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Reviewing New Chemicals under the Toxic Substances Control Act (TSCA)

Chemicals Determined Not Likely to Present an Unreasonable Risk Following Pre-Manufacture Notification Review

This page describes the chemical substances EPA has determined are “not likely to present an unreasonable risk” following review of pre-manufacture notifications under section 5 of TSCA, as amended by the Frank R. Lautenberg Chemical Safety for the 21st Century Act, P.L. 114-182.

Note:  For these “not likely to present an unreasonable risk” cases,” PMN submitters may commence manufacture upon notification by EPA, notwithstanding any remaining portion of the applicable review period, in accordance with section 5(g) of TSCA, as amended.

Certain of EPA’s determinations that a chemical is not likely to present unreasonable risk are based upon both the Agency’s risk assessment for the chemical substance under intended conditions of use described in the PMN and the issuance of a proposed SNUR to address certain reasonably foreseen uses. Conditions of use that fall under the restrictions of the proposed SNUR are not likely to present unreasonable risk of injury to health or the environment because (1) those conditions of use are not likely to be commenced during the pendency of proposed SNUR and (2) upon finalization of the SNUR those conditions of use would be prohibited unless and until EPA makes an affirmative determination that the significant new use is not likely to present an unreasonable risk or takes appropriate action under section 5(e) or 5(f). The links to the terms of these proposed SNURs are provided below along with the determination documents.

View the interim status of Section 5 pre-manufacture notices reviewed under TSCA.

Case
Number
Chemical
Identity
EPA Determination
Following PMN Review
Summary Review
Start Date
Decision
Date
P-17-0324 Specific: 2,4-Hexadien-1-ol, 1-acetate, (2E,4E)-; CASRN: 57006-69-6 The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) 'Not likely to present an unreasonable risk' section 5(a)(3)(C) determination.*

*In EPA’s original screening analysis for this PMN in 2017, EPA identified potential risks to workers, which resulted in the interim finding. Based on additional information provided by the submitter, EPA revised its assessment for the intended conditions of use. EPA’s final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA’s revised risk assessment for the new chemical substance under the intended conditions of use, where EPA expects that employers will require and workers will use appropriate personal protective equipment in a manner adequate to protect them, and EPA’s issuance of a proposed SNUR to address certain reasonably foreseen uses. Conditions of use that fall under the restrictions of the proposed SNUR are not likely to present unreasonable risk of injury to health or the environment because (1) those conditions of use are not likely to be commenced during the pendency of the proposed SNUR and (2) upon finalization of the SNUR those conditions of use would be prohibited unless and until EPA makes an affirmative determination that the significant new use is not likely to present an unreasonable risk or takes appropriate action under section 5(e) or 5(f). View the determination document and the terms of the SNUR.
06/16/2017 05/15/2020
P-20-0037 Specific: Lithium Chloride (6LiCl); CASRN: 20227-31-0 The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document and the terms of the SNUR. 02/12/2020 05/29/2020
P-20-0036 Specific: Carbonic acid, di(lithium-6Li) salt; CASRN: 25890-20-4 The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document and the terms of the SNUR. 02/06/2020 05/29/2020
P-19-0109 Specific: Copper, bis[2-(amino-.kappa.N)ethanolato-.kappa.O]- (CASRN 14215-52-2); Copper, (2-)]- (CASRN 21545-60-8) The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document and the terms of the SNUR. 01/09/2020 05/29/2020
P-19-0088 Specific: Ethanamine, N-ethyl-, 2-hydroxy-1,2,3-propanetricarboxylate (1:?); CASRN 23251-73-2 The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document and the terms of the SNUR. 05/13/2019 05/29/2020
P-19-0019 Generic: Haloalkane The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document and the terms of the SNUR. 11/08/2018 05/29/2020
P-18-0271 Generic: 2-Propanol, 1-butoxy-, 2,2'-ester The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document and the terms of the SNUR. 08/06/2018 05/29/2020
P-18-0151 Specific: Formaldehyde, reaction products with 1,3-benzenedimethanamine and p-tert-butylphenol: CASRN 158800-93-2 The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document and the terms of the SNUR. 04/19/2018 05/29/2020
P-17-0195 Generic: 1,3-Propanediol,2-methylene-, substituted The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) 'Not likely to present an unreasonable risk' section 5(a)(3)(C) determination*

*In EPA’s original screening analysis for this PMN in 2017, EPA determined that there was insufficient information to evaluate human health risks and identified potential risks to the environment, which resulted in the interim finding. The PMN submitter subsequently provided human health effects study data. EPA revised the risk assessment and determined that release and exposure patterns from reasonably foreseen uses would not differ from the intended conditions of use. EPA’s final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA’s revised risk assessment for the chemical substance under the intended conditions of use, where EPA expects that employers will require and workers will use appropriate personal protective equipment in a manner adequate to protect them and no environmental risk is expected. View the determination document.
01/05/2017 05/27/2020
P-10-0542 Generic: Amide, polyprotic acid The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) 'Not likely to present an unreasonable risk' section 5(a)(3)(C) determination*

*In EPA’s original screening analysis for this PMN, EPA identified environmental risk and exposure-based concerns, which resulted in the interim finding. EPA subsequently updated the risk assessment to reflect current science and policy. EPA’s final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA’s revised hazard and risk assessment for the chemical substance under the intended conditions of use, where EPA expects that employers will require and workers will use appropriate personal protective equipment in a manner adequate to protect them, and no unreasonable risk to the environment was identified. View the determination document.
06/22/2016 05/29/2020
P-18-0380 Generic: Butanoic acid ethyl amine The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 10/12/2018 05/29/2020
P-18-0332
P-18-0333
Specific (P-18-0332): Canola meal (CASRN: 121957-95-7)

Specific (P-18-0333): Flaxseed meal (CASRN: 2211120-89-5)
The chemical substances are not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substances are not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 09/25/2018 05/29/2020
J-20-0003
J-20-0004
Generic: Genetically modified microorganism The microorganisms are not likely to present an unreasonable risk (5(a)(3)(C)) The microorganisms are not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 03/16/2020 05/21/2020
P-20-0050 Specific: Benzenepentanol, .alpha.,.gamma.-dimethyl- (CASRN 72681-01-7) The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 02/05/2020 05/08/2020
P-20-0012 Generic: Polyol, polymer with alkyl diisocyanate, alkyl substituted heterocycle blocked The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 10/31/2019 05/08/2020
P-18-0362 Specific: 1,3-Propanediol, 2-ethyl-2-(hydroxymethyl)-, polymer with 2,4-diisocyanato-1-methylbenzene, .alpha.-hydro-.omega.-hydroxypoly[oxy(methyl-1,2-ethanediyl)] and .alpha.,.alpha.',.alpha.''-1,2,3-propanetriyltris[.omega.-hydroxypoly[oxy(methyl-1,2-ethanediyl)]], Me Et ketone oxime –blocked (CASRN: 1661004-48-3); polymer exemption flag

Polymer exemption flag: The chemical must be manufactured such that it meets the polymer exemption criteria as described under 40 CFR §723.250(e)(1), in addition to meeting the definition of polymer at 40 CFR §723.250(b).
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 09/28/2018 05/08/2020
P-18-0168 Generic: Alkoxylated triaryl methane (PROVISIONAL) The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 05/04/2018 03/26/2019
P-17-0389 Generic: Alkyl oil, polymer with 1,4-cyclohexanedimethanol, dehydrated Alkyl oil, hydrogentated rosin, phthalic anhydride and trimethylolpropane The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 09/12/2017 05/08/2020
P-17-0294 Specific: 2-Butanone, 3-methyl-, peroxide; CASRN: 182893-11-4 The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) 'Not likely to present an unreasonable risk' section 5(a)(3)(C) determination.*

*In EPA’s original screening analysis for this PMN in 2017, EPA identified potential for risks to workers from inhalation and dermal exposure, which resulted in the interim finding. Based on a respiratory breakthrough modeling study provided by the submitter, EPA revised its assessment for the intended conditions of use. EPA’s final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA’s revised risk assessment for the chemical substance under the intended conditions of use, where EPA expects that employers will require and workers will use appropriate personal protective equipment in a manner adequate to protect them, and EPA’s issuance of a proposed SNUR to address certain reasonably foreseen uses. View the determination document and the terms of the SNUR .
04/25/2017 04/29/2020
P-17-0086 Generic: Cycloalkyl, bis(ethoxyalkyl)-, trans-; Cycloalkyl, bis(ethoxyalkyl)-, cis- The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) 'Not likely to present an unreasonable risk' section 5(a)(3)(C) determination.*

*In EPA’s original screening analysis for this PMN in 2017, EPA identified potential risks to workers, the general population, and the environment, which resulted in the interim finding. Based on additional information provided by the submitter, EPA revised its assessment for the intended conditions of use. EPA’s final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA’s revised risk assessment for the chemical substance under the intended conditions of use and EPA’s issuance of a proposed SNUR to address certain reasonably foreseen uses. View the determination document and the terms of the SNUR .
11/07/2016 04/29/2020
P-20-0052 Specific: Oxirane, 2-methyl-, polymer with oxirane, mono(3,5,5-trimethylhexanoate); CASRN 148263-50-7 The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document and the terms of the SNUR . 02/05/2020 04/29/2020
P-20-0041 Specific: 1,3-Benzenedicarboxylic acid, polymer with 3-methyl-1,5-pentanediol (CASRN 76962-70-4) The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document and the terms of the SNUR. 01/07/2020 04/29/2020
P-19-0174 Generic: Octadecanoic acid, (alkylphosphinyl), polyol ester The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document and the terms of the SNUR . 12/11/2019 04/29/2020
P-19-0136 Generic: iso-alkylamine, N-isoalkyl-N-methyl The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document and the terms of the SNUR . 07/23/2019 04/29/2020
P-18-0262 Specific: 2-Propenoic acid, 2-methyl-, dodecyl ester, polymer with ammonium 2-methyl-2-[(1-oxo-2-propen-1-yl)amino]-1-propanesulfonate (1:1), N,N-dimethyl-2-propenamide and .alpha.-(2-methyl-1-oxo-2-propen-1-yl)-.omega.-(dodecyloxy)poly(oxy-1,2-ethanediyl); CASRN 1190091-71-4 The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document and the terms of the SNUR . 09/05/2018 04/29/2020
P-20-0054 Specific: Nitrile hydratase NH-6L (CAS provisional name) The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 02/07/2020 04/26/2020
P-19-0134 Generic: 5-isocyanato-1-(isocyanatomethyl)-1,3,3-trimethylcyclohexane], [Poly[oxy(methyl-1,2-ethanediyl)], .alpha.-hydro-.omega.-hydroxy-, polymer with 1,6-diisocyanatohexane], polymer with [Poly(oxy-1,4-butanediyl), .alpha.-hydro-.omega.-hydroxy-], [Cyclic amine - ketone adduct, reduced], and [1,3-Propanediol, 2-ethyl-2-(hydroxymethyl) The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 10/23/2019 04/29/2020
P-18-0098 Generic: Polyphosphoric acids, polymers with (alkoxyalkoxy)alkanol and substituted heteromonocycle The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 01/24/2018 04/21/2020
P-20-0027
P-20-0028
Generic (P-20-0027): Glycols, .alpha.,.omega.-, C2-6, polymers with adipic aicd, dodecanedioic acid, hydracrylic acid polyester, isophthalic acid, isophthalic acid, 1,1'-methylenebis[4-isocyanatobenzene], neopentyl glycol and terephthalic acid (PROVISIONAL)

Generic (P-20-0028): Glycols, .alpha.,.omega.-, C2-6, polymers with adipic acid, aromatic polyester, dodecanedioic acid, hydracrylic acid polyester, isophthalic acid, 1,1'-methylenebis[4-isocyanatobenzene], neopentyl glycol and terephthalic acid (PROVISIONAL)
The chemical substances are not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substances are not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 01/10/2020 04/08/2020
P-19-0189 Generic: Fatty acids, polymers with alkanediol and 1,1'-methylenebis[4-isocyanatobenzene] The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 09/30/2019 04/09/2020
P-18-0376 Generic: Thiosulfuric acid, aminoalkyl ester The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 10/10/2018 04/02/2020
P-18-0150 Generic: Tertiary amine, compounds with amino sulfonic acid blocked aliphatic isocyanate homopolymer The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 04/13/2018 04/01/2020
P-18-0381 Specific: Indium manganese yttrium oxide; CASRN: 1239902-45-4 The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document and the terms of the SNUR. 09/28/2018 03/31/2020
P-18-0060 Specific: 1-Butanaminium, 4-amino-N-(2-hydroxy-3-sulfopropyl)-N,N-dimethyl-4-oxo-, N-coco alkyl derivs., inner salts; CASRN 2041102-83-2 The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document and the terms of the SNUR. 10/10/2018 03/31/2020
P-18-0059 Specific: Butanoic acid, 4-(dimethylamino)-, ethyl ester; CASRN 22041-23-2 The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document and the terms of the SNUR. 10/10/2018 03/31/2020
P-16-0420 Generic: Dimethyl cyclohexenyl propanol The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) 'Not likely to present an unreasonable risk' section 5(a)(3)(C) determination.*

*In EPA’s original screening analysis for this PMN in 2016, EPA identified potential for risk to workers and the environment, which resulted in the interim finding. The PMN submitter provided additional data that changed the human health and environmental hazard profile. EPA’s final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA’s revised hazard and risk assessment for the new chemical substance. View the determination document.
06/22/2016 03/26/2019
P-18-0364 Generic: Alkali humates, polymers with substituted acrylamides The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 09/28/2018 03/19/2020
P-17-0240 Generic: Alkenoic acid, polymer with alkanepolyolpolyacrylate, 2,2'-azobis[2-methylbutanenitrile]-initiated The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) 'Not likely to present an unreasonable risk' section 5(a)(3)(C) determination.*

*In EPA’s original screening analysis for this PMN in 2017, EPA identified potential for risk to workers, which resulted in the interim finding. The PMN submitter provided additional data that changed the human health hazard profile and potential risk to workers. EPA’s final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA’s revised hazard and risk assessment for the chemical substance, where hazards were assessed to be low based on the additional data provided by the submitter. View the determination document.
02/23/2017 03/06/2020
J-20-0002 Generic: Microorganism with chromosomally-borne genetic modifications for the production of a chemical The microorganism is not likely to present an unreasonable risk (5(a)(3)(C)) The microorganism is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 12/23/2019 03/10/2020
P-20-0022 Generic: Polyalkoxycarbopolycycle hydroxy The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 12/09/2019 03/06/2020
P-17-0364 Generic: Dicyloalkyl-alkane-di-isocyanate homopolymer, alkyl alcohol and polyalkyl glycol mono-alkyl-ether-blocked The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) 'Not likely to present an unreasonable risk' section 5(a)(3)(C) determination.*

* In EPA’s original screening analysis for this PMN in 2017, EPA identified insufficient information to evaluate human health risks under the intended conditions of use, which resulted in the interim finding. EPA subsequently reassessed the hazard profile and environmental releases. EPA’s final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA’s revised hazard and risk assessment for the chemical substance under the intended conditions of use, where EPA expects that employers will require and workers will use appropriate personal protective equipment in a manner adequate to protect them, and no unreasonable risk to the environment was identified. View the determination document.
07/27/2017 02/11/2020
J-19-0001 Specific: Trichoderma reesei 3CH-3 The microorganism is not likely to present an unreasonable risk (5(a)(3)(C)) The microorganism is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document and the terms of the SNUR. 10/07/2019 02/28/2020
P-20-0013 Specific (P-20-0013): 2-Propenoic acid, 2-methyl-, (2-oxo-1,3-dioxolan-4-yl)methyl ester; CASRN: 13818-44-5 The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document and the terms of the SNUR . 10/17/2019 02/28/2020
P-18-0391 Specific: 1-Propanaminium, N-(carboxymethyl)-N, N-dimethyl-3-[(3,5, 5-trimethyl-1-oxohexyl), amino]- inner salt The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document and the terms of the SNUR . 09/28/2018 02/28/2020
P-18-0267
P-18-0268
P-18-0269
Generic (P-18-0267): Branched alkanoic acid, epoxy ester, reaction products with monocyclic dialkylamine and polycyclic alcohol epoxy polymer

Generic (P-18-0268): Branched alkanoic acid, epoxy ester, reaction products with monocyclicdialkanamine and polycyclic dialkanol ether polymer

Generic (P-18-0269): Branched alkanoic acid, epoxy ester, reaction products with monocyclicalkanamine, polycyclic alcohol ether homopolymer, and polycyclic alcohol epoxy polymer
The chemical substances are not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substances are not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 07/31/2018 02/21/2020
P-20-0024 Generic (P-20-0024): Phenol-formaldehyde polymer with amino-oxirane copolymer and nitrobenzoates. The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 12/04/2019 02/21/2020
P-20-0008 Generic: 7-Heteropolycyclicsulfonic acid, 2-[4-[2-[1-[[(2-methoxy-5-methyl-4-sulfophenyl)amino]carbonyl]-2-oxopropyl]diazenyl]phenyl]-6-methyl-, compd. with (alkylamino) alkanol and (hydroxyalkyl) amine The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 10/08/2019 02/28/2020
P-19-0170 Generic: Alkenoic acid, alkyl-substituted, epoxy ester, polymer with alkyl alkenoate, alkene, and polylactide The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 09/25/2019 02/21/2020
P-18-0389 Generic: Alkenoic acid, alkyl-substituted, epoxy ester, polymer with alkyl alkenoate, alkene, and polylactide The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 09/28/2018 02/28/2020
P-18-0211 Generic: Alkaneamine, (aminoalkyl)-, polymer with aziridine and 1,6-diisocyanatohexane, polyethylene glycol alkyl ether- and polyethylene-polypropylene glycol aminoalkyl alkyl ether- and alkenyl benzenated polyethylene glycol Ph ether The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 06/12/2018 02/21/2020
P-18-0187 Generic: Carboxylic acid-polyamine condensate The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 06/04/2018 02/28/2020
P-17-0355 Generic: Benzoic acid, 2-hydroxy-, -alkyl derivs The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 07/12/2017 02/11/2020
P-19-0164 Generic: Bis-alkoxy substituted alkane, polymer with aminoalkanol The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document and the terms of the proposed Significant New Use Rule (SNUR). 09/20/2019 01/31/2020
P-19-0158 Generic: Alkenoic acid polymer with 2-ethyl-2-(hydroxymethyl)-1,3-alkyldiol, 1,1'-methylenebis(4-isocyanatocarbomonocycle) and 3-methyl-1,5-aklydiol The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document and the terms of the proposed Significant New Use Rule (SNUR). 09/25/2019 01/31/2020
P-18-0367 Generic: Acid-modified polyether The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document and the terms of the proposed Significant New Use Rule (SNUR). 09/28/2018 01/31/2020
P-18-0199 Generic: Rare earth oxide The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document and the terms of the proposed Significant New Use Rule (SNUR). 06/01/2018 01/31/2020
P-18-0126 Specific: Calcium manganese titanium oxide; CASRN: 153728-36-0 The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document and the terms of the proposed Significant New Use Rule (SNUR). 03/09/2018 01/31/2020
P-18-0058 Specific: Phosphonium, trihexyltetradecyl-, salt with 1,1,1-trifluoro-N-[(trifluoromethyl)sulfonyl]methanesulfonamide (1:1); CASRN 460092-03-9 The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document and the terms of the proposed Significant New Use Rule (SNUR). 01/08/2018 01/31/2020
P-18-0236 Generic: Metal, alkenoic acid-alkyl alkenoate-alkyl substituted alkenoate polymer carbopolycycle complexes The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document and the terms of the proposed Significant New Use Rule (SNUR). 07/24/2018 01/27/2020
P-18-0108 Generic: Aromatic anhydride polymer with bisalkylbiphenylbisamine compound with alkylaminoalkyl acrylate ester The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 02/12/2018 01/22/2020
P-18-0031 Generic: Substituted dicarboxylic acid, polymer with various alkanediols The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 10/25/2017 01/22/2020
SN-17-0011 Generic: Polyfluorohydrocarbon The significant new use is not likely to present an unreasonable risk (5(a)(3)(C)) The significant new use is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 04/04/2017 01/22/2020
J-20-0001 Generic: Biofuel producing Saccharomyces cerevisiae modified, genetically stable The microorganism is not likely to present an unreasonable risk (5(a)(3)(C)) The microorganism is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 10/22/2019 01/16/2020
P-18-0328 Generic: Plant oil fatty acids, alkyl esters The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 09/25/2018 01/07/2020
P-18-0176 Generic: 5-Isobenzofurancarboxylic acid, 1,3-dihydro-1,3-dioxo-, polymer with aminoalcohol, 2,2-dimethyl-1,3-propanediol, 2,5-furandione, polyalkylene glycol and unsaturated anhydride The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 05/17/2018 02/27/2019
P-18-0067 Specific: Fatty acids, C14-18 and C16-18-unsatd., polymers with adipic acid and triethanolamine, di-Me sulfate-quaternized CASRN: 1211825-32-9 The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 12/18/2017 01/13/2020
P-17-0233 Generic: Oxyalkylene modified polyalkyl amine alkyl diacid polymer with 2-(chloromethyl)oxirane The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) 'Not likely to present an unreasonable risk' section 5(a)(3)(C) determination.*

