Chemicals Determined Not Likely to Present an Unreasonable Risk Following Pre-Manufacture Notification Review
This page describes the chemical substances EPA has determined are “not likely to present an unreasonable risk” following review of pre-manufacture notifications under section 5 of TSCA, as amended by the Frank R. Lautenberg Chemical Safety for the 21st Century Act, P.L. 114-182.
Note: For these “not likely to present an unreasonable risk” cases,” PMN submitters may commence manufacture upon notification by EPA, notwithstanding any remaining portion of the applicable review period, in accordance with section 5(g) of TSCA, as amended.
Certain of EPA’s determinations that a chemical is not likely to present unreasonable risk are based upon both the Agency’s risk assessment for the chemical substance under intended conditions of use described in the PMN and the issuance of a proposed SNUR to address certain reasonably foreseen uses. Conditions of use that fall under the restrictions of the proposed SNUR are not likely to present unreasonable risk of injury to health or the environment because (1) those conditions of use are not likely to be commenced during the pendency of proposed SNUR and (2) upon finalization of the SNUR those conditions of use would be prohibited unless and until EPA makes an affirmative determination that the significant new use is not likely to present an unreasonable risk or takes appropriate action under section 5(e) or 5(f). The links to the terms of these proposed SNURs are provided below along with the determination documents.
View the interim status of Section 5 pre-manufacture notices reviewed under TSCA.
| Case Number | Chemical Identity | EPA Determination Following PMN Review | Summary | Review Start Date | Decision Date |
|---|---|---|---|---|---|
| J-25-0003 | Generic: Strain of Escherichia coli modified with genetically-stable, plasmid-borne DNA for the production of an enzyme | The microorganism is not likely to present an unreasonable risk (5(a)(3)(C)). | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination The microorganism is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3)(C) Determination for Microbial Commercial Activity Notice (MCAN) J-25-0003 (pdf) | 12/05/2024 | 03/03/2025 |
| J-25-0004, J-25-0005 | Generic: Modified yeast, with chromosomal modifications to improve fermentation characteristics | The microorganisms are not likely to present an unreasonable risk (5(a)(3)(C)). | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The microorganisms are not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. TSCA Section 5(a)(3)(C) Determination for Microbial Commercial Activity Notices (MCANs) J-25-0004-0005 (pdf) | 01/14/2025 | 04/04/2025 |
| J-25-0006, J-25-0007, J-25-0008, J-25-0009, J-25-0010 | Generic: Chromosomally-modified Saccharomyces cerevisiae | The microorganisms are not likely to present an unreasonable risk (5(a)(3)(C)). | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The microorganisms are not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. TSCA Section 5(a)(3)(C) Determination for Microbial Commercial Activity Notices (MCANs) (J-25-0006-0010) (pdf) . | 01/31/2025 | 04/30/2025 |
| P-16-0218 | Generic: Acetoacetylated glycerin | The chemical substances are not likely to present an unreasonable risk (5(a)(3)(C)). | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. TSCA Section 5(a)(3) Determination for Premanufacture Notice (PMN) P-16-0218 (pdf) | 06/22/2016 | 05/06/2025 |
| P-21-0191 | Specific: Fatty acids, C18-unsatd., dimers, hydrogenated, polymers with polyethylene glycol, dihexanoates, CASRN: 2641992-22-3 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)). | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3) Determination for Premanufacture Notice (PMN) P-21-0191 (pdf) | 07/13/2021 | 03/10/2025 |
| P-21-0192 | Specific: Fatty acids, C18-unsatd., dimers, hydrogenated, polymers with polyethylene glycol, diesters with C8-10 fatty acids, CASRN: 2641992-26-7 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)). | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3) Determination for Premanufacture Notice (PMN) P-21-0192 (pdf) | 07/13/2021 | 03/10/2025 |
| P-25-0017 | Generic: Reaction product of aromatic acid with trifunctional polyol and pelargonic acid | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)). | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3) Determination for Premanufacture Notice (PMN) P-25-0017 (pdf) | 11/26/2024 | 05/30/2025 |
| J-25-0001 | Generic: Biofuel producing Saccharomyces cerevisiae modified, genetically stable | The microorganism is not likely to present an unreasonable risk (5(a)(3)(C)). | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The microorganism is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3)(C) Determination for Microbial Commercial Activity Notice (MCAN) J-25-0001 (pdf) | 11/13/2024 | 02/05/2025 |
| J-25-0002 | Generic: Strain of Escherichia coli modified with genetically-stable, plasmid-borne DNA for the production of plasmid-borne DNA | The microorganism is not likely to present an unreasonable risk (5(a)(3)(C)). | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The microorganism is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3)(C) Determination for Microbial Commercial Activity Notice (MCAN) J-25-0002 (pdf) | 11/27/2024 | 02/21/2025 |
| J-19-0026, J-19-0027 | Generic: Biofuel-producing modified microorganism(s), with chromosomally-borne modifications | The microorganisms are not likely to present an unreasonable risk (5(a)(3)(C)). | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The microorganisms are not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3)(C) Determination for Microbial Commercial Activity Notices (MCANs) J-19-0026, J-19-0027 (pdf) | 11/15/2019 | 01/23/2020 |
| J-23-0005, J-23-0006 | Generic: Microorganisms genetically transformed to express an enzyme | The microorganisms are not likely to present an unreasonable risk (5(a)(3)(C)). | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The microorganisms are not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3)(C) Determination for Microbial Commercial Activity Notices (MCANs) J-23-0005-0006 (pdf) | 08/30/2023 | 11/27/2023 |
| P-23-0028 | Generic: Gelatin and maltodextrin crosslinked with linear and cyclic aliphatic polyisocyanates | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)). | 'Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3) Determination for Premanufacture Notice (PMN) P-23-0028 (pdf) | 12/13/2022 | 12/14/2023 |
| P-23-0101 | Generic: Glycerides from fermentation of genetically modified microorganism, epoxidized | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)). | 'Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3) Determination for Premanufacture Notice (PMN) P-23-0101 (pdf) | 03/20/2023 | 11/13/2024 |
| P-23-0102 | Generic: Glycerides from fermentation of genetically modified microorganism | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)). | 'Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3) Determination for Premanufacture Notice (PMN) P-23-0102 (pdf) | 03/20/2023 | 06/07/2024 |
| P-23-0103 | Generic: Glycerides from fermentation of genetically modified microorganism, epoxidized, reaction products with ethanol | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)). | 'Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3) Determination for Premanufacture Notice (PMN) P-23-0103 (pdf) | 03/20/2023 | 11/13/2024 |
| P-23-0143 | Specific: L-Lysine, N-(3-carboxy-1-oxopropyl) derivs., sodium salts; CASRN 1917323-94-4 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)). | 'Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3) Determination for Premanufacture Notice (PMN) P-23-0143 (pdf) | 06/13/2023 | 08/22/2024 |
| P-24-0005 | Generic: Polycarbomonocyclic diol reaction products with cycloalkylcarbomonocycle and polysubstituted heteromonocycle | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)). | 'Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3) Determination for Premanufacture Notice (PMN) P-24-0005 (pdf) | 10/24/2023 | 07/16/2024 |
| P-24-0099 | Generic: Saturated and unsaturated hydrocarbon waxes, oxidized, polymers with alkenoic acid, alkanedioic acid, substituted carbomonocycle, alkyl alkenoate, alkenyl substituted substituted heteromonocycle, alkylene glycol, alkyl alkenoate, alkenedioic acid, polyalkylene glycol ether with substituted carbomonocycle (alkylidene)bis-, polyalkylene glycol ether with substituted carbomonocycle (alkylidene)bis-, alkanoic acid, alkyl alkenoate, disubstituted carbomonocycle, substituted heteropolycycle, alkyl peroxide-initiated | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)). | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3) Determination for Premanufacture Notice (PMN) P-24-0099 (pdf) | 03/14/2024 | 02/19/2025 |
| P-24-0161 | Specific: Fats and glyceridic oils, camelina sativa. Definition: Extractives and their physically modified derivatives. It consists primarily of the glycerides of the fatty acids docosenoic, eicosenoic, linoleic, linolenic, oleic, palmitic and stearic. (Camelina sativa); CASRN 943248-37-1 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)). | 'Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3) Determination for Premanufacture Notice (PMN) P-24-0161 (pdf) | 06/27/2024 | 02/12/2025 |
| P-24-0106, P-24-0107 | Generic: Glycerides, alkyl, epoxidized, alkyl esters | The chemical substances are not likely to present an unreasonable risk (5(a)(3)(C)). | 'Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The chemical substances are not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3) Determination for Premanufacture Notice (PMN) P-24-0106 and P-24-0107 (pdf) | 04/08/2024 | 12/19/2024 |
| P-24-0124 | Generic: Alkyl alkenoic acid, alkyl ester, polymer with substituted carbomonocycle, substituted alkyl alkyl alkenoate phosphate, substituted alkyl alkyl alkenoate, alkyl alkenoate, heteromonocycle polymer, substitutes alkenyl substituted alkyl ester, alkyl substituted alkyl alkanoate initiated | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)). | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3) Determination for Premanufacture Notice (PMN) P-24-0124 (pdf) | 04/16/2024 | 01/29/2025 |
| SN-24-0005, SN-24-0006 | Generic: Dicarboxylic acids, polymers with alkanoic acid, alkanediol, susbtituted-alkylalkanoic acid, substituted alkyl carbomonocyle, alkanedioic acid and alkanediol, alkanolamine blocked, compds with alkanolamine | The significant new uses are not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The significant new uses are not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3) Determination for Significant New Use Notices (SNUNs) SN-24-0005-0006 (pdf) | 04/17/2024 | 12/20/2024 |
| P-23-0148 | Generic: Amylopectin, 2-hydroxypropyl ether, modified | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3) Determination for Premanufacture Notice (PMN) P-23-0148 (pdf) | 11/27/2023 | 12/17/2024 |
| J-24-0020 | Generic: Genetically modified microorganism | The microorganism is not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The microorganism is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3)(C) Determination for Microbial Commercial Activity Notice (MCAN) J-24-0020 (pdf) | 05/21/2024 | 08/26/2024 |
| J-24-0016, J-24-0017,J-24-0018, J-24-0019 | Generic: Chromosomally-modified Saccharomyces cerevisiae | The microorganisms are not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The microorganisms are not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3)(C) Determination for Microbial Commercial Activity Notices (MCANs) J-24-0016-0019 (pdf) | 04/11/2024 | 07/09/2024 |
| J-24-0005, J-24-0006,J-24-0007, J-24-0008 | Generic: Biofuel-producing modified microorganism(s), with chromosomally-borne modifications | The microorganisms are not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The microorganisms are not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3)(C) Determination for Microbial Commercial Activity Notices (MCANs) J-24-0005-0008 (pdf) | 04/23/2024 | 07/19/2024 |
| J-24-0014, J-24-0015 | Generic: Biopolymer producing modified microorganism, with chromosomally located modifications | The microorganisms are not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The microorganisms are not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3)(C) Determination for Microbial Commercial Activity Notices (MCANs) J-24-0014-0015 (pdf) | 04/09/2024 | 07/03/2024 |
| P-24-0131 | Generic: Alkanoic acid, 2-alkylalkyl ester | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3) Determination for Premanufacture Notice (PMN) P-24-0131 (pdf) | 04/18/2024 | 06/25/2024 |
| P-22-0182 | Generic: Poly(ethylene terephthalate)-co-poly(propyl trimethylol alkanoate); polymer exemption flag | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3) Determination for Premanufacture Notice (PMN) P-22-0182 (pdf) | 01/16/2023 | 06/28/2024 |
| P-22-0166 | Generic: Dicarboxylic acid, calcium salt | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3) Determination for Premanufacture Notice (PMN) P-22-0166 (pdf) | 07/21/2023 | 05/30/2024 |
| P-22-0046 | Specific: Fibroins; CASRN 9007-76-5 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3) Determination for Premanufacture Notice (PMN) P-22-0046 (pdf) | 03/04/2022 | 05/23/2024 |
| P-23-0170 | Generic: Ethanaminium, 2-[3-(2,5-dioxo-1-heteromonocyclic) propoxy]-N,N,N-trimethyl-, monopolyisobutylene derivs., Me ethanedioate | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3) Determination for Premanufacture Notice (PMN) P-23-0170 (pdf) | 08/22/2023 | 05/20/2024 |
| P-23-0187 | Generic: substituted benzenedicarboxylic acid, sodium salt, polymer with benzenedicarboxylic acids and 1,2-ethanediol | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3) Determination for Premanufacture Notice (PMN) P-23-0187 (pdf) | 09/21/2023 | 05/20/2024 |
| P-21-0181 | Generic: 1,3-Benzenedicarboxamide, N1,N3-bis(carbomonocyclic)-5-[[(carbomonocyclic)amino]sulfonyl]- | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3) Determination for Premanufacture Notice (PMN) P-21-0181 (pdf) | 07/12/2021 | 05/07/2024 |
| J-24-0009, J-24-0010,J-24-0011, J-24-0012,J-24-0013, | Generic: Generic: Chromosomally-modified Saccharomyces cerevisiae | The microorganisms are not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The microorganisms are not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3)(C) Determination for Microbial Commercial Activity Notices (MCANs) (J-24-0009-0013) (pdf) | 02/01/2024 | 04/25/2024 |
| P-23-0062 | Generic: cashew, nutshell., polymer based polyether polyol | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3) Determination for Premanufacture Notice (PMN) P-23-0062 (pdf) | 03/22/2023 | 04/11/2024 |
| P-23-0129 | Generic: Benzyl fatty acid esters | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3) Determination for Premanufacture Notice (PMN) P-23-0129 (pdf) | 08/01/2023 | 04/10/2024 |
| P-23-0128 | Specific: Fatty acids, C16-18, reaction products with diethanolamine; CASRN: 91032-08-5 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3) Determination for Premanufacture Notice (PMN) P-23-0128 (pdf) | 05/17/2023 | 03/28/2024 |
| J-24-0001, J-24-0002 | Generic: Generic: Chromosomally-modified Saccharomyces cerevisiae | The microorganisms are not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The microorganisms are not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3)(C) Determination for Microbial Commercial Activity Notices (MCANs) (J-24-0001-0002) (pdf) | 12/13/2023 | 03/06/2024 |
| P-22-0181 | Generic: Fatty acids, polymers with polyethylene glycol ether with polyol | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3) Determination for Premanufacture Notice (PMN) P-22-0181 (pdf) | 09/12/2022 | 02/26/2024 |
| P-23-0068 | Specific: 1,3-Isobenzofurandione, hexahydro-, polymer with 1,4-cyclohexanedimethanol, isononanoate; CASRN 2773548-84-6 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3) Determination for Premanufacture Notice (PMN) P-23-0068 (pdf) | 01/30/2023 | 12/20/2023 |
| P-23-0017 | Generic: Hydrolyzed collagen, polymer with aromatic isocyanate, N-triethoxysylil-alkanamine, pectic polysaccharide and poly alkyl alcohol | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3) Determination for Premanufacture Notice (PMN) P-23-0017 (pdf) | 11/07/2022 | 12/18/2023 |
| P-23-0077 | Generic: Alkanepolyoxy acid, alkyl substituted | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3) Determination for Premanufacture Notice (PMN) P-23-0077 (pdf) | 02/06/2023 | 11/30/2023 |
| P-23-0031 | Generic: Glycerin, polyalkoxylated, mixed fatty acid and alkyl diacid esters | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3) Determination for Premanufacture Notice (PMN) P-23-0031 (pdf) | 11/21/2022 | 10/12/2023 |
| P-23-0012 | Generic: Starch, polymer with alkenoic acid, salt | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3) Determination for Premanufacture Notice (PMN) P-23-0012 (pdf) | 10/11/2022 | 10/17/2023 |
| P-22-0057 | Generic: Polysaccharide, polymer with 2-propenoic acid, sodium salt | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3) Determination for Premanufacture Notice (PMN) P-22-0057 (pdf) | 09/27/2022 | 09/18/2023 |
| P-22-0164 | Specific: Fatty acids, C18-unsatd., dimers, polymers with 1,4:3,6-dianhydro-D-glucitol, 1,3- propanediol and succinic acid; CASRN: 2651284-66-9 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3) Determination for Premanufacture Notice (PMN) P-22-0164 (pdf) | 09/01/2022 | 08/17/2023 |
| P-19-0095 | Generic: Poly hydroxy alkanoate | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: SCA Section 5(a)(3) Determination for Premanufacture Notice (PMN) P-19-0095 (pdf) | 06/04/2019 | 07/13/2023 |
| P-22-0127 | Specific: urea,N,N'-bis-[3-[[(4-methylphenyl)sulfonyl]oxy]phenyl]-; CASRN: 2292123-68-1 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3) Determination for Premanufacture Notice (PMN) P-22-0127 1 (pdf) | 06/14/2022 | 05/19/2023 |
| J-23-0004 | Generic: Genetically modified microorganism for the production of a chemical substance | The microorganism is not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The microorganism is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3)(C) Determination for Microbial Commercial Activity Notice (MCAN) J-23-0004 (pdf) | 02/08/2023 | 05/08/2023 |
| P-22-0118 | Specific: hexanedioic acid, polymer with 1,2,3-propanetriol and 1,3,5-tris(2-hydroxyethyl)-1,3,5-triazine-2,4,6(1H,3H,5H)-trione, 3-methyl-3-buten-1-yl ester; CASRN: 2760410-72-6 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3) Determination for Premanufacture Notice (PMN) P-22-0118 (pdf) | 06/16/2022 | 05/18/2023 |
| P-22-0051 | Generic: 2,5-Furandione, dihydro-, monopolyisobutylene derivs., reaction products with substituted alkylamine | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3) Determination for Premanufacture Notice (PMN) P-22-0051 (pdf) | 03/08/2022 | 02/27/2023 |
| J-22-0022, J-22-0025 | Generic: Microorganisms stably transformed to manufacture PHA | The microorganisms are not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The microorganisms are not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3)(C) Determination for Microbial Commercial Activity Notices (MCANs) (J-22-0022-0025) (pdf) | 09/23/2022 | 12/16/2022 |
| J-22-0019, J-22-0020 | Generic: Saccharomyces cerevisiae chromosomal integration modification | The microorganisms are not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The microorganisms are not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3)(C) Determination for Microbial Commercial Activity Notices (MCANs) (J-22-0019-0020) (pdf) | 10/03/2022 | 12/16/2022 |
| J-23-0001 | Generic: Saccharomyces cerevisiae, modified to express glucoamylase activity | The microorganism is not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The microorganism is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3)(C) Determination for Microbial Commercial Activity Notice (MCAN) J-23-0001 (pdf) | 10/06/2022 | 01/03/2023 |
| J-23-0002 | Generic: Microorganism stably transformed to express a recombinant protein | The microorganism is not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The microorganism is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3)(C) Determination for Microbial Commercial Activity Notice (MCAN) J-23-0002 (pdf) | 10/07/2022 | 12/29/2022 |
| P-22-0017 | Specific: 1-Eicosanol, manuf. of, distn., residues; CASRN 2682937-26-2 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3) Determination for Premanufacture Notice (PMN) P-22-0017 (pdf) | 12/14/2021 | 12/29/2022 |
| J-22-0021 | Generic: Genetically modified microorganism for the production of a chemical substance | The microorganism is not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The microorganism is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3)(C) Determination for Microbial Commercial Activity Notice (MCAN) J-22-0021 (pdf) | 09/07/2022 | 11/18/2022 |
| J-22-0017, J-22-0018 | Generic: Microorganisms transformed to express an enzyme | The microorganisms are not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The microorganisms are not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3)(C) Determination for Microbial Commercial Activity Notices (MCANs) J-22-0017-0018 (pdf) | 08/09/2022 | 11/01/2022 |
| P-21-0174 | Generic: Carbonic acid, ester, polymer with alkanediol (C=4,5) | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3) Determination for Premanufacture Notice (PMN) P-21-0174 (pdf) | 06/22/2021 | 11/15/2022 |
| J-22-0014, J-22-0015 | Generic: Modified yeast, chromosomally and stably modified to improve fermentation performance | The microorganisms are not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The microorganisms are not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3)(C) Determination for Microbial Commercial Activity Notices (MCANs) J-22-0014 and J-22-0015 (pdf) | 05/05/2022 | 08/01/2022 |
| J-22-0012, J-22-0013 | Generic: Genetically modified microorganism for the production of a chemical substance | The microorganisms are not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The microorganisms are not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3)(C) Determination for Microbial Commercial Activity Notices (MCANs) J-22-0012-0013 (pdf) | 04/01/2022 | 06/29/2022 |
| J-22-0011 | Generic: Biofuel producing Saccharomyces cerevisiae modified, genetically stable | The microorganism is not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The microorganism is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3)(C) Determination for Microbial Commercial Activity Notice (MCAN) J-22-0011 (pdf) | 01/24/2022 | 04/14/2022 |
| P-21-0176 | Generic: Alkane dioic acid, bis (poly aromatic triazine) alkanoic ether phenoxy ester | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3) Determination for Premanufacture Notice (PMN) P-21-0176 (pdf) | 06/29/2021 | 04/05/2022 |
| J-22-0009, J-22-0010 | Generic: Genetically modified microorganism for the production of a chemical substance | The microorganisms are not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The microorganisms are not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3)(C) Determination for Microbial Commercial Activity Notices (MCANs) J-22-0009-0010 (pdf) | 11/05/2021 | 03/09/2022 |
