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Reviewing New Chemicals under the Toxic Substances Control Act (TSCA)

Chemicals Determined Not Likely to Present an Unreasonable Risk Following Pre-Manufacture Notification Review

This page describes the chemical substances EPA has determined are “not likely to present an unreasonable risk” following review of pre-manufacture notifications under section 5 of TSCA, as amended by the Frank R. Lautenberg Chemical Safety for the 21st Century Act, P.L. 114-182.

Note:  For these “not likely to present an unreasonable risk” cases,” PMN submitters may commence manufacture upon notification by EPA, notwithstanding any remaining portion of the applicable review period, in accordance with section 5(g) of TSCA, as amended.

View the interim and final status of Section 5 pre-manufacture notices reviewed under TSCA.

Case
Number
Chemical
Identity
EPA Determination
Following PMN Review
Summary Review
Start Date
Decision
Date
J-17-0028 Generic: Biofuel producing Saccharomyces cerevisiae modified, genetically stable Microorganism not likely to present an unreasonable risk (5(a)(3)(C)) The microorganism is not likely to present an unreasonable risk based on low human
health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document. 
9/28/17 1/4/18
J-17-0022 Generic: Modified Trichoderma reesei Microorganism not likely to present an unreasonable risk (5(a)(3)(C)) The microorganism is not likely to present an unreasonable risk based on low human
health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document. 
10/9/17 1/4/18
J-17-0021 Generic: Modified Saccharomyces cerevisiae Microorganism not likely to present an unreasonable risk (5(a)(3)(C)) The microorganism is not likely to present an unreasonable risk based on low human
health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document. 
10/6/17 1/4/18
J-17-0015, 0016, 0017, 0018, and 0019 Generic: Saccharomyces cerevisiae modified Microorganisms not likely to present an unreasonable risk (5(a)(3)(C)) The microorganism is not likely to present an unreasonable risk based on low human
health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document. 
8/7/17 1/4/18
P-18-0026 Specific: Silsesquioxanes, 2,4,4-trimethylpentyl, hydroxy-terminated. (CASRN: 217654-68-7) Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 10/17/17 12/12/17
P-18-0032 Generic: Alkyl alkenoic acid, alkyl ester, polymer with alkyl alkenoate, dialkyl alkanediol, substituted carbomonocycle, disubstituted heteromonocycle,disubstituted heteropolycyclic, alkanediol, substituted alkyl alkyl alkenoate and substituted heteromonocycle, dialkyl peroxide initiated. Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 10/27/17 12/12/17
P-17-0153 Specific: D-Glucitol, 1-deoxy-1-(dimethylamino)-. (CASRN: 76326-99-3) Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 11/23/16 12/12/17
P-17-0390 Generic: Carbomonocyclic dicarboxylic acid, polymer with alkenedioic acid, substituted heteropolycycle, substituted heteromonocycle, alkanediol, alkanedioic acid, alkoxylated substituted dicarbomonocycle, alkoxylated substituted dicarbomonocycle and alkanetriol, carbomonocyclic carboxylate alkanoate Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 09/06/17 11/02/17
P-17-0190 Generic: Butanoic acid, 3-oxo-, 2-[(2-methyl-1-oxo-2-propen-1-yl)oxy]ethyl ester, polymer with cycloalkyl 2-methyl-2-propenoate, ethenylbenzene, 2-ethylhexyl 2- propenoate, methyl 2-methyl-2-propenoate and 2-methylpropyl 2-methyl-2- propenoate Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 12/26/16 09/06/17
J-17-0014 Generic: organic acid producing yeast, modified, genetically stable Microorganism not likely to present an unreasonable
risk (5(a)(3)(C))
The microorganism is not likely to present an unreasonable risk based on low human
health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document. 