*In EPA’s original screening analysis for this PMN in 2017, EPA identified potential for risk to workers, which resulted in the interim finding. The PMN submitter provided additional information that changed EPA’s assessment of potential exposure to workers. EPA’s final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA’s revised hazard and risk assessment for the chemical substance under the intended conditions of use, where EPA expects that employers will require and workers will use appropriate personal protective equipment in a manner adequate to protect them, and no unreasonable risk to the environment was identified. View the determination document.
02/07/2017 12/19/2019
P-17-0234 Specific: Oxirane, 2-(chloromethyl)-, polymer with 2-methyloxirane polymer with oxirane bis(2-aminopropyl) ether; CASRN: 78390-60-0 The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination.*

*In EPA’s original screening analysis for this PMN in 2017, EPA identified potential risks to workers, which resulted in the interim finding. EPA’s final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA’s revised risk assessment for the chemical substance under the intended conditions of use, where EPA expects that employers will require and workers will use appropriate personal protective equipment in a manner adequate to protect them, and EPA’s issuance of a proposed SNUR to address certain reasonably foreseen uses. Conditions of use that fall under the restrictions of the proposed SNUR are not likely to present unreasonable risk of injury to health or the environment because (1) those conditions of use are not likely to be commenced during the pendency of the proposed SNUR and (2) upon finalization of the SNUR those conditions of use would be prohibited unless and until EPA makes an affirmative determination that the significant new use is not likely to present an unreasonable risk or takes appropriate action under section 5(e) or 5(f). View the determination document and the terms of the proposed Significant New Use Rule (SNUR).
02/10/2017 12/18/2019
P-19-0155
P-19-0156
P-19-0157
Specific (P-19-0155): Amides, from C8-18 and C18-unsatd. glycerides and diethylenetriamine, ethoxylated, CASRN: 2173332-72-2

Specific (P-19-0156): Amides, from diethylenetriamine and palm kernel-oil, ethoxylated, CASRN: 2173332-69-7

Specific (P-19-0157): Amides, from coconut oil and diethylenetriamine, ethoxylated, CASRN: 2173332-70-0
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 09/18/2019 12/18/2019
P-19-0148
P-19-0149
P-19-0150
P-19-0151
Generic (P-19-0148): Iron, complexes with ethylenediamine-4-hydroxycarbomonocycle hetero-acid-2-oxoacetic acid reaction products, potassium salts

Generic (P-19-0149): Iron, complexes with ethylenediamine-4-hydroxycarbomonocycle hetero-acid potassium salt (1:1)-potassium 2-oxoacetate (1:1) reaction products, potassium salts

Generic (P-19-0150): Iron, complexes with ethylenediamine-4-hydroxycarbomonocycle hetero-acid-2-oxoacetic acid reaction products, sodium salts

Generic (P-19-0151): Iron, complexes with ethylenediamine-4-hydroxycarbomonocycle hetero-acid sodium salt (1:1)-sodium 2-oxoacetate (1:1) reaction products, sodium salts
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 08/22/2019 12/16/2019
P-19-0135 Generic: Alkyl polyoxyethylene ethers, carboxymethylated The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 09/06/2019 12/18/2019
P-18-0393 Generic: Alkenoic acid, alkyl, alkyl ester, polymer with alkyl propenoate, vinyl carbomonocyle, substituted alkyl propenoate, alkyl 2-alkyl 2-propenoate, alkanediol mono(2-alkyl-2-propenoate) and bicarbomonocylo alkyl 2-alkyl-2-alkenoate, tertiary alkyl substituted alkane peroxoate initiated; polymer exemption flag

Polymer exemption flag: The chemical must be manufactured such that it meets the polymer exemption criteria as described under 40 CFR §723.250(e)(1), in addition to meeting the definition of polymer at 40 CFR §723.250(b).
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 09/28/2018 12/19/2019
P-18-0341
P-18-0342
P-18-0343
P-18-0344
Generic (P-18-0341): Alkane dicarboxylic acid, polymer with alkoxylated polyalcohol , alkyl polyglycol, alkyl dialcohol, and functionalized carboxylic acid,

Generic (P-18-0342): Alkane dicarboxylic acid, polymer with alkyl polyglycol, alkyl dialcohol, and functionalized carboxylic acid,

Generic (P-18-0343): Alkane dicarboxylic acid, polymer with alkoxylated polyalcohol, and alkyl dialcohol, (hydroxy alkyl) ester,

Generic (P-18-0344): Aromatic dicarboxylic acid, polymer with alkane dicarboxylic acid, alkoxylated polyalcohol, and alkyl dialcohol,
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 10/11/2018 12/16/2019
P-18-0329 Generic: Substituted carbopolycyclic dicarboxylic acid dialkyl ester, polymer with alkanediol and carbopolycyclic bis (substituted carbopolycycle) bisalkanol The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 09/26/2018 12/19/2019
P-18-0114 Generic: Propanoic acid, hydroxy- (hydroxyalkyl)-alkyl-, polymer with 1,6-diisocyanatoalkane and poly[oxy(alkyl-alkanediyl)] ether with alkyl-(hydroxyalkyl)-alkanediol, 2-propenoate (ester), lithium salt, glycerol monoacrylate 1-neodecanoate- and alkylene glycol monoacrylate-blocked The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 02/19/2018 12/16/2019
P-17-0325 Specific: 2-Propenoic acid, polymer with 2-methyl-2-((1-oxo-2-propenyl)amino)-1-propanesulfonic acid; CASRN: 40623-75-4 The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 08/02/2017 12/19/2019
P-18-0232 Generic: Polyol, reaction products with formaldehyde and methanol The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination.*

*The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document and the terms of the proposed Significant New Use Rule (SNUR).
07/05/2018 11/26/2019
P-17-0298 Specific: Formaldehyde, homopolymer, reaction products with N-propyl-1-propanamine; CASRN: 1374859-50-3 The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) 'Not likely to present an unreasonable risk' section 5(a)(3)(C) determination.*

*In EPA’s original screening analysis for this PMN in 2017, EPA identified environmental risk and potential for risk to workers, which resulted in the interim finding. The PMN submitter provided additional information that changed EPA’s assessment of environmental releases, the human health hazard profile, and potential risk to workers. EPA’s final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA’s revised hazard and risk assessment for the chemical substance under the intended conditions of use, where EPA expects that employers will require and workers will use appropriate personal protective equipment in a manner adequate to protect them, and no unreasonable risk to the environment was identified. View the determination document.
05/02/2017 12/12/2019
P-20-0002 Specific: Fatty Acids, C18-unsatd., dimers, hydrogenated, polymers with .alpha-.hydro-.omega.-hydroxypoly(oxy-1,4-butanediyl) and nonanoic acid; CASRN 2359671-57-9 The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 10/02/2019 12/06/2019
P-20-0004 Specific: Fatty Acids, C18-unsatd., dimers, hydrogenated, polymers with hexanoic acid and .alpha.-hydro-.omega.hydroxypoly(oxy-1,4-butanediyl); CASRN 2359671-53-5 The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 10/02/2019 12/10/2019
P-17-0400 Generic: Terpolymer of vinylidene fluoride, tetrafluoroehylene and 2,3,3,3-tetrafluoropropene The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document and the terms of the proposed Significant New Use Rule (SNUR). 10/25/2017 11/26/2019
P-18-0214
P-18-0215
P-18-0216
Generic (P-18-0214): Polycyclic substituted alkane, polymer with cyclicalkylamine, epoxide, and polycyclic epoxide ether, reaction products with dialkylamine substituted alkyl amine.

Generic (P-18-0215): Polycyclic alkane, polymer with monocyclic amine, polycyclic epoxide ether, reaction products with dialkylamine alkyl amine.

Generic (P-18-0216): Polycyclic substituted alkane, polymer with epoxide, reaction products with cyclicalkylamine and dialkylamine substituted alkyl amine.
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 06/18/2018 11/26/2019
P-18-0133 Generic: Polyol adduct of bisaldehyde The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 03/20/2018 12/03/2019
P-18-0392 Generic: Heteromonocycle, alkenyl alkyl The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document and the terms of the proposed Significant New Use Rule (SNUR). 10/12/2018 12/06/2019
P-18-0385 Specific: D-Glucopyranose, oligomeric, Bu glycosides, polymers with epichlorohydrin, 2-hydroxy-3-sulfopropyl ethers, sodium salts; CASRN: 2139271-53-5 The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 11/14/2018 12/06/2019
P-18-0264 Generic: Phosphonomethylated ether diamine The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document and the terms of the proposed Significant New Use Rule (SNUR). 07/27/2018 12/04/2019
P-16-0291 Generic: 1,3-cyclohexanedimethanamine adduct The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) 'Not likely to present an unreasonable risk' section 5(a)(3)(C) determination.*

*In EPA’s original screening analysis for this PMN in 2016, EPA identified potential for risk to workers, potential for significant releases and exposures, and risk to the environment, which resulted in the interim finding. The PMN submitter amended the PMN and provided additional information on releases, processing, and use. EPA's final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA's revised risk assessment for the chemical substance under the intended conditions of use described in the amended PMN and EPA’s issuance of a proposed SNUR to address certain reasonably foreseen uses. View the determination document and the terms of the SNUR.
06/22/2016 11/26/2019
P-15-0632 Generic: Mixed amine salt The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) 'Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. View the determination document. 06/22/2016 11/26/2019
P-16-0486 Generic: Polychloropropane The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) 'Not likely to present an unreasonable risk' section 5(a)(3)(C) determination.*

*In EPA’s original screening analysis for this PMN in 2016, EPA identified potential risks to workers, which resulted in the interim finding. Based on additional information provided by the submitter, EPA revised its assessment for the intended conditions of use. EPA’s final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA’s revised risk assessment for the chemical substance under the intended conditions of use, where EPA expects that employers will require and workers will use appropriate personal protective equipment in a manner adequate to protect them, and EPA’s issuance of a proposed SNUR to address certain reasonably foreseen uses. View the determination document and the terms of the SNUR.
07/18/2016 11/26/2019
P-16-0451 Generic: Reaction product of bisalkoxysilylalkylamine, alkoxy oxiranylalkoxyalkylsilane and silica The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) 'Not likely to present an unreasonable risk' section 5(a)(3)(C) determination.*

*In EPA’s original screening analysis for this PMN in 2016, EPA identified potential for risk to human health, which resulted in the interim finding. EPA revised its assessment for the intended conditions of use. EPA’s final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA’s revised risk assessment for the chemical substance under the intended conditions of use, where EPA expects that employers will require and workers will use appropriate personal protective equipment in a manner adequate to protect them. View the determination document.
06/28/2016 12/03/2019
P-17-0184 Specific: 1-Propanaminium, 2-hydroxy-N,N-dimethyl-N-[3-[(1-oxooctyl)amino]propyl]-3-sulfo-, inner salt; CASRN 1612795-77-3 The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) 'Not likely to present an unreasonable risk' section 5(a)(3)(C) determination.*

*In EPA’s original screening analysis for this PMN in 2017, EPA identified potential risk to human health and the environment, which resulted in the interim finding. The PMN submitter provided acute toxicity studies that indicate the substance has low environmental hazard. EPA’s final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA’s revised hazard and risk assessment for the chemical substance under the intended conditions of use and EPA’s issuance of a proposed SNUR to address certain reasonably foreseen uses. View the determination document and the terms of the SNUR.
12/20/2016 12/03/2019
P-19-0152 Generic: Alkaneic acid, dialkyl ester polymer with alkanediol, [[(isocyanatocarbomonocycle) alkyl)carbomonocycle)carbamate The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 08/27/2019 09/17/2019
P-19-0146 Generic: Modified dimethyl sulfoxide The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 08/13/2019 11/26/2019
P-19-0058 Specific: Butanoic acid, 3-oxo-, 2-[(2-methyl-1-oxo-2-propen-1-yl)oxy]ethyl ester, polymer with butyl 2-propenoate, ethenylbenzene, methyl 2-methyl-2-propenoate and 2-methyl-2-popenoic acid, ammonium salt (CASRN 2131811-80-6); polymer exemption flag. The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 07/08/2019 11/21/2019
P-18-0213 Specific: 1,3-Benzenedicarboxylic acid, 5-sulfo-, calcium salt (2:1); CASRN 24806-09-5 The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 06/18/2018 11/14/2019
P-18-0167 Generic: Butanamide, 2-[2-[(substitutued phenyl)diazenyl]-N-(2-methoxyphenyl)-3-oxo- The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 05/07/2018 11/14/2019
P-18-0165
P-18-0166
Generic (P-18-0165): 2,5-Furandione, polymer with ethenylbenzene, 4-hydroxy-substituted butyl amide, sodium salts

Generic: (P-18-0166): 2,5-Furandione, polymer with ethenylbenzene, 4-hydroxy- substituted butyl [3-[2-[1-[[(2-methoxyphenyl)amino]carbonyl]-2-oxopropyl]diazenyl]phenyl]substituted, sodium salts
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) These chemical substances are not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 05/07/2018 11/07/2019
P-18-0258
P-18-0259
Generic (P-18-0258): Dioic acids, polymers with caprolactam and alkyldiamines

Generic (P-18-0259): Fatty acids, dimers, hydrogenated, polymers with caprolactam and alkyldiamine
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) These chemical substances are not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 07/23/2018 10/31/2019
P-17-0396 Generic: Aminoalkylated imidazole The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 09/12/2017 10/31/2019
P-18-0029 Generic: Fatty acids and fatty acid unsatd., reaction products with ethyleneamines and maleic anhydride The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 10/20/2017 11/04/2019
P-18-0019 Generic: Substituted Benzene, 4-[2-[2-hydroxy-3-[[(3-nitrophenyl)amino]carbonyl]-1-naphthalenyl]diazenyl]-, sodium salt (1:1) The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 10/13/2017 10/31/2019
P-18-0121 Specific: Benzene, 1,1'-oxybis-, branched eicosyl derivs.; CASRN 1800419-55-9 The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 03/08/2018 10/29/2019
P-17-0360 Specific: 2-Propanol, 1-amino-, compd. with .alpha.-sulfo-.omega.-(octyloxy)poly(oxy-1,2-ethanediyl) (1:1), CASRN 2098904-74-4; 2-Propanol, 1-amino-, compd. with .alpha.-sulfo- .omega.-(decyloxy)poly(oxy-1,2-ethanediyl) (1:1), CASRN 2098904-80-2 The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) 'Not likely to present an unreasonable risk' section 5(a)(3)(C) determination.*

*In EPA’s original screening analysis for this PMN in 2017, EPA identified potential for risk to human health under reasonably foreseen conditions of use and potential for substantial exposure and release to the environment, which resulted in the interim finding. EPA subsequently determined that there are no reasonably foreseen conditions of use. EPA’s final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA’s revised hazard and risk assessment for the chemical substance under the intended conditions of use, where EPA expects that employers will require and workers will use appropriate personal protective equipment in a manner adequate to protect them, and no unreasonable risk to the environment was identified. View the determination document.
07/18/2017 10/23/2019
P-17-0109 Generic: Alkyldiamine, aminoalkyl dimethylaminoalkyl dimethyl- The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) 'Not likely to present an unreasonable risk' section 5(a)(3)(C) determination.*