| J-21-0020, J-21-0021, J-21-0022, J-21-0023, J-21-0024, J-21-0025 | Generic: CinderBio-1 | The microorganisms are not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The microorganisms are not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3)(C) Determination for Microbial Commercial Activity Notices (MCANs) J-21-0020-0025 (pdf) | 11/05/2021 | 03/04/2022 |
| J-22-0008 | Generic: Modified Yeast | The microorganism is not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The microorganisms are not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3)(C) Determination for Microbial Commercial Activity Notice (MCAN) J-22-0008 (pdf) | 11/18/2021 | 02/22/2022 |
| P-21-0189 | Specific: Fats and Glyceridic oils, algae CASRN: 1353573-84-8 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3) Determination for Premanufacture Notice (PMN) P-21-0189 (pdf) | 07/16/2021 | 03/02/2022 |
| P-21-0200 | Generic: Saturated and unsaturated hydrocarbon waxes, oxidized, polymers with alkenoic acid, alkyl alkanoate, alkenedioic acid, polyalkylene glycol ether with substituted carbomonocycle (alkylidene)bis- , polyalkylene glycol ether with substituted carbomonocycle (alkylidene)bis-, substituted carbomonocycle, disubstituted carbomonocycle and substituted heteropolycycle, alkyl peroxide-initiated | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3) Determination for Premanufacture Notice (PMN) P-21-0200 (pdf) | 08/02/2021 | 01/26/2022 |
| J-22-0001, J-22-0002, J-22-0003, J-22-0004, J-22-0005, J-22-0006 | Generic: Chromosomally-modified Saccharomyces cerevisiae | The microorganisms are not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The microorganisms are not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3)(C) Determination for Microbial Commercial Activity Notices (MCANs) J-22-0001-0006 (pdf) | 10/26/2021 | 01/20/2022 |
| J-22-0007 | Generic: Strain of Escherichia coli modified with genetically-stable, plasmid-borne DNA for the production of plasmid-borne DNA. | The microorganism is not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The microorganisms are not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3)(C) Determination for Microbial Commercial Activity Notice (MCAN) J-22-0007 (pdf) | 10/27/2021 | 01/20/2022 |
| P-21-0186, P-21-0187 | Generic: glycerin, alkoxylated alkyl acid esters | The chemical substances are not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination* The chemical substances are not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3) Determination for Premanufacture Notice (PMN) P-21-0186-187 (pdf) | 07/20/2021 | 12/22/2021 |
| P-20-0018, P-20-0019, P-20-0020, P-20-0021 | P-20-0018, P-20-0019, P-20-0020: Fatty acid dimers, polymers with glycerol and triglycerides P-20-0021: Fatty acid dimers, polymers with glycerol and fatty acids | The chemical substances are not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination* The chemical substances are not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3) Determination for Premanufacture Notice (PMN) P-20-0018-0021 (pdf) | 11/26/2019 | 12/20/2021 |
| P-21-0128 | Specific: Fatty acids, C8-18 and C18-unsatd., mixed esters with C18-unsatd. fatty acid dimers, decanoic acid, octanoic acid and trimethylolpropane; CASRN 2411231-33-7. | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3) Determination for Premanufacture Notice (PMN) P-21-0128 (pdf) | 05/10/2021 | 01/03/2022 |
| P-21-0135 | Generic: Alkenoic acid, allyl-, (dialkylamino)alkyl ester, polymer with dialkyl-alkylene-alkanediyl)bis[carbomoncycle], alkylalkyl alkyl-alkenoate and alkanediol mono(2-alkyl-alkenoate), diazenediyl)bis[2-alkylalkanenitrile]-initiated, | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3) Determination for Premanufacture Notice (PMN) P-21-0135 (pdf) | 05/20/2021 | 12/20/2021 |
| P-21-0120 | Generic: 2-Alkenoic acid, 2-alkyl-, 2-hydroxyalkyl ester, homopolymer, ester with N-[3-[(carboxyamino)alkyl]-3,5,5- trialkylcycloalkyl]carbamic acid mono [2-(2-alkoxyethoxy)alkyl] ester, N-[3-[(carboxyamino)alkyl]-3,5,5- trialkylcycloalkyl] carbamic acid mono [2-(dialkylamino) alkyl] ester and 2-oxepanone polymer with tetrahydro- 2H-pyran-2-one 2-alkylhexyl ester N-[3-(carboxyamino)alkyl phenyl] carbamate, 1,1-dialkylpropyl 2-alkylhexaneperoxoate - initiated | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3) Determination for Premanufacture Notice (PMN) P-21-0120 (pdf) | 04/26/2021 | 12/20/2021 |
| P-18-0348 | Specific: Ethanol, 2,2'-[1,4-phenylenebis(oxy)]bis-, polymer with 1,6-diisocyanatohexane and .alpha.-hydro-.omega.-hydroxypoly(oxy-1,4-butanediyl) CASRN 1512871-02-1; polymer exemption flag. | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3) Determination for Premanufacture Notice (PMN) P-18-0348 (pdf) | 09/27/2018 | 12/17/2021 |
| J-21-0011 | Generic: Saccharomyces cerevisiae fermenting C5 sugars, modified | The microorganism is not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The microorganisms are not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3)(C) Determination for Microbial Commercial Activity Notice (MCAN) J-21-0011 (pdf) | 05/11/2021 | 09/21/2021 |
| P-21-0087 | Generic: Syrups, hydrolyzed starch, dehydrated, polymers with methacrylic acid and alkenenylbenzene | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination* The chemical substances are not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3) Determination for Premanufacture Notice (PMN) P-21-0087 (pdf) . | 04/06/2021 | 09/07/2021 |
| P-20-0148, P-20-0149, P-20-0150-0151 | Generic: Hydroxyalkanoic acid, salt, oxidized | The chemical substances are not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination* The chemical substances are not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3) Determination for Premanufacture Notices (PMNs) P-20-0148-0149- 0150-0151 (pdf) . | 11/12/2020 | 08/30/2021 |
| J-21-0014, J-21-0015, J-21-0016, J-21-0017, J-21-0018 | Generic: Chromosomally modified Saccharomyces cerevisiae | The microorganisms are not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The microorganisms are not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3)(C) Determination for Microbial Commercial Activity Notices (MCAN) J-21-0014, J-21-0018 (pdf) . | 04/19/2021 | 07/16/2021 |
| J-21-0019 | Generic: Strain of Escherichia coli modified with genetically-stable, plasmid-borne DNA for the production of plasmid-borne DNA | The microorganism is not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The microorganisms are not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3)(C) Determination for Microbial Commercial Activity Notice (MCAN) J-21-0019 (pdf) . | 04/22/2021 | 07/16/2021 |
| P-21-0037, P-21-0038 | P-21-0037: [1,1'-Biphenyl]-3,3',4,4'-tetracarboxamide, N3,N3',N4,N4'-tetraoctyl; CASRN: 2169674-18-2 P-21-0038: [1,1'-Biphenyl]-3,3',4,4'-tetracarboxamide, N3, N3', N4, N4'-tetradodecyl; CASRN: 2413095-68-6 | The chemical substances are not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination* The chemical substances are not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3)(C) Determination for Premanufacture Numbers (PMN) P-21-0037, P-21-0038 (pdf) . | 12/11/2020 | 07/16/2021 |
| P-21-0020 | Generic: Alkanedioic acid, dialkyl ester, polymer with dialkyl-alkanediol, alkyl (substituted alkyl)-alkanediol and heteropolycycle | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination* The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3)(C) Determination for Premanufacture Numbers (PMN) P-21-0020 (pdf) . | 01/22/2021 | 07/07/2021 |
| J-21-0013 | Generic: Yeast that has been stably modified for the production of an agricultural product | The microorganism is not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The microorganism is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3)(C) Determination for Microbial Commercial Activity Notice (MCAN) J-21-0013 (pdf) :. | 04/02/2021 | 06/28/2021 |
| J-21-0012 | Generic: Yeast that has been stably modified for the production of an agricultural product | The microorganism is not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The microorganism is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3)(C) Determination for Microbial Commercial Activity Notice (MCAN) J-21-0012 (pdf) . | 03/31/2021 | 06/28/2021 |
| P-21-0039, P-21-0040, P-21-0041 | Specific (P-21-0039): 1,2,4,5-Benzenetetracarboxamide, N1,N2,N4,N5-tetrahexyl-; CASRN: 1142038-73-0 Specific (P-21-0040): 1,2,4,5-Benzenetetracarboxamide, N1,N2,N4,N5-tetraoctyl-; CASRN: 1416081-40-7 Specific (P-21-0041): 1,2,4,5-Benzenetetracarboxamide, N1,N2,N4,N5-tetradodecyl-; CASRN: 911127-84-9 | The chemical substances are not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination* The chemical substances are not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3)(C) Determination for Premanufacture Numbers (PMN) P-21-0039, P-21- 0040, P-21-0041 (pdf) . | 02/03/2021 | 06/30/2021 |
| P-21-0103 | Specific: Urea, N-[3-[[(4-methylphenyl)sulfonyl]oxy]phenyl]-N'-phenyl-include; CASRN 2102522-55-2 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination* The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3)(C) Determination for Premanufacture Number (PMN) P-21-0103 (pdf) . | 04/05/2021 | 06/30/2021 |
| P-21-0085 | Specific: 1-Propanethiol, 3-(triethoxysilyl)-, reaction products with polybutadiene; CASRN: 2109699-92-3 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination* The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3)(C) Determination for Premanufacture Number (PMN) P-21-0085 (pdf) . | 02/08/2021 | 07/06/2021 |
| P-21-0005 | Generic: Carbonmonocyclic alkene polymer with alkyl alkenoate, alkyl alkenoate, alkyl alkenoate and polyalkyldiene alkenoate | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination* The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3) Determination for Premanufacture Notice (PMN) P-21-0005 (pdf) . | 01/22/2021 | 06/25/2021 |
| P-21-0078 | Generic: Phenol, polymer with alkyl-(alkylalkylenyl)cyclohexene, mixed dialkylcyclohexadienes, mixed alkyl-(alkylalkylidene)cyclohexenes and 3,7,7-trimethylbicyclo[4.1.0]hept-3-ene | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination* The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3)(C) Determination for Premanufacture Number (PMN) P-21-0078 (pdf) . | 02/23/2021 | 06/25/2021 |
| P-21-0095 | Generic: Alkene homopolymer hydrogenated | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination* The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3)(C) Determination for Premanufacture Number (PMN) P-21-0095 (pdf) . | 03/16/2021 | 06/17/2021 |
| J-21-0010 | Generic: Genetically modified microorganism for the production of a chemical substance | The microorganism is not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The microorganism is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3)(C) Determination for Microbial Commercial Activity Notice (MCAN) J-21-0010 (pdf) | 02/11/2021 | 05/03/2021 |
| J-21-0004 | Generic: Genetically modified microorganism for the production of a chemical substance | The microorganism is not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The microorganism is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. TSCA Section 5(a)(3)(C) Determination for Microbial Commercial Activity Notice (MCAN) J-21-0004 (pdf) | 12/31/2020 | 03/30/2021 |
| J-20-0019, J-20-0020, J-20-0021, J-20-0022, J-20-0023, J-20-0024 | Generic: Modified Saccharomyces cerevisiae | The microorganisms are not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The microorganisms are not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 12/31/2020 | 03/30/2021 |
| P-20-0168 | Generic: Polyolefin polyamine succinimide, carbopolycycle alkoxylated | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination* The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. TSCA Section 5(a)(3) Determination for Premanufacture Notice (PMN) P-20-0168 (pdf) . | 09/14/2020 | 04/22/2021 |
| J-21-0005, J-21-0006 | Generic: Modified Saccharomyces cerevisiae enhanced ethanol yield | The microorganisms are not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The microorganisms are not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 01/14/2021 | 04/13/2021 |
| P-20-0167 | Generic: Phenylene, alkyl and polycarbomonocycle substituted, 1,2-dicarboxylate | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination* The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 08/31/2020 | 03/26/2021 |
| J-21-0007, J-21-0008, J-21-0009 | Biofuel producing Saccharomyces cerevisiae modified, genetically stable | The microorganisms are not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The microorganisms are not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 12/28/2020 | 03/24/2021 |
| J-20-0019, J-20-0020, J-20-0021, J-20-0022, J-20-0023, J-20-0024 | Modified Saccharomyces cerevisiae | The microorganisms are not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The microorganisms are not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 12/31/2020 | 03/30/2021 |
| P-21-0051 | Specific: Fatty Acids, C18-unsatd., dimers, hydrogenated, polymers with 2-hydroxyethyl-terminated hydrogenated polybutadiene, bis(2,5-dihydro-2,5-dioxo-1H-pyrrole-1-hexanoate); CASRN: 2506146-94-5. | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination* The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 01/12/2021 | 03/10/2021 |
| P-20-0025 | Specific: Octadecanoic acid, 12-(acetoxy)-, 2-ethylhexyl ester; CASRN 61800-40-6 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination* The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 11/19/2019 | 03/08/2021 |
| J-21-0002, J-21-0003 | Generic: Saccharomyces cerevisiae modified | The microorganisms are not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The microorganisms are not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 12/02/2020 | 02/24/2021 |
| P-20-0132 | Specific: 1H-Pyrrole-2,5-dione, 3-methyl-, 1,1'-C36-alkylenebis-; CASRN: 2414071-06-8 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination* The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 07/02/2020 | 02/26/2021 |
| P-20-0097 | Generic: Butanedioic acid, monopolyisobutylene derivs., mixed dihydroxyalkyl and hydroxyalkoxyalkyl diesters | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination* The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 05/07/2020 | 02/19/2021 |
| P-20-0183 | Generic: Aryl ether epoxide, homopolymer, ether with alkanolamine | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination* The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 11/16/2020 | 02/11/2021 |
| J-20-0025 | Generic: Biofuel producing Saccharomyces cerevisiae modified, genetically stable | The microorganism is not likely to present an unreasonable risk (5(a)(3)(C)) | The microorganism is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 11/03/2020 | 01/27/2021 |
| P-21-0012 | Generic: Multialkylbicycloalkenyl substituted propanenitrile | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination* The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 10/28/2020 | 01/25/2021 |
| P-20-0136 | Generic: Arylcarboxylic acid, alkyl ester, polymer with alkanediol, ester with methyloxirane polymer with oxirane alkyl ether. | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination* The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 07/09/2020 | 02/01/2021 |
| P-20-0185 | Amines, C36-alkylenedi-, polymers with bicyclo[2.2.1]heptanedimethanamine, [5,5'-biisobenzofuran]-1,1',3,3'-tetrone and 3a,4,5,7atetrahydro-7-methyl-5-(tetrahydro-2,5-dioxo-3-furanyl)-1,3-isobenzofurandione, maleated | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination* The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 10/08/2020 | 01/27/2021 |
| P-20-0107 | Generic: Carbimide, polyalkylenepolyarylene ester, polymer with 1,2-alkanediol, 2-alkoxyalkyl methacrylate- and 3-(2-alkoxyalkyl)-2-heterocycle-blocked | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination* The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 06/28/2020 | 01/27/2021 |
| J-20-0013 J-20-0014 J-20-0015 J-20-0016 J-20-0017 J-20-0018 | Generic: Strains of Escherichia coli modified with genetically-stable, plasmid-borne DNA for the production of enzymes | The microorganisms are not likely to present an unreasonable risk (5(a)(3)(C)) | The microorganisms are not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 10/27/2020 | 01/15/2021 |
| J-20-0005 | Generic: Saccharomyces cerevisiae modified | The microorganism is not likely to present an unreasonable risk (5(a)(3)(C)) | The microorganism is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the document. TSCA Section 5(a)(3)(C) Determination for Microbial Commercial Activity Notice (MCAN) J-20-0005 (pdf) | 10/16/2020 | 01/05/2021 |
| P-20-0170 – P-20-0172 | Generic: Glycerin, alkoxylated alkyl acid esters | The chemical substances are not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination* The chemical substances are not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 09/09/2020 | 12/21/2020 |
| P-20-0102 | Specific: Coal, brown, ammoxidized; CASRN: 2413186-32-8 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 05/22/2020 | 12/16/2020 |
| SN-20-0006 | Specific: Phenol, 4,4'-[1-[4-[1-(4-hydroxyphenyl)-1-methylethyl]phenyl]ethylidene]bis-; CASRN: 110726-28-8 | The significant new use is not likely to present an unreasonable risk (5(a)(3)(C)) | The significant new use is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 06/03/2020 | 12/22/2020 |
| P-20-0094 | Generic: Alkanedioic acid, polymer with tri-alkyl-isocyanatocarbomonocycle, dialkylglycols, ester with 2,3-dihydroxypropyl alkyl ester, 2-hydroxyethyl methacrylate-blocked | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document and the terms of the SNUR. | 04/29/2020 | 11/30/2020 |
| P-20-0076 | Specific: Glycine, reaction products with sodium O-iso-Pr carbonodithioate, sodium salts, CASRN 2205080-23-3 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document and the terms of the SNUR. | 03/25/2020 | 11/30/2020 |
| P-19-0082 | Specific: Heptanal, 6-hydroxy-2,6-dimethyl; CASRN 62439-42-3 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document and the terms of the SNUR. | 05/03/2019 | 11/30/2020 |
| P-20-0161 | Specific: Propanedioic acid, 2-methylene-, 1,3-diethyl ester, polymer with 1,4-butanediol | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 08/18/2020 | 11/14/2020 |
| P-20-0154 | Generic: Polyamines, reaction products with succinic anhydride polyalkenyl derivs, borates | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 08/04/2020 | 11/04/2020 |
| P-20-0146 | Generic: Alkanoic acid, alkyl, carbopolycyclic alkyl ester | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View. the determination document. | 08/20/2020 | 11/10/2020 |
| P-19-0038 | Specific: Fatty acids, coco, iso-Bu esters, CASRN 91697-43-7 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document and the terms of the SNUR. | 02/04/2019 | 10/30/2020 |
| P-18-0175 | Specific: Formaldehyde, polymer with 4-(1,1-dimethylethyl) phenol and phenol, Bu ether; CASRN 2215936-67-5 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination* The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 05/11/2018 | 10/30/2020 |
| P-20-0048 P-20-0049 | Generic: P-20-0048: Reaction products of alkyl-terminated alkylaluminoxanes and dihalogeno(alkylcyclopentadienyl)(tetraalkylcyclopentadienyl)transition metal coordination compound P-20-0049: Reaction products of alkyl-aluminoxanes and bis(alkylcyclodialkylene)dihalogenozirconium | The chemical substances are not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination* These chemical substances are not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 04/09/2020 | 10/27/2020 |
| P-20-0160 | Specific: Amines, C-36-alkylenedi-, polymers with bicyclo[2.2.1]heptanedimethanamine, [5,5'-biisobenzofuran]-1,1',3,3'-tetrone and 3a,4,4a,7a,8,8a-hexahydro-4,8-etheno-1H,3H-benzo[1,2-c:4,5-c']difuran-1,3,5,7-tetrone, maleated; CASRN 2415902-37-1 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination* The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 08/11/2020 | 10/28/2020 |
| P-20-0143 | Specific: Cyclohexanemethanamine, 5-amino-1,3,3-trimethyl-, polymer with a-hydro-w-hydroxypoly(oxy-1,4-butanediyl), 5- isocyanato-1-(isocyanatomethyl)-1,3,3-trimethylcyclohexane and 1,1-methylenebis[4-isocyanatobenzene]; CASRN: 2417925-50-7 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination* The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 07/28/2020 | 10/28/2020 |
| P-20-0098 | Generic: Calcium cycloalkylcarboxylate | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination* The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 06/26/2020 | 10/22/2020 |
| P-20-0061 | Generic: Formaldehyde, polymer with alkylphenols, alkyl ether | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination* The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 03/03/2020 | 10/14/2020 |
| P-18-0355 | Generic: Alkanediol, substituted alkyl, polymer with carbomonocyle, alkanedioate substituted carbomonocycle, ester with substituted alkanoate | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination* The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 09/27/2018 | 10/22/2020 |
| P-20-0111 | Specific: 1,2,4-Benzenetricarboxylic acid, 1,2,4-trinonyl ester; CASRN 35415-27-1 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination* *The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 06/09/2020 | 09/30/2020 |
| P-16-0538 | Specific: 9-Octadecenoic acid (9Z)-, compound with N-cyclohexylcyclohexanamine (1:1), CASRN 22256-71-9 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination* *In EPA’s original screening analysis for this PMN in 2016, EPA determined there was insufficient information to evaluate effects for human health concerns for lung surfactancy and may present a risk for intended and foreseeable uses based on ecotoxicity concerns, which resulted in the interim finding. Based on additional information provided by the submitter, EPA revised its assessment for the intended conditions of use. The submitter provided toxicity data on the new chemical substance and clarification on their processes that lead to a revised risk assessment. EPA’s final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA’s revised risk assessment for the chemical substance under the intended conditions of use, where EPA expects that employers will require and workers will use appropriate personal protective equipment in a manner adequate to protect them, and EPA’s issuance of a proposed SNUR to address certain reasonably foreseen uses. Conditions of use that fall under the restrictions of the proposed SNUR are not likely to present unreasonable risk of injury to health or the environment because (1) those conditions of use are not likely to be commenced during the pendency of the proposed SNUR and (2) upon finalization of the SNUR those conditions of use would be prohibited unless and until EPA makes an affirmative determination that the significant new use is not likely to present an unreasonable risk or takes appropriate action under section 5(e) or 5(f). View the determination document and the terms of the SNUR. | 08/26/2016 | 09/14/2020 |
| P-18-0337 | Specific: Propanedioic acid, 2,2-bis(hydroxymethyl)-, 1,3-dicyclohexyl ester; CASRN 2222732-46-7 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination* *The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document and the terms of the SNUR. | 09/26/2018 | 09/30/2020 |
| P-18-0335 | Specific: Propanedioic acid, 1,3-dicyclohexyl ester; CASRN 1152-57-4 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination* *The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document and the terms of the SNUR. | 09/26/2018 | 09/30/2020 |