7/10/17 10/5/17
P-16-0508 Generic: Terephthalic acid and alcohol ester polymer hydroxy glycol and 2-Ethylhexyl alcohol; polymer exemption flag. Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 10/04/16 09/26/17
P-14-0314 Generic: Poly aliphatic phosphate Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 6/22/2016 7/31/2017
J-17-0008, 0009, 0010, 0011, 0012, and 0013 Generic: Modified microorganism Microorganism not likely to present
an unreasonable risk (§5(a)(3)(C))
The microorganisms are not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganisms and introduced genetic material. The introduced genetic modifications pose low concern for health and environmental hazard and do not include antibiotic resistance markers. View the determination document. 5/8/2017 7/27/2017
P-17-0117 & P-17-0118 Specific (P-17-0117): 1,6,10-Dodecatriene, 7,11-dimethyl-3-methylene-, (6E)-, homopolymer, 2-hydroxypropyl-terminated (CASRN: 1898242-86-8); polymer exemption flag.
Specific (P-17-0118): 1,6,10-Dodecatriene, 7,11-dimethyl-3-methylene-, (6E)-, homopolymer, 2-hydroxyethyl-terminated (CASRN: 2007163-32-6); polymer exemption flag
Polymer exemption flag: The chemical must be manufactured such that it meets the polymer exemption criteria as described under 40 CFR §723.250(e)(1), in addition to meeting the definition of polymer at 40 CFR §723.250(b).
Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 11/17/2016 7/24/2017
P-17-0293 Generic: Substituted carbomonocycle, polymer with substituted carbonomoncycles, alkyl substituted- alkanediols, alkanediol, alkanedioic acid, and dialkylene glycol; polymer exemption flag. Polymer exemption flag: The chemical must be manufactured such that it meets the polymer exemption criteria as described under 40 CFR §723.250(e)(1), in addition to meeting the definition of polymer at 40 CFR §723.250(b). Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 4/24/2017 7/21/2017
P-17-0266 Specific: Alcohols, C12-13-branched and linear, dimerized (CASRN: 2041102-78-5). Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 3/22/2017 7/27/2017
P-17-0219 Generic: Polyester of aliphatic glycols and aromatic diacids; polymer exemption flag. Polymer exemption flag: The chemical must be manufactured such that it meets the polymer exemption criteria as described under 40 CFR §723.250(e)(1), in addition to meeting the definition of polymer at 40 CFR §723.250(b). Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 1/25/2017 7/14/2017
P-17-0112 Specific: 1,4-Benzenedicarboxylic acid, polymer with hexanedioic acid and 1,6-hexanediol
(CASRN: 84191-80-0); polymer exemption flag.
Polymer exemption flag: The chemical must be manufactured such that it meets the polymer
exemption criteria as described under 40 CFR §723.250(e)(1), in addition to meeting the
definition of polymer at 40 CFR §723.250(b).
Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 11/16/2016 7/6/2017
P-17-0264 Generic: Alkanoic acid, 2-alkyl-, substituted alkyl ester, polymer with alkyl alkenoate, substituted carbomonocycle, substituted alkyl alkenoate and alkyl substituted alkenoate, substituted alkanenitrile-initiated; polymer exemption flag. Polymer exemption flag: The chemical must be manufactured such that it meets the polymer exemption criteria as described under 40 CFR §723.250(e)(1), in addition to meeting the definition of polymer at 40 CFR §723.250(b). Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 3/22/2017 6/29/2017
P-16-0426 Generic: Alkenyl bis-succinimide Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 6/30/2016 6/28/2017
P-17-0255 Generic: Carbomonocyclic dicarboxylic acid, polymer with carbomonocyclic dicarboxylic acid, alkanedioic acid, alkenedioic acid, substituted dioxoheteropolycyclic, substituted dioxoheteropolycyclic, alkanedioic acid, alkoxylated alkylidene dicarbomonocycle and alkoxylated alkylidene dicarbomonocycle, ester. Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 3/14/2017 6/7/2017