*In EPA’s original screening analysis for this PMN in 2017, EPA identified risks to workers and the general population under the intended conditions of use and potential environmental risk under reasonably foreseen conditions of use, which resulted in the interim finding. Based on additional information provided by the submitter, EPA revised its assessment for the intended conditions of use. EPA’s final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA’s revised risk assessment for the chemical substance under the intended conditions of use, where EPA expects that employers will require and workers will use appropriate personal protective equipment in a manner adequate to protect them, and EPA’s issuance of a proposed SNUR to address certain reasonably foreseen uses. View the determination document and the terms of the SNUR.
11/23/2016 09/30/2019
P-18-0092 Specific: Phosphonium, tributylmethyl-, iodide (1:1); CASRN 1702-42-7 The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document and the terms of the SNUR. 01/26/2018 09/30/2019
P-18-0207 Generic: Metal, oxo alkylcarboxylate complexes The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 06/06/2018 10/03/2019
SN-19-0004 Specific: Coke (coal), secondary pitch; CASRN 94113-91-4 The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The significant new use is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the SNUR and consent orders issued previously for this chemical substance. View the determination document. 08/16/2018 09/25/2019
SN-18-0005 Specific: Butanoic acid, 3-mercapto-,1,1'-[2-(hydroxymethyl)-2-[(3-mercapto-1-oxobutoxy)methyl]-1,3-propanediyl] ester; CASRN: 1027326-93-7; and Butanoic acid, 3-mercapto-,1,1'-[2,2-bis[(3-mercapto-1-oxobutoxy)methyl]-1,3-propanediyl] ester; CASRN: 31775-89-0 The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The significant new use is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 08/16/2018 09/25/2019
P-19-0137 Generic: Alkyl oligomeric reaction products The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 08/08/2019 09/23/2019
P-19-0132 Generic: Fatty acid, polymer with alkanedioic acid dialkyl ester, alkanoic acid, oxo alkyl ester, substituted carbomonocycle, alkyl substituted alkanediol, and alkylol substituted alkane The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 07/15/2019 09/27/2019
P-19-0130 Generic: Aminohydroxy naphthalenesulfonic acid, coupled with diazotized[(aminophenyl) sulfonyl]ethyl hydrogen sulfate and diazotized amino[[(sulfooxy)ethyl]sulfonyl]benzenesulfonic acid, salts The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document 07/08/2019 09/20/2019
P-19-0121 Generic: Plant based oils, polymer with 1,1'-methylenebis[4-isocyanatobenzene], pentaerythritol, phthalic esters, polypropylene glycol and polypropylene glycol ether with glycerol (3:1) The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 07/11/2019 09/25/2019
P-19-0117 Generic: Polycyclic amine, reaction products with polyalkylalkene, polymers The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 06/21/2019 09/18/2019
P-19-0113 Generic: Metal oxide-chloro The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document and the terms of the SNUR. 06/26/2019 09/30/2019
P-18-0302 Specific: D-Glucaric acid, ammonium salt (1:1); 6614-39-7 The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 09/10/2018 09/30/2019
P-18-0299 Generic: Alkenoic acid, alkyl-, polymers with alkyl methacrylate, cycloalkyl methacrylate, alkylene dimethacrylate, and polyalkene glycol hydrogen sulfate [(branched alkyloxy)alkyl]-(alkenyloxy)alkyl ethers ammonium salts, metal salts The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 09/07/2018 10/01/2019
P-18-0295 Specific: 1,3-Butanediol, (3R)-, CASRN 6290-03-5 The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document and the terms of the SNUR. 06/17/2018 09/30/2019
P-18-0105 Specific: Phosphorous acid, triisotridecyl ester; CASRN: 77745-66-5 The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document and the terms of the SNUR. 02/08/2018 09/30/2019
P-18-0034 Generic: Polyetheramine carboxylate salt The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 10/30/2017 09/30/2019
P-18-0192 Generic: Benzenesulfonic acid, (alkenediyl)bis[[[(hydroxyalkyl)amino]-(phenylamino)-triazin-2-yl]amino]-, N-(hydroxyalkyl) derivs., salts, compds. with polyalkyl-substituted(alkanol) The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 05/29/2019 09/13/2019
J-19-0024
J-19-0025
Generic: Biofuel producing Saccharomyces cerevisiae modified, genetically stable The microorganisms are not likely to present an unreasonable risk (5(a)(3)(C)) The microorganisms are not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document. 06/28/2019 09/12/2019
P-19-0120 Generic: Alkenoic acid, polymer with alkanediyl bis substituted alkylene bis heteromonocycle, substituted carbomonocycle and (alkylalkenyl) carbomonocycle, alkali metal salt The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 06/25/2019 08/29/2019
P-19-0118 Generic: Substituted polyalkylenepoly, reaction products with alkene polymer The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 06/21/2019 08/28/2019
P-19-0099 Specific: Propanoic acid, 3-hydroxy-2-(hydroxymethyl)-2-methyl-, polymer with dimethyl carbonate, 1,2-ethanediamine, 2-ethyl-2-(hydroxymethyl)-1,3-propanediol, 1,6-hexanediol and 1,1'-methylenebis[4-isocyanatocyclohexane], compd. with N,N-diethylethanamine, CASRN: 1178511-46-0 The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 06/18/2019 08/29/2019
P-19-0047 Specific: Propanoic acid, 3-hydroxy-2-(hydroxymethyl)-2-methyl-, polymer with 5-amino-1,3,3-trimethylcyclohexanemethanamine, .alpha.-hydro-.omega.-hydroxypoly(oxy-1,4-butanediyl), alpha.-hydro-.omega.-hydroxypoly[oxy(methyl-1,2-ethanediyl)], 5-isocyanato-1-(isocyanatomethyl)-1,3,3-trimethylcyclohexane and 1,1'-methylenebis[4-isocyanatobenzene], Pr alc.-blocked; CASRN 2283318-90-9 The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 07/31/2019 08/29/2019
P-19-0024 Specific: Silsesquioxanes, 3-(dimethyloctadecylammonio)propyl Me Pr, polymers with silicic acid (H4Si04) tetra-Et ester, (2-hydroxyethoxy)- and methoxyterminated, chlorides; CASRN: 2231249-14-0 The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document and the terms of the SNUR. 02/14/2019 08/30/2019
P-18-0384 Specific: Lithium, isotope of mass 6; CASRN: 14258-72-1 The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document and the terms of the SNUR. 09/28/2018 08/30/2019
P-18-0358 Specific: 1H-Imidazole-1-propanenitrile, 2-ethyl-ar-methyl-; CASRN: 568591-00-4 The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document and the terms of the SNUR. 09/27/2018 08/30/2019
P-18-0276 Specific: Benzenesulfonamide, N-[2-[[(phenylamino)carbonyl]amino]phenyl]-; CASRN: 215917-77-4 The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document and the terms of the SNUR. 08/15/2018 08/30/2019
P-18-0197 Generic: Metal, alkylcarboxylate oxo complexes The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 06/01/2018 08/09/2019
P-18-0172 Specific: Calcium, carbonate 2-ethylhexanoate neodecanoate propionate complex The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. 05/10/2018 08/23/2019
P-18-0109 Generic: 2-Alkenoic acid, 2-alkyl-, alkyl ester, polymer with 2-(dialkylamino)alkyl 2-alkyl-2-alkenoate, alkyl 2-alkyl-2-alkenoate and a-(2-alkyl-1-oxo-2-alken-1-yl)-o-alkoxypoly(oxy-1,2-alkanediyl), [(1-alkoxy-2-alkyl-1-alken-1-yl)oxy]trialkylsilane-initiated The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document and the terms of the SNUR. 02/16/2018 08/30/2019
P-17-0347
P-17-0348
P-17-0349
P-17-0350
P-17-0351
P-17-0352
Specific: Oxirane, 2-methyl-, polymer with oxirane, mono(2-butyloctyl) ether; CASRN:252756-20-0

Specific: Oxirane, 2-methyl-, polymer with oxirane, mono(2-hexyldecyl) ether; CASRN: 125005-52-9

Specific: Oxirane, 2-methyl-, polymer with oxirane, mono(2-octyldodecyl) ether; CASRN: 102640-44-8

Specific: Oxirane, 2-methyl-, polymer with oxirane, mono(2-decyltetradecyl) ether; CASRN: 72484-69-6

Specific: Oxirane, 2-methyl-, polymer with oxirane, mono(2-dodecylhexadecyl) ether; CASRN: 102640-42-6

Specific: Oxirane, 2-methyl-, polymer with oxirane, mono(2-tetradecyloctadecyl) ether; CASRN: 102640-46-0
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) 'Not likely to present an unreasonable risk' section 5(a)(3)(C) determination.

*In EPA’s original screening analysis for this PMN in 2017, EPA identified potential risks to workers, which resulted in the interim finding. Based on additional information provided by the submitter, EPA revised its assessment for the intended conditions of use. EPA’s final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA’s revised risk assessment for the chemical substance under the intended conditions of use, where EPA expects that employers will require and workers will use appropriate personal protective equipment in a manner adequate to protect them, and EPA’s issuance of a proposed SNUR to address certain reasonably foreseen uses. Conditions of use that fall under the restrictions of the proposed SNUR are not likely to present unreasonable risk of injury to health or the environment because (1) those conditions of use are not likely to be commenced during the pendency of the proposed SNUR and (2) upon finalization of the SNUR those conditions of use would be prohibited unless and until EPA makes an affirmative determination that the significant new use is not likely to present an unreasonable risk or takes appropriate action under section 5(e) or 5(f). View the determination document and the terms of the SNUR.
07/06/2017 08/28/2019
P-16-0541 Specific: Soybean meal, reaction products with phosphoric trichloride; CASRN: 1962913-92-3 The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) 'Not likely to present an unreasonable risk' section 5(a)(3)(C) determination.

*In EPA’s original screening analysis for this PMN in 2016, EPA identified insufficient information to evaluate human health risks and the potential for environmental risk under the intended conditions of use, which resulted in the interim finding. The submitter clarified information regarding assumptions made during the initial assessment, and EPA reassessed the hazard profile and environmental releases. EPA’s final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA’s revised hazard and risk assessment for the chemical substance under the intended conditions of use, where EPA expects that employers will require and workers will use appropriate personal protective equipment in a manner adequate to protect them, and no unreasonable risk to the environment was identified. View the determination document.
08/29/2016 08/28/2019
P-18-0387
P-18-0388
Generic (P-18-0387): Alkanal, reaction products with alkanediyl bis[alkyl-tris(alkyl-heterocycle)-1,3,5-triazine-2,4,6-triamine and hydrogen peroxide

Generic (P-18-0388): 1,3,5-triazine-2,4,6-triamine, alkanediyl bis[alkyl-tris(alkyl-heterocycle)-, allyl derivs., oxidized, hydrogenated,
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substances are not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. 09/28/2018 08/15/2019
P-17-0299 Generic: 2-Propenoic acid, alkyl -, polymers with alkyl acrylate and polyethylene glycol methacrylate alkyl ether The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) 'Not likely to present an unreasonable risk' section 5(a)(3)(C) determination.

*In EPA’s original screening analysis for this PMN in 2017, EPA identified a potential for lung effects in workers, which resulted in the interim finding. EPA’s final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA’s revised hazard and risk assessment for the chemical substance under the intended conditions of use, where EPA expects that employers will require and workers will use appropriate personal protective equipment in a manner adequate to protect them, and no unreasonable risk to the environment was identified. View the determination document.
05/02/2017 08/15/2019
P-18-0155
P-18-0156
Generic (P-18-0155): Crosslinked polymer of alkyl acrylamides, acrylate esters, and alkyl acrylamide sulfonate salt

Generic (P-18-0156): Crosslinked polymer of alkyl acrylamides, acrylate esters, and alkyl acrylamide sulfonic acid
The chemical substances are not likely to present an unreasonable risk (5(a)(3)(C)) 'Not likely to present an unreasonable risk' section 5(a)(3)(C) determination.

*In EPA’s original screening analysis for this PMN in 2017, EPA identified potential risks to the environment, workers, and the general population, which resulted in the interim finding. Based on amendments provided by the submitter that include measures to reduce worker inhalation exposure to the new chemical substance and clarifying releases to water, EPA revised its assessment for the intended conditions of use. EPA’s final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA’s revised risk assessment for the chemical substance under the intended conditions of use, where EPA expects that employers will require and workers will use appropriate personal protective equipment in a manner adequate to protect them, and EPA’s issuance of a proposed SNUR to address certain reasonably foreseen uses. Conditions of use that fall under the restrictions of the proposed SNUR are not likely to present unreasonable risk of injury to health or the environment because (1) those conditions of use are not likely to be commenced during the pendency of the proposed SNUR and (2) upon finalization of the SNUR those conditions of use would be prohibited unless and until EPA makes an affirmative determination that the significant new use is not likely to present an unreasonable risk or takes appropriate action under section 5(e) or 5(f). View the determination document and the terms of the SNUR.
04/26/2018 08/06/2019
SN-19-0005 Generic: Functionalized multi-walled carbon nanotubes The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. 05/20/2019 08/09/2019
P-19-0085 Generic: Aliphatic hydrocarbons, C16-18-branched and linear The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. 05/10/2019 08/07/2019
P-18-0190
P-18-0191
Generic (P-18-0190): 2,5-Furandione, polymer with ethenylbenzene, 4-hydroxy-substituted butyl amide, polymers with epichlorohydrin and trimethylolpropane, sodium salts

Generic: (P-18-0191): 2,5-Furandione, polymer with ethenylbenzene, 4-hydroxy-substituted butyl [3-[2-[1-[[(substituted phenyl)amino]carbonyl]-2-oxopropyl]diazenyl]phenyl]methyl amide, polymers with epichlorohydrin and trimthylolpropane, sodium salts
The chemical substances are not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substances are not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. 05/25/2018 08/06/2019
P-18-0035 Generic: Methacrylic acid heterocyclic alkyl ester The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. 10/30/2017 07/31/2019
P-18-0009 Generic: Phosphonic acid, dimethyl ester, polymer with alkyl diols The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. 10/04/2017 07/31/2019
P-17-0395 Generic: Alkyl tri dithiocarbmate tri salt The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. 09/26/2017 07/31/2019
P-17-0346 Specific: Phosphonium, triphenylpropyl-, bromide; CASRN: 6228-47-3 The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) 'Not likely to present an unreasonable risk' section 5(a)(3)(C) determination.

*In EPA’s original screening analysis for this PMN in 2017, EPA identified potential risks to the environment, workers, and the general population, which resulted in the interim finding. Based on amendments provided by the submitter that include measures to reduce worker inhalation exposure to the new chemical substance and clarifying releases to water, EPA revised its assessment for the intended conditions of use. EPA’s final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA’s revised risk assessment for the chemical substance under the intended conditions of use, where EPA expects that employers will require and workers will use appropriate personal protective equipment in a manner adequate to protect them, and EPA’s issuance of a proposed SNUR to address certain reasonably foreseen uses. Conditions of use that fall under the restrictions of the proposed SNUR are not likely to present unreasonable risk of injury to health or the environment because (1) those conditions of use are not likely to be commenced during the pendency of the proposed SNUR and (2) upon finalization of the SNUR those conditions of use would be prohibited unless and until EPA makes an affirmative determination that the significant new use is not likely to present an unreasonable risk or takes appropriate action under section 5(e) or 5(f). View the determination document and the terms of the SNUR.
07/10/2017 07/31/2019
P-17-0312
P-17- 0313
P-17-0314
P-17-0315
P-17-0316
P-17-0317
Generic (P-17-0312): Organic acid, compds. with bisphenol A-epichlorohydrin-polypropylene glycol diglycidyl ether polymer-disubstituted amine-disubstituted polypropylene glycol reaction products,

Generic (P-17-0313): Phenol, 4,4'-(1-methylethylidene)bis-, polymer with 2-(chloromethyl)oxirane and alpha-(2-oxiranylmethyl)-omega-(2-oxiranylmethoxy)poly[oxy(methyl-1,2-ethanediyl)], reaction products with disubstituted amine and disubstituted polypropylene glycol, organic acid salts,

Generic (P-17-0314): Organic acid, 2-substituted-, compds. with bisphenol A-epichlorohydrin-polypropylene glycol diglycidyl ether polymer-disubstituted aminedisubstituted polypropylene glycol reaction products,

Generic (P-17-0315): Phenol, 4,4'-(1-methylethylidene)bis-, polymer with alpha-(2-substituted-methylethyl)-omega-(2-substituted-methylethoxy)poly[oxy(methyl-1,2-ethanediyl)], 2-(chloromethyl)oxirane and alpha-(2-oxiranylmethyl)-omega-(2-oxiranylmethoxy)poly[oxy(methyl-1,2-ethanediyl)], alkylphenyl ethers, reaction products with disubstituted amine, organic acid salts,

Generic (P-17-0316): Organic acid, compds. with bisphenol A-epichlorohydrin-disubstituted polypropylene glycol-polypropylene glycol diglycidyl ether polymer alkylphenyl ethers-disubstituted amine reaction products,

Generic (P-17-0317): Organic acid, compds. with bisphenol A-epichlorohydrin-polypropylene glycol diglycidyl ether polymer-disubstituted polypropylene glycol reaction products
The chemical substances are not likely to present an unreasonable risk (5(a)(3)(C)) 'Not likely to present an unreasonable risk' section 5(a)(3)(C) determination.

*In EPA’s original screening analysis for this PMN in 2017, EPA identified potential for risk to workers and the environment under foreseeable conditions of use, which resulted in the interim finding. EPA subsequently determined that there are no reasonably foreseen conditions of use for the new chemical substances and the PMN submitter provided additional information that changed the environmental hazard profile of the new chemical substance. EPA’s final determination that the new chemical substances are not likely to present unreasonable risk is based on EPA’s revised hazard and risk assessment for the chemical substances under the intended conditions of use, where EPA expects that employers will require and workers will use appropriate personal protective equipment in a manner adequate to protect them, and no unreasonable risk to the environment was identified. View the determination document.
05/24/2017 07/31/2019
P-19-0096 Generic: Benzofuranone, bis(branched alkyl)-[dialkyl[tetrakis(branched alkyl)-alkyl-dibenzo-substitutedphosphite-yl] phenyl]- The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. 05/29/2019 07/31/2019
P-19-0062 Generic: Hydrochlorofluoroolefin The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. 02/27/2019 07/31/2019
P-19-0029 Specific: Phosphonium, tributylethyl-, diethyl phosphate (1:1); CASRN 20445-94-7 The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. 11/29/2018 07/31/2019
P-18-0394 Generic: substituted benzylic ether polyethylene glycol alkyl ether derivative The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. 09/28/2018 07/29/2019
P-18-0300 Generic: Heteromonocycle, alkenoic 1:1 salt, polymer with alpha-(2-methyl-1-oxo-2-propen-1-y)l-omegamethoxypoly(oxy-1,2-ethanediyl) and methylalkenoic acid The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. 09/10/2018 07/29/2019
P-18-0286 Specific: Propane, 1,1,1,3,3,3-hexafluoro-2-methoxy- CASRN: 13171-18-1 The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. 8/27/2018 07/31/2019
P-18-0257 Specific: Phosphoric acid, potassium salt (2:3); CASRN: 66923-00-0 The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. 07/23/2018 07/26/2019
P-18-0103 Generic: Alkylnitrile imidazole The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. 02/05/2018 07/31/2019
P-16-0442
P-16-0443
P-16-0444
P-16-0445
Generic:
P-16-0442 - Carboxylic acids, unsaturated, polymers with disubstituted amine, alkanediol, substituted alkylpropanoic acid, alkanedioic acid and substituted isocyanatocycloalkane, compds with alkylamine

P-16-0443 – Carboxylic acids, unsaturated, hydrogenated polymers with disubstituted amine, alkanediol, substituted alkylpropanoic acid, alkanedioic acid and substituted isocyanatocycloalkane, compds with alkylamine

P-16-0444 - Carboxylic acids, unsaturated, polymers with substituted alkanediamine, alkanediol, substituted alkylpropanoic acid, alkanedioic acid and substituted isocyanatocycloalkane, compds with alkylamineAmine salted polyurethane

P-16-0445 - Carboxylic acids, unsaturated, hydrogenated polymers with substituted alkanediamine, alkanediol, substituted alkylpropanoic acid, alkanedioic acid and substituted isocyanatocycloalkane, compds with alkylamine
The chemical substances are not likely to present an unreasonable risk (5(a)(3)(C)) 'Not likely to present an unreasonable risk' section 5(a)(3)(C) determination.

*In EPA’s original screening analysis for this PMN in 2016, EPA identified a potential for risk to workers, which resulted in the interim finding. The PMN submitter provided additional information that changed the human health hazard profile and potential risk to workers. EPA’s final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA’s revised hazard and risk assessment for the chemical substance under the intended conditions of use, where EPA expects that employers will require and workers will use appropriate personal protective equipment in a manner adequate to protect them, and no unreasonable risk to the environment was identified. View the determination document.
06/23/2016 07/31/2019
P-16-0092 Generic: Polymeric polyamine The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) 'Not likely to present an unreasonable risk' section 5(a)(3)(C) determination.

*In EPA’s original screening analysis for this PMN in 2015, EPA determined that certain exposure criteria were met and identified concerns for ecotoxicity, which resulted in an interim decision to require testing by order. The submitter provided the proposed test data during the review period, removing the basis for the order. The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment for the intended conditions of use and EPA’s issuance of a proposed SNUR to address certain reasonable foreseen uses. View the determination document and the terms of the SNUR.
06/22/2016 07/31/2019
P-18-0401 Specific: Glycerides, C16-18 and CI8-unsatd. mono- and di-, citrates; CASRN: 91052-16-3 The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. 09/29/2018 07/24/2019
P-18-0177 Specific: Waxes and Waxy substances, rice bran, oxidized; CASRN: 1883583-80-9 The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. 05/15/2018 07/26/2019
P-17-0362 Generic: Aliphatic phosphoric amide ester The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) 'Not likely to present an unreasonable risk' section 5(a)(3)(C) determination.