| P-18-0334 | Specific: Propanedioic acid, 1,3-dihexyl ester; CASRN 1431-37-4 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination* *The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document and the terms of the SNUR. | 09/26/2018 | 09/30/2020 |
| P-18-0330 | Generic: Formaldehyde, polymer with alkyl aryl ketone | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination* *The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document and the terms of the SNUR. | 09/25/2018 | 09/30/2020 |
| P-18-0289 | Generic: 2-(2(Methylcaboxymonocyclic)amino)ethoxy)-alcohol | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination* *The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document and the terms of the SNUR. | 09/20/2018 | 09/30/2020 |
| P-20-0099 | Generic: Mixed Metal Oxide | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination* *The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 06/11/2020 | 09/21/2020 |
| P-20-0066 | Generic: 2-Propenoic acid, 2-hydroxyethyl ester, reaction products with dialkyl hydrogen heterosubstituted phosphate and dimethyl phosphonate | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination* *The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 03/09/2020 | 09/18/2020 |
| P-19-0162 | Generic: Fatty acid alkyl amide, (dialkyl) amino alkyl, alkyl quaternized, salts | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination* *The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 09/11/2019 | 09/29/2020 |
| P-18-0336 | Specific: Propanedioic acid, 2,2-bis(hydroxymethyl)-, 1,3-dihexyl ester; CASRN 2222732-45-6 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination* *The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 09/26/2018 | 09/30/2020 |
| P-17-0115 | Generic: Aminoalkyl alkoxysilane | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination* *In EPA’s original screening analysis for this PMN in 2017, EPA identified chronic environmental risk and human health concerns for risks to workers and the general population, which resulted in the interim finding. Based on chronic ecotoxicity and human health testing data provided by the submitter, EPA revised its hazard and risk assessment. EPA’s final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA’s revised hazard and risk assessment for the chemical substance under the intended conditions of use, where EPA expects that employers will require and workers will use appropriate personal protective equipment in a manner adequate to protect them, and no unreasonable risk to the environment was identified. View the determination document. | 11/16/2016 | 08/26/2020 |
| J-20-0009 J-20-0011 | Generic: Biofuel producing Saccharomyces cerevisiae modified, genetically stable | The microorganisms are not likely to present an unreasonable risk (5(a)(3)(C)) | The microorganisms are not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 06/12/2020 | 08/25/2020 |
| J-20-0007 J-20-0008 | Generic: Biofuel producing Saccharomyces cerevisiae modified, genetically stable | The microorganisms are not likely to present an unreasonable risk (5(a)(3)(C)) | The microorganisms are not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 06/03/2020 | 08/20/2020 |
| J-20-0012 | Generic: Biofuel producing Saccharomyces cerevisiae modified, genetically stable | The microorganism is not likely to present an unreasonable risk (5(a)(3)(C)) | The microorganism is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 06/12/2020 | 08/20/2020 |
| P-18-0308 | Generic: Bis((hydroxyalkoxy)aryl)carbopolycyclic | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document and the terms of the SNUR. | 09/18/2018 | 08/31/2020 |
| P-18-0370 P-18-0371 | Generic: Salt of a maleic anhydride and substituted alkene copolymer Generic: Salt of a maleic anhydride - substituted alkene copolymer | The chemical substances are not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substances are not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 09/28/2018 | 08/19/2020 |
| P-18-0369 | Generic: Maleic anhydride - substituted alkene copolymer | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 09/28/2018 | 08/19/2020 |
| P-19-0147 | Generic: Alkoxylated butyl alkyl ester | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 09/09/2019 | 08/18/2020 |
| P-18-0036 | Specific: Siloxanes and Silicones, di-Me, 3-[3-carboxy-2(or 3)-(octenyl)-1-oxopropoxy]propyl group-terminated; CASRN: 403616-34-2 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 10/30/2017 | 08/31/2020 |
| P-18-0382 | Generic: Xanthylium, bis[dicarboxycyclic]sulfonylamino-alkylcyclicamino-disulfo-sulfocyclic-, inner salt, monocationic salt | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 09/28/2018 | 08/25/2020 |
| P-18-0359 | Generic: Methoxy vinyl ether-vinylidene fluoride polymer | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 09/28/2018 | 08/13/2020 |
| P-19-0059 | Specific: Butanoic acid, 3-oxo-, 2-[(2-methyl-1-oxo-2-propen-1-yl)oxy]ethyl ester, polymer with butyl 2-propenoate, ethenylbenzene, 1,1'-[(1-methyl-1,2 ethanediyl)bis[oxy(methyl-2,1- ethanediyl)]] di-2-propenoate, methyl 2-methyl-2- propenoate and 2-methyl-2-propenoic acid, ammonium salt; CASRN 2260965-80-6 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document. | 07/30/2019 | 09/06/2019 |
| P-17-0333 | Generic: Fatty acid dimers, polymer with acrylic acid and pentaerythritol reaction products | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination* *In EPA’s original screening analysis for this PMN in 2017, EPA identified potential risks to workers from inhalation and dermal exposures and the environment from releases to water, and exposure-based concerns, which resulted in the interim finding. Based on additional information provided by the PMN submitter, EPA revised its assessment for the intended conditions of use. EPA’s final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA’s revised risk assessment for the chemical substance under the intended conditions of use, where EPA expects that employers will require and workers will use appropriate personal protective equipment in a manner adequate to protect them, and EPA’s issuance of a proposed SNUR to address certain reasonably foreseen uses. Conditions of use that fall under the restrictions of the proposed SNUR are not likely to present unreasonable risk of injury to health or the environment because (1) those conditions of use are not likely to be commenced during the pendency of the proposed SNUR and (2) upon finalization of the SNUR those conditions of use would be prohibited unless and until EPA makes an affirmative determination that the significant new use is not likely to present an unreasonable risk or takes appropriate action under section 5(e) or 5(f). View the determination document. | 06/26/2017 | 06/30/2020 |
| P-20-0068 | Specific: 1,3-Propanediol, 2,2-dimethyl-, 1,3-diacetate; CASRN: 13431-57-7 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document. | 03/11/2020 | 07/31/2020 |
| P-20-0040 | Generic: 2-Propenoic acid, cycloalkyl ester | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document. | 01/06/2020 | 06/30/2020 |
| P-20-0038 | Specific: 1,3,5-Triazine-2,4,6(1H,3H,5H)-trione, 1,3,5-tris[3-(2-oxiranyl)propyl]-; CASRN: 91403-64-4 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document. | 12/23/2019 | 06/30/2020 |
| P-20-0015 | Generic: N-alkyl heteromonocyclic diphenolamide, polymer with Bisphenol A, haloaryl-substituted sulfone, compd. with cyclic sulfonate ester, polyaryl alcohol terminated | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document. | 01/13/2020 | 06/30/2020 |
| P-18-0400 | Generic: Rosin adduct ester, polymer with polyols, potassium salt | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document. | 12/12/2018 | 07/31/2020 |
| P-18-0399 | Generic: Rosin adduct ester, polymer with polyols, compd. with ethanolamine | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document. | 12/12/2018 | 07/31/2020 |
| P-18-0363 | Generic: Phenol, polymer with formaldehyde, substituted phenol ,sodium sal | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document. | 12/12/2018 | 06/30/2020 |
| P-18-0320 | Generic: Alkane, diisocyanato-(isocyanatoalkyl)- | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document. | 09/21/2018 | 06/30/2020 |
| P-16-0313 | Specific: Tar acids (shale oil), C6–9 fraction, alkylphenols, low-boiling; CASRN 1887000-93-2 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document. | 06/22/2016 | 06/30/2020 |
| P-16-0512 | Generic: Fatty acid dimers, polymer with acrylic acid and pentaerythritol reaction products | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination* * In EPA’s original screening analysis for this PMN in 2016, EPA identified that information was insufficient to evaluate human health risks, and identified exposure-based concerns, which resulted in the interim finding. EPA subsequently determined that there are no reasonably foreseen conditions of use for the new chemical substance and the PMN submitter provided clarifying information that changed the human health hazard profile. EPA’s final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA’s revised hazard and risk assessment for the chemical substance under the intended conditions of use, where EPA expects that employers will require and workers will use appropriate personal protective equipment in a manner adequate to protect them, and no unreasonable risk to the environment was identified. View the determination document. | 08/08/2016 | 06/30/2020 |
| P-20-0103 | Generic: Cycloaliphatic amine formate | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 06/05/2020 | 07/28/2020 |
| P-20-0090 | Generic: Poly(oxy-1,2-ethanediyl), .alpha.-(alkyl-hydroxyalkyl)-.omega.-hydroxy-, .omega.-alkyl ethers | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 04/23/2020 | 07/30/2020 |
| P-20-0086 | Generic: 2-Oxepanone, homopolymer, ester with hydroxyalkyl trioxo heteromonocyclic (3:1) | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 04/22/2020 | 07/02/2020 |
| P-20-0035 | Generic: Substituted aromatic, 3,3'-[[6-[(substituted alkyl amino)]-1,3,5-triazine-2,4-diyl]bis[imino[2-(substituted)-5-[substituted alkoxy]-4,1-phenylene]-2,1- diazenediyl]]bis[substituted, sodium salt] | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 12/19/2019 | 07/08/2020 |
| P-20-0011 | Generic: Tetraoxaspiro[5.5]alkyl-3,9-diylbis(alkyl-2,1-diyl) bis(2-cyano-3-(3,4-dimethoxyphenyl)acrylate) | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 10/28/2019 | 07/17/2020 |
| SN-19-0006 | Specific: 2-Propen-1-one, 1-(4-morpholinyl)- (CASRN: 5117-12-4) | The significant new use is not likely to present an unreasonable risk (5(a)(3)(C)) | The significant new use is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 09/30/2019 | 06/30/2020 |
| P-18-0378 | Generic: Acrylic and Methacrylic acids and esters, polymer with alkenylimidazole, alkyl polyalkylene glycol, alkenylbenzene, alkylbenzeneperoxoic acid ester initiated, compds. with Dialkylaminoalkanol | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 10/04/2018 | 07/30/2020 |
| P-18-0263 | Generic: Mixed alkyl esters-, polymer with N1-(2-aminoethyl)- l,2-ethanediamine, aziridine, Nacetyl derivs., acetates (salts) | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 07/27/2018 | 06/29/2020 |
| P-15-0633 | Specific: 1(2H)-Naphthalenone,4-ethyloctahydro-8-methyl- (CAS RN: 870515-09-6) | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination.* * In EPA’s original screening analysis for this PMN in 2016, EPA identified potential risks to workers and environmental concerns which resulted in the interim finding. The PMN submitter provided additional information about the substance and also provided an updated Safety Data Sheet. EPA revised its assessment for the intended conditions of use. EPA’s final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA’s revised risk assessment for the chemical substance under the intended conditions of use, where EPA expects that employers will require and workers will use appropriate personal protective equipment in a manner adequate to protect them. View the determination document. | 06/22/2016 | 06/09/2020 |
| P-20-0074 | Specific: Oxirane, 2-methyl-, polymer with oxirane, monoundecyl ether, branched and linear; CASRN: 2222805-23-2 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 03/23/2020 | 06/11/2020 |
| P-20-0069 | Generic: 2-Propenoic acid, 2-methyl-, polymer with 2-hydroxyethyl 2-methyl-2-propenoate phosphate and 2-propenoic acid salt, peroxydisulfuric acid ([(HO)S(O)2]2O2) sodium salt (1:2)- and sodium (disulfite) (2:1)-initiated | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 03/21/2020 | 06/17/2020 |
| P-20-0057 | Generic: Arene, trimethoxysilyl-, hydrolyzed | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 02/11/2020 | 06/22/2020 |
| P-20-0056 | Generic: Polyphosphoric acids, 2-[(alkyl-1-oxo-alkene-1-yl)oxy]alkyl esters, polymers with acrylic acid, alkyl acrylate, alkyl methacrylate, hydroxyalkyl methacrylate and carbomonocycle, 2,2'-(1,2-diazenediyl)bis[2,4-dialkylalkanenitrogensubstituted]-initiated | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 02/12/2020 | 06/09/2020 |
| P-19-0161 | Generic: Alkanol amine salt mixture | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 09/07/2019 | 04/27/2020 |
| P-19-0116 | Generic: sr-(Wasp Spider Polypeptide-1 Oligopeptide-178) | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 03/24/2020 | 06/19/2020 |
| P-19-0064 | Generic: 4,4'-Methylenebis[2,6-dimethyl phenol] polymer with 2-(chloromethyl)oxirane, 1,4-benzyl diol, 2-methyl-2-propenoic acid, butyl 2-methyl 2-propenoate, ethyl 2-methyl 2-propenoate, and ethyl 2-propenoate, reaction products with 2-(dimethylamino) ethanol | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 03/18/2019 | 06/29/2020 |
| P-18-0396 | Generic: Alkenoic acid, alkyl, polymer with carbomonocyle alkyl propenoate and substituted alkyl alkenoate, ester with substituted alkyl alkanoate, tert-butyl substituted peroxoate-initiated | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 09/28/2018 | 06/11/2020 |
| P-16-0449 | Specific: 2,7-Decadienal, (2E,7Z)-; CASRN: 52711-52-1 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 06/27/2016 | 06/25/2020 |
| P-16-0326 | Specific: Propanoic acid, 2,2-dimethyl-, 1-methyl-2-(1-methylethoxy)-2-oxoethyl ester; (CASRN 1821051-37-9) | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 06/22/2016 | 06/09/2020 |
| P-17-0324 | Specific: 2,4-Hexadien-1-ol, 1-acetate, (2E,4E)-; CASRN: 57006-69-6 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination.* *In EPA’s original screening analysis for this PMN in 2017, EPA identified potential risks to workers, which resulted in the interim finding. Based on additional information provided by the submitter, EPA revised its assessment for the intended conditions of use. EPA’s final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA’s revised risk assessment for the new chemical substance under the intended conditions of use, where EPA expects that employers will require and workers will use appropriate personal protective equipment in a manner adequate to protect them, and EPA’s issuance of a proposed SNUR to address certain reasonably foreseen uses. Conditions of use that fall under the restrictions of the proposed SNUR are not likely to present unreasonable risk of injury to health or the environment because (1) those conditions of use are not likely to be commenced during the pendency of the proposed SNUR and (2) upon finalization of the SNUR those conditions of use would be prohibited unless and until EPA makes an affirmative determination that the significant new use is not likely to present an unreasonable risk or takes appropriate action under section 5(e) or 5(f). View the determination document and the terms of the SNUR. | 06/16/2017 | 05/15/2020 |
| P-20-0037 | Specific: Lithium Chloride (6LiCl); CASRN: 20227-31-0 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document and the terms of the SNUR. | 02/12/2020 | 05/29/2020 |
| P-20-0036 | Specific: Carbonic acid, di(lithium-6Li) salt; CASRN: 25890-20-4 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document and the terms of the SNUR. | 02/06/2020 | 05/29/2020 |
| P-19-0109 | Specific: Copper, bis[2-(amino-.kappa.N)ethanolato-.kappa.O]- (CASRN 14215-52-2); Copper, [[2,2',2''-(nitrilo-.kappa.N)tris[ethanolato-.kappa.O]](2-)]- (CASRN 21545-60-8) | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document and the terms of the SNUR. | 01/09/2020 | 05/29/2020 |
| P-19-0088 | Specific: Ethanamine, N-ethyl-, 2-hydroxy-1,2,3-propanetricarboxylate (1:?); CASRN 23251-73-2 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document and the terms of the SNUR. | 05/13/2019 | 05/29/2020 |
| P-19-0019 | Generic: Haloalkane | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document and the terms of the SNUR. | 11/08/2018 | 05/29/2020 |
| P-18-0271 | Generic: 2-Propanol, 1-butoxy-, 2,2'-ester | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document and the terms of the SNUR. | 08/06/2018 | 05/29/2020 |
| P-18-0151 | Specific: Formaldehyde, reaction products with 1,3-benzenedimethanamine and p-tert-butylphenol: CASRN 158800-93-2 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document and the terms of the SNUR. | 04/19/2018 | 05/29/2020 |
| P-17-0195 | Generic: 1,3-Propanediol,2-methylene-, substituted | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination* *In EPA’s original screening analysis for this PMN in 2017, EPA determined that there was insufficient information to evaluate human health risks and identified potential risks to the environment, which resulted in the interim finding. The PMN submitter subsequently provided human health effects study data. EPA revised the risk assessment and determined that release and exposure patterns from reasonably foreseen uses would not differ from the intended conditions of use. EPA’s final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA’s revised risk assessment for the chemical substance under the intended conditions of use, where EPA expects that employers will require and workers will use appropriate personal protective equipment in a manner adequate to protect them and no environmental risk is expected. View the determination document. | 01/05/2017 | 05/27/2020 |
| P-10-0542 | Generic: Amide, polyprotic acid | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination* *In EPA’s original screening analysis for this PMN, EPA identified environmental risk and exposure-based concerns, which resulted in the interim finding. EPA subsequently updated the risk assessment to reflect current science and policy. EPA’s final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA’s revised hazard and risk assessment for the chemical substance under the intended conditions of use, where EPA expects that employers will require and workers will use appropriate personal protective equipment in a manner adequate to protect them, and no unreasonable risk to the environment was identified. View the determination document. | 06/22/2016 | 05/29/2020 |
| P-18-0380 | Generic: Butanoic acid ethyl amine | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 10/12/2018 | 05/29/2020 |
| P-18-0332 P-18-0333 | Specific (P-18-0332): Canola meal (CASRN: 121957-95-7) Specific (P-18-0333): Flaxseed meal (CASRN: 2211120-89-5) | The chemical substances are not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substances are not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 09/25/2018 | 05/29/2020 |
| J-20-0003 J-20-0004 | Generic: Genetically modified microorganism | The microorganisms are not likely to present an unreasonable risk (5(a)(3)(C)) | The microorganisms are not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 03/16/2020 | 05/21/2020 |
| P-20-0050 | Specific: Benzenepentanol, .alpha.,.gamma.-dimethyl- (CASRN 72681-01-7) | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 02/05/2020 | 05/08/2020 |
| P-20-0012 | Generic: Polyol, polymer with alkyl diisocyanate, alkyl substituted heterocycle blocked | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 10/31/2019 | 05/08/2020 |
| P-18-0362 | Specific: 1,3-Propanediol, 2-ethyl-2-(hydroxymethyl)-, polymer with 2,4-diisocyanato-1-methylbenzene, .alpha.-hydro-.omega.-hydroxypoly[oxy(methyl-1,2-ethanediyl)] and .alpha.,.alpha.',.alpha.''-1,2,3-propanetriyltris[.omega.-hydroxypoly[oxy(methyl-1,2-ethanediyl)]], Me Et ketone oxime –blocked (CASRN: 1661004-48-3); polymer exemption flag Polymer exemption flag: The chemical must be manufactured such that it meets the polymer exemption criteria as described under 40 CFR §723.250(e)(1), in addition to meeting the definition of polymer at 40 CFR §723.250(b). | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 09/28/2018 | 05/08/2020 |
| P-18-0168 | Generic: Alkoxylated triaryl methane (PROVISIONAL) | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 05/04/2018 | 03/26/2019 |
| P-17-0389 | Generic: Alkyl oil, polymer with 1,4-cyclohexanedimethanol, dehydrated Alkyl oil, hydrogenated rosin, phthalic anhydride and trimethylolpropane | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 09/12/2017 | 05/08/2020 |
| P-17-0294 | Specific: 2-Butanone, 3-methyl-, peroxide; CASRN: 182893-11-4 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination.* *In EPA’s original screening analysis for this PMN in 2017, EPA identified potential for risks to workers from inhalation and dermal exposure, which resulted in the interim finding. Based on a respiratory breakthrough modeling study provided by the submitter, EPA revised its assessment for the intended conditions of use. EPA’s final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA’s revised risk assessment for the chemical substance under the intended conditions of use, where EPA expects that employers will require and workers will use appropriate personal protective equipment in a manner adequate to protect them, and EPA’s issuance of a proposed SNUR to address certain reasonably foreseen uses. View the determination document and the terms of the SNUR . | 04/25/2017 | 04/29/2020 |
| P-17-0086 | Generic: Cycloalkyl, bis(ethoxyalkyl)-, trans-; Cycloalkyl, bis(ethoxyalkyl)-, cis- | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination.* *In EPA’s original screening analysis for this PMN in 2017, EPA identified potential risks to workers, the general population, and the environment, which resulted in the interim finding. Based on additional information provided by the submitter, EPA revised its assessment for the intended conditions of use. EPA’s final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA’s revised risk assessment for the chemical substance under the intended conditions of use and EPA’s issuance of a proposed SNUR to address certain reasonably foreseen uses. View the determination document and the terms of the SNUR . | 11/07/2016 | 04/29/2020 |
| P-20-0052 | Specific: Oxirane, 2-methyl-, polymer with oxirane, mono(3,5,5-trimethylhexanoate); CASRN 148263-50-7 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document and the terms of the SNUR . | 02/05/2020 | 04/29/2020 |
| P-20-0041 | Specific: 1,3-Benzenedicarboxylic acid, polymer with 3-methyl-1,5-pentanediol (CASRN 76962-70-4) | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document and the terms of the SNUR. | 01/07/2020 | 04/29/2020 |
| P-19-0174 | Generic: Octadecanoic acid, (alkylphosphinyl), polyol ester | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document and the terms of the SNUR . | 12/11/2019 | 04/29/2020 |
