B926 PRIA Fee Category

PRIA 5 Fee Determination Decision Tree:

New Registration - New Active Ingredient - Non-Food Use

Below is the fee for your selected Fee Category for Fiscal Years 2025-2026

Action Code	Description	FY'25-FY'26 Fee	Decision Time (months)
B926	Registration application; new active ingredient; exogenous applications of RNA to elicit the RNA interference pathway in pests; non-food/feed. ⁽⁵⁾ ⁽¹²⁾ ⁽¹⁴⁾	$86,446	17

Do you plan to request either of the following types of waivers?

Waiver	Pay	Amount
50% waiver	You pay ---->>>>>	$43,223
75% waiver	You pay ---->>>>>	$21,612

To pay the fee shown above, go to Paying PRIA Application Fees web page and follow the instructions.

How to submit your application directly to EPA.

Action Code Interpretation
An application for registration of a new exogenous RNA active ingredient. Exogenous RNA is defined as formulations of gene silencing/interfering RNAs applied by spraying, injection, spreading, bait formulations, mechanical inoculation, root/seek soaking, or other non-transgenic methods. No tolerance or tolerance exemption because all uses are non‐food/feed. The Agency will provide the applicant with a pre-decisional determination 2 weeks prior to the PRIA decision review time due date which specifies any label changes that have to be made in order to grant the requested new active ingredient registration. If the label issues cannot be resolved prior to the PRIA decision review time due date and if a PRIA due date time extension has not been agreed upon, then the Agency will issue to the applicant its regulatory decision with the specific label changes and supporting documentation on or just before the PRIA decision review time due date. At that time the applicant must either (a) agree to all of the label changes and submit a revised label that incorporates all of these label changes; or (b) does not agree with one or more of the label changes and request up to 30 days to reach agreement with the Agency and submit a revised label that incorporates all of the agreed upon label changes, which the Agency has 2 business days to review; or (c) withdraw the application without prejudice.

Action Code Interpretation

An application for registration of a new exogenous RNA active ingredient. Exogenous RNA is defined as formulations of gene silencing/interfering RNAs applied by spraying, injection, spreading, bait formulations, mechanical inoculation, root/seek soaking, or other non-transgenic methods. No tolerance or tolerance exemption because all uses are non‐food/feed.

The Agency will provide the applicant with a pre-decisional determination 2 weeks prior to the PRIA decision review time due date which specifies any label changes that have to be made in order to grant the requested new active ingredient registration. If the label issues cannot be resolved prior to the PRIA decision review time due date and if a PRIA due date time extension has not been agreed upon, then the Agency will issue to the applicant its regulatory decision with the specific label changes and supporting documentation on or just before the PRIA decision review time due date. At that time the applicant must either (a) agree to all of the label changes and submit a revised label that incorporates all of these label changes; or (b) does not agree with one or more of the label changes and request up to 30 days to reach agreement with the Agency and submit a revised label that incorporates all of the agreed upon label changes, which the Agency has 2 business days to review; or (c) withdraw the application without prejudice.

Go to the start of the Decision Tree

B926 PRIA Fee Category

PRIA 5 Fee Determination Decision Tree:

New Registration - New Active Ingredient - Non-Food Use

Below is the fee for your selected Fee Category for Fiscal Years 2025-2026

PRIA Fees