*In EPA’s original screening analysis for this PMN in 2017, EPA identified environmental risk under reasonably foreseen conditions of use and potential for risk to workers, which resulted in the interim finding. EPA subsequently determined that although there are reasonably foreseen conditions of use for the new chemical substance, the chemical substance has low human health hazard and low environmental hazard based on data submitted on the new chemical substance that changed the human health hazard and environmental hazard profiles and potential risk to workers and the environment. EPA’s final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA’s revised hazard and risk assessment for the chemical substance under the conditions of use, where EPA believes that this chemical substance is not likely to present an unreasonable risk even if potential exposures were high. View the determination document.
07/26/2017 07/24/2019
P-19-0081 Generic: 2-Propenoic acid, alkyl ester, reaction products with mixed substituted alkyl esters of phosphorodithioic acid and propylene oxide The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. 05/01/2019 07/23/2019
P-18-0185 Generic: Fatty acid, polymer with alkanedioic acid dialkyl ester, hydroxyl alkyl substituted alkanediol, substituted carbomonocycle and alkylol substituted alkane; polymer exemption flag

Polymer exemption flag: The chemical must be manufactured such that it meets the polymer exemption criteria as described under 40 CFR §723.250(e)(1), in addition to meeting the definition of polymer at 40 CFR §723.250(b).
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. 05/21/2018 07/14/2019
P-18-0285 Specific: Butanedioic acid, 2-methylene-, polymer with 2-methyl-2-[(1-oxo-2-propen-1-yl)amino]-1-propanesulfonic acid, sodium zinc salt; CASRN: 2220235-78-7 The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. 08/27/2018 07/23/2019
P-18-0223 Generic: Alkane, bis(alkoxymethyl)-dimethyl- The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. 06/26/2018 07/17/2019
P-19-0068 Generic: 1,4-benzenedicarboxylic acid, polymer with diol, 5-amino-1,3,3-trimethylcyclohexanemethanamine, 1,2-ethanediol and urea The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. 04/16/2019 07/12/2019
P-16-0417 Generic: Isocyanate terminated polyurethane resin The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) 'Not likely to present an unreasonable risk' section 5(a)(3)(C) determination.

*In EPA’s original screening analysis for this PMN in 2016, EPA identified concern for risks to human health and the environment under the reasonably foreseen conditions of use, which resulted in the interim finding. EPA’s final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA’s risk assessment for the chemical substance under the intended conditions of use, where EPA expects that employers will require and workers will use appropriate personal protective equipment in a manner adequate to protect them, and EPA’s issuance of a proposed SNUR to address certain reasonably foreseen uses. Conditions of use that fall under the restrictions of the proposed SNUR are not likely to present unreasonable risk of injury to health or the environment because (1) those conditions of use are not likely to be commenced during the pendency of the proposed SNUR and (2) upon finalization of the SNUR those conditions of use would be prohibited unless and until EPA makes an affirmative determination that the significant new use is not likely to present an unreasonable risk or takes appropriate action under section 5(e) or 5(f). View the determination document and the terms of the SNUR.
06/22/2016 06/30/2019
J-19-0021
J-19-0022
Generic: Saccharomyces cerevisiae strain CBI The microorganisms are not likely to present an unreasonable risk (5(a)(3)(C)) The microorganisms are not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document.  04/04/2019 06/25/2019
P-18-0241
P-18-0244
P-18-0245
Generic: 2-Propenoic acid, 2-methyl-, methyl ester, polymer with ethenylbenzene, ethyl 2-propenoate, 2-oxiranylmethyl 2-methyl-2-propenoate and 1,2-propanediol mono(2-methyl-2-propenoate), reaction products with diethanolamine, polymers with substituted-alkyl acrylate, formates (salts), (P-18-0241)

2-Propenoic acid, 2-methyl, methyl ester, polymer with ethenylbenzene, ethyl 2-propenoate, 2-oxiranylmethyl 2-methyl-2-propenoate and 1,2-propanediol mono(2-methyl-2-propenoate), reaction products with diethanolamine, polymers with substituted-alkyl methacrylate, formates (salts), (P-18-0244)

2-Propenoic acid, 2-methyl-, methyl ester, polymer with ethenylbenzene, ethyl 2-propenoate, 2-oxiranylmethyl 2-methyl-2-propenoate, and 1,2-propanediol mono(2-methyl-2-propenoate), reaction products with diethanolamine, polymers with alkylene glycol monoacrylate, formates (salts), (P-18-0245).
The chemical substances are not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. 07/16/2018 06/30/2019
P-19-0071 Generic: Trimethylolpropane, alkenoic acid, triester. The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. 03/22/2019 06/19/2019
P-19-0031 Generic: Phenol, 4,4'-(1-methylethylidene)bis-, polymer with formaldehyde, 2-(chloromethyl)oxirane, alpha-hydro-omega-hydroxypoly(oxy-1,2-ethanediyl), and polyamines The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. 12/28/2018 06/21/2019
P-18-0402 Generic: Phenol, alkanepolyolbis(heteroalkylene)bis-, polyalkylene derivs. The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. 03/11/2019 06/30/2019
P-18-0397 Generic: Substituted alkanedioic acid, polymer with substituted alkanoic acid The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. 09/29/2018 06/21/2019
P-19-0072 Specific: 1-Butanol, reaction products with 2-[(2-propen-1-yloxy)methyl]oxirane; CASRN: None The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. 03/26/2019 06/21/2019
P-18-0170 Specific: 1-Propanaminium, N,N'-(oxydi-2,1-ethanediyl)bis[3-chloro-2-hydroxy-N,N-dimethyl-, chloride (1:2); CASRN: 96320-92-2 The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. 05/10/2018 06/27/2019
P-18-0011 Specific: 1H-Imidazole, 1,2,4,5-tetramethyl-; CASRN: 1739‐83‐9 The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. 10/05/2017 06/30/2019
P-18-0239
P-18-0240
Generic (P-18-0239): N-alkyl propanamide
Generic (P-18-0240): N-alkyl acetamide
The chemical substances are not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment for the intended conditions of use and EPA’s issuance of a proposed SNUR to address certain reasonably foreseen uses. View the determination document and the terms of the SNUR. 07/16/2018 06/30/2019
J-19-0019
J-19-0020
Generic: Genetically modified microorganism
for the production of an enzyme substance
The microorganisms are not likely to present an unreasonable risk (5(a)(3)(C)) The microorganisms are not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document.  03/20/2019 06/13/2019
P-19-0065 Specific: 2lambda5, 4lambda5, 6lambda5
- 1,3,5,2,4,6 Triazatriphosphorine, 2,2,4,4,6,6 – hexaphenoxy-; CASRN: 1184-10-7
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. 03/22/2019 06/14/2019
P-19-0012 Generic: Benzenedicarboxylic acid, reaction
products with isobenzofurandione and diethylene glycol
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. 12/20/2018 06/14/2019
P-18-0404 Generic: alkylmultiheteroatom,2-functionalisedalkyl-2-hydroxyalkyl-,
polymer with alkylheteroatom-multialkylfunctionalised carbomonocyleheteroatom
and multiglycidylether difunctionalised polyalkylene glycol
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. 10/19/2018 06/14/2019
P-18-0260 Generic: Fatty acids, polymers with alkanoic acid and substituted carbomonocycle,
peroxide-initiated, polymers with alkanoic
acid esters and substituted carbomonocycle,
ammonium salts; polymer
exemption flag
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. 07/26/2018 06/14/2019
P-18-0125 Generic: Oxoalkylcarboxylic acid, sodium salt The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment for the intended conditions of use and EPA’s issuance of a proposed SNUR to address certain reasonably foreseen uses. View the determination document and the terms of the SNUR. 03/07/2018 06/14/2019
P-18-0282 Generic: Fatty acid ester, polyether,
diisocyanate polymer
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. 08/24/2018 05/30/2019
P-17-0108 Specific: Carbonodithioic acid, O-[2-
[(dithiocarboxy)amino]-2-methylpropyl]
ester, sodium salt (1:2); CASRN: 1947332-67-3
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) "Not likely to present an unreasonable risk" section 5(a)(3)(C) determination*

*In EPA’s original screening analysis for this PMN in 2016, EPA identified potential risk to workers, substantial releases and significant exposure, and risk to the environment, which resulted in the interim finding. The PMN submitter clarified that the new chemical substance would not be released to surface water and provided an updated Safety Data Sheet. EPA’s final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA’s risk assessment for the chemical substance under the intended conditions of use, where worker exposure is expected be controlled through the use of appropriate PPE and release to water is not expected. View the determination document.
11/09/2016 05/01/2019
P-16-0429 Generic: Endcapped polysiloxane The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) "Not likely to present an unreasonable risk" section 5(a)(3)(C) determination*

*In EPA’s original screening analysis for this PMN in 2016, EPA identified potential for risk to workers, which resulted in the interim finding. EPA's final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA's risk assessment for the chemical substance under the intended conditions of use described in the PMN where EPA expects that employers will require and workers will use appropriate personal protective equipment in a manner adequate to protect them. View the determination document.
06/22/2016 05/17/2019
P-16-0225 Specific: Isomer mixture of Cyclohexanol,
4-ethylidene-2-propoxy- (CASRN: 1631145-48-6) (35-45%) and Cyclohexanol, 5-
ethylidene-2-propoxy-
(CASRN: 1631145-49-7) (45-55%)
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. 06/22/2016 05/07/2019
P-16-0470 Specific: 2,7-Nonadien-4-ol, 4,8-dimethyl-;
CASRN: 103983-77-3
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) "Not likely to present an unreasonable risk" section 5(a)(3)(C) determination*

*In EPA’s original screening analysis for this PMN in 2016, EPA identified environmental risk under reasonably foreseen conditions of use and potential for risk to workers, which resulted in the interim finding. EPA subsequently determined that there are no reasonably foreseen conditions of use for the new chemical substance and the PMN submitter provided additional information that changed the human health hazard profile and potential risk to workers. EPA’s final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA’s revised hazard and risk assessment for the chemical substance under the intended conditions of use, where EPA expects that employers will require and workers will use appropriate personal protective equipment in a manner adequate to protect them, and no unreasonable risk to the environment was identified. View the determination document.
07/14/2016 05/17/2019
P-19-0034 Generic: Metal, bis(2,4-pentanedionato-
kO2,kO4)-, (T-4)-,
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment for the intended conditions of use and EPA’s issuance of a proposed SNUR to address certain reasonably foreseen uses. View the determination document and the terms of the SNUR. 12/06/2018 05/31/2019
P-19-0028 Generic: Alkyl salicylate, metal salts The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. 02/22/2019 05/21/2019
P-19-0020 Generic: Alkylphenol, reaction products
with carbon dioxide, distn. residues from
manuf. of alkylphenol derivs. and calcium
alkylphenol derivs.
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. 01/31/2019 04/30/2019
P-19-0004 Generic: Aromatic dianhydride, polymer
with aromatic diamine and heteroatom
bridged aromatic diamine, reaction products
with aromatic anhydride
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment for the intended conditions of use and EPA’s issuance of a proposed SNUR to address certain reasonably foreseen uses. View the determination document and the terms of the SNUR. 12/21/2018 05/31/2019
P-18-0322 Generic: Heteromonocycle, 4,6-dimethyl-2-(1
-phenylethyl)-
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment for the intended conditions of use and EPA’s issuance of a proposed SNUR to address certain reasonably foreseen uses. View the determination document and the terms of the SNUR. 09/21/2018 05/31/2019
P-18-0321 Generic: Poly(oxy-ethanediyl), (methyl ethanediyl) bis[hydroxy-, The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. 09/21/2018 05/31/2019
P-18-0270 Generic: Ethanol, 2-butoxy-, 1,1'-ester The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment for the intended conditions of use and EPA’s issuance of a proposed SNUR to address certain reasonably foreseen uses. View the determination document and the terms of the SNUR. 08/06/2018 05/31/2019
P-18-0247
P-18-0248
P-18-0249
P-18-0250
P-18-0251
P-18-0252
Generic (P-18-0247): Isocyanic acid,
polymethylenepolyphenylene ester, polymer
with 2-ethyl-2-(hydroxymethyl)-1,3-propanediol, polyetherpolyol, .alpha.,alpha.'
-[(1- methylethylidene)di-4,1-phenylene]bis[.omega.
-hydroxypoly(oxy-1,2-ethanediyl)] and 1,2-
propanediol, iso-Bu alc.- and 2-butoxyethanol- and 2-(2-butoxyethoxy)ethanol- and Et alc.- and methanol-and 1-methoxy-2-propanol-blocked,

Generic (P-18-248): Isocyanic acid,
polymethylenepolyphenylene ester, polymer with polyetherpolyol, 2-butoxyethanol- and 2-(2-butoxyethoxy) ethanol- and methanol blocked,

Generic (P-18-249): Isocyanic acid,
polymethylenepolyphenylene ester, polymer with polyetherpolyol, 2-butoxyethanol- and 2-(2-butoxyethoxy)ethanol- and methanol and 1-methoxy-2-propanol-blocked

Generic (P-18-0250): is Isocyanic acid,
polymethylenepolyphenylene ester, polymer
with polyetherpolyol, 2-butoxyethanol- and 2-(2-butoxyethoxy)ethanol- and 1(or2)-(2-methoxymethylethoxy)propanol-blocked

Specific (P-18-0251): Isocyanic acid,
polymethylenepolyphenylene ester, 2-butoxyethanol-and 2-(2-butoxyethoxy)ethanol- and methanol-
and 1(or2)-(2-methoxymethylethoxy)propanol-blocked

Specific (P-18-0252): Isocyanic acid,
polymethylenepolyphenylene ester, 2-butoxyethanol-and 2-(2-butoxyethoxy)ethanol- and methanol-
and 1-methoxy-2-propanol-blocked
The chemical substances are not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. 07/18/2018 04/29/2019
P-18-0234 Generic: Alkenoic acid, reaction products with bis substituted alkane and ether polyol The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment for the intended conditions of use and EPA’s issuance of a proposed SNUR to address certain reasonably foreseen uses. View the determination document and the terms of the SNUR. 07/06/2018 05/31/2019
P-18-0228 Generic: Branched alkenyl acid, alkyl ester,homopolymer The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment for the intended conditions of use and EPA’s issuance of a proposed SNUR to address certain reasonably foreseen uses. View the determination document and the terms of the SNUR. 08/30/2018 05/31/2019
P-18-0091 Generic: Vegetable oil, polymers with diethylene glycol- and polyol- and polyethylene glycol-depolymd poly(ethylene terephthalate) waste plastics and
arylcarboxylic acid anhydride
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. 01/17/2018 05/31/2019
P-17-0253 Generic: Oxirane, 2-methyl-, polymer with oxirane, methyl 2-(substituted carbomonocycle isoquinolin-
2(3H)-yl) propyl ether
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) 'Not likely to present an unreasonable risk' section 5(a)(3)(C) determination*

*In EPA’s original screening analysis for this PMN in 2017, EPA identified potential for risk to workers for lung effects, which resulted in the interim finding. The PMN submitter provided acute and 5-day inhalation toxicity studies and also provided an updated Safety Data Sheet. EPA's final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA's risk assessment for the chemical substance under the intended conditions of use described in the PMN where, based on the submitted data, a lower level of respiratory protection is expected to mitigate lung effects than the level estimated in the original screening analysis, and employers will require and workers will use appropriate personal protective equipment in a manner adequate to protect them. View the determination document.
03/14/2017 04/24/2019
P-16-0425 Generic: Amino-silane The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) 'Not likely to present an unreasonable risk' section 5(a)(3)(C) determination*

*In EPA’s original screening analysis for this PMN in 2016, EPA identified potential risks to workers, which resulted in the interim finding. Based on additional information provided by the submitter, EPA revised its assessment for the intended conditions of use. EPA’s final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA’s revised risk assessment for the chemical substance under the intended conditions of use, where EPA expects that employers will require and workers will use appropriate personal protective equipment in a manner adequate to protect them, and EPA’s issuance of a proposed SNUR to address certain reasonably foreseen uses. Conditions of use that fall under the restrictions of the proposed SNUR are not likely to present unreasonable risk of injury to health or the environment because (1) those conditions of use are not likely to be commenced during the pendency of the proposed SNUR and (2) upon finalization of the SNUR those conditions of use would be prohibited unless and until EPA makes an affirmative determination that the significant new use is not likely to present an unreasonable risk or takes appropriate action under section 5(e) or 5(f). View the determination document and the terms of the SNUR.
06/22/2016 05/31/2019
P-16-0314 Specific: Ethanone, 1-(5-propyl-1,3-benzodioxol-2-yl)- The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. 06/22/2016 05/28/2019
J-19-0018 Generic: Protein-producing modified microorganism, with chromosomally-borne modifications The microorganism is not likely to present an unreasonable risk (5(a)(3)(C)) The microorganisms are not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document.  03/05/19 05/29/19
P-18-0339 Generic: Alkyl heteromonocycle with heteroatom substituted alkyl cycloalkane and 2-hydroxyethyl heteromonocycle methacrylate-blocked homopolymer The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. 09/26/2018 05/20/2019
P-18-0220 Generic: Heteromonocycle [(alkylalkylidene)bis (substituted carbomoncycle)]bis-, polymer with
alkyl isocyanate, alkenoate (ester)
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. 06/21/2018 05/21/2019
P-18-0120 Specific: 1H-Pyrrole-2,5-dione, 1,1'-C36-
alkylenebis-; CASRN: 1911605-95-2
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. 02/28/2018 05/20/2019
P-19-0057 Generic: Alkanamine, [(Alkoxy)alkoxy]alkyl] alkyl The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. 02/21/2019 05/14/2019
P-19-0060
P-19-0061
P-19-0060: Aliphatic hydrocarbons, C8-C18-branched and linear

P-19-0061: Aliphatic hydrocarbons, C16-20-branched and linear
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. 02/23/2019 05/15/2019
P-19-0056 Generic: P-19-0056: Aliphatic hydrocarbons, C8-C20-branched and linear
P-19-0060: Aliphatic hydrocarbons, C8-C18-
branched and linear
P-19-0061: Aliphatic hydrocarbons, C16-20-
branched and linear
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. 02/15/2019 05/15/2019
P-19-0054 Generic: Polyamines, reaction products with
succinic anhydride polyalkenyl derivs, metal
salts, Polyamines, reaction products with
succinic anhydride polyalkenyl derivs, metal
salts.
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. 02/11/2019 05/10/2019
P-17-0245 Generic: Unsaturated polyfluoro ester The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) 'Not likely to present an unreasonable risk' section 5(a)(3)(C) determination