| P-19-0136 | Generic: iso-alkylamine, N-isoalkyl-N-methyl | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document and the terms of the SNUR . | 07/23/2019 | 04/29/2020 |
| P-18-0262 | Specific: 2-Propenoic acid, 2-methyl-, dodecyl ester, polymer with ammonium 2-methyl-2-[(1-oxo-2-propen-1-yl)amino]-1-propanesulfonate (1:1), N,N-dimethyl-2-propenamide and .alpha.-(2-methyl-1-oxo-2-propen-1-yl)-.omega.-(dodecyloxy)poly(oxy-1,2-ethanediyl); CASRN 1190091-71-4 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document and the terms of the SNUR . | 09/05/2018 | 04/29/2020 |
| P-20-0054 | Specific: Nitrile hydratase NH-6L (CAS provisional name) | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 02/07/2020 | 04/26/2020 |
| P-19-0134 | Generic: 5-isocyanato-1-(isocyanatomethyl)-1,3,3-trimethylcyclohexane], [Poly[oxy(methyl-1,2-ethanediyl)], .alpha.-hydro-.omega.-hydroxy-, polymer with 1,6-diisocyanatohexane], polymer with [Poly(oxy-1,4-butanediyl), .alpha.-hydro-.omega.-hydroxy-], [Cyclic amine - ketone adduct, reduced], and [1,3-Propanediol, 2-ethyl-2-(hydroxymethyl) | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 10/23/2019 | 04/29/2020 |
| P-18-0098 | Generic: Polyphosphoric acids, polymers with (alkoxyalkoxy)alkanol and substituted heteromonocycle | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 01/24/2018 | 04/21/2020 |
| P-20-0027 P-20-0028 | Generic (P-20-0027): Glycols, .alpha.,.omega.-, C2-6, polymers with adipic aicd, dodecanedioic acid, hydracrylic acid polyester, isophthalic acid, isophthalic acid, 1,1'-methylenebis[4-isocyanatobenzene], neopentyl glycol and terephthalic acid (PROVISIONAL) Generic (P-20-0028): Glycols, .alpha.,.omega.-, C2-6, polymers with adipic acid, aromatic polyester, dodecanedioic acid, hydracrylic acid polyester, isophthalic acid, 1,1'-methylenebis[4-isocyanatobenzene], neopentyl glycol and terephthalic acid (PROVISIONAL) | The chemical substances are not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substances are not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 01/10/2020 | 04/08/2020 |
| P-19-0189 | Generic: Fatty acids, polymers with alkanediol and 1,1'-methylenebis[4-isocyanatobenzene] | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 09/30/2019 | 04/09/2020 |
| P-18-0376 | Generic: Thiosulfuric acid, aminoalkyl ester | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 10/10/2018 | 04/02/2020 |
| P-18-0150 | Generic: Tertiary amine, compounds with amino sulfonic acid blocked aliphatic isocyanate homopolymer | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 04/13/2018 | 04/01/2020 |
| P-18-0381 | Specific: Indium manganese yttrium oxide; CASRN: 1239902-45-4 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document and the terms of the SNUR. | 09/28/2018 | 03/31/2020 |
| P-18-0060 | Specific: 1-Butanaminium, 4-amino-N-(2-hydroxy-3-sulfopropyl)-N,N-dimethyl-4-oxo-, N-coco alkyl derivs., inner salts; CASRN 2041102-83-2 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document and the terms of the SNUR. | 10/10/2018 | 03/31/2020 |
| P-18-0059 | Specific: Butanoic acid, 4-(dimethylamino)-, ethyl ester; CASRN 22041-23-2 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document and the terms of the SNUR. | 10/10/2018 | 03/31/2020 |
| P-16-0420 | Generic: Dimethyl cyclohexenyl propanol | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination.* *In EPA’s original screening analysis for this PMN in 2016, EPA identified potential for risk to workers and the environment, which resulted in the interim finding. The PMN submitter provided additional data that changed the human health and environmental hazard profile. EPA’s final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA’s revised hazard and risk assessment for the new chemical substance. View the determination document. | 06/22/2016 | 03/26/2019 |
| P-18-0364 | Generic: Alkali humates, polymers with substituted acrylamides | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 09/28/2018 | 03/19/2020 |
| P-17-0240 | Generic: Alkenoic acid, polymer with alkanepolyolpolyacrylate, 2,2'-azobis[2-methylbutanenitrile]-initiated | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination.* *In EPA’s original screening analysis for this PMN in 2017, EPA identified potential for risk to workers, which resulted in the interim finding. The PMN submitter provided additional data that changed the human health hazard profile and potential risk to workers. EPA’s final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA’s revised hazard and risk assessment for the chemical substance, where hazards were assessed to be low based on the additional data provided by the submitter. View the determination document. | 02/23/2017 | 03/06/2020 |
| J-20-0002 | Generic: Microorganism with chromosomally-borne genetic modifications for the production of a chemical | The microorganism is not likely to present an unreasonable risk (5(a)(3)(C)) | The microorganism is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 12/23/2019 | 03/10/2020 |
| P-20-0022 | Generic: Polyalkoxycarbopolycycle hydroxy | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 12/09/2019 | 03/06/2020 |
| P-17-0364 | Generic: Dicyloalkyl-alkane-di-isocyanate homopolymer, alkyl alcohol and polyalkyl glycol mono-alkyl-ether-blocked | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination.* * In EPA’s original screening analysis for this PMN in 2017, EPA identified insufficient information to evaluate human health risks under the intended conditions of use, which resulted in the interim finding. EPA subsequently reassessed the hazard profile and environmental releases. EPA’s final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA’s revised hazard and risk assessment for the chemical substance under the intended conditions of use, where EPA expects that employers will require and workers will use appropriate personal protective equipment in a manner adequate to protect them, and no unreasonable risk to the environment was identified. View the determination document. | 07/27/2017 | 02/11/2020 |
| J-19-0001 | Specific: Trichoderma reesei 3CH-3 | The microorganism is not likely to present an unreasonable risk (5(a)(3)(C)) | The microorganism is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document and the terms of the SNUR. | 10/07/2019 | 02/28/2020 |
| P-20-0013 | Specific (P-20-0013): 2-Propenoic acid, 2-methyl-, (2-oxo-1,3-dioxolan-4-yl)methyl ester; CASRN: 13818-44-5 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document and the terms of the SNUR . | 10/17/2019 | 02/28/2020 |
| P-18-0391 | Specific: 1-Propanaminium, N-(carboxymethyl)-N, N-dimethyl-3-[(3,5, 5-trimethyl-1-oxohexyl), amino]- inner salt | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document and the terms of the SNUR . | 09/28/2018 | 02/28/2020 |
| P-18-0267 P-18-0268 P-18-0269 | Generic (P-18-0267): Branched alkanoic acid, epoxy ester, reaction products with monocyclic dialkylamine and polycyclic alcohol epoxy polymer Generic (P-18-0268): Branched alkanoic acid, epoxy ester, reaction products with monocyclicdialkanamine and polycyclic dialkanol ether polymer Generic (P-18-0269): Branched alkanoic acid, epoxy ester, reaction products with monocyclicalkanamine, polycyclic alcohol ether homopolymer, and polycyclic alcohol epoxy polymer | The chemical substances are not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substances are not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 07/31/2018 | 02/21/2020 |
| P-20-0024 | Generic (P-20-0024): Phenol-formaldehyde polymer with amino-oxirane copolymer and nitrobenzoates. | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 12/04/2019 | 02/21/2020 |
| P-20-0008 | Generic: 7-Heteropolycyclicsulfonic acid, 2-[4-[2-[1-[[(2-methoxy-5-methyl-4-sulfophenyl)amino]carbonyl]-2-oxopropyl]diazenyl]phenyl]-6-methyl-, compd. with (alkylamino) alkanol and (hydroxyalkyl) amine | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 10/08/2019 | 02/28/2020 |
| P-19-0170 | Generic: Alkenoic acid, alkyl-substituted, epoxy ester, polymer with alkyl alkenoate, alkene, and polylactide | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 09/25/2019 | 02/21/2020 |
| P-18-0389 | Generic: Alkenoic acid, alkyl-substituted, epoxy ester, polymer with alkyl alkenoate, alkene, and polylactide | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 09/28/2018 | 02/28/2020 |
| P-18-0211 | Generic: Alkaneamine, (aminoalkyl)-, polymer with aziridine and 1,6-diisocyanatohexane, polyethylene glycol alkyl ether- and polyethylene-polypropylene glycol aminoalkyl alkyl ether- and alkenyl benzenated polyethylene glycol Ph ether | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 06/12/2018 | 02/21/2020 |
| P-18-0187 | Generic: Carboxylic acid-polyamine condensate | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 06/04/2018 | 02/28/2020 |
| P-17-0355 | Generic: Benzoic acid, 2-hydroxy-, -alkyl derivs | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 07/12/2017 | 02/11/2020 |
| P-19-0164 | Generic: Bis-alkoxy substituted alkane, polymer with aminoalkanol | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document and the terms of the proposed Significant New Use Rule (SNUR). | 09/20/2019 | 01/31/2020 |
| P-19-0158 | Generic: Alkenoic acid polymer with 2-ethyl-2-(hydroxymethyl)-1,3-alkyldiol, 1,1'-methylenebis(4-isocyanatocarbomonocycle) and 3-methyl-1,5-aklydiol | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document and the terms of the proposed Significant New Use Rule (SNUR). | 09/25/2019 | 01/31/2020 |
| P-18-0367 | Generic: Acid-modified polyether | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document and the terms of the proposed Significant New Use Rule (SNUR). | 09/28/2018 | 01/31/2020 |
| P-18-0199 | Generic: Rare earth oxide | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document and the terms of the proposed Significant New Use Rule (SNUR). | 06/01/2018 | 01/31/2020 |
| P-18-0126 | Specific: Calcium manganese titanium oxide; CASRN: 153728-36-0 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document and the terms of the proposed Significant New Use Rule (SNUR). | 03/09/2018 | 01/31/2020 |
| P-18-0058 | Specific: Phosphonium, trihexyltetradecyl-, salt with 1,1,1-trifluoro-N-[(trifluoromethyl)sulfonyl]methanesulfonamide (1:1); CASRN 460092-03-9 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document and the terms of the proposed Significant New Use Rule (SNUR). | 01/08/2018 | 01/31/2020 |
| P-18-0236 | Generic: Metal, alkenoic acid-alkyl alkenoate-alkyl substituted alkenoate polymer carbopolycycle complexes | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document and the terms of the proposed Significant New Use Rule (SNUR). | 07/24/2018 | 01/27/2020 |
| P-18-0108 | Generic: Aromatic anhydride polymer with bisalkylbiphenylbisamine compound with alkylaminoalkyl acrylate ester | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 02/12/2018 | 01/22/2020 |
| P-18-0031 | Generic: Substituted dicarboxylic acid, polymer with various alkanediols | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 10/25/2017 | 01/22/2020 |
| SN-17-0011 | Generic: Polyfluorohydrocarbon | The significant new use is not likely to present an unreasonable risk (5(a)(3)(C)) | The significant new use is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 04/04/2017 | 01/22/2020 |
| J-20-0001 | Generic: Biofuel producing Saccharomyces cerevisiae modified, genetically stable | The microorganism is not likely to present an unreasonable risk (5(a)(3)(C)) | The microorganism is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 10/22/2019 | 01/16/2020 |
| P-18-0328 | Generic: Plant oil fatty acids, alkyl esters | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 09/25/2018 | 01/07/2020 |
| P-18-0176 | Generic: 5-Isobenzofurancarboxylic acid, 1,3-dihydro-1,3-dioxo-, polymer with aminoalcohol, 2,2-dimethyl-1,3-propanediol, 2,5-furandione, polyalkylene glycol and unsaturated anhydride | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 05/17/2018 | 02/27/2019 |
| P-18-0067 | Specific: Fatty acids, C14-18 and C16-18-unsatd., polymers with adipic acid and triethanolamine, di-Me sulfate-quaternized CASRN: 1211825-32-9 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 12/18/2017 | 01/13/2020 |
| P-17-0233 | Generic: Oxyalkylene modified polyalkyl amine alkyl diacid polymer with 2-(chloromethyl)oxirane | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination.* *In EPA’s original screening analysis for this PMN in 2017, EPA identified potential for risk to workers, which resulted in the interim finding. The PMN submitter provided additional information that changed EPA’s assessment of potential exposure to workers. EPA’s final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA’s revised hazard and risk assessment for the chemical substance under the intended conditions of use, where EPA expects that employers will require and workers will use appropriate personal protective equipment in a manner adequate to protect them, and no unreasonable risk to the environment was identified. View the determination document. | 02/07/2017 | 12/19/2019 |
| P-17-0234 | Specific: Oxirane, 2-(chloromethyl)-, polymer with 2-methyloxirane polymer with oxirane bis(2-aminopropyl) ether; CASRN: 78390-60-0 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination.* *In EPA’s original screening analysis for this PMN in 2017, EPA identified potential risks to workers, which resulted in the interim finding. EPA’s final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA’s revised risk assessment for the chemical substance under the intended conditions of use, where EPA expects that employers will require and workers will use appropriate personal protective equipment in a manner adequate to protect them, and EPA’s issuance of a proposed SNUR to address certain reasonably foreseen uses. Conditions of use that fall under the restrictions of the proposed SNUR are not likely to present unreasonable risk of injury to health or the environment because (1) those conditions of use are not likely to be commenced during the pendency of the proposed SNUR and (2) upon finalization of the SNUR those conditions of use would be prohibited unless and until EPA makes an affirmative determination that the significant new use is not likely to present an unreasonable risk or takes appropriate action under section 5(e) or 5(f). View the determination document and the terms of the proposed Significant New Use Rule (SNUR). | 02/10/2017 | 12/18/2019 |
| P-19-0155 P-19-0156 P-19-0157 | Specific (P-19-0155): Amides, from C8-18 and C18-unsatd. glycerides and diethylenetriamine, ethoxylated, CASRN: 2173332-72-2 Specific (P-19-0156): Amides, from diethylenetriamine and palm kernel-oil, ethoxylated, CASRN: 2173332-69-7 Specific (P-19-0157): Amides, from coconut oil and diethylenetriamine, ethoxylated, CASRN: 2173332-70-0 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 09/18/2019 | 12/18/2019 |
| P-19-0148 P-19-0149 P-19-0150 P-19-0151 | Generic (P-19-0148): Iron, complexes with ethylenediamine-4-hydroxycarbomonocycle hetero-acid-2-oxoacetic acid reaction products, potassium salts Generic (P-19-0149): Iron, complexes with ethylenediamine-4-hydroxycarbomonocycle hetero-acid potassium salt (1:1)-potassium 2-oxoacetate (1:1) reaction products, potassium salts Generic (P-19-0150): Iron, complexes with ethylenediamine-4-hydroxycarbomonocycle hetero-acid-2-oxoacetic acid reaction products, sodium salts Generic (P-19-0151): Iron, complexes with ethylenediamine-4-hydroxycarbomonocycle hetero-acid sodium salt (1:1)-sodium 2-oxoacetate (1:1) reaction products, sodium salts | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 08/22/2019 | 12/16/2019 |
| P-19-0135 | Generic: Alkyl polyoxyethylene ethers, carboxymethylated | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 09/06/2019 | 12/18/2019 |
| P-18-0393 | Generic: Alkenoic acid, alkyl, alkyl ester, polymer with alkyl propenoate, vinyl carbomonocyle, substituted alkyl propenoate, alkyl 2-alkyl 2-propenoate, alkanediol mono(2-alkyl-2-propenoate) and bicarbomonocylo alkyl 2-alkyl-2-alkenoate, tertiary alkyl substituted alkane peroxoate initiated; polymer exemption flag Polymer exemption flag: The chemical must be manufactured such that it meets the polymer exemption criteria as described under 40 CFR §723.250(e)(1), in addition to meeting the definition of polymer at 40 CFR §723.250(b). | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 09/28/2018 | 12/19/2019 |
| P-18-0341 P-18-0342 P-18-0343 P-18-0344 | Generic (P-18-0341): Alkane dicarboxylic acid, polymer with alkoxylated polyalcohol , alkyl polyglycol, alkyl dialcohol, and functionalized carboxylic acid, Generic (P-18-0342): Alkane dicarboxylic acid, polymer with alkyl polyglycol, alkyl dialcohol, and functionalized carboxylic acid, Generic (P-18-0343): Alkane dicarboxylic acid, polymer with alkoxylated polyalcohol, and alkyl dialcohol, (hydroxy alkyl) ester, Generic (P-18-0344): Aromatic dicarboxylic acid, polymer with alkane dicarboxylic acid, alkoxylated polyalcohol, and alkyl dialcohol, | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 10/11/2018 | 12/16/2019 |
| P-18-0329 | Generic: Substituted carbopolycyclic dicarboxylic acid dialkyl ester, polymer with alkanediol and carbopolycyclic bis (substituted carbopolycycle) bisalkanol | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 09/26/2018 | 12/19/2019 |
| P-18-0114 | Generic: Propanoic acid, hydroxy- (hydroxyalkyl)-alkyl-, polymer with 1,6-diisocyanatoalkane and poly[oxy(alkyl-alkanediyl)] ether with alkyl-(hydroxyalkyl)-alkanediol, 2-propenoate (ester), lithium salt, glycerol monoacrylate 1-neodecanoate- and alkylene glycol monoacrylate-blocked | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 02/19/2018 | 12/16/2019 |
| P-17-0325 | Specific: 2-Propenoic acid, polymer with 2-methyl-2-((1-oxo-2-propenyl)amino)-1-propanesulfonic acid; CASRN: 40623-75-4 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 08/02/2017 | 12/19/2019 |
| P-18-0232 | Generic: Polyol, reaction products with formaldehyde and methanol | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination.* *The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document and the terms of the proposed Significant New Use Rule (SNUR). | 07/05/2018 | 11/26/2019 |
| P-17-0298 | Specific: Formaldehyde, homopolymer, reaction products with N-propyl-1-propanamine; CASRN: 1374859-50-3 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination.* *In EPA’s original screening analysis for this PMN in 2017, EPA identified environmental risk and potential for risk to workers, which resulted in the interim finding. The PMN submitter provided additional information that changed EPA’s assessment of environmental releases, the human health hazard profile, and potential risk to workers. EPA’s final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA’s revised hazard and risk assessment for the chemical substance under the intended conditions of use, where EPA expects that employers will require and workers will use appropriate personal protective equipment in a manner adequate to protect them, and no unreasonable risk to the environment was identified. View the determination document. | 05/02/2017 | 12/12/2019 |
| P-20-0002 | Specific: Fatty Acids, C18-unsatd., dimers, hydrogenated, polymers with .alpha-.hydro-.omega.-hydroxypoly(oxy-1,4-butanediyl) and nonanoic acid; CASRN 2359671-57-9 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 10/02/2019 | 12/06/2019 |
| P-20-0004 | Specific: Fatty Acids, C18-unsatd., dimers, hydrogenated, polymers with hexanoic acid and .alpha.-hydro-.omega.hydroxypoly(oxy-1,4-butanediyl); CASRN 2359671-53-5 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 10/02/2019 | 12/10/2019 |
| P-17-0400 | Generic: Terpolymer of vinylidene fluoride, tetrafluoroethylene and 2,3,3,3-tetrafluoropropene | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document and the terms of the proposed Significant New Use Rule (SNUR). | 10/25/2017 | 11/26/2019 |
| P-18-0214 P-18-0215 P-18-0216 | Generic (P-18-0214): Polycyclic substituted alkane, polymer with cyclicalkylamine, epoxide, and polycyclic epoxide ether, reaction products with dialkylamine substituted alkyl amine. Generic (P-18-0215): Polycyclic alkane, polymer with monocyclic amine, polycyclic epoxide ether, reaction products with dialkylamine alkyl amine. Generic (P-18-0216): Polycyclic substituted alkane, polymer with epoxide, reaction products with cyclicalkylamine and dialkylamine substituted alkyl amine. | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 06/18/2018 | 11/26/2019 |
| P-18-0133 | Generic: Polyol adduct of bisaldehyde | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 03/20/2018 | 12/03/2019 |
| P-18-0392 | Generic: Heteromonocycle, alkenyl alkyl | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document and the terms of the proposed Significant New Use Rule (SNUR). | 10/12/2018 | 12/06/2019 |
| P-18-0385 | Specific: D-Glucopyranose, oligomeric, Bu glycosides, polymers with epichlorohydrin, 2-hydroxy-3-sulfopropyl ethers, sodium salts; CASRN: 2139271-53-5 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 11/14/2018 | 12/06/2019 |
| P-18-0264 | Generic: Phosphonomethylated ether diamine | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document and the terms of the proposed Significant New Use Rule (SNUR). | 07/27/2018 | 12/04/2019 |
| P-16-0291 | Generic: 1,3-cyclohexanedimethanamine adduct | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination.* *In EPA’s original screening analysis for this PMN in 2016, EPA identified potential for risk to workers, potential for significant releases and exposures, and risk to the environment, which resulted in the interim finding. The PMN submitter amended the PMN and provided additional information on releases, processing, and use. EPA's final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA's revised risk assessment for the chemical substance under the intended conditions of use described in the amended PMN and EPA’s issuance of a proposed SNUR to address certain reasonably foreseen uses. View the determination document and the terms of the SNUR. | 06/22/2016 | 11/26/2019 |
| P-15-0632 | Generic: Mixed amine salt | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. View the determination document. | 06/22/2016 | 11/26/2019 |
| P-16-0486 | Generic: Polychloropropane | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination.* *In EPA’s original screening analysis for this PMN in 2016, EPA identified potential risks to workers, which resulted in the interim finding. Based on additional information provided by the submitter, EPA revised its assessment for the intended conditions of use. EPA’s final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA’s revised risk assessment for the chemical substance under the intended conditions of use, where EPA expects that employers will require and workers will use appropriate personal protective equipment in a manner adequate to protect them, and EPA’s issuance of a proposed SNUR to address certain reasonably foreseen uses. View the determination document and the terms of the SNUR. | 07/18/2016 | 11/26/2019 |
| P-16-0451 | Generic: Reaction product of bisalkoxysilylalkylamine, alkoxy oxiranylalkoxyalkylsilane and silica | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination.* *In EPA’s original screening analysis for this PMN in 2016, EPA identified potential for risk to human health, which resulted in the interim finding. EPA revised its assessment for the intended conditions of use. EPA’s final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA’s revised risk assessment for the chemical substance under the intended conditions of use, where EPA expects that employers will require and workers will use appropriate personal protective equipment in a manner adequate to protect them. View the determination document. | 06/28/2016 | 12/03/2019 |