P-16-0587 Specific: Galactoarabinoxylan (CASRN: 37324-70-2). Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 9/22/2016 6/15/2017
P-16-0401 Generic: Alkyl acrylate polymer; polymer exemption flag. Polymer exemption flag: The chemical must be manufactured such that it meets the polymer exemption criteria as described under 40 CFR §723.250(e)(1), in addition to meeting the definition of polymer at 40 CFR §723.250(b). Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 6/22/2016 6/15/2017
P-16-0588 Generic: Alkyl methacrylate, polymer with alkyl acrylate and polyesters; polymer exemption flag. Polymer exemption flag: The chemical must be manufactured such that it meets the polymer exemption criteria as described under 40 CFR §723.250(e)(1), in addition to meeting the definition of polymer at 40 CFR §723.250(b). Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 9/22/2016 5/30/2017
P-16-0303 Generic: Alkyl methyacrylate polymer with styrene, amino acrylate and acrylic acid, ammonium salt; polymer exemption flag. Polymer exemption flag: The chemical must be manufactured such that it meets the polymer exemption criteria as described under 40 CFR §723.250(e)(1), in addition to meeting the definition of polymer at 40 CFR §723.250(b). Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 6/22/2016 5/30/2017
P-17-0237-0238 Specific (P-17-0237): 1,6,10-Dodecatriene, 7,11-dimethyl-3-methylene-, (6E)-, homopolymer, hydrogenated, 2-hydroxyethyl-terminated (CASRN: 2007163-33-7).
Specific (P-17-0238): 1,6,10-Dodecatriene, 7,11-dimethyl-3-methylene-, (6E)-, homopolymer, 2-hydroxypropyl-terminated, hydrogenated (CASRN: 1912453-88-3).
Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 2/23/2017 5/19/2017
P-17-0256 Generic: Carbopolycyclic dicarboxylic acid, dialkyl ester, polymer with dialkyl carbomonocyclic diester, dialkyl substituted carbomonocyclic diester alkali metal salt and alkanediol; polymer exemption flag. Polymer exemption flag: The chemical must be manufactured such that it meets the polymer exemption criteria as described under 40 CFR §723.250(e)(1), in addition to meeting the definition of polymer at 40 CFR §723.250(b). Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 3/14/2017 5/18/2017
P-17-0207 Generic: 2-alkenoic acid, 2 alkyl, 2 alkyl ester, polymer with alkyl alkenoate, carbomonocyle, alkyl alkenoate and alkyl alkenoate, alkyl peroxide initiated; polymer exemption flag. Polymer exemption flag: The chemical must be manufactured such that it meets the polymer exemption criteria as described under 40 CFR §723.250(e)(1), in addition to meeting the definition of polymer at 40 CFR §723.250(b). Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 1/23/2017 5/18/2017
P-17-0246 Generic: Polycarbonate polyol. Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 2/28/2017 5/11/2017
P-16-0578 Generic: Alkenoic acid, alkyester, polymer with N-(dialkyl-oxoalkyl)-alkenamide, alkenylbenzene, alkyl alkenoate and alkenoic acid; polymer exemption flag.

Chemical substance not likely to present
an unreasonable risk (§5(a)(3)(C)).

Polymer exemption flag: The chemical must be manufactured such that it meets the polymer
exemption criteria as described under 40 CFR §723.250(e)(1), in addition to meeting the
definition of polymer at 40 CFR §723.250(b).

The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 9/18/2016 5/15/2017
J-17-0007 Generic: Biofuel producing Saccharomyces cerevisiae modified, genetically stable Microorganism not likely to present
an unreasonable risk (§5(a)(3)(C))
The microorganism is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document. 2/1/2017 4/27/2017
P-17-0227 Generic: 2-Alkenoic acid, 2-alkyl-, alkyl ester, polymer with 2-alkyl 2-propenoate and -(2-alkyl-1-oxo-2-alken-1-yl--alkoxypoly(oxy-1,2-alkanediyl), ester with -2-alken-1-yl--hydroxypoly(oxy-1,2-alkanediyl); polymer exemption flag.