*In EPA’s original screening analysis for this PMN in 2017, EPA identified potential risk to workers and the general population and that the substance may degrade to a persistent, bioaccumulative, and toxic chemical, which resulted in the interim finding. The submitter provided additional information indicating there will be no releases to water and that disposal of wastes will be by RCRA-certified hazardous waste incineration. EPA’s final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA’s risk assessment for the chemical substance under the intended conditions of use described in the PMN and EPA’s issuance of a proposed SNUR to address certain reasonably foreseen uses. Conditions of use that fall under the restrictions of the proposed SNUR are not likely to present unreasonable risk of injury to health or the environment because (1) those conditions of use are not likely to be commenced during the pendency of the proposed SNUR and (2) upon finalization of the SNUR those conditions of use would be prohibited unless and until EPA makes an affirmative determination that the significant new use is not likely to present an unreasonable risk or takes appropriate action under section 5(e) or 5(f). View the determination document and the terms of the SNUR.
02/28/2017 04/15/2019
P-17-0152 Generic: Poly-(2-methyl-1-oxo-2-propen-1-yl)
ester with Ethanaminium, N,N,N-trialkyl,
chloride and methoxypoly(oxy-1,2-ethanediyl)
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) 'Not likely to present an unreasonable risk' section 5(a)(3)(C) determination

*In EPA’s original screening analysis for this PMN in 2017, EPA identified potential for lung effects from cationic binding and risk to the environment, which resulted in the interim finding. Based on amendments to the PMN, EPA revised its assessment for the intended conditions of use. EPA’s final determination that the new chemical is not likely to present unreasonable risk is based on EPA’s risk assessment for the chemical substance under the intended conditions of use described in the amended PMN where estimated releases to water are lower than in the initial assessment and inhalation exposures are not expected, and EPA’s issuance of a proposed SNUR to address certain reasonably foreseen uses. Conditions of use that fall under the restrictions of the proposed SNUR are not likely to present unreasonable risk of injury to health or the environment because (1) those conditions of use are not likely to be commenced during the pendency of the proposed SNUR and (2) upon finalization of the SNUR those conditions of use would be prohibited unless and until EPA makes an affirmative determination that the significant new use is not likely to present an unreasonable risk or takes appropriate action under section 5(e) or 5(f). View the determination document and the terms of the SNUR.
11/23/2016 04/15/2019
P-16-0422 Specific: 1,2-Cyclohexanedicarboxylic acid, 1-
(phenylmethyl) ester, ester with 2,2,4-trimethyl-1,3-pentanediol mono(2-methylpropanoate)
(CASRN: 1661012-65-2)
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) 'Not likely to present an unreasonable risk' section 5(a)(3)(C) determination

*In EPA’s original screening analysis for this PMN in 2016, EPA identified potential human health risk to workers and chronic risk to the environment, which resulted in the interim finding. The submitter provided new information including a proposed new analogue to be used in the human health and environmental assessment, new process information including waste water treatment efficiency, and new information on releases. EPA’s final determination that the new chemical is not likely to present unreasonable risk is based on EPA’s risk assessment for the chemical substance under the intended conditions of use described in the amended PMN, where worker exposure is expected to be controlled through the use of appropriate PPE, where submitter controls will keep water releases below the concentration of concern, and EPA’s issuance of a proposed SNUR to address certain reasonably foreseen uses. Conditions of use that fall under the restrictions of the proposed SNUR are not likely to present unreasonable risk of injury to health or the environment because (1) those conditions of use are not likely to be commenced during the pendency of the proposed SNUR and (2) upon finalization of the SNUR those conditions of use would be prohibited unless and until EPA makes an affirmative determination that the significant new use is not likely to present an unreasonable risk or takes appropriate action under section 5(e) or 5(f). View the determination document and the terms of the SNUR.
06/22/2016 04/15/2019
P-14-0482 Generic: Organic salt The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) 'Not likely to present an unreasonable risk' section 5(a)(3)(C) determination

*In EPA’s original screening analysis for this PMN in 2014, EPA identified potential human health risk to workers, substantial releases, and risk to the environment, which resulted in the interim finding. The submitter amended the PMN, revising the production volume and intended conditions of use. EPA’s final determination that the new chemical is not likely to present unreasonable risk is based on EPA’s risk assessment for the chemical substance under the intended conditions of use described in the amended PMN where worker exposure is expected to be controlled through the use of appropriate PPE, expected releases to the environment are lower than originally estimated, and EPA’s issuance of a proposed SNUR to address certain reasonably foreseen uses. Conditions of use that fall under the restrictions of the proposed SNUR are not likely to present unreasonable risk of injury to health or the environment because (1) those conditions of use are not likely to be commenced during the pendency of the proposed SNUR and (2) upon finalization of the SNUR those conditions of use would be prohibited unless and until EPA makes an affirmative determination that the significant new use is not likely to present an unreasonable risk or takes appropriate action under section 5(e) or 5(f). View the determination document and the terms of the SNUR.
06/22/2016 04/15/2019
P-19-0046 Specific: 1,2,4-Benzenetricarboxylic acid, mixed decyl and octyl triesters; CASRN 90218-76-1 The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document.  01/31/2018 04/26/2019
P-18-0266 Specific: Alkanes, C20-45 branched and linear; CASRN: 2133415-24-2 The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document.  07/30/2018 04/25/2019
P-18-0188 Generic: Alkyl substituted alkenoic acid, alkyl
ester, polymer with alkanediol alkyl-alkenoate, reaction products with alkenoic acid, isocyanato -(isocyanatoalkyl)-alkyl substituted carbomonocycle and substituted alkanediol
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document.  05/23/2018 05/02/2019
P-18-0406 Generic: Formaldehyde, polymer with alkyl
aryl ketones
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document.  09/30/2018 05/02/2019
P-18-0305 Generic: Alkenoic acid, alkyl-,alkyl ester, polymer with alkyl alkenoate, substituted heteromonocycycle, substituted carbomonocycle, substituted alkanediol
and alkenoic acid, alkali metal salt
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document.  09/12/2018 02/23/2019
P-18-0186 Generic: Polyolefin ester The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document.  5/22/2018 04/24/2019
J-19-0012,
J-19-0013
J-19-0014
J-19-0015
Generic: Biofuel producing Saccharomyces cerevisiae modified, genetically stable The microorganisms are not likely to present an unreasonable risk (5(a)(3)(C)) The microorganisms are not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material.  View the determination document.  01/31/19 04/26/19
J-19-0017 Generic: Genetically modified microorganism for the production of a chemical substance The microorganism is not likely to present an unreasonable risk (5(a)(3)(C)) The microorganisms are not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document.  02/01/19 04/18/19
J-19-0011 Generic: Genetically modified microorganism for the production of a chemical substance The microorganism is not likely to present an unreasonable risk (5(a)(3)(C)) The microorganisms are not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document.  01/31/19 04/18/19
P-19-0045 Generic: Non-metal tetrakis (hydroxyalkyl)-, halide, polymer with amide oxidized The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document.  12/21/2018 04/18/2019
P-19-0032 Generic: Carbonic dichloride, polymer with 4,4'-(1-methylethylidene)bis[phenol] ester, polymer with tetrol and polyether tetrol The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document.  12/19/2018 04/17/2019
P-19-0030 Generic: Triethanolamine modified
Phosphinicocarboxylates, sodium salts
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document.  12/18/2018 04/24/2019
P-18-0375 Specific: Fats and Glyceridic oils, vegetable, sulfonated,sodium salts (CASRN: 97489-04-8) The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document.  10/10/2018 04/18/2019
P-18-0312 Generic: Formaldehyde, polymer with 2-
phenoxyalkanol and .alpha.-phenyl-.omega.
hydroxypoly(oxy-1,2-alkylnediyl), dihydrogen
phosphate 2-phenoxyalkyl hydrogen phosphate, alkaline salt
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document.  09/20/2018 04/18/2019
P-18-0122 Generic: Alkylamide, polymer with alkylamine, formaldehyde, and polycyanamide, alkyl acid salt The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment for the intended conditions of use and EPA’s issuance of a proposed SNUR to address certain reasonably foreseen uses. View the determination document. and the terms of the SNUR. 03/01/2018 04/15/2019
P-19-0040 Generic: Alkyl bis(dialkylamino alkyl) amide, The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document.  12/20/2018 04/18/2019
P-19-0010 Generic: Hydrogenated fatty acid dimers,
polymers with 1,1'-methylenebis[4-
isocyanatobenzene], polypropylene glycol,
polypropylene glycol ether with
trimethylolpropane (3:1), and 1,3-propanediol,
propylene glycol monomethacrylate-blocked
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment for the intended conditions of use and EPA’s issuance of a proposed SNUR to address certain reasonably foreseen uses. View the determination document. and the terms of the SNUR. 10/29/2018 04/15/2019
P-18-0222 Generic: Silane, alkenylalkoxy-, polymer with alkene
and alkene
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment for the intended conditions of use and EPA’s issuance of a proposed SNUR to address certain reasonably foreseen uses. View the determination document. and the terms of the SNUR. 06/22/2018 04/15/2019
P-18-0162 Generic: Cashew nutshell liquid, polymer with
diisocyanatoalkane, substituted-polyoxyalkyldiol
and polyether polyol
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment for the intended conditions of use and EPA’s issuance of a proposed SNUR to address certain reasonably foreseen uses. View the determination document. and the terms of the SNUR. 05/08/2018 04/15/2019
P-17-0239 Generic: Substituted carboxylic acid, polymer with
2,4-diisocyanato-1-methylbenzene, hexanedioic acid,
alpha-hydro-omega-hydroxypoly[oxy(methyl-1,2-
ethanediyl)], 1,1'-methylenebis[4-
isocyanatobenzene], 2,2'-oxybis[ethanol], 1,1'-oxybis
[2-propanol] and 1,2-propanediol.
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment for the intended conditions of use and EPA’s issuance of a proposed SNUR to address certain reasonably foreseen uses. View the determination document. and the terms of the SNUR. 06/05/2017 04/15/2019
P-18-0073 Specific: Sulfuric acid, ammonium salt (1:?) The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment for the intended conditions of use and EPA’s issuance of a proposed SNUR to address certain reasonably foreseen uses. View the determination document. and the terms of the SNUR. 12/21/2017 04/15/2019
P-18-0048 Specific: Acetic acid, 2-(2-butoxyethoxy) -;
(CASRN: 82941-26-2)
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment for the intended conditions of use and EPA’s issuance of a proposed SNUR to address certain reasonably foreseen uses. View the determination document. and the terms of the SNUR. 11/13/2017 04/15/2019
P-17-0284 Specific: 2-Heptanone, 4-hydroxy-, CASRN: 25290-14-6 The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document.  04/13/17 04/10/19
P-17-0285 Specific: 4-Hepten-2-one, CASRN: 24332-22-7 The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) "Not likely to present an unreasonable risk" section 5(a)(3)(C) determination*

*In EPA’s original screening analysis for this PMN in 2017, EPA identified potential for risk to workers from inhalation and dermal exposure and risk to the general population from exposure from drinking water, which resulted in the interim finding. The PMN submitter provided additional information on potential releases to water and also provided an updated Safety Data Sheet. EPA's final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA's risk assessment for the chemical substance under the intended conditions of use described in the PMN where expected releases to water are lower than those estimated in the original screening analysis, and workers will use appropriate personal protective equipment in a manner adequate to protect them. View the determination document. 
04/13/2017 04/10/2019
P-19-0035 Specific: Acetamide, 2-(4-methylphenoxy)-N-1H-pyrazol-3-yl-N-(2-thienylmethyl)-;CASRN: 1374760-95-8 The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document.  12/11/18 03/28/19
P-19-0037 Generic: D-Glucaric acid, mixed alkali metal salt The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document.  12/11/18 04/12/19
P-16-0602 Generic: Carbonic acid, dialkyl ester, polymers
with 5-amino-1,3,3-
trimethylcycloalkanemethanamine, 2-ethyl-1-
alcohol-blocked 1,6-diisocyanatoalkane
homopolymer and 1,6-alkanediol and
trimethylolakane
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) "Not likely to present an unreasonable risk" section 5(a)(3)(C) determination*

*In EPA’s original screening analysis for this PMN in 2016, EPA identified potential for risk for lung effects, which resulted in the interim finding. The PMN submitter provided additional information on the intended use, which indicated inhalation exposure to workers is not expected. EPA's final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA's risk assessment for the chemical substance under the intended conditions of use described in the PMN where inhalation exposure is not expected.  View the determination document. 
09/30/16 04/10/19
P-16-0446 Generic: Fatty acids, reaction products with alkylamine,
polymers with substituted carbomonocycle, substituted
alkylamines, heteromonocycle and substituted alkanoate,
lactates (salts)
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) "Not likely to present an unreasonable risk" section 5(a)(3)(C) determination*

*In EPA’s original screening analysis for this PMN in 2016, EPA identified potential for risk for lung effects from cationic binding and potential for high releases and risk to the environment, which resulted in the interim finding. The PMN submitter provided an acute inhalation toxicity study and clarified release and exposure parameters. EPA's final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA's risk assessment for the chemical substance under the intended conditions of use described in the PMN where expected releases to water are lower than those estimated in the original screening analysis, and lung effects are no longer expected based on the submitted data as well as particle size and the proportion of cationic amine moieties present in the polymer.  View the determination document. 
06/24/16 04/16/19
P-19-0003 Generic: Polyaromatic ether symmetrical dicarboxylic
anhydride
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document.  12/20/18 04/19/19
P-18-0174 Generic: Enzyme The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document.  05/09/18 04/16/19
P-18-0229 Generic: Modified branched alkenyl acid, alkyl ester,
homopolymer,
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document.  08/30/18 03/28/19
P-18-0179
P-18-0180
P-18-0181
Generic (P-18-0179): Phenol, polymer with
formaldehyde and phenolic resin, sodium salt

Generic (P-18-0180): Phenol, polymer with
formaldehyde and phenolic resin, potassium salt

Generic (P-18-0181): Phenol, polymer with
formaldehyde and phenolic resin, potassium
sodium salt
The chemical substances are not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substances are not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document.  05/16/18 03/28/19
P-19-0027 Generic: Substituted Carbomoncycle, polymer
with haloalkyl substituted heteromonocycle,
dialkyl-alkanediamine and hydro-hydroxypoly
[oxy(alkylalkanediyl)], reaction products with
metal oxide and dialkanolamine, acetates (salts).
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document.  11/28/18 04/03/19
P-18-0085 Generic: Fatty acids reaction products with
ethyleneamines and dialkyl ester
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document.  01/08/18 03/15/19
P-18-0101 Generic: Pentaerythritol, mixed esters with
linear and branched fatty acids
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document.  01/26/18 03/29/19
P-17-0191 Generic: Alkyldiamine, aminoalkyl
dimethylaminoalkyl dimethyl-, reaction products
with propylene oxide
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) "Not likely to present an unreasonable risk" section 5(a)(3)(C) determination*

*In EPA’s original screening analysis for this PMN in 2017, EPA identified neurotoxicity and corrosion as hazards and the potential for risk to workers from dermal exposure and risk to the general population from exposure from drinking water and fish ingestion, which resulted in the interim finding. The PMN submitter clarified that the new chemical substance would not be released to water, and wastes would be incinerated. EPA's final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA's risk assessment for the chemical substance under the intended conditions of use described in the PMN where there will be no releases to water, and workers will use appropriate personal protective equipment in a manner adequate to protect them. View the determination document.
01/25/17 03/28/19
P-17-0220 Generic: 2-Oxepanone, reaction products with
alkylenediamine-alkyleneimine polymer, 2-[[(2-alkyl)oxy]alkyl]oxirane and tetrahydro-2H-
pyran-2-one
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) "Not likely to present an unreasonable risk" section 5(a)(3)(C) determination*

*In EPA’s original screening analysis for this PMN in 2017, EPA identified potential for risk for lung effects from cationic binding and potential for risk to the environment, which resulted in the interim finding. The PMN submitter clarified the processes used for equipment cleaning and handling of wastes and provided processing information indicating that although there may be potential for worker inhalation exposure, cationic binding will not occur because of interaction of the new chemical substance with another substance in the formulation. EPA's final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA's risk assessment for the chemical substance under the intended conditions of use described in the PMN where estimated surface water concentrations indicate unreasonable risk to the environment is not likely and lung effects are not likely. View the determination document. 
01/25/17 03/28/19
P-19-0026 Generic: Alkanoic acid, compounds with
substituted carbomonocycle-dialkyl-
alkanediaminehalosubstitued heteromonocycle-
polyalkylene glycol polymerdialkanolamine reaction
products
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document.  11/27/18 03/26/19
P-18-0307 Generic: Alkyl Alkenoic acid, alkyl ester, telomer
with alkyl alkenoate, substituted alkyl alkyl alkenoate,
alkylthiol, substituted carbomonocycle, hydroxyalkyl
alkyl alkenoate and alkyl alkyl alkenoate
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document.  09/14/18 03/21/19
P-19-0009 Generic: Carbonmonocycles, polymer with haloalkyl
substituted heteromonocycle and hydro-hydroxypoly
[oxy(alkyl-alkanediyl)], dialkyl-
alkanediamineterminated, hydroxyalkylated,
acetates (salts).
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document.  10/23/18 03/15/19
P-18-0284 Generic: Inorganic acid, reaction products
with alkyl alcohol
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document.  08/27/18 03/15/19
P-18-0278 Generic: Isophthalic acid, polymer with terephthalic
acid and C4 and C6 dialkyl amines
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document.  08/16/18 03/13/19
J-19-0006
J-19-0007
J-19-0008
Generic: Genetically modified microorganism for
the production of a chemical substance
The microorganisms are not likely to present an unreasonable risk (5(a)(3)(C)) The microorganisms are not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document.  11/16/18 03/08/19
P-19-0025 Specific: 11-Docosene, CASRN 62978-77-2 The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document.  11/19/18 03/08/19
P-19-0021
P-19-0022
P-19-0021: Generic: Hydroxyalkyl carboxylic acid,
polymer with alkylamine, alkylene carbonate,
alkanediol, isocyanate, compd. with alkylamine

P-19-0022: Generic: Hydroxyalkyl carboxylic acid,
polymer with alkylamine, alkyl carbonate,
alkanediol, isocyanate, compd. with alkylamine
The chemical substances are not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document.  11/12/18 03/08/19
P-19-0002 Generic: Polyaromatic symmetrical tetracarboxylic
acid
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document.  12/28/18 03/08/19
P-18-0272 Generic: Metal, alkylcarboxylate oxo complexes The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document.  08/07/18 03/08/19
P-18-0169 Generic: Propanoic acid, 3-hydroxy-2-
(hydroxymethyl)-2-methyl-, polymer with dimethyl
carbonate, 1,6-hexanediol, diamine and 1,1'-
methylenebis[4-isocyanatocyclohexane], acrylate-
blocked, compds. with triethylamine
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document.  05/07/18 02/28/19
P-17-0119 Generic: Alkyl alkenoic acid, alkoxyalkyl ester,
polymer with alkyl alkenoate, alkyl alkyl alkenoate
and tris alkyl silyl alkyl alkenaote
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document.  06/26/17 02/28/19
P-18-0077 Specific: Urea, reaction products with N-
butylphosphorothioic triamide and formaldehyde
(CASRN: 2093385-47-6)
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document.  12/27/17 12/03/18
P-18-0132 Generic: Substituted benzene, 4-methoxy-2-nitro-
5-[2-[(1E)-1-[[(2-methoxyphenyl)amino]carbonyl]-2-oxopropylidene]hydrazinyl]-, sodium salt (1:1)
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document.  03/20/18 02/26/19
P-18-0107 Generic: Alcohol capped polycarbodiimide from diethyldiisocyanatobenzene. The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document.  02/06/18 02/28/19
P-18-0118
P-18-0119
Generic (P-18-0118): Oxirane, 2-methyl-, polymer
with methoxirane homopolymer, 1,1'-methylenebis[4-isocyanatobenzene], and glycerol-propylene oxide
polymer.