| P-17-0184 | Specific: 1-Propanaminium, 2-hydroxy-N,N-dimethyl-N-[3-[(1-oxooctyl)amino]propyl]-3-sulfo-, inner salt; CASRN 1612795-77-3 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination.* *In EPA’s original screening analysis for this PMN in 2017, EPA identified potential risk to human health and the environment, which resulted in the interim finding. The PMN submitter provided acute toxicity studies that indicate the substance has low environmental hazard. EPA’s final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA’s revised hazard and risk assessment for the chemical substance under the intended conditions of use and EPA’s issuance of a proposed SNUR to address certain reasonably foreseen uses. View the determination document and the terms of the SNUR. | 12/20/2016 | 12/03/2019 |
| P-19-0152 | Generic: Alkaneic acid, dialkyl ester polymer with alkanediol, [[(isocyanatocarbomonocycle) alkyl)carbomonocycle)carbamate | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 08/27/2019 | 09/17/2019 |
| P-19-0146 | Generic: Modified dimethyl sulfoxide | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 08/13/2019 | 11/26/2019 |
| P-19-0058 | Specific: Butanoic acid, 3-oxo-, 2-[(2-methyl-1-oxo-2-propen-1-yl)oxy]ethyl ester, polymer with butyl 2-propenoate, ethenylbenzene, methyl 2-methyl-2-propenoate and 2-methyl-2-popenoic acid, ammonium salt (CASRN 2131811-80-6); polymer exemption flag. | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 07/08/2019 | 11/21/2019 |
| P-18-0213 | Specific: 1,3-Benzenedicarboxylic acid, 5-sulfo-, calcium salt (2:1); CASRN 24806-09-5 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 06/18/2018 | 11/14/2019 |
| P-18-0167 | Generic: Butanamide, 2-[2-[(substitutued phenyl)diazenyl]-N-(2-methoxyphenyl)-3-oxo- | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 05/07/2018 | 11/14/2019 |
| P-18-0165 P-18-0166 | Generic (P-18-0165): 2,5-Furandione, polymer with ethenylbenzene, 4-hydroxy-substituted butyl amide, sodium salts Generic: (P-18-0166): 2,5-Furandione, polymer with ethenylbenzene, 4-hydroxy- substituted butyl [3-[2-[1-[[(2-methoxyphenyl)amino]carbonyl]-2-oxopropyl]diazenyl]phenyl]substituted, sodium salts | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | These chemical substances are not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 05/07/2018 | 11/07/2019 |
| P-18-0258 P-18-0259 | Generic (P-18-0258): Dioic acids, polymers with caprolactam and alkyldiamines Generic (P-18-0259): Fatty acids, dimers, hydrogenated, polymers with caprolactam and alkyldiamine | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | These chemical substances are not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 07/23/2018 | 10/31/2019 |
| P-17-0396 | Generic: Aminoalkylated imidazole | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 09/12/2017 | 10/31/2019 |
| P-18-0029 | Generic: Fatty acids and fatty acid unsatd., reaction products with ethyleneamines and maleic anhydride | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 10/20/2017 | 11/04/2019 |
| P-18-0019 | Generic: Substituted Benzene, 4-[2-[2-hydroxy-3-[[(3-nitrophenyl)amino]carbonyl]-1-naphthalenyl]diazenyl]-, sodium salt (1:1) | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 10/13/2017 | 10/31/2019 |
| P-18-0121 | Specific: Benzene, 1,1'-oxybis-, branched eicosyl derivs.; CASRN 1800419-55-9 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 03/08/2018 | 10/29/2019 |
| P-17-0360 | Specific: 2-Propanol, 1-amino-, compd. with .alpha.-sulfo-.omega.-(octyloxy)poly(oxy-1,2-ethanediyl) (1:1), CASRN 2098904-74-4; 2-Propanol, 1-amino-, compd. with .alpha.-sulfo- .omega.-(decyloxy)poly(oxy-1,2-ethanediyl) (1:1), CASRN 2098904-80-2 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination.* *In EPA’s original screening analysis for this PMN in 2017, EPA identified potential for risk to human health under reasonably foreseen conditions of use and potential for substantial exposure and release to the environment, which resulted in the interim finding. EPA subsequently determined that there are no reasonably foreseen conditions of use. EPA’s final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA’s revised hazard and risk assessment for the chemical substance under the intended conditions of use, where EPA expects that employers will require and workers will use appropriate personal protective equipment in a manner adequate to protect them, and no unreasonable risk to the environment was identified. View the determination document. | 07/18/2017 | 10/23/2019 |
| P-17-0109 | Generic: Alkyldiamine, aminoalkyl dimethylaminoalkyl dimethyl- | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination.* *In EPA’s original screening analysis for this PMN in 2017, EPA identified risks to workers and the general population under the intended conditions of use and potential environmental risk under reasonably foreseen conditions of use, which resulted in the interim finding. Based on additional information provided by the submitter, EPA revised its assessment for the intended conditions of use. EPA’s final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA’s revised risk assessment for the chemical substance under the intended conditions of use, where EPA expects that employers will require and workers will use appropriate personal protective equipment in a manner adequate to protect them, and EPA’s issuance of a proposed SNUR to address certain reasonably foreseen uses. View the determination document and the terms of the SNUR. | 11/23/2016 | 09/30/2019 |
| P-18-0092 | Specific: Phosphonium, tributylmethyl-, iodide (1:1); CASRN 1702-42-7 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document and the terms of the SNUR. | 01/26/2018 | 09/30/2019 |
| P-18-0207 | Generic: Metal, oxo alkylcarboxylate complexes | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 06/06/2018 | 10/03/2019 |
| SN-19-0004 | Specific: Coke (coal), secondary pitch; CASRN 94113-91-4 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The significant new use is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the SNUR and consent orders issued previously for this chemical substance. View the determination document. | 08/16/2018 | 09/25/2019 |
| SN-18-0005 | Specific: Butanoic acid, 3-mercapto-,1,1'-[2-(hydroxymethyl)-2-[(3-mercapto-1-oxobutoxy)methyl]-1,3-propanediyl] ester; CASRN: 1027326-93-7; and Butanoic acid, 3-mercapto-,1,1'-[2,2-bis[(3-mercapto-1-oxobutoxy)methyl]-1,3-propanediyl] ester; CASRN: 31775-89-0 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The significant new use is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 08/16/2018 | 09/25/2019 |
| P-19-0137 | Generic: Alkyl oligomeric reaction products | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 08/08/2019 | 09/23/2019 |
| P-19-0132 | Generic: Fatty acid, polymer with alkanedioic acid dialkyl ester, alkanoic acid, oxo alkyl ester, substituted carbomonocycle, alkyl substituted alkanediol, and alkylol substituted alkane | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 07/15/2019 | 09/27/2019 |
| P-19-0130 | Generic: Aminohydroxy naphthalenesulfonic acid, coupled with diazotized[(aminophenyl) sulfonyl]ethyl hydrogen sulfate and diazotized amino[[(sulfooxy)ethyl]sulfonyl]benzenesulfonic acid, salts | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document | 07/08/2019 | 09/20/2019 |
| P-19-0121 | Generic: Plant based oils, polymer with 1,1'-methylenebis[4-isocyanatobenzene], pentaerythritol, phthalic esters, polypropylene glycol and polypropylene glycol ether with glycerol (3:1) | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 07/11/2019 | 09/25/2019 |
| P-19-0117 | Generic: Polycyclic amine, reaction products with polyalkylalkene, polymers | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 06/21/2019 | 09/18/2019 |
| P-19-0113 | Generic: Metal oxide-chloro | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document and the terms of the SNUR. | 06/26/2019 | 09/30/2019 |
| P-18-0302 | Specific: D-Glucaric acid, ammonium salt (1:1); 6614-39-7 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 09/10/2018 | 09/30/2019 |
| P-18-0299 | Generic: Alkenoic acid, alkyl-, polymers with alkyl methacrylate, cycloalkyl methacrylate, alkylene dimethacrylate, and polyalkene glycol hydrogen sulfate [(branched alkyloxy)alkyl]-(alkenyloxy)alkyl ethers ammonium salts, metal salts | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 09/07/2018 | 10/01/2019 |
| P-18-0295 | Specific: 1,3-Butanediol, (3R)-, CASRN 6290-03-5 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document and the terms of the SNUR. | 06/17/2018 | 09/30/2019 |
| P-18-0105 | Specific: Phosphorous acid, triisotridecyl ester; CASRN: 77745-66-5 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document and the terms of the SNUR. | 02/08/2018 | 09/30/2019 |
| P-18-0034 | Generic: Polyetheramine carboxylate salt | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 10/30/2017 | 09/30/2019 |
| P-18-0192 | Generic: Benzenesulfonic acid, (alkenediyl)bis[[[(hydroxyalkyl)amino]-(phenylamino)-triazin-2-yl]amino]-, N-(hydroxyalkyl) derivs., salts, compds. with polyalkyl-substituted(alkanol) | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 05/29/2019 | 09/13/2019 |
| J-19-0024 J-19-0025 | Generic: Biofuel producing Saccharomyces cerevisiae modified, genetically stable | The microorganisms are not likely to present an unreasonable risk (5(a)(3)(C)) | The microorganisms are not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document. | 06/28/2019 | 09/12/2019 |
| P-19-0120 | Generic: Alkenoic acid, polymer with alkanediyl bis substituted alkylene bis heteromonocycle, substituted carbomonocycle and (alkylalkenyl) carbomonocycle, alkali metal salt | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 06/25/2019 | 08/29/2019 |
| P-19-0118 | Generic: Substituted polyalkylenepoly, reaction products with alkene polymer | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 06/21/2019 | 08/28/2019 |
| P-19-0099 | Specific: Propanoic acid, 3-hydroxy-2-(hydroxymethyl)-2-methyl-, polymer with dimethyl carbonate, 1,2-ethanediamine, 2-ethyl-2-(hydroxymethyl)-1,3-propanediol, 1,6-hexanediol and 1,1'-methylenebis[4-isocyanatocyclohexane], compd. with N,N-diethylethanamine, CASRN: 1178511-46-0 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 06/18/2019 | 08/29/2019 |
| P-19-0047 | Specific: Propanoic acid, 3-hydroxy-2-(hydroxymethyl)-2-methyl-, polymer with 5-amino-1,3,3-trimethylcyclohexanemethanamine, .alpha.-hydro-.omega.-hydroxypoly(oxy-1,4-butanediyl), alpha.-hydro-.omega.-hydroxypoly[oxy(methyl-1,2-ethanediyl)], 5-isocyanato-1-(isocyanatomethyl)-1,3,3-trimethylcyclohexane and 1,1'-methylenebis[4-isocyanatobenzene], Pr alc.-blocked; CASRN 2283318-90-9 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 07/31/2019 | 08/29/2019 |
| P-19-0024 | Specific: Silsesquioxanes, 3-(dimethyloctadecylammonio)propyl Me Pr, polymers with silicic acid (H4Si04) tetra-Et ester, (2-hydroxyethoxy)- and methoxyterminated, chlorides; CASRN: 2231249-14-0 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document and the terms of the SNUR. | 02/14/2019 | 08/30/2019 |
| P-18-0384 | Specific: Lithium, isotope of mass 6; CASRN: 14258-72-1 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document and the terms of the SNUR. | 09/28/2018 | 08/30/2019 |
| P-18-0358 | Specific: 1H-Imidazole-1-propanenitrile, 2-ethyl-ar-methyl-; CASRN: 568591-00-4 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document and the terms of the SNUR. | 09/27/2018 | 08/30/2019 |
| P-18-0276 | Specific: Benzenesulfonamide, N-[2-[[(phenylamino)carbonyl]amino]phenyl]-; CASRN: 215917-77-4 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document and the terms of the SNUR. | 08/15/2018 | 08/30/2019 |
| P-18-0197 | Generic: Metal, alkylcarboxylate oxo complexes | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 06/01/2018 | 08/09/2019 |
| P-18-0172 | Specific: Calcium, carbonate 2-ethylhexanoate neodecanoate propionate complex | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 05/10/2018 | 08/23/2019 |
| P-18-0109 | Generic: 2-Alkenoic acid, 2-alkyl-, alkyl ester, polymer with 2-(dialkylamino)alkyl 2-alkyl-2-alkenoate, alkyl 2-alkyl-2-alkenoate and a-(2-alkyl-1-oxo-2-alken-1-yl)-o-alkoxypoly(oxy-1,2-alkanediyl), [(1-alkoxy-2-alkyl-1-alken-1-yl)oxy]trialkylsilane-initiated | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented and the terms of the proposed Significant New Use Rule (SNUR). View the determination document and the terms of the SNUR. | 02/16/2018 | 08/30/2019 |
| P-17-0347 P-17-0348 P-17-0349 P-17-0350 P-17-0351 P-17-0352 | Specific: Oxirane, 2-methyl-, polymer with oxirane, mono(2-butyloctyl) ether; CASRN:252756-20-0 Specific: Oxirane, 2-methyl-, polymer with oxirane, mono(2-hexyldecyl) ether; CASRN: 125005-52-9 Specific: Oxirane, 2-methyl-, polymer with oxirane, mono(2-octyldodecyl) ether; CASRN: 102640-44-8 Specific: Oxirane, 2-methyl-, polymer with oxirane, mono(2-decyltetradecyl) ether; CASRN: 72484-69-6 Specific: Oxirane, 2-methyl-, polymer with oxirane, mono(2-dodecylhexadecyl) ether; CASRN: 102640-42-6 Specific: Oxirane, 2-methyl-, polymer with oxirane, mono(2-tetradecyloctadecyl) ether; CASRN: 102640-46-0 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. *In EPA’s original screening analysis for this PMN in 2017, EPA identified potential risks to workers, which resulted in the interim finding. Based on additional information provided by the submitter, EPA revised its assessment for the intended conditions of use. EPA’s final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA’s revised risk assessment for the chemical substance under the intended conditions of use, where EPA expects that employers will require and workers will use appropriate personal protective equipment in a manner adequate to protect them, and EPA’s issuance of a proposed SNUR to address certain reasonably foreseen uses. Conditions of use that fall under the restrictions of the proposed SNUR are not likely to present unreasonable risk of injury to health or the environment because (1) those conditions of use are not likely to be commenced during the pendency of the proposed SNUR and (2) upon finalization of the SNUR those conditions of use would be prohibited unless and until EPA makes an affirmative determination that the significant new use is not likely to present an unreasonable risk or takes appropriate action under section 5(e) or 5(f). View the determination document and the terms of the SNUR. | 07/06/2017 | 08/28/2019 |
| P-16-0541 | Specific: Soybean meal, reaction products with phosphoric trichloride; CASRN: 1962913-92-3 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. *In EPA’s original screening analysis for this PMN in 2016, EPA identified insufficient information to evaluate human health risks and the potential for environmental risk under the intended conditions of use, which resulted in the interim finding. The submitter clarified information regarding assumptions made during the initial assessment, and EPA reassessed the hazard profile and environmental releases. EPA’s final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA’s revised hazard and risk assessment for the chemical substance under the intended conditions of use, where EPA expects that employers will require and workers will use appropriate personal protective equipment in a manner adequate to protect them, and no unreasonable risk to the environment was identified. View the determination document. | 08/29/2016 | 08/28/2019 |
| P-18-0387 P-18-0388 | Generic (P-18-0387): Alkanal, reaction products with alkanediyl bis[alkyl-tris(alkyl-heterocycle)-1,3,5-triazine-2,4,6-triamine and hydrogen peroxide Generic (P-18-0388): 1,3,5-triazine-2,4,6-triamine, alkanediyl bis[alkyl-tris(alkyl-heterocycle)-, allyl derivs., oxidized, hydrogenated, | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substances are not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 09/28/2018 | 08/15/2019 |
| P-17-0299 | Generic: 2-Propenoic acid, alkyl -, polymers with alkyl acrylate and polyethylene glycol methacrylate alkyl ether | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. *In EPA’s original screening analysis for this PMN in 2017, EPA identified a potential for lung effects in workers, which resulted in the interim finding. EPA’s final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA’s revised hazard and risk assessment for the chemical substance under the intended conditions of use, where EPA expects that employers will require and workers will use appropriate personal protective equipment in a manner adequate to protect them, and no unreasonable risk to the environment was identified. View the determination document. | 05/02/2017 | 08/15/2019 |
| P-18-0155 P-18-0156 | Generic (P-18-0155): Crosslinked polymer of alkyl acrylamides, acrylate esters, and alkyl acrylamide sulfonate salt Generic (P-18-0156): Crosslinked polymer of alkyl acrylamides, acrylate esters, and alkyl acrylamide sulfonic acid | The chemical substances are not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. *In EPA’s original screening analysis for this PMN in 2017, EPA identified potential risks to the environment, workers, and the general population, which resulted in the interim finding. Based on amendments provided by the submitter that include measures to reduce worker inhalation exposure to the new chemical substance and clarifying releases to water, EPA revised its assessment for the intended conditions of use. EPA’s final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA’s revised risk assessment for the chemical substance under the intended conditions of use, where EPA expects that employers will require and workers will use appropriate personal protective equipment in a manner adequate to protect them, and EPA’s issuance of a proposed SNUR to address certain reasonably foreseen uses. Conditions of use that fall under the restrictions of the proposed SNUR are not likely to present unreasonable risk of injury to health or the environment because (1) those conditions of use are not likely to be commenced during the pendency of the proposed SNUR and (2) upon finalization of the SNUR those conditions of use would be prohibited unless and until EPA makes an affirmative determination that the significant new use is not likely to present an unreasonable risk or takes appropriate action under section 5(e) or 5(f). View the determination document and the terms of the SNUR. | 04/26/2018 | 08/06/2019 |
| SN-19-0005 | Generic: Functionalized multi-walled carbon nanotubes | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 05/20/2019 | 08/09/2019 |
| P-19-0085 | Generic: Aliphatic hydrocarbons, C16-18-branched and linear | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 05/10/2019 | 08/07/2019 |
| P-18-0190 P-18-0191 | Generic (P-18-0190): 2,5-Furandione, polymer with ethenylbenzene, 4-hydroxy-substituted butyl amide, polymers with epichlorohydrin and trimethylolpropane, sodium salts Generic: (P-18-0191): 2,5-Furandione, polymer with ethenylbenzene, 4-hydroxy-substituted butyl [3-[2-[1-[[(substituted phenyl)amino]carbonyl]-2-oxopropyl]diazenyl]phenyl]methyl amide, polymers with epichlorohydrin and trimthylolpropane, sodium salts | The chemical substances are not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substances are not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 05/25/2018 | 08/06/2019 |
| P-18-0035 | Generic: Methacrylic acid heterocyclic alkyl ester | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 10/30/2017 | 07/31/2019 |
| P-18-0009 | Generic: Phosphonic acid, dimethyl ester, polymer with alkyl diols | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 10/04/2017 | 07/31/2019 |
| P-17-0395 | Generic: Alkyl tri dithiocarbmate tri salt | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 09/26/2017 | 07/31/2019 |
| P-17-0346 | Specific: Phosphonium, triphenylpropyl-, bromide; CASRN: 6228-47-3 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. *In EPA’s original screening analysis for this PMN in 2017, EPA identified potential risks to the environment, workers, and the general population, which resulted in the interim finding. Based on amendments provided by the submitter that include measures to reduce worker inhalation exposure to the new chemical substance and clarifying releases to water, EPA revised its assessment for the intended conditions of use. EPA’s final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA’s revised risk assessment for the chemical substance under the intended conditions of use, where EPA expects that employers will require and workers will use appropriate personal protective equipment in a manner adequate to protect them, and EPA’s issuance of a proposed SNUR to address certain reasonably foreseen uses. Conditions of use that fall under the restrictions of the proposed SNUR are not likely to present unreasonable risk of injury to health or the environment because (1) those conditions of use are not likely to be commenced during the pendency of the proposed SNUR and (2) upon finalization of the SNUR those conditions of use would be prohibited unless and until EPA makes an affirmative determination that the significant new use is not likely to present an unreasonable risk or takes appropriate action under section 5(e) or 5(f). View TSCA Section 5(a)(3) Determination for Premanufacture Notice (PMN) P-17-0346 (pdf) and the terms of the SNUR. | 07/10/2017 | 07/31/2019 |
| P-17-0312 P-17- 0313 P-17-0314 P-17-0315 P-17-0316 P-17-0317 | Generic (P-17-0312): Organic acid, compds. with bisphenol A-epichlorohydrin-polypropylene glycol diglycidyl ether polymer-disubstituted amine-disubstituted polypropylene glycol reaction products, Generic (P-17-0313): Phenol, 4,4'-(1-methylethylidene)bis-, polymer with 2-(chloromethyl)oxirane and alpha-(2-oxiranylmethyl)-omega-(2-oxiranylmethoxy)poly[oxy(methyl-1,2-ethanediyl)], reaction products with disubstituted amine and disubstituted polypropylene glycol, organic acid salts, Generic (P-17-0314): Organic acid, 2-substituted-, compds. with bisphenol A-epichlorohydrin-polypropylene glycol diglycidyl ether polymer-disubstituted aminedisubstituted polypropylene glycol reaction products, Generic (P-17-0315): Phenol, 4,4'-(1-methylethylidene)bis-, polymer with alpha-(2-substituted-methylethyl)-omega-(2-substituted-methylethoxy)poly[oxy(methyl-1,2-ethanediyl)], 2-(chloromethyl)oxirane and alpha-(2-oxiranylmethyl)-omega-(2-oxiranylmethoxy)poly[oxy(methyl-1,2-ethanediyl)], alkylphenyl ethers, reaction products with disubstituted amine, organic acid salts, Generic (P-17-0316): Organic acid, compds. with bisphenol A-epichlorohydrin-disubstituted polypropylene glycol-polypropylene glycol diglycidyl ether polymer alkylphenyl ethers-disubstituted amine reaction products, Generic (P-17-0317): Organic acid, compds. with bisphenol A-epichlorohydrin-polypropylene glycol diglycidyl ether polymer-disubstituted polypropylene glycol reaction products | The chemical substances are not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. *In EPA’s original screening analysis for this PMN in 2017, EPA identified potential for risk to workers and the environment under foreseeable conditions of use, which resulted in the interim finding. EPA subsequently determined that there are no reasonably foreseen conditions of use for the new chemical substances and the PMN submitter provided additional information that changed the environmental hazard profile of the new chemical substance. EPA’s final determination that the new chemical substances are not likely to present unreasonable risk is based on EPA’s revised hazard and risk assessment for the chemical substances under the intended conditions of use, where EPA expects that employers will require and workers will use appropriate personal protective equipment in a manner adequate to protect them, and no unreasonable risk to the environment was identified. View the determination document. | 05/24/2017 | 07/31/2019 |