Chemical substance not likely to present
an unreasonable risk (§5(a)(3)(C)).

Polymer exemption flag: The chemical must be manufactured such that it meets the polymer
exemption criteria as described under 40 CFR §723.250(e)(1), in addition to meeting the
definition of polymer at 40 CFR §723.250(b).

The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 2/1/2017 4/27/2017
P-17-0194 Generic: Hydrogenated dihalo dialkyl diindolotriphenodioxazine, dihydrodisubstituted isoindolyl alkyl derivs. Chemical substance not likely to present
an unreasonable risk (§5(a)(3)(C))
The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 1/4/2017 3/13/2017
P-17-0215 Generic: Copolymer of alpha-olefin and dibutyl maleate. Chemical substance not likely to present
an unreasonable risk (§5(a)(3)(C))
The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 1/16/2017 3/13/2017
P-17-0214 Generic: 2-Propenoic acid, polymer with alkene and alkenyl acetate, alkyl 2-alkyl isoalkyl esters. Chemical substance not likely to present
an unreasonable risk (§5(a)(3)(C))
The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 1/16/2017 3/13/2017
P-17-0014 Specific: Fatty acids, C8-10, mixed esters with C18-unsatd. fatty acid dimers and .alpha.-hydro-.omega.-hydroxypoly(oxy-1,4-butanediyl) (CASRN: None). Chemical substance not likely to present
an unreasonable risk (§5(a)(3)(C))
The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 2/6/2017 3/13/2017
P-17-0008 Generic: Modified 1,3-isobenzofurandione, polymer with 1,2-ethanediol, 2-ethyl-2-(alkoxyalkyl)-1,3-propanediol and 1,3-Isobenzofurandione, alkanoate Chemical substance not likely to present
an unreasonable risk (§5(a)(3)(C))
The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 11/2/2016 3/30/2017
P-16-0592 Specific: Fatty acids, C8-10, diesters with .alpha.-hydro-.omega.-hydroxypoly(oxy-1,4-butanediyl) (CASRN: None) Chemical substance not likely to present
an unreasonable risk (§5(a)(3)(C))
The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 1/23/2017 3/13/2017
P-17-0185 Generic: Fatty acids, C18-unsatd., dimers, hydrogenated, polymers with C18-unsatd. fatty acid trimers, alkylenediamine and hydroxyalkanoic acid. Chemical substance not likely to present
an unreasonable risk (§5(a)(3)(C))
The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 12/30/2016 2/13/2017
P-17-0182 Generic: Alkyldioic acid, polymer with 2,2-dimethyl-1,3-propanediol, heteropolycyclic carboxy acid anhydride and 1,3-propanediol. Chemical substance not likely to present
an unreasonable risk (§5(a)(3)(C))
The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 12/30/2016 2/13/2017
P-17-0160-0161 Generic: 2-Propenoic acid, alkyl-, alkyl ester, polymer with alkyl 2-propenoate, dialkyloxoalkyl-2-propenamide and alkyl 2-propenoate. Generic: 2-Propenoic acid, alkyl-, alkyl ester, polymer with alkyl 2-propenoate, dialkyloxoalkyl-2-propenamide, ethenylbenzene and alkyl 2-propenoate. Chemical substances not likely to present
an unreasonable risk (§5(a)(3)(C))
The chemical substances are not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 11/30/2016 2/13/2017
P-17-0158 Generic: Perylene bisimide Chemical substance not likely to present
an unreasonable risk (§5(a)(3)(C))
The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 11/30/2016 2/13/2017
J-17-0006 Generic: Saccharomyces cerevisiae modified Microorganism not likely to present
an unreasonable risk (§5(a)(3)(C))
The microorganism is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document. 11/23/2016 2/13/2017
P-17-0144 Specific: Amines, C36-alkylenedi-, polymers with octahydro-4,7-methano-1H-indenedimethanamine and pyromellitic dianhydride, maleated (CASRN: 2020378-57-6). Chemical substance not likely to present
an unreasonable risk (§5(a)(3)(C))
The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 11/18/2016 1/18/2017
J-17-0001-0005 Generic: Saccharomyces cerevisiae modified Microorganisms not likely to present
an unreasonable risk (§5(a)(3)(C))
The microorganisms are not likely to present an unreasonable risk based on low human
health hazard and low environmental hazard associated with the recipient microorganism and
introduced genetic material. View the determination document.
