to address data gaps in species sensitivity and reduce reliance on uncertainty factors in ecological risk assessment.

The Acute-to-Chronic Estimation (ACE) with Time-Concentration-Effect Models software allows prediction of chronic toxicity from acute toxicity datasets. ACE uses linear regression and accelerated life testing to predict no-effect and low-effect concentrations for chronic mortality.

Specifications
Current Version: 2.0
Release Date: December 2003
Development Status: General Release
Development Information: Release Notes - changes and known deficiencies
Operating System: Win 9x, NT, 2000, XP
Development Language: Visual Basic, Fortran
Intended Audience: Scientist/Biologist
Key Words: acute, chronic, toxicity, concentration, exposure
Related Web Sites: Web-ICE Model Page
EPA Center for Public Health and Environmental Assessment (CPHEA)
Text Files (ASCII Format)
File Name File Description
ABSTRACT.TXT Summary of functions, theory, and applicability.
README.TXT Important installation and usage information.
Download Files
File Type /
Priority
File Name /
Format /
Size
File Description
Install /
Required
Install_ACE.EXE /
Self-extracting Executable /
4.3 MB
Setup file for version 2.0 of the ACE system. See README.TXT for important installation instructions.
Document /
Recommended
ACE User's Manual /
Self-extracting Zip /
0.3 MB
Acute - to - Chronic Estimation (ACE) with Time - Concentration - Effect Models User Manual (EPA/600/R-03/107), in Adobe Acrobat format.

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Last updated on February 3, 2025
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