| P-19-0096 | Generic: Benzofuranone, bis(branched alkyl)-[dialkyl[tetrakis(branched alkyl)-alkyl-dibenzo-substitutedphosphite-yl] phenyl]- | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 05/29/2019 | 07/31/2019 |
| P-19-0062 | Generic: Hydrochlorofluoroolefin | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 02/27/2019 | 07/31/2019 |
| P-19-0029 | Specific: Phosphonium, tributylethyl-, diethyl phosphate (1:1); CASRN 20445-94-7 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 11/29/2018 | 07/31/2019 |
| P-18-0394 | Generic: substituted benzylic ether polyethylene glycol alkyl ether derivative | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 09/28/2018 | 07/29/2019 |
| P-18-0300 | Generic: Heteromonocycle, alkenoic 1:1 salt, polymer with alpha-(2-methyl-1-oxo-2-propen-1-y)l-omegamethoxypoly(oxy-1,2-ethanediyl) and methylalkenoic acid | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 09/10/2018 | 07/29/2019 |
| P-18-0286 | Specific: Propane, 1,1,1,3,3,3-hexafluoro-2-methoxy- CASRN: 13171-18-1 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 08/27/2018 | 07/31/2019 |
| P-18-0257 | Specific: Phosphoric acid, potassium salt (2:3); CASRN: 66923-00-0 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 07/23/2018 | 07/26/2019 |
| P-18-0103 | Generic: Alkylnitrile imidazole | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 02/05/2018 | 07/31/2019 |
| P-16-0442 P-16-0443 P-16-0444 P-16-0445 | Generic: P-16-0442 - Carboxylic acids, unsaturated, polymers with disubstituted amine, alkanediol, substituted alkylpropanoic acid, alkanedioic acid and substituted isocyanatocycloalkane, compds with alkylamine P-16-0443 – Carboxylic acids, unsaturated, hydrogenated polymers with disubstituted amine, alkanediol, substituted alkylpropanoic acid, alkanedioic acid and substituted isocyanatocycloalkane, compds with alkylamine P-16-0444 - Carboxylic acids, unsaturated, polymers with substituted alkanediamine, alkanediol, substituted alkylpropanoic acid, alkanedioic acid and substituted isocyanatocycloalkane, compds with alkylamineAmine salted polyurethane P-16-0445 - Carboxylic acids, unsaturated, hydrogenated polymers with substituted alkanediamine, alkanediol, substituted alkylpropanoic acid, alkanedioic acid and substituted isocyanatocycloalkane, compds with alkylamine | The chemical substances are not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. *In EPA’s original screening analysis for this PMN in 2016, EPA identified a potential for risk to workers, which resulted in the interim finding. The PMN submitter provided additional information that changed the human health hazard profile and potential risk to workers. EPA’s final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA’s revised hazard and risk assessment for the chemical substance under the intended conditions of use, where EPA expects that employers will require and workers will use appropriate personal protective equipment in a manner adequate to protect them, and no unreasonable risk to the environment was identified. View the determination document. | 06/23/2016 | 07/31/2019 |
| P-16-0092 | Generic: Polymeric polyamine | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. *In EPA’s original screening analysis for this PMN in 2015, EPA determined that certain exposure criteria were met and identified concerns for ecotoxicity, which resulted in an interim decision to require testing by order. The submitter provided the proposed test data during the review period, removing the basis for the order. The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment for the intended conditions of use and EPA’s issuance of a proposed SNUR to address certain reasonable foreseen uses. View the determination document and the terms of the SNUR. | 06/22/2016 | 07/31/2019 |
| P-18-0401 | Specific: Glycerides, C16-18 and CI8-unsatd. mono- and di-, citrates; CASRN: 91052-16-3 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 09/29/2018 | 07/24/2019 |
| P-18-0177 | Specific: Waxes and Waxy substances, rice bran, oxidized; CASRN: 1883583-80-9 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 05/15/2018 | 07/26/2019 |
| P-17-0362 | Generic: Aliphatic phosphoric amide ester | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. *In EPA’s original screening analysis for this PMN in 2017, EPA identified environmental risk under reasonably foreseen conditions of use and potential for risk to workers, which resulted in the interim finding. EPA subsequently determined that although there are reasonably foreseen conditions of use for the new chemical substance, the chemical substance has low human health hazard and low environmental hazard based on data submitted on the new chemical substance that changed the human health hazard and environmental hazard profiles and potential risk to workers and the environment. EPA’s final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA’s revised hazard and risk assessment for the chemical substance under the conditions of use, where EPA believes that this chemical substance is not likely to present an unreasonable risk even if potential exposures were high. View the determination document. | 07/26/2017 | 07/24/2019 |
| P-19-0081 | Generic: 2-Propenoic acid, alkyl ester, reaction products with mixed substituted alkyl esters of phosphorodithioic acid and propylene oxide | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 05/01/2019 | 07/23/2019 |
| P-18-0185 | Generic: Fatty acid, polymer with alkanedioic acid dialkyl ester, hydroxyl alkyl substituted alkanediol, substituted carbomonocycle and alkylol substituted alkane; polymer exemption flag Polymer exemption flag: The chemical must be manufactured such that it meets the polymer exemption criteria as described under 40 CFR §723.250(e)(1), in addition to meeting the definition of polymer at 40 CFR §723.250(b). | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 05/21/2018 | 07/14/2019 |
| P-18-0285 | Specific: Butanedioic acid, 2-methylene-, polymer with 2-methyl-2-[(1-oxo-2-propen-1-yl)amino]-1-propanesulfonic acid, sodium zinc salt; CASRN: 2220235-78-7 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 08/27/2018 | 07/23/2019 |
| P-18-0223 | Generic: Alkane, bis(alkoxymethyl)-dimethyl- | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 06/26/2018 | 07/17/2019 |
| P-19-0068 | Generic: 1,4-benzenedicarboxylic acid, polymer with diol, 5-amino-1,3,3-trimethylcyclohexanemethanamine, 1,2-ethanediol and urea | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 04/16/2019 | 07/12/2019 |
| P-16-0417 | Generic: Isocyanate terminated polyurethane resin | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. *In EPA’s original screening analysis for this PMN in 2016, EPA identified concern for risks to human health and the environment under the reasonably foreseen conditions of use, which resulted in the interim finding. EPA’s final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA’s risk assessment for the chemical substance under the intended conditions of use, where EPA expects that employers will require and workers will use appropriate personal protective equipment in a manner adequate to protect them, and EPA’s issuance of a proposed SNUR to address certain reasonably foreseen uses. Conditions of use that fall under the restrictions of the proposed SNUR are not likely to present unreasonable risk of injury to health or the environment because (1) those conditions of use are not likely to be commenced during the pendency of the proposed SNUR and (2) upon finalization of the SNUR those conditions of use would be prohibited unless and until EPA makes an affirmative determination that the significant new use is not likely to present an unreasonable risk or takes appropriate action under section 5(e) or 5(f). View the determination document and the terms of the SNUR. | 06/22/2016 | 06/30/2019 |
| J-19-0021 J-19-0022 | Generic: Saccharomyces cerevisiae strain CBI | The microorganisms are not likely to present an unreasonable risk (5(a)(3)(C)) | The microorganisms are not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document. | 04/04/2019 | 06/25/2019 |
| P-18-0241 P-18-0244 P-18-0245 | Generic: 2-Propenoic acid, 2-methyl-, methyl ester, polymer with ethenylbenzene, ethyl 2-propenoate, 2-oxiranylmethyl 2-methyl-2-propenoate and 1,2-propanediol mono(2-methyl-2-propenoate), reaction products with diethanolamine, polymers with substituted-alkyl acrylate, formates (salts), (P-18-0241) 2-Propenoic acid, 2-methyl, methyl ester, polymer with ethenylbenzene, ethyl 2-propenoate, 2-oxiranylmethyl 2-methyl-2-propenoate and 1,2-propanediol mono(2-methyl-2-propenoate), reaction products with diethanolamine, polymers with substituted-alkyl methacrylate, formates (salts), (P-18-0244) 2-Propenoic acid, 2-methyl-, methyl ester, polymer with ethenylbenzene, ethyl 2-propenoate, 2-oxiranylmethyl 2-methyl-2-propenoate, and 1,2-propanediol mono(2-methyl-2-propenoate), reaction products with diethanolamine, polymers with alkylene glycol monoacrylate, formates (salts), (P-18-0245). | The chemical substances are not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 07/16/2018 | 06/30/2019 |
| P-19-0071 | Generic: Trimethylolpropane, alkenoic acid, triester. | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 03/22/2019 | 06/19/2019 |
| P-19-0031 | Generic: Phenol, 4,4'-(1-methylethylidene)bis-, polymer with formaldehyde, 2-(chloromethyl)oxirane, alpha-hydro-omega-hydroxypoly(oxy-1,2-ethanediyl), and polyamines | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 12/28/2018 | 06/21/2019 |
| P-18-0402 | Generic: Phenol, alkanepolyolbis(heteroalkylene)bis-, polyalkylene derivs. | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 03/11/2019 | 06/30/2019 |
| P-18-0397 | Generic: Substituted alkanedioic acid, polymer with substituted alkanoic acid | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 09/29/2018 | 06/21/2019 |
| P-19-0072 | Specific: 1-Butanol, reaction products with 2-[(2-propen-1-yloxy)methyl]oxirane; CASRN: None | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 03/26/2019 | 06/21/2019 |
| P-18-0170 | Specific: 1-Propanaminium, N,N'-(oxydi-2,1-ethanediyl)bis[3-chloro-2-hydroxy-N,N-dimethyl-, chloride (1:2); CASRN: 96320-92-2 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 05/10/2018 | 06/27/2019 |
| P-18-0011 | Specific: 1H-Imidazole, 1,2,4,5-tetramethyl-; CASRN: 1739‐83‐9 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 10/05/2017 | 06/30/2019 |
| P-18-0239 P-18-0240 | Generic (P-18-0239): N-alkyl propanamide Generic (P-18-0240): N-alkyl acetamide | The chemical substances are not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment for the intended conditions of use and EPA’s issuance of a proposed SNUR to address certain reasonably foreseen uses. View the determination document and the terms of the SNUR. | 07/16/2018 | 06/30/2019 |
| J-19-0019 J-19-0020 | Generic: Genetically modified microorganism for the production of an enzyme substance | The microorganisms are not likely to present an unreasonable risk (5(a)(3)(C)) | The microorganisms are not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document. | 03/20/2019 | 06/13/2019 |
| P-19-0065 | Specific: 2lambda5, 4lambda5, 6lambda5 - 1,3,5,2,4,6 Triazatriphosphorine, 2,2,4,4,6,6 – hexaphenoxy-; CASRN: 1184-10-7 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 03/22/2019 | 06/14/2019 |
| P-19-0012 | Generic: Benzenedicarboxylic acid, reaction products with isobenzofurandione and diethylene glycol | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 12/20/2018 | 06/14/2019 |
| P-18-0404 | Generic: alkylmultiheteroatom,2-functionalisedalkyl-2-hydroxyalkyl-, polymer with alkylheteroatom-multialkylfunctionalised carbomonocyleheteroatom and multiglycidylether difunctionalised polyalkylene glycol | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 10/19/2018 | 06/14/2019 |
| P-18-0260 | Generic: Fatty acids, polymers with alkanoic acid and substituted carbomonocycle, peroxide-initiated, polymers with alkanoic acid esters and substituted carbomonocycle, ammonium salts; polymer exemption flag | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 07/26/2018 | 06/14/2019 |
| P-18-0125 | Generic: Oxoalkylcarboxylic acid, sodium salt | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment for the intended conditions of use and EPA’s issuance of a proposed SNUR to address certain reasonably foreseen uses. View the determination document and the terms of the SNUR. | 03/07/2018 | 06/14/2019 |
| P-18-0282 | Generic: Fatty acid ester, polyether, diisocyanate polymer | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 08/24/2018 | 05/30/2019 |
| P-17-0108 | Specific: Carbonodithioic acid, O-[2- [(dithiocarboxy)amino]-2-methylpropyl] ester, sodium salt (1:2); CASRN: 1947332-67-3 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk section 5(a)(3)(C) determination* *In EPA’s original screening analysis for this PMN in 2016, EPA identified potential risk to workers, substantial releases and significant exposure, and risk to the environment, which resulted in the interim finding. The PMN submitter clarified that the new chemical substance would not be released to surface water and provided an updated Safety Data Sheet. EPA’s final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA’s risk assessment for the chemical substance under the intended conditions of use, where worker exposure is expected be controlled through the use of appropriate PPE and release to water is not expected. View the determination document. | 11/09/2016 | 05/01/2019 |
| P-16-0429 | Generic: Endcapped polysiloxane | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk section 5(a)(3)(C) determination* *In EPA’s original screening analysis for this PMN in 2016, EPA identified potential for risk to workers, which resulted in the interim finding. EPA's final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA's risk assessment for the chemical substance under the intended conditions of use described in the PMN where EPA expects that employers will require and workers will use appropriate personal protective equipment in a manner adequate to protect them. View the determination document. | 06/22/2016 | 05/17/2019 |
| P-16-0225 | Specific: Isomer mixture of Cyclohexanol, 4-ethylidene-2-propoxy- (CASRN: 1631145-48-6) (35-45%) and Cyclohexanol, 5- ethylidene-2-propoxy- (CASRN: 1631145-49-7) (45-55%) | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 06/22/2016 | 05/07/2019 |
| P-16-0470 | Specific: 2,7-Nonadien-4-ol, 4,8-dimethyl-; CASRN: 103983-77-3 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk section 5(a)(3)(C) determination* *In EPA’s original screening analysis for this PMN in 2016, EPA identified environmental risk under reasonably foreseen conditions of use and potential for risk to workers, which resulted in the interim finding. EPA subsequently determined that there are no reasonably foreseen conditions of use for the new chemical substance and the PMN submitter provided additional information that changed the human health hazard profile and potential risk to workers. EPA’s final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA’s revised hazard and risk assessment for the chemical substance under the intended conditions of use, where EPA expects that employers will require and workers will use appropriate personal protective equipment in a manner adequate to protect them, and no unreasonable risk to the environment was identified. View the determination document. | 07/14/2016 | 05/17/2019 |
| P-19-0034 | Generic: Metal, bis(2,4-pentanedionato- kO2,kO4)-, (T-4)-, | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment for the intended conditions of use and EPA’s issuance of a proposed SNUR to address certain reasonably foreseen uses. View the determination document and the terms of the SNUR. | 12/06/2018 | 05/31/2019 |
| P-19-0028 | Generic: Alkyl salicylate, metal salts | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 02/22/2019 | 05/21/2019 |
| P-19-0020 | Generic: Alkylphenol, reaction products with carbon dioxide, distn. residues from manuf. of alkylphenol derivs. and calcium alkylphenol derivs. | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 01/31/2019 | 04/30/2019 |
| P-19-0004 | Generic: Aromatic dianhydride, polymer with aromatic diamine and heteroatom bridged aromatic diamine, reaction products with aromatic anhydride | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment for the intended conditions of use and EPA’s issuance of a proposed SNUR to address certain reasonably foreseen uses. View the determination document and the terms of the SNUR. | 12/21/2018 | 05/31/2019 |
| P-18-0322 | Generic: Heteromonocycle, 4,6-dimethyl-2-(1 -phenylethyl)- | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment for the intended conditions of use and EPA’s issuance of a proposed SNUR to address certain reasonably foreseen uses. View the determination document and the terms of the SNUR. | 09/21/2018 | 05/31/2019 |
| P-18-0321 | Generic: Poly(oxy-ethanediyl), (methyl ethanediyl) bis[hydroxy-, | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 09/21/2018 | 05/31/2019 |
| P-18-0270 | Generic: Ethanol, 2-butoxy-, 1,1'-ester | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment for the intended conditions of use and EPA’s issuance of a proposed SNUR to address certain reasonably foreseen uses. View the determination document and the terms of the SNUR. | 08/06/2018 | 05/31/2019 |
| P-18-0247 P-18-0248 P-18-0249 P-18-0250 P-18-0251 P-18-0252 | Generic (P-18-0247): Isocyanic acid, polymethylenepolyphenylene ester, polymer with 2-ethyl-2-(hydroxymethyl)-1,3-propanediol, polyetherpolyol, .alpha.,alpha.' -[(1- methylethylidene)di-4,1-phenylene]bis[.omega. -hydroxypoly(oxy-1,2-ethanediyl)] and 1,2- propanediol, iso-Bu alc.- and 2-butoxyethanol- and 2-(2-butoxyethoxy)ethanol- and Et alc.- and methanol-and 1-methoxy-2-propanol-blocked, Generic (P-18-248): Isocyanic acid, polymethylenepolyphenylene ester, polymer with polyetherpolyol, 2-butoxyethanol- and 2-(2-butoxyethoxy) ethanol- and methanol blocked, Generic (P-18-249): Isocyanic acid, polymethylenepolyphenylene ester, polymer with polyetherpolyol, 2-butoxyethanol- and 2-(2-butoxyethoxy)ethanol- and methanol and 1-methoxy-2-propanol-blocked Generic (P-18-0250): is Isocyanic acid, polymethylenepolyphenylene ester, polymer with polyetherpolyol, 2-butoxyethanol- and 2-(2-butoxyethoxy)ethanol- and 1(or2)-(2-methoxymethylethoxy)propanol-blocked Specific (P-18-0251): Isocyanic acid, polymethylenepolyphenylene ester, 2-butoxyethanol-and 2-(2-butoxyethoxy)ethanol- and methanol- and 1(or2)-(2-methoxymethylethoxy)propanol-blocked Specific (P-18-0252): Isocyanic acid, polymethylenepolyphenylene ester, 2-butoxyethanol-and 2-(2-butoxyethoxy)ethanol- and methanol- and 1-methoxy-2-propanol-blocked | The chemical substances are not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 07/18/2018 | 04/29/2019 |
| P-18-0234 | Generic: Alkenoic acid, reaction products with bis substituted alkane and ether polyol | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment for the intended conditions of use and EPA’s issuance of a proposed SNUR to address certain reasonably foreseen uses. View the determination document and the terms of the SNUR. | 07/06/2018 | 05/31/2019 |
| P-18-0228 | Generic: Branched alkenyl acid, alkyl ester,homopolymer | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment for the intended conditions of use and EPA’s issuance of a proposed SNUR to address certain reasonably foreseen uses. View the determination document and the terms of the SNUR. | 08/30/2018 | 05/31/2019 |
| P-18-0091 | Generic: Vegetable oil, polymers with diethylene glycol- and polyol- and polyethylene glycol-depolymd poly(ethylene terephthalate) waste plastics and arylcarboxylic acid anhydride | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 01/17/2018 | 05/31/2019 |
| P-17-0253 | Generic: Oxirane, 2-methyl-, polymer with oxirane, methyl 2-(substituted carbomonocycle isoquinolin- 2(3H)-yl) propyl ether | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination* *In EPA’s original screening analysis for this PMN in 2017, EPA identified potential for risk to workers for lung effects, which resulted in the interim finding. The PMN submitter provided acute and 5-day inhalation toxicity studies and also provided an updated Safety Data Sheet. EPA's final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA's risk assessment for the chemical substance under the intended conditions of use described in the PMN where, based on the submitted data, a lower level of respiratory protection is expected to mitigate lung effects than the level estimated in the original screening analysis, and employers will require and workers will use appropriate personal protective equipment in a manner adequate to protect them. View the determination document. | 03/14/2017 | 04/24/2019 |
| P-16-0425 | Generic: Amino-silane | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination* *In EPA’s original screening analysis for this PMN in 2016, EPA identified potential risks to workers, which resulted in the interim finding. Based on additional information provided by the submitter, EPA revised its assessment for the intended conditions of use. EPA’s final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA’s revised risk assessment for the chemical substance under the intended conditions of use, where EPA expects that employers will require and workers will use appropriate personal protective equipment in a manner adequate to protect them, and EPA’s issuance of a proposed SNUR to address certain reasonably foreseen uses. Conditions of use that fall under the restrictions of the proposed SNUR are not likely to present unreasonable risk of injury to health or the environment because (1) those conditions of use are not likely to be commenced during the pendency of the proposed SNUR and (2) upon finalization of the SNUR those conditions of use would be prohibited unless and until EPA makes an affirmative determination that the significant new use is not likely to present an unreasonable risk or takes appropriate action under section 5(e) or 5(f). View the determination document and the terms of the SNUR. | 06/22/2016 | 05/31/2019 |
| P-16-0314 | Specific: Ethanone, 1-(5-propyl-1,3-benzodioxol-2-yl)- | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 06/22/2016 | 05/28/2019 |
| J-19-0018 | Generic: Protein-producing modified microorganism, with chromosomally-borne modifications | The microorganism is not likely to present an unreasonable risk (5(a)(3)(C)) | The microorganisms are not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document. | 03/05/2019 | 05/29/2019 |
| P-18-0339 | Generic: Alkyl heteromonocycle with heteroatom substituted alkyl cycloalkane and 2-hydroxyethyl heteromonocycle methacrylate-blocked homopolymer | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 09/26/2018 | 05/20/2019 |