10/24/2016 1/18/2017
P-17-0016-0021
  • Generic: (P-17-0016): Hydroxyl alkyl acrylate ester, polymer with acrylates, aromatic vinyl
    monomer, cycloaliphatic lactone, and alkyl carboxylic acid, peroxide initiated
  • Generic (P-17-0017): Hydroxyl alkyl acrylate ester, polymer with acrylates, aromatic vinyl
    monomer, cycloaliphatic lactone, and alkyl carboxylic acid, peroxide initiated.
  • Generic (P-17-0018): Hydroxyl alkyl acrylate ester, polymer with acrylates, aromatic vinyl
    monomer, cycloaliphatic lactone, and alkyl carboxylic acid, Azobis[aliphatic nitrile] initiated
  • Generic (P-17-0019): Hydroxyl alkyl acrylate ester, polymer with acrylates, aromatic vinyl
    monomer, cycloaliphatic lactone, and alkyl carboxylic acid, peroxide initiated
  • Generic (P-17-0020): Hydroxyl alkyl acrylate ester, polymer with acrylates, aromatic vinyl
    monomer, cycloaliphatic lactone, and alkyl carboxylic acid, peroxide initiated
  • Generic (P-17-0021): Hydroxyl alkyl acrylate ester, polymer with acrylates, aromatic vinyl
    monomer, cycloaliphatic lactone, and alkyl carboxylic acid, Azobis[aliphatic nitrile] initiated
Chemical substances not likely to present
an unreasonable risk (§5(a)(3)(C))
The chemical substances are not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 10/25/2016 12/19/2016
P-17-0009 Generic: Depolymerized waste plastics Chemical substance not likely to present
an unreasonable risk (§5(a)(3)(C))
The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 10/13/2016 12/1/2016
J-16-0033 Generic: Saccharomyces cerevisiae modified to express glucoamylase activity Microorganism not likely to present
an unreasonable risk (§5(a)(3)(C))
The microorganism is not likely to present an unreasonable risk based on low human
health hazard and low environmental hazard associated with the recipient microorganism and
introduced genetic material. View the determination document.
8/22/2016 12/1/2016
J-16-0034 Generic: Saccharomyces cerevisiae modified Microorganism not likely to present
an unreasonable risk (§5(a)(3)(C))
The microorganism is not likely to present an unreasonable risk based on low human
health hazard and low environmental hazard associated with the recipient microorganism and
introduced genetic material. View the determination document.
8/23/2016 12/1/2016
J-16-0036 --0041 Generic: Biofuel producing modified microorganism(s), with chromosomally-borne modifications Microorganism not likely to present
an unreasonable risk (§5(a)(3)(C))
The microorganisms are not likely to present an unreasonable risk based on low human
health hazard and low environmental hazard associated with the recipient microorganism and
introduced genetic material. View the determination document.
9/7/2016 12/1/2016
J-16-0035 Generic: Saccharomyces cerevisiae modified Microorganism not likely to present
an unreasonable risk (§5(a)(3)(C))
The microorganism is not likely to present an unreasonable risk based on low human
health hazard and low environmental hazard associated with the recipient microorganism and
introduced genetic material. View the determination document.