Generic (P-18-0119): Oxirane, 2-methyl-, polymer with
methoxirane homopolymer, 1,1'- methylenebis
[isocyanatobenzene], and glycerol-propylene oxide
polymer.
The chemical substances are not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document.  02/26/18 02/28/19
P-18-0379 Generic: Cashew nutshell liquid polymer with
Epichlorohydrin, formaldehyde, phenol, amines
and glycol.
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document.  09/28/18 02/28/19
P-18-0277 Generic: Poly[2-(Dimethylamino)ethyl acrylate
chloride salt, vinyl acetate, methacrylic acid and
alkyl acrylates]
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document.  08/28/18 02/28/19
P-19-0007 Generic: Alkenoic acid, alkyl-, hydroxyalkyl ester,
polymer with alkyl-alkenoate, alkenylcarbomonocycle,
hydroxyalkyl-alkenoate, alkyl substituted alkenoate and heteromonocycle, alkyl substituted peroxoate-initiated,
polymers with [substituted alkanenitrile]-initiated acrylic
acid-alkane acrylates-alkyl substituted carbomoncycle
polymer; polymer exemption flag.

Polymer exemption flag: The chemical must be
manufactured such that it meets the polymer
exemption criteria as described under 40 CFR
§723.250(e)(1), in addition to meeting the definition
of polymer at 40 CFR §723.250(b).
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document.  10/16/18 02/28/19
P-17-0387
P-17-0388
Generic: Dicarboxylic acids, polymers with alkanoic
acid, alkanediol, susbtituted-alkylalkanoic acid,
substituted alkyl carbomonocyle, alkanedioic acid
and alkanediol, alkanolamine blocked compds with
alkanolamine.
The chemical substances are not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substances are not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document.  08/30/17 02/28/19
P-19-0008 Generic: Substitued polyalkylenepolycarbomonocycle
ester, polymer with dialkanolamine, (hydroxyalkoxy)
carbonyl] derivs., (alkoxyalkoxy) alkanol blocked
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document.  10/22/18 02/08/19
P-18-0238 Generic: Saccharide reaction products with acid
anhydride, etherified
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document.  7/16/16 02/13/19
P-16-0400 Specific: Alkanes, C11-16-branched and linear;
CASRN: 1809170-78-2
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) "Not likely to present an unreasonable risk" section 5(a)(3)(C) determination*

*In EPA’s original screening analysis for this PMN in 2016, EPA identified potential for health effects and risk to the environment, which resulted in the interim finding. Upon further review of submitted data on analogous chemical substances, EPA revised its hazard and risk assessment for the new chemical substance. EPA's final determination that the chemical substance is not likely to present unreasonable risk is based on EPA's revised risk assessment for the chemical substance under the conditions of use. View the determination document. 
06/22/16 12/21/18
P-18-0020 Specific: Butanedioic acid, polymer with 2-ethyl-2-
(hydroxymethyl)-1,3-propanediol, 2,5-furandione
and 1,3-propanediol, 3a,4,5,6,7,7a-hexahydro-4,7-
methano-1H-inden-5(or 6)-yl ester
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document.  10/16/17 02/05/19
J-18-0045 Generic: Biofuel producing Saccharomyces cerevisiae
modified, genetically stable
The microorganism is not likely to present an unreasonable risk (5(a)(3)(C)) The microorganism is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. S. cerevisiae is not pathogenic to humans or animals and has an extensive history of safe use in food processing. View the determination document.  09/27/18 12/19/18
J-18-0046
J-18-0047
Generic: Genetically modified microorganism The microorganisms are not likely to present an unreasonable risk (5(a)(3)(C)) The microorganisms are not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document.  09/30/18 12/19/18
J-19-0002
J-19-0002
J-19-0004
Generic: Genetically modified microorganism The microorganisms are not likely to present an unreasonable risk (5(a)(3)(C)) The microorganisms are not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document.  10/05/18 12/19/18
P-18-0221 Generic: Polyglycerol reaction product with acid
anhydride, etherified
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document.  06/21/18 12/21/18
P-18-0324 Generic: Organic acid dimethyl ester, polymer
with mixed alkanediols and 5-isocyanato-1-
(isocyanatomethyl)-1,3,3-trimethylcyclohexane, trimethoxysilylalkylalkanamine-blocked
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document.  9/24/18 12/20/18
P-19-0006 Generic: Diisocyanate polymer blocked with alkoxyamine The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document.  10/09/18 12/20/18
P-17-0281 Generic: Polysiloxane-polyester polyol carboxylate The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C))* *In EPA's original screening analysis for this PMN in 2017, EPA identified potential for risk to workers. EPA's final determination that the chemical substance is not likely to present unreasonable risk is based on EPA's risk assessment for the chemical substance under the intended and reasonably foreseen conditions of use where EPA expects that workers will use appropriate personal protective equipment, consistent with the Safety Data Sheet (SDS) prepared by the PMN submitter, in a manner adequate to protect them. View the determination document.  04/21/17 12/04/18
P-18-0007
P-18-0008
Specific (P-18-0007): Glycerides, soya mono-
and di-, epoxidized, acetates (CASRN: 2097734-14-8)

Specific (P-18-0008): Glycerides, C16-18 and C18-
unsatd. mono- and di-, epoxidized, acetates
(CASRN: 2097734-15-9)
The chemical substances are not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substances are not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document.  10/04/17 12/11/18
P-18-0212 Generic: Substituted carbomonocycle, polymer
with alkyl alkenoate, alkenyl substituted
carbomonocycle, substituted alkanediol,
heteropolycycle, alkylene glycol and alkenoic
acid, compd. with alkylamino alkanol; polymer
exemption flag. Polymer exemption flag: The
chemical must be manufactured such that it
meets the polymer exemption criteria as described
under 40 CFR §723.250(e)(1), in addition to meeting
the definition of polymer at 40 CFR §723.250(b)
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document.  06/14/18 11/30/18
SN-15-0009 Generic: Fatty acid amide The significant new use is not likely to present an unreasonable risk (5(a)(3)(C)) The significant new use is not likely to present an unreasonable risk of injury to health or the environment under the conditions of use, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator, based on the risk assessment. View the determination document.  06/22/16 12/12/18
P-18-0219 Generic: Polythioether, short chain diol polymer
terminated with aliphatic diisocyanate
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document.  06/20/18 12/12/18
P-18-0068 Generic: Metal, oxo alkylcarboxylate complexes The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document.  12/13/17 12/12/18
J-18-0042
J-18-0043
Generic: Biofuel producing Saccharomyces cerevisiae
modified, genetically stable
The microorganisms are not likely to present an unreasonable risk (5(a)(3)(C)) The microorganisms are not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. S. cerevisiae is not pathogenic to humans or animals and has an extensive history of safe use in food processing. View the determination document.  08/15/18 11/29/18
P-18-0319 Generic: Plant oil fatty acids, alkyl esters The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document.  09/20/18 12/04/18
P-18-0152 eneric: Hydrolyzed functionalized di-amino silanol
polymer
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document.  04/20/18 11/29/18
P-18-0147 Generic: Phenol, 4-ethenyl-, 1-substituted, polymer
with 1-(1,1-substituted)-4-ethenylbenzene and
ethenylbenzene, 2, 2'-(1,2-diazenediyl)bis[2-
substituted]-initiated, hydrolyzed
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented below. Although EPA estimated that the new chemical substance could be very persistent, the chemical substance has low potential for bioaccumulation, such that repeated exposures are not expected to be cumulative. Based on analogous chemical substances, EPA estimates that the chemical substance has low environmental hazard and the potential for the following human health hazard: irritation. EPA concludes that the new chemical substance is not likely to present an unreasonable risk to human health or the environment under the conditions of use. View the determination document.  04/04/18 11/29/18
P-18-0279 Generic: Substituted heteromonocycle, polymer
with substituted alkanediol and diisocyanate
substituted carbomonocyle, alkylene glycol
acrylate-blocked
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented below. Although EPA estimated that the new chemical substance could be very persistent, the new chemical substance has low potential for bioaccumulation, such that repeated exposures are not expected to be cumulative. Based on EPA’s TSCA New Chemicals Program Chemical Category for Acrylates and test data on analogous chemical substances, EPA estimates that the chemical substance has low environmental hazard and potential for the following human health hazards: irritation and sensitization. EPA concludes that the new chemical substance is not likely to present an unreasonable risk under the conditions of use.View the determination document.  08/16/18 11/21/18
P-18-0136 Generic: 1-Butanaminium, N,N,N-tributyl-, 2(or5)- [[benzoyldihydrodioxo[(sulfophenyl)amino]
heteropolycycle]oxy]-5(or 2)-(1,1- dimethylpropyl)benzenesulfonate (2:1)
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented below. Although EPA estimated that the new chemical substance could be very persistent, the new chemical substance has low potential for bioaccumulation, such that repeated exposures are not expected to be cumulative. Based on EPA’s TSCA New Chemicals Program Chemical Category for Acid Dyes and Amphoteric Dyes2 and test data on the chemical substance and analogous chemical substances, EPA estimates that the chemical substance has moderate environmental hazard and potential for the following human health hazards: systemic toxicity from repeated exposures. EPA concludes that the new chemical substance is not likely to present an unreasonable risk under the conditions of use. View the determination document.  04/09/18 11/20/18
P-17-0382 Specific: Amides, tallow, N,N-bis(2-hydroxypropyl), CASRN 1454803-04-3 The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document.  08/24/17 11/21/18
P-18-0054 Generic: 2-Alkenoic acid, 2-alkyl-, 2-alkyl
ester, polymer with alkyl 2-alkenoate, 2-substitutedalkyl 2-alkenoate and 2-substitutedalkyl 2-alkyl-2-alkenoate,
esters with carboxylic acids, tert
alkylperoxoate initiated; polymer
exemption flag.
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document.  11/20/17 11/21/18
P-18-0078 Generic: 2-Alkenoic acid, 2-alkyl-, 2-
alkyl ester, polymer with alkyl 2-
alkenoate, 2-substitutedalkyl 2-
alkenoate and 2-substitutedalkyl 2-
alkyl-2-alkenoate, tert alkylperoxoate
initiated; polymer exemption flag.
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document.  12/27/17 11/21/18
P-18-0261 Generic: Metal, alkylcarboxylate oxo
complexes
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document.  07/26/18 11/20/18
J-18-0044 Specific: Saccharomyces cerevisiae NE095 The microorganism is not likely to present an unreasonable risk (5(a)(3)(C)) The microorganism is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document.  08/30/18 11/20/18
J-18-0041 Generic: E. coli K-12 C003: Arsenic
detecting strain of E. coli with extra-chromosomal elements, including an intergeneric screening marker
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The new microorganism is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document.  08/09/18 11/07/18
P-18-0233 Generic: Alkyl Alkenoic acid, alkyl ester,
telomer with alkylthiol, substituted carbomonocycle, substituted alkyl
alkyl alkenoate and hydroxyalkyl
alkenoate, tert-butyl alkyl peroxoate
-initiated
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document.  07/06/18 11/02/18
P-18-0224
P-18-0225
Generic (P-18-0224): Alkenoic acid,
polymer with alkenylcarbomonocycle, [alkanediylbis(substitutedalkylene)] bis[heteromonocycle] and (alkylalkenyl) aromatic, salt

Generic (P-18-0225): Alkenoic acid,
polymer with substituted alkyloxirane, alkenylcarbomonocycle, alkyl
substituted alkyl alkanediol and
(alkylalkenyl) aromatic salt
The chemical substances are not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substances are not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document.  06/27/18 10/30/18
P-18-0030 Generic: Poly[oxy(methyl-alkylendiyl)], a,a',a''-1,2,3-alkanetriyltris[w-hydroxy-,
polymer with 1,1'-alkylenebis[4-isocyanatocarbomonocycle], 2-
substituted ethyl acrylate- and 2-
substituted ethyl methacrylate-
blocked
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document.  10/23/17 10/30/18
J-18-0019
J-18-0020
J-18-0021
Generic: Genetically modified microorganism The microorganisms are not likely to present an unreasonable risk (5(a)(3)(C)) The microorganisms are not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document.  08/02/18 10/30/18
J-18-0026
J-18-0027
Generic: Biopolymer producing
modified microorganism(s) with chromosomally-borne modifications
The microorganisms are not likely to present an unreasonable risk (5(a)(3)(C)) The microorganisms are not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material.  View the determination document.  07/23/18 10/19/18
P-18-0041 Specific: 2,5-Furandione, polymer
with 2-ethyl-2-(hydroxymethyl)-1,3-
propanediol, 3a,4,5,6,7,7a-hexahydro-
4,7-methano-1H-inden-5(or 6)-yl ester,
ester with 2,3-dihydroxypropyl
neodecanoate; CASRN: none
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented.  View the determination document.  11/06/17 10/02/18
P-16-0581 Generic (P-16-0581): alpha 1,3-
polysaccharide
The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C))* *In EPA’s original screening analysis for this PMN in 2016, EPA identified potential for risk for inhalation of respirable particles, which resulted in the interim finding. Based on an amendment to the PMN indicating that respirable particles are not expected under the intended conditions of use, EPA revised its assessment for the intended conditions of use.  EPA's final determination that the chemical substance is not likely to present unreasonable risk is based on EPA's risk assessment for the chemical substance under intended conditions of use in the PMN and EPA's issuance of a proposed SNUR to address certain reasonably foreseen uses. Conditions of use that fall under the restrictions of the proposed SNUR are not likely to present unreasonable risk of injury to health or the environment because (1) those conditions of use are not likely to be commenced during the pendency of proposed SNUR and (2) upon finalization of the SNUR those conditions of use would be prohibited unless and until EPA makes an affirmative determination that the significant new use is not likely to present an unreasonable risk or takes appropriate action under section 5(e) or 5(f). View the determination document and the terms of the SNUR 09/19/16 10/09/18
P-16-0575 Specific (P-16-0575, non-CBI): Glucosyltransferase (International Union of Biochemistry and Molecular Biology (IUBMB) enzyme nomenclature recommendations: IUBMB Number 2.4.1.5) The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C))* *In EPA's original screening analysis for this PMN in 2016, EPA identified potential for risk if the substance is inhaled under reasonably foreseen conditions of use, which resulted in the interim finding. EPA's final determination that the chemical substance is not like to present unreasonable risk is based on EPA's risk assessment for the chemical substance under the intended conditions of use in the PMN where inhalation exposure is not expected, and EPA's issuance of a proposed SNUR to address certain reasonably foreseen uses. Conditions of use that fall under the restrictions of the proposed SNUR are not likely to present unreasonable risk of injury to health or the environment because (1) those conditions of use are not likely to be commenced during the pendency of proposed SNUR and (2) upon finalization of the SNUR those conditions of use would be prohibited unless and until EPA makes an affirmative determination that the significant new use is not likely to present an unreasonable risk or takes appropriate action under section 5(e) or 5(f). View the determination document and the terms of the SNUR 09/15/16 10/09/18
P-16-0483
P-16-0484
Generic (P-16-0483): Inorganic acids, metal salts, compds. with modified heteroaromatics

Generic (P-16-0484): Inorganic acid, metal salt, compd. with substituted aromatic heterocycle
The chemical substances are not likely to present an unreasonable risk (5(a)(3)(C)) *EPA's final determination that the chemical substances are not likely to present unreasonable risk is based on EPA's risk assessment for the chemical substances under intended conditions of use described in the PMN and EPA's  issuance of a proposed SNUR to address certain reasonably foreseen uses. Conditions of use that fall under the restrictions of the proposed SNUR are not likely to present unreasonable risk of injury to health or the environment because (1) those conditions of use are not likely to be commenced during the pendency of proposed SNUR and (2) upon finalization of the SNUR those conditions of use would be prohibited unless and until EPA makes an affirmative determination that the significant new use is not likely to present an unreasonable risk or takes appropriate action under section 5(e) or 5(f). View the determination document and the terms of the SNUR 07/18/16 10/09/18
P-16-0380
P-16-0381
P-16-0382
P-16-0383
P-16-0384
P-16-0385
Generic (P-16-0380): Formic acid, compds. with hydrolyzed bisphenol A-epichlorohydrin-polyethylene glycol ether with bisphenol A (2:1) polymer-N1-(1,3-dimethylbutylidene)- N2-[2-[(1, 3-dimethylbutylidene) amino]ethyl]-1,2-ethanediamine- dialdehyde-2-(methylamino)ethanol reaction products acetates (salts).

Generic (P-16-0381): Propanoic acid, 2-hydroxy-, compds. with hydrolyzed bisphenol A-epichlorohydrin- polyethylene glycol ether with bisphenol A (2:1) polymer-N1-(1,3-dimethylbutylidene)-N2-[2-[(1, 3-dimethylbutylidene)amino]ethyl]-1,2-ethanediamine-dialdehyde-2-(methylamino)ethanol reaction products formates (salts).

Generic (P-16-0382): Formic acid, compds. with hydrolyzed bisphenol A- epichlorohydrin-polyethylene glycol ether with bisphenol A (2:1) polymer- N1-(1,3-dimethylbutylidene)-N2-[2-[(1, 3-dimethylbutylidene)amino]ethyl]- 1,2-ethanediamine-dialdehyde-2-(methylamino)ethanol reaction products sulfamates(salts).

Generic (P-16-0383): Formic acid, compds. with hydrolyzed bisphenol A-epichlorohydrin-polyethylene glycol ether with bisphenol A (2:1) polymer-N1-(1,3-dimethylbutylidene)- N2-[2-[(1, 3-dimethylbutylidene)amino] ethyl]-1,2-ethanediamine-dialdehyde-2-(methylamino)ethanol reaction products acetates (salts).

Generic (P-16-0384): Propanoic acid, 2- hydroxy-, compds. with hydrolyzed bisphenol A-epichlorohydrin- polyethylene glycol ether with bisphenol A (2:1) polymer-N1-(1,3-dimethylbutylidene)-N2-[2-[(1, 3-dimethylbutylidene)amino]ethyl]-1,2-ethanediamine-dialdehyde-2-(methylamino)ethanol reaction products formates (salts).