| P-18-0220 | Generic: Heteromonocycle [(alkylalkylidene)bis (substituted carbomoncycle)]bis-, polymer with alkyl isocyanate, alkenoate (ester) | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 06/21/2018 | 05/21/2019 |
| P-18-0120 | Specific: 1H-Pyrrole-2,5-dione, 1,1'-C36- alkylenebis-; CASRN: 1911605-95-2 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 02/28/2018 | 05/20/2019 |
| P-19-0057 | Generic: Alkanamine, [(Alkoxy)alkoxy]alkyl] alkyl | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 02/21/2019 | 05/14/2019 |
| P-19-0060 P-19-0061 | P-19-0060: Aliphatic hydrocarbons, C8-C18-branched and linear P-19-0061: Aliphatic hydrocarbons, C16-20-branched and linear | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 02/23/2019 | 05/15/2019 |
| P-19-0056 | Generic: P-19-0056: Aliphatic hydrocarbons, C8-C20-branched and linear P-19-0060: Aliphatic hydrocarbons, C8-C18- branched and linear P-19-0061: Aliphatic hydrocarbons, C16-20- branched and linear | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 02/15/2019 | 05/15/2019 |
| P-19-0054 | Generic: Polyamines, reaction products with succinic anhydride polyalkenyl derivs, metal salts, Polyamines, reaction products with succinic anhydride polyalkenyl derivs, metal salts. | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 02/11/2019 | 05/10/2019 |
| P-17-0245 | Generic: Unsaturated polyfluoro ester | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination *In EPA’s original screening analysis for this PMN in 2017, EPA identified potential risk to workers and the general population and that the substance may degrade to a persistent, bioaccumulative, and toxic chemical, which resulted in the interim finding. The submitter provided additional information indicating there will be no releases to water and that disposal of wastes will be by RCRA-certified hazardous waste incineration. EPA’s final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA’s risk assessment for the chemical substance under the intended conditions of use described in the PMN and EPA’s issuance of a proposed SNUR to address certain reasonably foreseen uses. Conditions of use that fall under the restrictions of the proposed SNUR are not likely to present unreasonable risk of injury to health or the environment because (1) those conditions of use are not likely to be commenced during the pendency of the proposed SNUR and (2) upon finalization of the SNUR those conditions of use would be prohibited unless and until EPA makes an affirmative determination that the significant new use is not likely to present an unreasonable risk or takes appropriate action under section 5(e) or 5(f). View the determination document and the terms of the SNUR. | 02/28/2017 | 04/15/2019 |
| P-17-0152 | Generic: Poly-(2-methyl-1-oxo-2-propen-1-yl) ester with Ethanaminium, N,N,N-trialkyl, chloride and methoxypoly(oxy-1,2-ethanediyl) | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination *In EPA’s original screening analysis for this PMN in 2017, EPA identified potential for lung effects from cationic binding and risk to the environment, which resulted in the interim finding. Based on amendments to the PMN, EPA revised its assessment for the intended conditions of use. EPA’s final determination that the new chemical is not likely to present unreasonable risk is based on EPA’s risk assessment for the chemical substance under the intended conditions of use described in the amended PMN where estimated releases to water are lower than in the initial assessment and inhalation exposures are not expected, and EPA’s issuance of a proposed SNUR to address certain reasonably foreseen uses. Conditions of use that fall under the restrictions of the proposed SNUR are not likely to present unreasonable risk of injury to health or the environment because (1) those conditions of use are not likely to be commenced during the pendency of the proposed SNUR and (2) upon finalization of the SNUR those conditions of use would be prohibited unless and until EPA makes an affirmative determination that the significant new use is not likely to present an unreasonable risk or takes appropriate action under section 5(e) or 5(f). View the determination document and the terms of the SNUR. | 11/23/2016 | 04/15/2019 |
| P-16-0422 | Specific: 1,2-Cyclohexanedicarboxylic acid, 1- (phenylmethyl) ester, ester with 2,2,4-trimethyl-1,3-pentanediol mono(2-methylpropanoate) (CASRN: 1661012-65-2) | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination *In EPA’s original screening analysis for this PMN in 2016, EPA identified potential human health risk to workers and chronic risk to the environment, which resulted in the interim finding. The submitter provided new information including a proposed new analogue to be used in the human health and environmental assessment, new process information including waste water treatment efficiency, and new information on releases. EPA’s final determination that the new chemical is not likely to present unreasonable risk is based on EPA’s risk assessment for the chemical substance under the intended conditions of use described in the amended PMN, where worker exposure is expected to be controlled through the use of appropriate PPE, where submitter controls will keep water releases below the concentration of concern, and EPA’s issuance of a proposed SNUR to address certain reasonably foreseen uses. Conditions of use that fall under the restrictions of the proposed SNUR are not likely to present unreasonable risk of injury to health or the environment because (1) those conditions of use are not likely to be commenced during the pendency of the proposed SNUR and (2) upon finalization of the SNUR those conditions of use would be prohibited unless and until EPA makes an affirmative determination that the significant new use is not likely to present an unreasonable risk or takes appropriate action under section 5(e) or 5(f). View the determination document and the terms of the SNUR. | 06/22/2016 | 04/15/2019 |
| P-14-0482 | Generic: Organic salt | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk' section 5(a)(3)(C) determination *In EPA’s original screening analysis for this PMN in 2014, EPA identified potential human health risk to workers, substantial releases, and risk to the environment, which resulted in the interim finding. The submitter amended the PMN, revising the production volume and intended conditions of use. EPA’s final determination that the new chemical is not likely to present unreasonable risk is based on EPA’s risk assessment for the chemical substance under the intended conditions of use described in the amended PMN where worker exposure is expected to be controlled through the use of appropriate PPE, expected releases to the environment are lower than originally estimated, and EPA’s issuance of a proposed SNUR to address certain reasonably foreseen uses. Conditions of use that fall under the restrictions of the proposed SNUR are not likely to present unreasonable risk of injury to health or the environment because (1) those conditions of use are not likely to be commenced during the pendency of the proposed SNUR and (2) upon finalization of the SNUR those conditions of use would be prohibited unless and until EPA makes an affirmative determination that the significant new use is not likely to present an unreasonable risk or takes appropriate action under section 5(e) or 5(f). View the determination document and the terms of the SNUR. | 06/22/2016 | 04/15/2019 |
| P-19-0046 | Specific: 1,2,4-Benzenetricarboxylic acid, mixed decyl and octyl triesters; CASRN 90218-76-1 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 01/31/2018 | 04/26/2019 |
| P-18-0266 | Specific: Alkanes, C20-45 branched and linear; CASRN: 2133415-24-2 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 07/30/2018 | 04/25/2019 |
| P-18-0188 | Generic: Alkyl substituted alkenoic acid, alkyl ester, polymer with alkanediol alkyl-alkenoate, reaction products with alkenoic acid, isocyanato -(isocyanatoalkyl)-alkyl substituted carbomonocycle and substituted alkanediol | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 05/23/2018 | 05/02/2019 |
| P-18-0406 | Generic: Formaldehyde, polymer with alkyl aryl ketones | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 09/30/2018 | 05/02/2019 |
| P-18-0305 | Generic: Alkenoic acid, alkyl-,alkyl ester, polymer with alkyl alkenoate, substituted heteromonocycycle, substituted carbomonocycle, substituted alkanediol and alkenoic acid, alkali metal salt | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 09/12/2018 | 02/23/2019 |
| P-18-0186 | Generic: Polyolefin ester | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 05/22/2018 | 04/24/2019 |
| J-19-0012, J-19-0013 J-19-0014 J-19-0015 | Generic: Biofuel producing Saccharomyces cerevisiae modified, genetically stable | The microorganisms are not likely to present an unreasonable risk (5(a)(3)(C)) | The microorganisms are not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document. | 01/31/2019 | 04/26/2019 |
| J-19-0017 | Generic: Genetically modified microorganism for the production of a chemical substance | The microorganism is not likely to present an unreasonable risk (5(a)(3)(C)) | The microorganisms are not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document. | 02/01/2019 | 04/18/2019 |
| J-19-0011 | Generic: Genetically modified microorganism for the production of a chemical substance | The microorganism is not likely to present an unreasonable risk (5(a)(3)(C)) | The microorganisms are not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document. | 01/31/2019 | 04/18/2019 |
| P-19-0045 | Generic: Non-metal tetrakis (hydroxyalkyl)-, halide, polymer with amide oxidized | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 12/21/2018 | 04/18/2019 |
| P-19-0032 | Generic: Carbonic dichloride, polymer with 4,4'-(1-methylethylidene)bis[phenol] ester, polymer with tetrol and polyether tetrol | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 12/19/2018 | 04/17/2019 |
| P-19-0030 | Generic: Triethanolamine modified Phosphinicocarboxylates, sodium salts | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 12/18/2018 | 04/24/2019 |
| P-18-0375 | Specific: Fats and Glyceridic oils, vegetable, sulfonated,sodium salts (CASRN: 97489-04-8) | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 10/10/2018 | 04/18/2019 |
| P-18-0312 | Generic: Formaldehyde, polymer with 2- phenoxyalkanol and .alpha.-phenyl-.omega. hydroxypoly(oxy-1,2-alkylnediyl), dihydrogen phosphate 2-phenoxyalkyl hydrogen phosphate, alkaline salt | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 09/20/2018 | 04/18/2019 |
| P-18-0122 | Generic: Alkylamide, polymer with alkylamine, formaldehyde, and polycyanamide, alkyl acid salt | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment for the intended conditions of use and EPA’s issuance of a proposed SNUR to address certain reasonably foreseen uses. View the determination document. and the terms of the SNUR. | 03/01/2018 | 04/15/2019 |
| P-19-0040 | Generic: Alkyl bis(dialkylamino alkyl) amide, | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 12/20/2018 | 04/18/2019 |
| P-19-0010 | Generic: Hydrogenated fatty acid dimers, polymers with 1,1'-methylenebis[4- isocyanatobenzene], polypropylene glycol, polypropylene glycol ether with trimethylolpropane (3:1), and 1,3-propanediol, propylene glycol monomethacrylate-blocked | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment for the intended conditions of use and EPA’s issuance of a proposed SNUR to address certain reasonably foreseen uses. View the determination document. and the terms of the SNUR. | 10/29/2018 | 04/15/2019 |
| P-18-0222 | Generic: Silane, alkenylalkoxy-, polymer with alkene and alkene | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment for the intended conditions of use and EPA’s issuance of a proposed SNUR to address certain reasonably foreseen uses. View the determination document. and the terms of the SNUR. | 06/22/2018 | 04/15/2019 |
| P-18-0162 | Generic: Cashew nutshell liquid, polymer with diisocyanatoalkane, substituted-polyoxyalkyldiol and polyether polyol | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment for the intended conditions of use and EPA’s issuance of a proposed SNUR to address certain reasonably foreseen uses. View the determination document. and the terms of the SNUR. | 05/08/2018 | 04/15/2019 |
| P-17-0239 | Generic: Substituted carboxylic acid, polymer with 2,4-diisocyanato-1-methylbenzene, hexanedioic acid, alpha-hydro-omega-hydroxypoly[oxy(methyl-1,2- ethanediyl)], 1,1'-methylenebis[4- isocyanatobenzene], 2,2'-oxybis[ethanol], 1,1'-oxybis [2-propanol] and 1,2-propanediol. | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment for the intended conditions of use and EPA’s issuance of a proposed SNUR to address certain reasonably foreseen uses. View the determination document. and the terms of the SNUR. | 06/05/2017 | 04/15/2019 |
| P-18-0073 | Specific: Sulfuric acid, ammonium salt (1:?) | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment for the intended conditions of use and EPA’s issuance of a proposed SNUR to address certain reasonably foreseen uses. View the determination document. and the terms of the SNUR. | 12/21/2017 | 04/15/2019 |
| P-18-0048 | Specific: Acetic acid, 2-(2-butoxyethoxy) -; (CASRN: 82941-26-2) | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment for the intended conditions of use and EPA’s issuance of a proposed SNUR to address certain reasonably foreseen uses. View the determination document. and the terms of the SNUR. | 11/13/2017 | 04/15/2019 |
| P-17-0284 | Specific: 2-Heptanone, 4-hydroxy-, CASRN: 25290-14-6 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 04/13/2017 | 04/10/2019 |
| P-17-0285 | Specific: 4-Hepten-2-one, CASRN: 24332-22-7 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk section 5(a)(3)(C) determination* *In EPA’s original screening analysis for this PMN in 2017, EPA identified potential for risk to workers from inhalation and dermal exposure and risk to the general population from exposure from drinking water, which resulted in the interim finding. The PMN submitter provided additional information on potential releases to water and also provided an updated Safety Data Sheet. EPA's final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA's risk assessment for the chemical substance under the intended conditions of use described in the PMN where expected releases to water are lower than those estimated in the original screening analysis, and workers will use appropriate personal protective equipment in a manner adequate to protect them. View the determination document. | 04/13/2017 | 04/10/2019 |
| P-19-0035 | Specific: Acetamide, 2-(4-methylphenoxy)-N-1H-pyrazol-3-yl-N-(2-thienylmethyl)-;CASRN: 1374760-95-8 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 12/11/2018 | 03/28/2019 |
| P-19-0037 | Generic: D-Glucaric acid, mixed alkali metal salt | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 12/11/2018 | 04/12/2019 |
| P-16-0602 | Generic: Carbonic acid, dialkyl ester, polymers with 5-amino-1,3,3- trimethylcycloalkanemethanamine, 2-ethyl-1- alcohol-blocked 1,6-diisocyanatoalkane homopolymer and 1,6-alkanediol and trimethylolakane | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk section 5(a)(3)(C) determination* *In EPA’s original screening analysis for this PMN in 2016, EPA identified potential for risk for lung effects, which resulted in the interim finding. The PMN submitter provided additional information on the intended use, which indicated inhalation exposure to workers is not expected. EPA's final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA's risk assessment for the chemical substance under the intended conditions of use described in the PMN where inhalation exposure is not expected. View the determination document. | 09/30/2016 | 04/10/2019 |
| P-16-0446 | Generic: Fatty acids, reaction products with alkylamine, polymers with substituted carbomonocycle, substituted alkylamines, heteromonocycle and substituted alkanoate, lactates (salts) | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk section 5(a)(3)(C) determination* *In EPA’s original screening analysis for this PMN in 2016, EPA identified potential for risk for lung effects from cationic binding and potential for high releases and risk to the environment, which resulted in the interim finding. The PMN submitter provided an acute inhalation toxicity study and clarified release and exposure parameters. EPA's final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA's risk assessment for the chemical substance under the intended conditions of use described in the PMN where expected releases to water are lower than those estimated in the original screening analysis, and lung effects are no longer expected based on the submitted data as well as particle size and the proportion of cationic amine moieties present in the polymer. View the determination document. | 06/24/2016 | 04/16/2019 |
| P-19-0003 | Generic: Polyaromatic ether symmetrical dicarboxylic anhydride | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 12/20/2018 | 04/19/2019 |
| P-18-0174 | Generic: Enzyme | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 05/09/2018 | 04/16/2019 |
| P-18-0229 | Generic: Modified branched alkenyl acid, alkyl ester, homopolymer, | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 08/30/2018 | 03/28/2019 |
| P-18-0179 P-18-0180 P-18-0181 | Generic (P-18-0179): Phenol, polymer with formaldehyde and phenolic resin, sodium salt Generic (P-18-0180): Phenol, polymer with formaldehyde and phenolic resin, potassium salt Generic (P-18-0181): Phenol, polymer with formaldehyde and phenolic resin, potassium sodium salt | The chemical substances are not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substances are not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 05/16/2018 | 03/28/2019 |
| P-19-0027 | Generic: Substituted Carbomoncycle, polymer with haloalkyl substituted heteromonocycle, dialkyl-alkanediamine and hydro-hydroxypoly [oxy(alkylalkanediyl)], reaction products with metal oxide and dialkanolamine, acetates (salts). | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 11/28/2018 | 04/03/2019 |
| P-18-0085 | Generic: Fatty acids reaction products with ethyleneamines and dialkyl ester | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 01/08/2018 | 03/15/2019 |
| P-18-0101 | Generic: Pentaerythritol, mixed esters with linear and branched fatty acids | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 01/26/2018 | 03/29/2019 |
| P-17-0191 | Generic: Alkyldiamine, aminoalkyl dimethylaminoalkyl dimethyl-, reaction products with propylene oxide | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk section 5(a)(3)(C) determination* *In EPA’s original screening analysis for this PMN in 2017, EPA identified neurotoxicity and corrosion as hazards and the potential for risk to workers from dermal exposure and risk to the general population from exposure from drinking water and fish ingestion, which resulted in the interim finding. The PMN submitter clarified that the new chemical substance would not be released to water, and wastes would be incinerated. EPA's final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA's risk assessment for the chemical substance under the intended conditions of use described in the PMN where there will be no releases to water, and workers will use appropriate personal protective equipment in a manner adequate to protect them. View the determination document. | 01/25/2017 | 03/28/2019 |
| P-17-0220 | Generic: 2-Oxepanone, reaction products with alkylenediamine-alkyleneimine polymer, 2-[[(2-alkyl)oxy]alkyl]oxirane and tetrahydro-2H- pyran-2-one | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk section 5(a)(3)(C) determination* *In EPA’s original screening analysis for this PMN in 2017, EPA identified potential for risk for lung effects from cationic binding and potential for risk to the environment, which resulted in the interim finding. The PMN submitter clarified the processes used for equipment cleaning and handling of wastes and provided processing information indicating that although there may be potential for worker inhalation exposure, cationic binding will not occur because of interaction of the new chemical substance with another substance in the formulation. EPA's final determination that the new chemical substance is not likely to present unreasonable risk is based on EPA's risk assessment for the chemical substance under the intended conditions of use described in the PMN where estimated surface water concentrations indicate unreasonable risk to the environment is not likely and lung effects are not likely. View the determination document. | 01/25/2017 | 03/28/2019 |
| P-19-0026 | Generic: Alkanoic acid, compounds with substituted carbomonocycle-dialkyl- alkanediaminehalosubstitued heteromonocycle- polyalkylene glycol polymerdialkanolamine reaction products | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 11/27/2018 | 03/26/2019 |
| P-18-0307 | Generic: Alkyl Alkenoic acid, alkyl ester, telomer with alkyl alkenoate, substituted alkyl alkyl alkenoate, alkylthiol, substituted carbomonocycle, hydroxyalkyl alkyl alkenoate and alkyl alkyl alkenoate | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 09/14/2018 | 03/21/2019 |
| P-19-0009 | Generic: Carbonmonocycles, polymer with haloalkyl substituted heteromonocycle and hydro-hydroxypoly [oxy(alkyl-alkanediyl)], dialkyl- alkanediamineterminated, hydroxyalkylated, acetates (salts). | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 10/23/2018 | 03/15/2019 |
| P-18-0284 | Generic: Inorganic acid, reaction products with alkyl alcohol | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 08/27/2018 | 03/15/2019 |
| P-18-0278 | Generic: Isophthalic acid, polymer with terephthalic acid and C4 and C6 dialkyl amines | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 08/16/2018 | 03/13/2019 |
| J-19-0006 J-19-0007 J-19-0008 | Generic: Genetically modified microorganism for the production of a chemical substance | The microorganisms are not likely to present an unreasonable risk (5(a)(3)(C)) | The microorganisms are not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document. | 11/16/2018 | 03/08/2019 |
| P-19-0025 | Specific: 11-Docosene, CASRN 62978-77-2 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 11/19/2018 | 03/08/2019 |
| P-19-0021 P-19-0022 | P-19-0021: Generic: Hydroxyalkyl carboxylic acid, polymer with alkylamine, alkylene carbonate, alkanediol, isocyanate, compd. with alkylamine P-19-0022: Generic: Hydroxyalkyl carboxylic acid, polymer with alkylamine, alkyl carbonate, alkanediol, isocyanate, compd. with alkylamine | The chemical substances are not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 11/12/2018 | 03/08/2019 |
| P-19-0002 | Generic: Polyaromatic symmetrical tetracarboxylic acid | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 12/28/2018 | 03/08/2019 |
| P-18-0272 | Generic: Metal, alkylcarboxylate oxo complexes | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 08/07/2018 | 03/08/2019 |
| P-18-0169 | Generic: Propanoic acid, 3-hydroxy-2- (hydroxymethyl)-2-methyl-, polymer with dimethyl carbonate, 1,6-hexanediol, diamine and 1,1'- methylenebis[4-isocyanatocyclohexane], acrylate- blocked, compds. with triethylamine | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 05/07/2018 | 02/28/2019 |
| P-17-0119 | Generic: Alkyl alkenoic acid, alkoxyalkyl ester, polymer with alkyl alkenoate, alkyl alkyl alkenoate and tris alkyl silyl alkyl alkenaote | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 06/26/2017 | 02/28/2019 |