8/23/2016 12/1/2016
P-16-0580 Generic: Trimethylolpropane ester of mixed linear and branched carboxylic acids Chemical substance not likely to present
an unreasonable risk (§5(a)(3)(C))
The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 9/19/2016 11/10/2016
J-16-0025 Generic: Trichoderma reesei modified Microorganism not likely to present
an unreasonable risk (§5(a)(3)(C))
The microorganism is not likely to present an unreasonable risk based on low human
health hazard and low environmental hazard associated with the recipient microorganism and
introduced genetic material. View the determination document.
7/29/2016 11/14/2016
J-16-0024 Generic: Trichoderma reesei modified Microorganism not likely to present
an unreasonable risk (§5(a)(3)(C))
The microorganism is not likely to present an unreasonable risk based on low human
health hazard and low environmental hazard associated with the recipient microorganism and
introduced genetic material. View the determination document.
7/28/2016 11/14/2016
P-16-0519 Generic: Polyalkylether polyester Chemical substances not likely to present
an unreasonable risk (§5(a)(3)(C))
The chemical substance is not likely to present an unreasonable risk based on low
human health hazard and low environmental hazard. View the determination document.
8/12/2016 11/17/2016
P-16-0518 Generic: Polyalkylether polyester Chemical substances not likely to present
an unreasonable risk (§5(a)(3)(C))
The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 8/12/2016 11/17/2016
P-16-0403 Generic: Heteropolycyclic carboxylic acid, polymer with 2-ethyl-2-(hydroxymethyl)-1,3-propanediol and 4-substitutedbenzene, substituted carbomonocycle- and alkyl-substituted carbomonocycle-blocked Chemical substances not likely to present
an unreasonable risk (§5(a)(3)(C))
The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 6/22/2016 11/17/2016
P-16-0545 Generic: substituted siloxane polymer Chemical substances not likely to present
an unreasonable risk (§5(a)(3)(C))
The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard.View the determination document. 9/2/2016 11/10/2016
P-16-0515 Generic: Diamine substituted arylimidazole Chemical substances not likely to present
an unreasonable risk (§5(a)(3)(C))
The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 8/9/2016 11/10/2016
P-16-0492 Generic: Polyester-amide polymer of 'isophthalic acid' with diamino-alkane, cyclohexanedialcohol, alkanetriol, di-isocyanate and acrylic acid-ethylene copolymer Chemical substances not likely to present
an unreasonable risk (§5(a)(3)(C))
The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 7/25/2016 11/10/2016
J-16-0023 Generic: Trichoderma reesei modified Microorganism not likely to present
an unreasonable risk (§5(a)(3)(C))
The microorganism is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document. 7/16/2016 10/19/2016
J-16-0022 Generic: Trichoderma reesei modified Microorganism not likely to present
an unreasonable risk (§5(a)(3)(C))
The microorganism is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document. 7/15/2016 10/19/2016
J-16-0021 Generic: Trichoderma reesei modified Microorganism not likely to present
an unreasonable risk (§5(a)(3)(C))
The microorganism is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document. 7/15/2016 10/19/2016
J-16-0020 Generic: Trichoderma reesei modified Microorganism not likely to present
an unreasonable risk (§5(a)(3)(C))
The microorganism is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document. 6/29/2016 10/4/2016
J-16-0019 Generic: Trichoderma reesei modified Microorganism not likely to present
an unreasonable risk (§5(a)(3)(C))
The microorganism is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document. 6/29/2016 10/4/2016
P-16-0459 Generic: Carbomonocyclic dicarboxylic acid, polymer with alkanedioic acid, substituted heteropolycycle, substituted carbomonocycle, alkyl alkenoate, alkanedioic acid, alkoxylated substituted dicarbomonocycle, alkoxylated substituted dicarbomonocycle, alkenoic acid, oxo alkyl initiated. Chemical substances not likely to present
an unreasonable risk (§5(a)(3)(C))
The chemical substances are not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. Although EPA estimated that the new chemical substances would be very persistent, this did not indicate a likelihood that the chemical substances would present an unreasonable risk, given that the chemical substances have low potential for bioaccumulation, low human health hazard, and low environmental hazard. View the determination document. 7/8/2016 10/4/2016
P-16-0343 and P-16-0344 Generic: Modified urethane polymer. Chemical substances not likely to present