Generic (P-16-0385): Formic acid, compds. with hydrolyzed bisphenol A-epichlorohydrin-polyethylene glycol ether with bisphenol A (2:1) polymer-N1-(1,3-dimethylbutylidene)- N2-[2-[(1,3-dimethylbutylidene)amino] ethyl]-1,2-ethanediamine-dialdehyde-2-(methylamino)ethanol reaction products sulfamates(salts).
The chemical substances are not likely to present an unreasonable risk (5(a)(3)(C))* *In EPA’s original screening analysis for these PMNs in 2016, EPA identified potential for health effects if inhaled and risk to the environment, which resulted in the interim finding. After additional evaluation, EPA determined that inhalation exposure is not a condition of use for these PMNs. Based on an amendment to the PMNs addressing water releases, EPA revised its assessment for the intended conditions of use. EPA's final determination that the chemical substance is not likely to present unreasonable risk is based on EPA's risk assessment for the chemical substances under intended conditions of use described in the amended PMNs, and EPA's issuance of a proposed SNUR that addresses a certain reasonably foreseen use. The condition of use that falls under the restrictions of the proposed SNUR is not likely to present unreasonable risk of injury to health or the environment because (1) the condition of use is not likely to be commenced during the pendency of proposed SNUR and (2) upon finalization of the SNUR the condition of use would be prohibited unless and until EPA makes an affirmative determination that the significant new use is not likely to present an unreasonable risk or takes appropriate action under section 5(e) or 5(f). View the determination document and the terms of the SNUR. 06/22/16 10/09/18
P-16-0354
P-16-0355
Generic (P-16-0354 and P-16-0355): Esteramine The chemical substances are not likely to present an unreasonable risk (5(a)(3)(C))* *In EPA’s original screening analysis for these PMNs in 2016, EPA identified potential for risk to the environment, which resulted in the interim finding. Based on an amendment to the PMNs addressing water releases under the intended conditions of use, EPA revised its assessment for the intended conditions of use. EPA's final determination that the chemical substance is not likely to present unreasonable risk is based on EPA's risk assessment for the chemical substances under intended conditions of use described in the PMN and EPA's issuance of a proposed SNUR that addresses certain reasonably foreseen uses. Conditions of use that fall under the restrictions of the proposed SNUR are not likely to present unreasonable risk of injury to health or the environment because (1) those conditions of use are not likely to be commenced during the pendency of proposed SNUR and (2) upon finalization of the SNUR those conditions of use would be prohibited unless and until EPA makes an affirmative determination that the significant new use is not likely to present an unreasonable risk or takes appropriate action under section 5(e) or 5(f). View the determination document and the terms of the SNUR. 06/22/16 10/09/18
P-16-0192 Generic (P-16-0192): Silanized amorphous silica The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C))* *In EPA’s original screening analysis for this PMN in 2016, EPA identified potential for risk for lung effects for reasonably foreseen conditions of use, which resulted in the interim finding. EPA's final determination that the chemical substance is not likely to present unreasonable risk is based on EPA's risk assessment for the chemical substance under the intended conditions of use described in the PMN where the substance is manufactured in an amorphous form and EPA's issuance of a proposed SNUR to address certain reasonably foreseen uses. Conditions of use that fall under the restrictions of the proposed SNUR are not likely to present unreasonable risk of injury to health or the environment because (1) those conditions of use are not likely to be commenced during the pendency of proposed SNUR and (2) upon finalization of the SNUR those conditions of use would be prohibited unless and until EPA makes an affirmative determination that the significant new use is not likely to present an unreasonable risk or takes appropriate action under section 5(e) or 5(f).  View the determination document and the terms of the SNUR 06/22/16 10/09/18
P-18-0070 Generic: Waste plastics, polyester, depolymd. with glycols, polymers with dicarboxylic acids The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented.  View the determination document.  01/04/18 10/05/18
P-18-0100 Generic: Substituted alkanoic acid polymer with alkylcarbonate, alkanediols and isocyanate substituted carbomonocycles, sodium salt, alkenoic acid substituted polyol reaction products-blocked. The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document.  01/26/18 10/05/18
P-18-0102 Generic: Alkenoic acid, ester with [oxybis(alkylene)]bis[alkyl-substituted alkanediol], polymer with alkylcarbonate, alkanediols, substituted alkanoic acid and isocyanate and alkyl substituted carbomonocycle, sodium salt. The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document.  01/26/18 10/05/18
P-18-0116 Generic: Fatty acid oil reaction product with fatty acid oil The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented.  View the determination document.  02/26/18 10/05/18
P-18-0137 Generic: Alkylsilsesquioxane, ethoxy-terminated The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document.  03/23/18 10/05/18
P-18-0227 Specific: D-Glucaric acid (CASRN: 87-73-0) The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented.  View the determination document.  06/29/18 10/05/18
P-18-0231 Generic: Alkanoic acid, substituted alkyl-, polymer with isocyanatoalkane, alkyl carbonate, alkanediol and polyalkylene glycol ether with alkyl(substituted alkyl) alkanediol alkenoate, glycerol monoacrylate alkanoate-blocked The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document.  06/29/18 09/26/18
J-18-0022
J-18-0023
J-18-0024
J-18-0025
Generic: Modified Saccharomyces cerevisiae The microorganisms are not likely to present an unreasonable risk (5(a)(3)(C)) The microorganisms are not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganisms and introduced genetic material. S. cerevisiae is not pathogenic to humans or animals and has an extensive history of safe use in food processing. The introduced genetic modifications pose low concern for health and environmental hazard and do not include antibiotic resistance markers. View the determination document.  07/13/18 09/27/18
P-18-0230 Specific: Waxes and Waxy substances, rice bran, oxidized, calcium salts (CASRN 1850357-57-1) The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document.  06/29/18 09/18/18
P-17-0332 Generic: Benzenesulfonic acid, (alkenediyl)bis[[[(hydroxyalkyl)amino]-(phenylamino)-triazin-2- yl]amino]-, N-(hydroxyalkyl) derivs., salts The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented below. Although EPA estimated that the new chemical substance could be very persistent, the chemical substance has low potential for bioaccumulation, such that repeated exposures are not expected to be cumulative. Based on test data on the new chemical substance and analogous chemical substances, EPA estimates that the chemical substance has moderate environmental hazard and low human health hazard. EPA determines that the new chemical substance is not likely to present an unreasonable risk under the conditions of use. View the determination document.  06/19/17 09/18/18
J-18-0028
J-18-0029
J-18-0030
Generic: Saccharomyces cerevisiae modified The microorganisms are not likely to present an unreasonable risk (5(a)(3)(C)) The microorganisms are not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. S. cerevisiae is not pathogenic to humans or animals and has an extensive history of safe use in food processing. View the determination document.  07/03/18 09/14/18
P-16-0532 Generic: Substituted heteromonocycle Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental concerns. View the determination document.  08/25/18 09/06/18
J-18-0004
J-18-0005
J-18-0006
J-18-0007
J-18-0008
J-18-0009
Generic: Biofuel-producing modified microorganisms, with chromosomally-borne modifications The microorganisms are not likely to present an unreasonable risk (5(a)(3)(C)) The microorganisms are not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document.  06/14/18 09/06/18
J-18-0012 Generic: Genetically modified yeast Microorganism not likely to present an unreasonable risk (5(a)(3)(C)) The microorganism is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document.  06/06/18 08/27/18
J-18-0001 Generic: Modified Corynebacterium glutamicum Microorganism not likely to present an unreasonable risk (5(a)(3)(C)) The microorganism is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document.  12/08/17 08/02/18
P-16-0510 Specific: Oxirane, 2-methyl-, polymer with oxirane, bis[2-[(1-oxo-2-propen-1-yl)amino]propyl] ether (CASRN: 1792208-65-1) Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. Although EPA estimated that the new chemical substance could be very persistent, the chemical substance has low potential for bioaccumulation, such that repeated exposures are not expected to be cumulative. Based on EPA’s TSCA New Chemicals Program Chemical Categories for Acrylates and Acrylamides and test data on analogous chemical substances, EPA estimates that the chemical substance has low to moderate environmental hazard and the potential for the following human health hazards: irritation, mutagenicity, developmental/reproductive toxicity, neurotoxicity, and carcinogenicity. Based on test data on structural analogues to the low molecular weight components of the PMN substance, systemic effects were used as the endpoint for evaluation. EPA determines that the conditions of use would not produce these potential unreasonable risks because the PMN submitter would import the chemical substance in solution at a concentration of 50% or less for processing which would result in a deodorizer for use at a concentration of 2% by weight in the formulation of the final product. View the determination document. 08/05/16 07/30/18
P-18-0142 Generic: Alkanoic acid, alkyl-, alkyl ester, polymer with substituted alkenoates, alkenoic acid, alkyl peroxoate-initiated; polymer exemption flag. Polymer exemption flag: The chemical must be manufactured such that it meets the polymer exemption criteria as described under 40 CFR §723.250(e)(1), in addition to meeting the definition of polymer at 40 CFR §723.250(b). Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental concerns. View the determination document.  03/27/18 07/27/18
J-18-0002
J-18-0003
Generic: Saccharomyces cerevisiae modified Microorganisms not likely to present an unreasonable risk (5(a)(3)(C)) The microorganisms are not likely to present an unreasonable risk based on low human
health hazard and low environmental hazard associated with the recipient microorganisms and introduced genetic material. View the determination document. 
02/12/18 06/12/18
P-18-0083 Specific: 2-Propenoic acid, telomers with Bu alc.-2-[(2-propen-1-yloxy) methyl]oxirane reaction products, sodium bisulfite and sodium 2- hydroxy-3-(2-propen-1-yloxy)-1-propanesulfonate(1:1), sodium salts, peroxydisulfuric acid ([(HO)S(O)2]2O2) sodium salt (1:2)- initiated. (CASRN: 2118944-42-4) Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental concerns. View the determination document. 01/03/18 03/23/18
P-18-0044
P-18-0045
Generic (P-18-0044): Fatty acids

Generic (P-18-0045): Fatty acids, alkyl esters
Chemical substances not likely to present an unreasonable risk (5(a)(3)(C)) These chemical substances are not likely to present an unreasonable risk based on low/moderate human health hazard and low environmental hazard. View the determination document.  11/7/17 03/23/18
P-18-0021 Generic: Dicarboxylic acids, polymers with substituted poly( substituted alkendiyl) ,3-hydroxy-2-(hydroxyalkyl)-2-alkylalkenoic acid, 5-substituted-1-(substituted alkyl)- 1,3,3-trialkyl carbomonocyle, alkanediol, alkane-triol, alcohol blocked compounds with aminoalcohol; polymer exemption flag. Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document.  10/16/17 03/23/18
P-18-0002 Generic: Phosphinic acid, P,P-alkyl-, salt Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk of injury to health or the environment. View the determination document.  10/02/17 03/19/18
P-16-0415 Generic: Polyurethane; polymer exemption flag. Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk based on low human health concern and low environmental hazard when made in accordance with the polymer exemption. View the determination document.  06/22/16 03/19/18
J-17-0028 Generic: Biofuel producing Saccharomyces cerevisiae modified, genetically stable Microorganism not likely to present an unreasonable risk (5(a)(3)(C)) The microorganism is not likely to present an unreasonable risk based on low human
health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document.
09/28/17 01/04/18
J-17-0022 Generic: Modified Trichoderma reesei Microorganism not likely to present an unreasonable risk (5(a)(3)(C)) The microorganism is not likely to present an unreasonable risk based on low human
health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document.
10/09/17 01/04/18
J-17-0021 Generic: Modified Saccharomyces cerevisiae Microorganism not likely to present an unreasonable risk (5(a)(3)(C)) The microorganism is not likely to present an unreasonable risk based on low human
health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document.
10/06/17 01/04/18
J-17-0015
J-17-0016
J-17-0017
J-17-0018
J-17-0019
Generic: Saccharomyces cerevisiae modified Microorganisms not likely to present an unreasonable risk (5(a)(3)(C)) The microorganisms are not likely to present an unreasonable risk based on low human
health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document.
08/7/17 01/04/18
P-18-0026 Specific: Silsesquioxanes, 2,4,4- trimethylpentyl, hydroxy-terminated. (CASRN: 217654-68-7) Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 10/17/17 12/12/17
P-18-0032 Generic: Alkyl alkenoic acid, alkyl ester, polymer with alkyl alkenoate, dialkyl alkanediol, substituted carbomonocycle, disubstituted heteromonocycle,disubstituted heteropolycyclic, alkanediol, substituted alkyl alkyl alkenoate and substituted heteromonocycle, dialkyl peroxide initiated. Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 10/27/17 12/12/17
P-17-0153 Specific: D-Glucitol, 1-deoxy-1-(dimethylamino)-. (CASRN: 76326-99-3) Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 11/23/16 12/12/17
P-17-0390 Generic: Carbomonocyclic dicarboxylic acid, polymer with alkenedioic acid, substituted heteropolycycle, substituted heteromonocycle, alkanediol, alkanedioic acid, alkoxylated substituted dicarbomonocycle, alkoxylated substituted dicarbomonocycle and alkanetriol, carbomonocyclic carboxylate alkanoate Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 09/06/17 11/02/17
P-17-0190 Generic: Butanoic acid, 3-oxo-, 2-[(2- methyl-1-oxo-2-propen-1-yl)oxy]ethyl ester, polymer with cycloalkyl 2-methyl-2-propenoate, ethenylbenzene, 2- ethylhexyl 2- propenoate, methyl 2- methyl-2-propenoate and 2- methylpropyl 2-methyl-2- propenoate Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 12/26/16 09/06/17
J-17-0014 Generic: organic acid producing yeast, modified, genetically stable Microorganism not likely to present an unreasonable
risk (5(a)(3)(C))
The microorganism is not likely to present an unreasonable risk based on low human
health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document. 
07/10/17 10/05/17
P-16-0508 Generic: Terephthalic acid and alcohol ester polymer hydroxy glycol and 2- Ethylhexyl alcohol; polymer exemption flag. Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 10/04/16 09/26/17
P-14-0314 Generic: Poly aliphatic phosphate Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 06/22/2016 07/31/2017
J-17-0008
J-17-0009
J-17-0010
J-17-0011
J-17-0012
J-17-0013
Generic: Modified microorganism Microorganism not likely to present
an unreasonable risk (§5(a)(3)(C))
The microorganisms are not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganisms and introduced genetic material. The introduced genetic modifications pose low concern for health and environmental hazard and do not include antibiotic resistance markers. View the determination document. 05/08/2017 07/27/2017
P-17-0117
P-17-0118
Specific (P-17-0117): 1,6,10- Dodecatriene, 7,11-dimethyl-3-methylene-, (6E)-, homopolymer, 2-hydroxypropyl-terminated (CASRN: 1898242-86-8); polymer exemption flag.
Specific (P-17-0118): 1,6,10- Dodecatriene, 7,11-dimethyl-3- methylene-, (6E)-, homopolymer, 2-hydroxyethyl-terminated (CASRN: 2007163-32-6); polymer exemption flag
Polymer exemption flag: The chemical must be manufactured such that it meets the polymer exemption criteria as described under 40 CFR §723.250(e)(1), in addition to meeting the definition of polymer at 40 CFR §723.250(b).
Chemical substances are not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substances are not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 11/17/2016 07/24/2017
P-17-0293 Generic: Substituted carbomonocycle, polymer with substituted carbonomoncycles, alkyl substituted- alkanediols, alkanediol, alkanedioic acid, and dialkylene glycol; polymer exemption flag. Polymer exemption flag: The chemical must be manufactured such that it meets the polymer exemption criteria as described under 40 CFR §723.250(e)(1), in addition to meeting the definition of polymer at 40 CFR §723.250(b). Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 04/24/2017 07/21/2017
P-17-0266 Specific: Alcohols, C12-13-branched and linear, dimerized (CASRN: 2041102-78-5). Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 03/22/2017 07/27/2017
P-17-0219 Generic: Polyester of aliphatic glycols and aromatic diacids; polymer exemption flag. Polymer exemption flag: The chemical must be manufactured such that it meets the polymer exemption criteria as described under 40 CFR §723.250(e)(1), in addition to meeting the definition of polymer at 40 CFR §723.250(b). Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 01/25/2017 07/14/2017
P-17-0112 Specific: 1,4-Benzenedicarboxylic acid, polymer with hexanedioic acid and 1,6-hexanediol (CASRN: 84191-80-0); polymer exemption flag.
Polymer exemption flag: The chemical must be manufactured such that it meets the polymer exemption criteria as described under 40 CFR §723.250(e)(1), in addition to meeting the definition of polymer at 40 CFR §723.250(b).
Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 11/16/2016 07/06/2017
P-17-0264 Generic: Alkanoic acid, 2-alkyl-, substituted alkyl ester, polymer with alkyl alkenoate, substituted carbomonocycle, substituted alkyl alkenoate and alkyl substituted alkenoate, substituted alkanenitrile- initiated; polymer exemption flag.
Polymer exemption flag: The chemical must be manufactured such that it meets the polymer exemption criteria as described under 40 CFR §723.250(e)(1), in addition to meeting the definition of polymer at 40 CFR §723.250(b).
Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 03/22/2017 06/29/2017
P-16-0426 Generic: Alkenyl bis-succinimide Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 06/30/2016 06/28/2017
P-17-0255 Generic: Carbomonocyclic dicarboxylic acid, polymer with carbomonocyclic dicarboxylic acid, alkanedioic acid, alkenedioic acid, substituted dioxoheteropolycyclic, substituted dioxoheteropolycyclic, alkanedioic acid, alkoxylated alkylidene dicarbomonocycle and alkoxylated alkylidene dicarbomonocycle, ester. Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 03/14/2017 06/07/2017
P-16-0587 Specific: Galactoarabinoxylan (CASRN: 37324-70-2). Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 09/22/2016 06/15/2017
P-16-0401 Generic: Alkyl acrylate polymer; polymer exemption flag. Polymer exemption flag: The chemical must be manufactured such that it meets the polymer exemption criteria as described under 40 CFR §723.250(e)(1), in addition to meeting the definition of polymer at 40 CFR §723.250(b). Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 06/22/2016 06/15/2017
P-16-0588 Generic: Alkyl methacrylate, polymer with alkyl acrylate and polyesters; polymer exemption flag. Polymer exemption flag: The chemical must be manufactured such that it meets the polymer exemption criteria as described under 40 CFR §723.250(e)(1), in addition to meeting the definition of polymer at 40 CFR §723.250(b). Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 09/22/2016 05/30/2017
P-16-0303 Generic: Alkyl methyacrylate polymer with styrene, amino acrylate and acrylic acid, ammonium salt; polymer exemption flag. Polymer exemption flag: The chemical must be manufactured such that it meets the polymer exemption criteria as described under 40 CFR §723.250(e)(1), in addition to meeting the definition of polymer at 40 CFR §723.250(b). Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 06/22/2016 05/30/2017
P-17-0237
P-17-0238
Specific (P-17-0237): 1,6,10- Dodecatriene, 7,11-dimethyl-3- methylene-, (6E)-, homopolymer, hydrogenated, 2-hydroxyethyl- terminated (CASRN: 2007163-33-7).
Specific (P-17-0238): 1,6,10- Dodecatriene, 7,11-dimethyl-3- methylene-, (6E)-, homopolymer, 2-hydroxypropyl-terminated, hydrogenated (CASRN: 1912453-88-3).
Chemical substances are not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substances are not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 02/23/2017 05/19/2017
P-17-0256 Generic: Carbopolycyclic dicarboxylic acid, dialkyl ester, polymer with dialkyl carbomonocyclic diester, dialkyl substituted carbomonocyclic diester alkali metal salt and alkanediol; polymer exemption flag. Polymer exemption flag: The chemical must be manufactured such that it meets the polymer exemption criteria as described under 40 CFR §723.250(e)(1), in addition to meeting the definition of polymer at 40 CFR §723.250(b). Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 03/14/2017 05/18/2017
P-17-0207 Generic: 2-alkenoic acid, 2 alkyl, 2 alkyl ester, polymer with alkyl alkenoate, carbomonocyle, alkyl alkenoate and alkyl alkenoate, alkyl peroxide initiated; polymer exemption flag. Polymer exemption flag: The chemical must be manufactured such that it meets the polymer exemption criteria as described under 40 CFR §723.250(e)(1), in addition to meeting the definition of polymer at 40 CFR §723.250(b). Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 01/23/2017 05/18/2017
P-17-0246 Generic: Polycarbonate polyol. Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 02/28/2017 05/11/2017
P-16-0578 Generic: Alkenoic acid, alkyester, polymer with N-(dialkyl-oxoalkyl)- alkenamide, alkenylbenzene, alkyl alkenoate and alkenoic acid; polymer exemption flag. Chemical substance not likely to present an unreasonable risk (§5(a)(3)(C)).,

