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EPA Announces Opportunity to Nominate Additional Experts to Serve as Ad Hoc Members for the FIFRA Scientific Advisory Panel Reviewing Physiologically-Based Pharmacokinetic (PBPK) Modeling

For Release:  December 21, 2017

On December 18, 2017, the Agency published a Federal Register notice to announce the opportunity to provide additional nominations for experts to serve as ad hoc members for the Federal Insecticide, Fungicide, and Rodenticide Act Scientific Advisory Panel (FIFRA SAP) reviewing PBPK modeling to address pharmacokinetic differences between and within species on six selected pesticidal active ingredients. The public can provide nominations until January 17, 2018. Nominations can be provided by following the instructions in the Federal Register announcement (EPA-HQ-OPP-2017-0180) or by forwarding the nomination to the Designated Federal Official listed below.

Nominations should include scientists who have sufficient professional qualifications, including training and experience, to be capable of providing expert comments on the following issues: PBPK modeling, pharmacokinetics, pharmacodynamic modeling, in vitro to in vivo extrapolation, human health risk assessment, neurotoxicity, organophosphate pesticides, pyrethroids pesticides, N-methyl carbamate pesticides, fungicides, acetylcholinesterase inhibition, and exposure assessment.

The FIFRA SAP serves as a primary scientific peer review mechanism of EPA’s Office of Chemical Safety and Pollution Prevention and is structured to provide scientific advice, information and recommendations to the EPA Administrator on pesticides and pesticide-related issues as to the impact of regulatory actions on health and the environment.

Additional information may be found in the docket, on the FIFRA SAP website or by contacting the Designated Federal Official, Dr. Marquea D. King ( or 202-564-3626