an unreasonable risk (§5(a)(3)(C))
The chemical substances are not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. Although EPA estimated that the new chemical substances would be very persistent, this did not indicate a likelihood that the chemical substances would present an unreasonable risk, given that the chemical substances have low potential for bioaccumulation, low human health hazard, and low environmental hazard. View the determination document. 6/22/2016 9/16/2016
P-16-0391 Generic: Polyester polyol polymer with aliphatic isocyanate and phenol derivates Chemical substance not likely to present
an unreasonable risk (§5(a)(3)(C))
The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. Although EPA estimated that the new chemical substance would be very persistent, this did not indicate a likelihood that the chemical substance would present an unreasonable risk, given that the chemical substance has low potential for bioaccumulation, low human health hazard, and low environmental hazard. View the determination document. 6/22/2016 9/14/2016
J-16-0010 Generic: Saccharomyces cerevisiae modified Microorganism not likely to present
an unreasonable risk (§5(a)(3)(C))
The microorganism is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. S. cerevisiae is not pathogenic to humans or animals and has an extensive history of safe use in food processing. The introduced genetic modifications pose low concern for health and environmental hazard and do not include antibiotic resistance markers. View the determination document. 6/22/2016 9/14/2016
J-16-0011, J-16-0012, J-16-0013, J-16-0014, J-16-0015, and J-16-0016 Generic: Biofuel Producing Organism Microorganism not likely to present
an unreasonable risk (§5(a)(3)(C))
The microorganisms are not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. The recipient microorganism is not pathogenic to humans or animals and has an extensive history of safe use. The introduced genetic modifications pose low concern for health and environmental hazard and do not include antibiotic resistance markers. View the determination document. 6/22/2016 9/14/2016
J-16-0017 Generic: Saccharomyces cerevisiae modified Microorganism not likely to present
an unreasonable risk (§5(a)(3)(C))
The microorganism is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. S. cerevisiae is not pathogenic to humans or animals and has an extensive history of safe use in food processing. The introduced genetic modifications pose low concern for health and environmental hazard and do not include antibiotic resistance markers. View the determination document. 6/22/2016 9/14/2016
J-16-0018 Generic: Saccharomyces cerevisiae modified Microorganism not likely to present
an unreasonable risk (§5(a)(3)(C))
The microorganism is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. S. cerevisiae is not pathogenic to humans or animals and has an extensive history of safe use in food processing. The introduced genetic modifications pose low concern for health and environmental hazard and do not include antibiotic resistance markers. View the determination document. 6/22/2016 9/14/2016
P-16-0366 Generic: Blocked polyisocyanate Chemical substance not likely to present
an unreasonable risk (§5(a)(3)(C))
The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. Although EPA estimated that the new chemical substance would be very persistent, this did not indicate a likelihood that the chemical substance would present an unreasonable risk, given that the chemical substance has low potential for bioaccumulation, low human health hazard, and low environmental hazard. View the determination document. 6/22/2016 9/12/2016
P-16-0373 Generic: Tris(alkyloxyphenyl)triazine compounds Chemical substance not likely to present
an unreasonable risk (§5(a)(3)(C))
The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. Although EPA estimated that the new chemical substance would be very persistent, this did not indicate a likelihood that the chemical substance would present an unreasonable risk, given that the chemical substance has low potential for bioaccumulation, low human health hazard, and low environmental hazard. View the determination document. 6/22/2016 9/12/2016
P-16-0466 Generic: 2,5-Furandione, telomer with ethenylbenzene and (alkylethyl)benzene, amides with polyethylene-polypropylene glycol aminoalkyl Me ether, alkali salts Chemical substance not likely to present
an unreasonable risk (§5(a)(3)(C))
