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Evidence Integration in Chemical Assessments Workshop (Jun 2019)

A committee of the National Academies of Sciences (NAS) hosted a workshop to discuss evidence integration, which is the summary step of the systematic review process conducted by the US Environmental Protection Agency (EPA) Office of Research and Development.

Topic areas include: 

  • Lessons Learned from Recent International Workshops on Evidence integration in Risk Assessment,
  • Best Practices in Evidence Integration,
  • Approaches for Using Mechanistic Data to Integrate Evidence from Animal and Human Studies: General Considerations,
  • Systematic Review-Enabled Evidence Integration: Case Studies, and
  • Practical Approaches to Expedited Evidence Integration.

During evidence integration, also referred to as weight-of-evidence evaluation, conclusions are drawn from each line of evidence that is relevant to the predefined PECO criteria.  Evidence integration generally involves subjecting the relevant evidence to a causal analysis,  which can be conducted using both qualitative and quantitative approaches.

PECO refers to population, exposure, comparators, and outcomes.

This is a structured process by which conclusions are drawn regarding the potential health effects in exposed humans, incorporating judgments about the strength of the human and animal evidence (both within and across lines of evidence) as well as information from mechanistic data necessary to answer key questions. 

The objective of the workshop was to explore relevant strategies for addressing challenges that arise for EPA during evidence integration in chemical assessments, with a primary focus on the use of mechanistic data. Poster sessions accompanied the workshop in order to address topics that are relevant to the workshop session topics.

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