Polymer exemption flag: The chemical must be manufactured such that it meets the polymer exemption criteria as described under 40 CFR §723.250(e)(1), in addition to meeting the definition of polymer at 40 CFR §723.250(b).
The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 09/18/2016 05/15/2017
J-17-0007 Generic: Biofuel producing Saccharomyces cerevisiae modified, genetically stable Microorganism not likely to present an unreasonable risk (§5(a)(3)(C)) The microorganism is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document. 02/01/2017 04/27/2017
P-17-0227 Generic: 2-Alkenoic acid, 2-alkyl-, alkyl ester, polymer with 2-alkyl 2- propenoate and -(2-alkyl-1-oxo-2- alken-1-yl--alkoxypoly(oxy-1,2- alkanediyl), ester with -2-alken-1-yl--hydroxypoly(oxy-1,2-alkanediyl); polymer exemption flag. Chemical substance not likely to present an unreasonable risk (§5(a)(3)(C)).,

Polymer exemption flag: The chemical must be manufactured such that it meets the polymer exemption criteria as described under 40 CFR §723.250(e)(1), in addition to meeting the definition of polymer at 40 CFR §723.250(b).
The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 02/01/2017 04/27/2017
P-17-0194 Generic: Hydrogenated dihalo dialkyl diindolotriphenodioxazine, dihydrodisubstituted isoindolyl alkyl derivs. Chemical substance not likely to present an unreasonable risk (§5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 01/04/2017 03/13/2017
P-17-0215 Generic: Copolymer of alpha-olefin and dibutyl maleate. Chemical substance not likely to present an unreasonable risk (§5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 01/16/2017 03/13/2017
P-17-0214 Generic: 2-Propenoic acid, polymer with alkene and alkenyl acetate, alkyl 2-alkyl isoalkyl esters. Chemical substance not likely to present an unreasonable risk (§5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 01/16/2017 03/13/2017
P-17-0014 Specific: Fatty acids, C8-10, mixed esters with C18-unsatd. fatty acid dimers and .alpha.-hydro-.omega.-hydroxypoly(oxy-1,4-butanediyl) (CASRN: None). Chemical substance not likely to present an unreasonable risk (§5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 02/06/2017 03/13/2017
P-17-0008 Generic: Modified 1,3- isobenzofurandione, polymer with 1,2-ethanediol, 2-ethyl-2-(alkoxyalkyl)-1,3-propanediol and 1,3- Isobenzofurandione, alkanoate Chemical substance not likely to present an unreasonable risk (§5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 11/02/2016 03/30/2017
P-16-0592 Specific: Fatty acids, C8-10, diesters with .alpha.-hydro-.omega.- hydroxypoly(oxy-1,4-butanediyl) (CASRN: None) Chemical substance not likely to present an unreasonable risk (§5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 01/23/2017 03/13/2017
P-17-0185 Generic: Fatty acids, C18-unsatd., dimers, hydrogenated, polymers with C18-unsatd. fatty acid trimers, alkylenediamine and hydroxyalkanoic acid. Chemical substance not likely to present an unreasonable risk (§5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 12/30/2016 02/13/2017
P-17-0182 Generic: Alkyldioic acid, polymer with 2,2-dimethyl-1,3-propanediol, heteropolycyclic carboxy acid anhydride and 1,3-propanediol. Chemical substance not likely to present an unreasonable risk (§5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 12/30/2016 02/13/2017
P-17-0160
P-17-0161
Generic: 2-Propenoic acid, alkyl-, alkyl ester, polymer with alkyl 2- propenoate, dialkyloxoalkyl-2- propenamide and alkyl 2-propenoate.

Generic: 2-Propenoic acid, alkyl-, alkyl ester, polymer with alkyl 2- propenoate, dialkyloxoalkyl-2- propenamide, ethenylbenzene and alkyl 2-propenoate.
Chemical substances are not likely to present an unreasonable risk (§5(a)(3)(C)) The chemical substances are not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 11/30/2016 02/13/2017
P-17-0158 Generic: Perylene bisimide Chemical substance not likely to present an unreasonable risk (§5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 11/30/2016 02/13/2017
J-17-0006 Generic: Saccharomyces cerevisiae modified Microorganism not likely to present an unreasonable risk (§5(a)(3)(C)) The microorganism is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document. 11/23/2016 02/13/2017
P-17-0144 Specific: Amines, C36-alkylenedi-, polymers with octahydro-4,7- methano-1H- indenedimethanamine and pyromellitic dianhydride, maleated (CASRN: 2020378-57-6). Chemical substance not likely to present an unreasonable risk (§5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 11/18/2016 01/18/2017
J-17-0001
J-17-0002
J-17-0003
J-17-0004
J-17-0005
Generic: Saccharomyces cerevisiae modified Microorganisms are not likely to present an unreasonable risk (§5(a)(3)(C)) The microorganisms are not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document. 10/24/2016 01/18/2017
P-17-0016
P-17-0017
P-17-0018
P-17-0019
P-17-0020
P-17-0021
Generic: (P-17-0016): Hydroxyl alkyl acrylate ester, polymer with acrylates, aromatic vinyl monomer, cycloaliphatic lactone, and alkyl carboxylic acid, peroxide initiated

Generic (P-17-0017): Hydroxyl alkyl acrylate ester, polymer with acrylates, aromatic vinyl monomer, cycloaliphatic lactone, and alkyl carboxylic acid, peroxide initiated.

Generic (P-17-0018): Hydroxyl alkyl acrylate ester, polymer with acrylates, aromatic vinyl monomer, cycloaliphatic lactone, and alkyl carboxylic acid, Azobis[aliphatic nitrile] initiated

Generic (P-17-0019): Hydroxyl alkyl acrylate ester, polymer with acrylates, aromatic vinyl monomer, cycloaliphatic lactone, and alkyl carboxylic acid, peroxide initiated

Generic (P-17-0020): Hydroxyl alkyl acrylate ester, polymer with acrylates, aromatic vinyl monomer, cycloaliphatic lactone, and alkyl carboxylic acid, peroxide initiated

Generic (P-17-0021): Hydroxyl alkyl acrylate ester, polymer with acrylates, aromatic vinyl monomer, cycloaliphatic lactone, and alkyl carboxylic acid, Azobis[aliphatic nitrile] initiated
Chemical substances are not likely to present an unreasonable risk (§5(a)(3)(C)) The chemical substances are not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 10/25/2016 12/19/2016
P-17-0009 Generic: Depolymerized waste plastics Chemical substance not likely to present
an unreasonable risk (§5(a)(3)(C))
The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 10/13/2016 12/01/2016
J-16-0033 Generic: Saccharomyces cerevisiae modified to express glucoamylase activity Microorganism not likely to present
an unreasonable risk (§5(a)(3)(C))
The microorganism is not likely to present an unreasonable risk based on low human
health hazard and low environmental hazard associated with the recipient microorganism and
introduced genetic material. View the determination document.
08/22/2016 12/01/2016
J-16-0034 Generic: Saccharomyces cerevisiae modified Microorganism not likely to present
an unreasonable risk (§5(a)(3)(C))
The microorganism is not likely to present an unreasonable risk based on low human
health hazard and low environmental hazard associated with the recipient microorganism and
introduced genetic material. View the determination document.
08/23/2016 12/01/2016
J-16-0036
J-16-0037
J-16-0038
J-16-0039
J-16-0040
J-16-0041
Generic: Biofuel producing modified microorganism(s), with chromosomally-borne modifications Microorganisms are not likely to present
an unreasonable risk (§5(a)(3)(C))
The microorganisms are not likely to present an unreasonable risk based on low human
health hazard and low environmental hazard associated with the recipient microorganism and
introduced genetic material. View the determination document.
09/07/2016 12/01/2016
J-16-0035 Generic: Saccharomyces cerevisiae modified Microorganism not likely to present
an unreasonable risk (§5(a)(3)(C))
The microorganism is not likely to present an unreasonable risk based on low human
health hazard and low environmental hazard associated with the recipient microorganism and
introduced genetic material. View the determination document.
08/23/2016 12/01/2016
P-16-0580 Generic: Trimethylolpropane ester of mixed linear and branched carboxylic acids Chemical substance not likely to present
an unreasonable risk (§5(a)(3)(C))
The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 09/19/2016 11/10/2016
J-16-0025 Generic: Trichoderma reesei modified Microorganism not likely to present
an unreasonable risk (§5(a)(3)(C))
The microorganism is not likely to present an unreasonable risk based on low human
health hazard and low environmental hazard associated with the recipient microorganism and
introduced genetic material. View the determination document.
07/29/2016 11/14/2016
J-16-0024 Generic: Trichoderma reesei modified Microorganism not likely to present
an unreasonable risk (§5(a)(3)(C))
The microorganism is not likely to present an unreasonable risk based on low human
health hazard and low environmental hazard associated with the recipient microorganism and
introduced genetic material. View the determination document.
07/28/2016 11/14/2016
P-16-0519 Generic: Polyalkylether polyester Chemical substances not likely to present
an unreasonable risk (§5(a)(3)(C))
The chemical substance is not likely to present an unreasonable risk based on low
human health hazard and low environmental hazard. View the determination document.
08/12/2016 11/17/2016
P-16-0518 Generic: Polyalkylether polyester Chemical substances not likely to present
an unreasonable risk (§5(a)(3)(C))
The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 08/12/2016 11/17/2016
P-16-0403 Generic: Heteropolycyclic carboxylic acid, polymer with 2-ethyl-2-(hydroxymethyl)-1, 3-propanediol and 4- substitutedbenzene, substituted carbomonocycle- and alkyl-substituted carbomonocycle-blocked Chemical substances not likely to present
an unreasonable risk (§5(a)(3)(C))
The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 06/22/2016 11/17/2016
P-16-0545 Generic: substituted siloxane polymer Chemical substances not likely to present
an unreasonable risk (§5(a)(3)(C))
The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard.View the determination document. 09/02/2016 11/10/2016
P-16-0515 Generic: Diamine substituted arylimidazole Chemical substances not likely to present
an unreasonable risk (§5(a)(3)(C))
The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 08/09/2016 11/10/2016
P-16-0492 Generic: Polyester-amide polymer of 'isophthalic acid' with diamino-alkane, cyclohexanedialcohol, alkanetriol, di-isocyanate and acrylic acid-ethylene copolymer Chemical substances not likely to present
an unreasonable risk (§5(a)(3)(C))
The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 07/25/2016 11/10/2016
J-16-0023 Generic: Trichoderma reesei modified Microorganism not likely to present
an unreasonable risk (§5(a)(3)(C))
The microorganism is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document. 07/16/2016 10/19/2016
J-16-0022 Generic: Trichoderma reesei modified Microorganism not likely to present
an unreasonable risk (§5(a)(3)(C))
The microorganism is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document. 07/15/2016 10/19/2016
J-16-0021 Generic: Trichoderma reesei modified Microorganism not likely to present
an unreasonable risk (§5(a)(3)(C))
The microorganism is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document. 07/15/2016 10/19/2016
J-16-0020 Generic: Trichoderma reesei modified Microorganism not likely to present
an unreasonable risk (§5(a)(3)(C))
The microorganism is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document. 06/29/2016 10/04/2016
J-16-0019 Generic: Trichoderma reesei modified Microorganism not likely to present
an unreasonable risk (§5(a)(3)(C))
The microorganism is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document. 06/29/2016 10/04/2016
P-16-0459 Generic: Carbomonocyclic dicarboxylic acid, polymer with alkanedioic acid, substituted heteropolycycle, substituted carbomonocycle, alkyl alkenoate, alkanedioic acid, alkoxylated substituted dicarbomonocycle, alkoxylated substituted dicarbomonocycle, alkenoic acid, oxo alkyl initiated. Chemical substances not likely to present
an unreasonable risk (§5(a)(3)(C))
The chemical substances are not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. Although EPA estimated that the new chemical substances would be very persistent, this did not indicate a likelihood that the chemical substances would present an unreasonable risk, given that the chemical substances have low potential for bioaccumulation, low human health hazard, and low environmental hazard. View the determination document. 07/8/2016 10/04/2016
P-16-0343
P-16-0344
Generic: Modified urethane polymer. Chemical substances are not likely to present
an unreasonable risk (§5(a)(3)(C))
The chemical substances are not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. Although EPA estimated that the new chemical substances would be very persistent, this did not indicate a likelihood that the chemical substances would present an unreasonable risk, given that the chemical substances have low potential for bioaccumulation, low human health hazard, and low environmental hazard. View the determination document. 06/22/2016 09/16/2016
P-16-0391 Generic: Polyester polyol polymer with aliphatic isocyanate and phenol derivates Chemical substance not likely to present
an unreasonable risk (§5(a)(3)(C))
The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. Although EPA estimated that the new chemical substance would be very persistent, this did not indicate a likelihood that the chemical substance would present an unreasonable risk, given that the chemical substance has low potential for bioaccumulation, low human health hazard, and low environmental hazard. View the determination document. 06/22/2016 09/14/2016
J-16-0010 Generic: Saccharomyces cerevisiae modified Microorganism not likely to present
an unreasonable risk (§5(a)(3)(C))
The microorganism is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. S. cerevisiae is not pathogenic to humans or animals and has an extensive history of safe use in food processing. The introduced genetic modifications pose low concern for health and environmental hazard and do not include antibiotic resistance markers. View the determination document. 06/22/2016 09/14/2016
J-16-0011
J-16-0012
J-16-0013
J-16-0014
J-16-0015
J-16-0016
Generic: Biofuel Producing Organism Microorganisms are not likely to present
an unreasonable risk (§5(a)(3)(C))
The microorganisms are not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. The recipient microorganism is not pathogenic to humans or animals and has an extensive history of safe use. The introduced genetic modifications pose low concern for health and environmental hazard and do not include antibiotic resistance markers. View the determination document. 06/22/2016 09/14/2016
J-16-0017 Generic: Saccharomyces cerevisiae modified Microorganism not likely to present
an unreasonable risk (§5(a)(3)(C))
The microorganism is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. S. cerevisiae is not pathogenic to humans or animals and has an extensive history of safe use in food processing. The introduced genetic modifications pose low concern for health and environmental hazard and do not include antibiotic resistance markers. View the determination document. 06/22/2016 09/14/2016
J-16-0018 Generic: Saccharomyces cerevisiae modified Microorganism not likely to present
an unreasonable risk (§5(a)(3)(C))
The microorganism is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. S. cerevisiae is not pathogenic to humans or animals and has an extensive history of safe use in food processing. The introduced genetic modifications pose low concern for health and environmental hazard and do not include antibiotic resistance markers. View the determination document. 06/22/2016 09/14/2016
P-16-0366 Generic: Blocked polyisocyanate Chemical substance not likely to present
an unreasonable risk (§5(a)(3)(C))
The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. Although EPA estimated that the new chemical substance would be very persistent, this did not indicate a likelihood that the chemical substance would present an unreasonable risk, given that the chemical substance has low potential for bioaccumulation, low human health hazard, and low environmental hazard. View the determination document. 06/22/2016 09/12/2016
P-16-0373 Generic: Tris(alkyloxyphenyl)triazine compounds Chemical substance not likely to present
an unreasonable risk (§5(a)(3)(C))
The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. Although EPA estimated that the new chemical substance would be very persistent, this did not indicate a likelihood that the chemical substance would present an unreasonable risk, given that the chemical substance has low potential for bioaccumulation, low human health hazard, and low environmental hazard. View the determination document. 06/22/2016 09/12/2016
P-16-0466 Generic: 2,5-Furandione, telomer with ethenylbenzene and (alkylethyl)benzene, amides with polyethylene-polypropylene glycol aminoalkyl Me ether, alkali salts Chemical substance not likely to present
an unreasonable risk (§5(a)(3)(C))
The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental toxicity. Although EPA estimated that the new chemical substance would be very persistent, this did not indicate a likelihood that the chemical substance would present an unreasonable risk, given that the chemical substance has low potential for bioaccumulation, low human health hazard, and low environmental hazard. View the determination document. 07/11/2016 09/02/2016
J-16-0006 Generic: Trichoderma reesei modified Microorganism not likely to present
an unreasonable risk (§5(a)(3)(C))
The microorganism is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. T. reesei is not pathogenic to humans or animals and has a long history of safe use for production of enzymes. The introduced genetic modifications pose low concern for health and environmental hazard, do not include antibiotic resistance markers, and do not provide a growth advantage over the parental strain. View the determination document. 06/22/2016 09/2/2016
P-16-0348 Generic: Polypentaerythritol, mixed esters with linear and branched monoacids Chemical substance not likely to present
an unreasonable risk (§5(a)(3)(C))
The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. Although EPA estimated that the new chemical substance would be very persistent, this did not indicate a likelihood that the chemical substance would present an unreasonable risk, given that the chemical substance has low potential for bioaccumulation, low human health hazard, and low environmental hazard. View the determination document. 06/22/2016 09/2/2016
P-16-0392 Generic: Modified vegetable oil Not likely to present
an unreasonable risk (§5(a)(3)(C))
The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental toxicity. Although EPA estimated that the new chemical substance would be very persistent, this did not indicate a likelihood that the chemical substance would present an unreasonable risk, given that the chemical substance has low potential for bioaccumulation, low human health hazard, and low environmental hazard. View the determination document. 06/22/2016 07/29/2016
P-16-0351 Generic: Glycerides, C14-18 and C16-C18 unsaturated, from fermentation Not likely to present
an unreasonable risk (§5(a)(3)(C))
The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental toxicity. Although EPA estimated that the new chemical substance would be persistent, this did not indicate a likelihood that the chemical substance would present an unreasonable risk, given that the chemical substance has low potential for bioaccumulation, low human health hazard, and low environmental hazard. View the determination document. 06/22/2016 07/29/2016
P-16-0340 Generic: Glycerides, C8-18 and C18 unsaturated, from fermentation Not likely to present
an unreasonable risk (§5(a)(3)(C))
The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental toxicity. Although EPA estimated that the new chemical substance would be persistent, this did not indicate a likelihood that the chemical substance would present an unreasonable risk, given that the chemical substance has low potential for bioaccumulation, low human health hazard, and low environmental hazard. View the determination document. 06/22/2016 07/29/2016
P-16-0302 Generic: Organic modified propyl silsesquioxane Not likely to present
an unreasonable risk (§5(a)(3)(C))
The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental toxicity. Although EPA estimated that the new chemical substance would be very persistent, this did not indicate likelihood that the chemical substance would present an unreasonable risk, given that the chemical substance has low potential for bioaccumulation, low human health hazard, and low environmental hazard. View the determination document. 06/22/2016 07/20/2016
P-16-0301 Generic: Propyl silsesquioxanes, hydrogen-terminated Not likely to present
an unreasonable risk (§5(a)(3)(C))
The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 06/22/2016 07/20/2016
P-16-0292 Generic: Depolymerized waste plastics. Not likely to present
an unreasonable risk (§5(a)(3)(C))
The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. Although EPA estimated that the new chemical substance would be very persistent, this did not indicate a likelihood that the chemical substance would present an unreasonable risk, given that the chemical substance has low potential for bioaccumulation, low human health hazard, and low environmental hazard. View the determination document. 06/22/2016 07/20/2016
P-16-0281 Generic: Fatty alcohols-dimers, trimers, polymers Not likely to present
an unreasonable risk (§5(a)(3)(C))
The chemical substance is not likely to present an unreasonable risk based on low health hazard concern and low environmental toxicity. View the determination document. 06/22/2016 07/15/2016