The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental toxicity. Although EPA estimated that the new chemical substance would be very persistent, this did not indicate a likelihood that the chemical substance would present an unreasonable risk, given that the chemical substance has low potential for bioaccumulation, low human health hazard, and low environmental hazard. View the determination document. 7/11/2016 9/2/2016
J-16-0006 Generic: Trichoderma reesei modified Microorganism not likely to present
an unreasonable risk (§5(a)(3)(C))
The microorganism is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. T. reesei is not pathogenic to humans or animals and has a long history of safe use for production of enzymes. The introduced genetic modifications pose low concern for health and environmental hazard, do not include antibiotic resistance markers, and do not provide a growth advantage over the parental strain. View the determination document. 6/22/2016 9/2/2016
P-16-0348 Generic: Polypentaerythritol, mixed esters with linear and branched monoacids Chemical substance not likely to present
an unreasonable risk (§5(a)(3)(C))
The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. Although EPA estimated that the new chemical substance would be very persistent, this did not indicate a likelihood that the chemical substance would present an unreasonable risk, given that the chemical substance has low potential for bioaccumulation, low human health hazard, and low environmental hazard. View the determination document. 6/22/2016 9/2/2016
P-16-0392 Generic: Modified vegetable oil Not likely to present
an unreasonable risk (§5(a)(3)(C))
The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental toxicity. Although EPA estimated that the new chemical substance would be very persistent, this did not indicate a likelihood that the chemical substance would present an unreasonable risk, given that the chemical substance has low potential for bioaccumulation, low human health hazard, and low environmental hazard. View the determination document. 6/22/2016 7/29/2016
P-16-0351 Generic: Glycerides, C14-18 and C16-C18 unsaturated, from fermentation Not likely to present
an unreasonable risk (§5(a)(3)(C))
The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental toxicity. Although EPA estimated that the new chemical substance would be persistent, this did not indicate a likelihood that the chemical substance would present an unreasonable risk, given that the chemical substance has low potential for bioaccumulation, low human health hazard, and low environmental hazard. View the determination document. 6/22/2016 7/29/2016
P-16-0340 Generic: Glycerides, C8-18 and C18 unsaturated, from fermentation Not likely to present
an unreasonable risk (§5(a)(3)(C))
The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental toxicity. Although EPA estimated that the new chemical substance would be persistent, this did not indicate a likelihood that the chemical substance would present an unreasonable risk, given that the chemical substance has low potential for bioaccumulation, low human health hazard, and low environmental hazard. View the determination document. 6/22/2016 7/29/2016
P-16-0302 Generic: Organic modified propyl silsesquioxane Not likely to present
an unreasonable risk (§5(a)(3)(C))
The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental toxicity. Although EPA estimated that the new chemical substance would be very persistent, this did not indicate likelihood that the chemical substance would present an unreasonable risk, given that the chemical substance has low potential for bioaccumulation, low human health hazard, and low environmental hazard. View the determination document. 6/22/2016 7/20/2016
P-16-0301 Generic: Propyl silsesquioxanes, hydrogen-terminated Not likely to present
an unreasonable risk (§5(a)(3)(C))
The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. 6/22/2016 7/20/2016
P-16-0292 Generic: Depolymerized waste plastics. Not likely to present
an unreasonable risk (§5(a)(3)(C))
The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. Although EPA estimated that the new chemical substance would be very persistent, this did not indicate a likelihood that the chemical substance would present an unreasonable risk, given that the chemical substance has low potential for bioaccumulation, low human health hazard, and low environmental hazard. View the determination document. 6/22/2016 7/20/2016
P-16-0281 Generic: Fatty alcohols-dimers, trimers, polymers Not likely to present
an unreasonable risk (§5(a)(3)(C))
The chemical substance is not likely to present an unreasonable risk based on low health hazard concern and low environmental toxicity. View the determination document. 6/22/2016 7/15/2016