| P-18-0077 | Specific: Urea, reaction products with N- butylphosphorothioic triamide and formaldehyde (CASRN: 2093385-47-6) | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 12/27/2017 | 12/03/2018 |
| P-18-0132 | Generic: Substituted benzene, 4-methoxy-2-nitro- 5-[2-[(1E)-1-[[(2-methoxyphenyl)amino]carbonyl]-2-oxopropylidene]hydrazinyl]-, sodium salt (1:1) | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 03/20/2018 | 02/26/2019 |
| P-18-0107 | Generic: Alcohol capped polycarbodiimide from diethyldiisocyanatobenzene. | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 02/06/2018 | 02/28/2019 |
| P-18-0118 P-18-0119 | Generic (P-18-0118): Oxirane, 2-methyl-, polymer with methoxirane homopolymer, 1,1'-methylenebis[4-isocyanatobenzene], and glycerol-propylene oxide polymer. Generic (P-18-0119): Oxirane, 2-methyl-, polymer with methoxirane homopolymer, 1,1'- methylenebis [isocyanatobenzene], and glycerol-propylene oxide polymer. | The chemical substances are not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 02/26/2018 | 02/28/2019 |
| P-18-0379 | Generic: Cashew nutshell liquid polymer with Epichlorohydrin, formaldehyde, phenol, amines and glycol. | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 09/28/2018 | 02/28/2019 |
| P-18-0277 | Generic: Poly[2-(Dimethylamino)ethyl acrylate chloride salt, vinyl acetate, methacrylic acid and alkyl acrylates] | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 08/28/2018 | 02/28/2019 |
| P-19-0007 | Generic: Alkenoic acid, alkyl-, hydroxyalkyl ester, polymer with alkyl-alkenoate, alkenylcarbomonocycle, hydroxyalkyl-alkenoate, alkyl substituted alkenoate and heteromonocycle, alkyl substituted peroxoate-initiated, polymers with [substituted alkanenitrile]-initiated acrylic acid-alkane acrylates-alkyl substituted carbomoncycle polymer; polymer exemption flag. Polymer exemption flag: The chemical must be manufactured such that it meets the polymer exemption criteria as described under 40 CFR §723.250(e)(1), in addition to meeting the definition of polymer at 40 CFR §723.250(b). | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 10/16/2018 | 02/28/2019 |
| P-17-0387 P-17-0388 | Generic: Dicarboxylic acids, polymers with alkanoic acid, alkanediol, susbtituted-alkylalkanoic acid, substituted alkyl carbomonocyle, alkanedioic acid and alkanediol, alkanolamine blocked compds with alkanolamine. | The chemical substances are not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substances are not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 08/30/2017 | 02/28/2019 |
| P-19-0008 | Generic: Substitued polyalkylenepolycarbomonocycle ester, polymer with dialkanolamine, (hydroxyalkoxy) carbonyl] derivs., (alkoxyalkoxy) alkanol blocked | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 10/22/2018 | 02/08/2019 |
| P-18-0238 | Generic: Saccharide reaction products with acid anhydride, etherified | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 07/16/2016 | 02/13/2019 |
| P-16-0400 | Specific: Alkanes, C11-16-branched and linear; CASRN: 1809170-78-2 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | Not likely to present an unreasonable risk section 5(a)(3)(C) determination* *In EPA’s original screening analysis for this PMN in 2016, EPA identified potential for health effects and risk to the environment, which resulted in the interim finding. Upon further review of submitted data on analogous chemical substances, EPA revised its hazard and risk assessment for the new chemical substance. EPA's final determination that the chemical substance is not likely to present unreasonable risk is based on EPA's revised risk assessment for the chemical substance under the conditions of use. View the determination document. | 06/22/2016 | 12/21/2018 |
| P-18-0020 | Specific: Butanedioic acid, polymer with 2-ethyl-2- (hydroxymethyl)-1,3-propanediol, 2,5-furandione and 1,3-propanediol, 3a,4,5,6,7,7a-hexahydro-4,7- methano-1H-inden-5(or 6)-yl ester | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 10/16/2017 | 02/05/2019 |
| J-18-0045 | Generic: Biofuel producing Saccharomyces cerevisiae modified, genetically stable | The microorganism is not likely to present an unreasonable risk (5(a)(3)(C)) | The microorganism is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. S. cerevisiae is not pathogenic to humans or animals and has an extensive history of safe use in food processing. View the determination document. | 09/27/2018 | 12/19/2018 |
| J-18-0046 J-18-0047 | Generic: Genetically modified microorganism | The microorganisms are not likely to present an unreasonable risk (5(a)(3)(C)) | The microorganisms are not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document. | 09/30/2018 | 12/19/2018 |
| J-19-0002 J-19-0002 J-19-0004 | Generic: Genetically modified microorganism | The microorganisms are not likely to present an unreasonable risk (5(a)(3)(C)) | The microorganisms are not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document. | 10/05/2018 | 12/19/2018 |
| P-18-0221 | Generic: Polyglycerol reaction product with acid anhydride, etherified | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 06/21/2018 | 12/21/2018 |
| P-18-0324 | Generic: Organic acid dimethyl ester, polymer with mixed alkanediols and 5-isocyanato-1- (isocyanatomethyl)-1,3,3-trimethylcyclohexane, trimethoxysilylalkylalkanamine-blocked | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 09/24/2018 | 12/20/2018 |
| P-19-0006 | Generic: Diisocyanate polymer blocked with alkoxyamine | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 10/09/2018 | 12/20/2018 |
| P-17-0281 | Generic: Polysiloxane-polyester polyol carboxylate | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C))* | *In EPA's original screening analysis for this PMN in 2017, EPA identified potential for risk to workers. EPA's final determination that the chemical substance is not likely to present unreasonable risk is based on EPA's risk assessment for the chemical substance under the intended and reasonably foreseen conditions of use where EPA expects that workers will use appropriate personal protective equipment, consistent with the Safety Data Sheet (SDS) prepared by the PMN submitter, in a manner adequate to protect them. View the determination document. | 04/21/2017 | 12/04/2018 |
| P-18-0007 P-18-0008 | Specific (P-18-0007): Glycerides, soya mono- and di-, epoxidized, acetates (CASRN: 2097734-14-8) Specific (P-18-0008): Glycerides, C16-18 and C18- unsatd. mono- and di-, epoxidized, acetates (CASRN: 2097734-15-9) | The chemical substances are not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substances are not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 10/04/2017 | 12/11/2018 |
| P-18-0212 | Generic: Substituted carbomonocycle, polymer with alkyl alkenoate, alkenyl substituted carbomonocycle, substituted alkanediol, heteropolycycle, alkylene glycol and alkenoic acid, compd. with alkylamino alkanol; polymer exemption flag. Polymer exemption flag: The chemical must be manufactured such that it meets the polymer exemption criteria as described under 40 CFR §723.250(e)(1), in addition to meeting the definition of polymer at 40 CFR §723.250(b) | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 06/14/2018 | 11/30/2018 |
| SN-15-0009 | Generic: Fatty acid amide | The significant new use is not likely to present an unreasonable risk (5(a)(3)(C)) | The significant new use is not likely to present an unreasonable risk of injury to health or the environment under the conditions of use, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator, based on the risk assessment. View the determination document. | 06/22/2016 | 12/12/2018 |
| P-18-0219 | Generic: Polythioether, short chain diol polymer terminated with aliphatic diisocyanate | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 06/20/2018 | 12/12/2018 |
| P-18-0068 | Generic: Metal, oxo alkylcarboxylate complexes | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 12/13/2017 | 12/12/2018 |
| J-18-0042 J-18-0043 | Generic: Biofuel producing Saccharomyces cerevisiae modified, genetically stable | The microorganisms are not likely to present an unreasonable risk (5(a)(3)(C)) | The microorganisms are not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. S. cerevisiae is not pathogenic to humans or animals and has an extensive history of safe use in food processing. View the determination document. | 08/15/2018 | 11/29/2018 |
| P-18-0319 | Generic: Plant oil fatty acids, alkyl esters | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 09/20/2018 | 12/04/2018 |
| P-18-0152 | eneric: Hydrolyzed functionalized di-amino silanol polymer | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 04/20/2018 | 11/29/2018 |
| P-18-0147 | Generic: Phenol, 4-ethenyl-, 1-substituted, polymer with 1-(1,1-substituted)-4-ethenylbenzene and ethenylbenzene, 2, 2'-(1,2-diazenediyl)bis[2- substituted]-initiated, hydrolyzed | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented below. Although EPA estimated that the new chemical substance could be very persistent, the chemical substance has low potential for bioaccumulation, such that repeated exposures are not expected to be cumulative. Based on analogous chemical substances, EPA estimates that the chemical substance has low environmental hazard and the potential for the following human health hazard: irritation. EPA concludes that the new chemical substance is not likely to present an unreasonable risk to human health or the environment under the conditions of use. View the determination document. | 04/04/2018 | 11/29/2018 |
| P-18-0279 | Generic: Substituted heteromonocycle, polymer with substituted alkanediol and diisocyanate substituted carbomonocyle, alkylene glycol acrylate-blocked | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented below. Although EPA estimated that the new chemical substance could be very persistent, the new chemical substance has low potential for bioaccumulation, such that repeated exposures are not expected to be cumulative. Based on EPA’s TSCA New Chemicals Program Chemical Category for Acrylates and test data on analogous chemical substances, EPA estimates that the chemical substance has low environmental hazard and potential for the following human health hazards: irritation and sensitization. EPA concludes that the new chemical substance is not likely to present an unreasonable risk under the conditions of use.View the determination document. | 08/16/2018 | 11/21/2018 |
| P-18-0136 | Generic: 1-Butanaminium, N,N,N-tributyl-, 2(or5)- [[benzoyldihydrodioxo[(sulfophenyl)amino] heteropolycycle]oxy]-5(or 2)-(1,1- dimethylpropyl)benzenesulfonate (2:1) | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented below. Although EPA estimated that the new chemical substance could be very persistent, the new chemical substance has low potential for bioaccumulation, such that repeated exposures are not expected to be cumulative. Based on EPA’s TSCA New Chemicals Program Chemical Category for Acid Dyes and Amphoteric Dyes2 and test data on the chemical substance and analogous chemical substances, EPA estimates that the chemical substance has moderate environmental hazard and potential for the following human health hazards: systemic toxicity from repeated exposures. EPA concludes that the new chemical substance is not likely to present an unreasonable risk under the conditions of use. View the determination document. | 04/09/2018 | 11/20/2018 |
| P-17-0382 | Specific: Amides, tallow, N,N-bis(2-hydroxypropyl), CASRN 1454803-04-3 | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 08/24/2017 | 11/21/2018 |
| P-18-0054 | Generic: 2-Alkenoic acid, 2-alkyl-, 2-alkyl ester, polymer with alkyl 2-alkenoate, 2-substitutedalkyl 2-alkenoate and 2-substitutedalkyl 2-alkyl-2-alkenoate, esters with carboxylic acids, tert alkylperoxoate initiated; polymer exemption flag. | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 11/20/2017 | 11/21/2018 |
| P-18-0078 | Generic: 2-Alkenoic acid, 2-alkyl-, 2- alkyl ester, polymer with alkyl 2- alkenoate, 2-substitutedalkyl 2- alkenoate and 2-substitutedalkyl 2- alkyl-2-alkenoate, tert alkylperoxoate initiated; polymer exemption flag. | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 12/27/2017 | 11/21/2018 |
| P-18-0261 | Generic: Metal, alkylcarboxylate oxo complexes | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 07/26/2018 | 11/20/2018 |
| J-18-0044 | Specific: Saccharomyces cerevisiae NE095 | The microorganism is not likely to present an unreasonable risk (5(a)(3)(C)) | The microorganism is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document. | 08/30/2018 | 11/20/2018 |
| J-18-0041 | Generic: E. coli K-12 C003: Arsenic detecting strain of E. coli with extra-chromosomal elements, including an intergeneric screening marker | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The new microorganism is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 08/09/2018 | 11/07/2018 |
| P-18-0233 | Generic: Alkyl Alkenoic acid, alkyl ester, telomer with alkylthiol, substituted carbomonocycle, substituted alkyl alkyl alkenoate and hydroxyalkyl alkenoate, tert-butyl alkyl peroxoate -initiated | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 07/06/2018 | 11/02/2018 |
| P-18-0224 P-18-0225 | Generic (P-18-0224): Alkenoic acid, polymer with alkenylcarbomonocycle, [alkanediylbis(substitutedalkylene)] bis[heteromonocycle] and (alkylalkenyl) aromatic, salt Generic (P-18-0225): Alkenoic acid, polymer with substituted alkyloxirane, alkenylcarbomonocycle, alkyl substituted alkyl alkanediol and (alkylalkenyl) aromatic salt | The chemical substances are not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substances are not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 06/27/2018 | 10/30/2018 |
| P-18-0030 | Generic: Poly[oxy(methyl-alkylendiyl)], a,a',a''-1,2,3-alkanetriyltris[w-hydroxy-, polymer with 1,1'-alkylenebis[4-isocyanatocarbomonocycle], 2- substituted ethyl acrylate- and 2- substituted ethyl methacrylate- blocked | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. View the determination document. | 10/23/2017 | 10/30/2018 |
| J-18-0019 J-18-0020 J-18-0021 | Generic: Genetically modified microorganism | The microorganisms are not likely to present an unreasonable risk (5(a)(3)(C)) | The microorganisms are not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document. | 08/02/2018 | 10/30/2018 |
| J-18-0026 J-18-0027 | Generic: Biopolymer producing modified microorganism(s) with chromosomally-borne modifications | The microorganisms are not likely to present an unreasonable risk (5(a)(3)(C)) | The microorganisms are not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document. | 07/23/2018 | 10/19/2018 |
| P-18-0041 | Specific: 2,5-Furandione, polymer with 2-ethyl-2-(hydroxymethyl)-1,3- propanediol, 3a,4,5,6,7,7a-hexahydro- 4,7-methano-1H-inden-5(or 6)-yl ester, ester with 2,3-dihydroxypropyl neodecanoate; CASRN: none | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 11/06/2017 | 10/02/2018 |
| P-16-0581 | Generic (P-16-0581): alpha 1,3- polysaccharide | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C))* | *In EPA’s original screening analysis for this PMN in 2016, EPA identified potential for risk for inhalation of respirable particles, which resulted in the interim finding. Based on an amendment to the PMN indicating that respirable particles are not expected under the intended conditions of use, EPA revised its assessment for the intended conditions of use. EPA's final determination that the chemical substance is not likely to present unreasonable risk is based on EPA's risk assessment for the chemical substance under intended conditions of use in the PMN and EPA's issuance of a proposed SNUR to address certain reasonably foreseen uses. Conditions of use that fall under the restrictions of the proposed SNUR are not likely to present unreasonable risk of injury to health or the environment because (1) those conditions of use are not likely to be commenced during the pendency of proposed SNUR and (2) upon finalization of the SNUR those conditions of use would be prohibited unless and until EPA makes an affirmative determination that the significant new use is not likely to present an unreasonable risk or takes appropriate action under section 5(e) or 5(f). View the determination document and the terms of the SNUR. | 09/19/2016 | 10/09/2018 |
| P-16-0575 | Specific (P-16-0575, non-CBI): Glucosyltransferase (International Union of Biochemistry and Molecular Biology (IUBMB) enzyme nomenclature recommendations: IUBMB Number 2.4.1.5) | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C))* | *In EPA's original screening analysis for this PMN in 2016, EPA identified potential for risk if the substance is inhaled under reasonably foreseen conditions of use, which resulted in the interim finding. EPA's final determination that the chemical substance is not like to present unreasonable risk is based on EPA's risk assessment for the chemical substance under the intended conditions of use in the PMN where inhalation exposure is not expected, and EPA's issuance of a proposed SNUR to address certain reasonably foreseen uses. Conditions of use that fall under the restrictions of the proposed SNUR are not likely to present unreasonable risk of injury to health or the environment because (1) those conditions of use are not likely to be commenced during the pendency of proposed SNUR and (2) upon finalization of the SNUR those conditions of use would be prohibited unless and until EPA makes an affirmative determination that the significant new use is not likely to present an unreasonable risk or takes appropriate action under section 5(e) or 5(f). View the determination document and the terms of the SNUR. | 09/15/2016 | 10/09/2018 |
| P-16-0483 P-16-0484 | Generic (P-16-0483): Inorganic acids, metal salts, compds. with modified heteroaromatics Generic (P-16-0484): Inorganic acid, metal salt, compd. with substituted aromatic heterocycle | The chemical substances are not likely to present an unreasonable risk (5(a)(3)(C)) | *EPA's final determination that the chemical substances are not likely to present unreasonable risk is based on EPA's risk assessment for the chemical substances under intended conditions of use described in the PMN and EPA's issuance of a proposed SNUR to address certain reasonably foreseen uses. Conditions of use that fall under the restrictions of the proposed SNUR are not likely to present unreasonable risk of injury to health or the environment because (1) those conditions of use are not likely to be commenced during the pendency of proposed SNUR and (2) upon finalization of the SNUR those conditions of use would be prohibited unless and until EPA makes an affirmative determination that the significant new use is not likely to present an unreasonable risk or takes appropriate action under section 5(e) or 5(f). View the determination document and the terms of the SNUR. | 07/18/2016 | 10/09/2018 |
| P-16-0380 P-16-0381 P-16-0382 P-16-0383 P-16-0384 P-16-0385 | Generic (P-16-0380): Formic acid, compds. with hydrolyzed bisphenol A-epichlorohydrin-polyethylene glycol ether with bisphenol A (2:1) polymer-N1-(1,3-dimethylbutylidene)- N2-[2-[(1, 3-dimethylbutylidene) amino]ethyl]-1,2-ethanediamine- dialdehyde-2-(methylamino)ethanol reaction products acetates (salts). Generic (P-16-0381): Propanoic acid, 2-hydroxy-, compds. with hydrolyzed bisphenol A-epichlorohydrin- polyethylene glycol ether with bisphenol A (2:1) polymer-N1-(1,3-dimethylbutylidene)-N2-[2-[(1, 3-dimethylbutylidene)amino]ethyl]-1,2-ethanediamine-dialdehyde-2-(methylamino)ethanol reaction products formates (salts). Generic (P-16-0382): Formic acid, compds. with hydrolyzed bisphenol A- epichlorohydrin-polyethylene glycol ether with bisphenol A (2:1) polymer- N1-(1,3-dimethylbutylidene)-N2-[2-[(1, 3-dimethylbutylidene)amino]ethyl]- 1,2-ethanediamine-dialdehyde-2-(methylamino)ethanol reaction products sulfamates(salts). Generic (P-16-0383): Formic acid, compds. with hydrolyzed bisphenol A-epichlorohydrin-polyethylene glycol ether with bisphenol A (2:1) polymer-N1-(1,3-dimethylbutylidene)- N2-[2-[(1, 3-dimethylbutylidene)amino] ethyl]-1,2-ethanediamine-dialdehyde-2-(methylamino)ethanol reaction products acetates (salts). Generic (P-16-0384): Propanoic acid, 2- hydroxy-, compds. with hydrolyzed bisphenol A-epichlorohydrin- polyethylene glycol ether with bisphenol A (2:1) polymer-N1-(1,3-dimethylbutylidene)-N2-[2-[(1, 3-dimethylbutylidene)amino]ethyl]-1,2-ethanediamine-dialdehyde-2-(methylamino)ethanol reaction products formates (salts). Generic (P-16-0385): Formic acid, compds. with hydrolyzed bisphenol A-epichlorohydrin-polyethylene glycol ether with bisphenol A (2:1) polymer-N1-(1,3-dimethylbutylidene)- N2-[2-[(1,3-dimethylbutylidene)amino] ethyl]-1,2-ethanediamine-dialdehyde-2-(methylamino)ethanol reaction products sulfamates(salts). | The chemical substances are not likely to present an unreasonable risk (5(a)(3)(C))* | *In EPA’s original screening analysis for these PMNs in 2016, EPA identified potential for health effects if inhaled and risk to the environment, which resulted in the interim finding. After additional evaluation, EPA determined that inhalation exposure is not a condition of use for these PMNs. Based on an amendment to the PMNs addressing water releases, EPA revised its assessment for the intended conditions of use. EPA's final determination that the chemical substance is not likely to present unreasonable risk is based on EPA's risk assessment for the chemical substances under intended conditions of use described in the amended PMNs, and EPA's issuance of a proposed SNUR that addresses a certain reasonably foreseen use. The condition of use that falls under the restrictions of the proposed SNUR is not likely to present unreasonable risk of injury to health or the environment because (1) the condition of use is not likely to be commenced during the pendency of proposed SNUR and (2) upon finalization of the SNUR the condition of use would be prohibited unless and until EPA makes an affirmative determination that the significant new use is not likely to present an unreasonable risk or takes appropriate action under section 5(e) or 5(f). View the determination document and the terms of the SNUR. | 06/22/2016 | 10/09/2018 |
| P-16-0354 P-16-0355 | Generic (P-16-0354 and P-16-0355): Esteramine | The chemical substances are not likely to present an unreasonable risk (5(a)(3)(C))* | *In EPA’s original screening analysis for these PMNs in 2016, EPA identified potential for risk to the environment, which resulted in the interim finding. Based on an amendment to the PMNs addressing water releases under the intended conditions of use, EPA revised its assessment for the intended conditions of use. EPA's final determination that the chemical substance is not likely to present unreasonable risk is based on EPA's risk assessment for the chemical substances under intended conditions of use described in the PMN and EPA's issuance of a proposed SNUR that addresses certain reasonably foreseen uses. Conditions of use that fall under the restrictions of the proposed SNUR are not likely to present unreasonable risk of injury to health or the environment because (1) those conditions of use are not likely to be commenced during the pendency of proposed SNUR and (2) upon finalization of the SNUR those conditions of use would be prohibited unless and until EPA makes an affirmative determination that the significant new use is not likely to present an unreasonable risk or takes appropriate action under section 5(e) or 5(f). View the determination document and the terms of the SNUR. | 06/22/2016 | 10/09/2018 |
| P-16-0192 | Generic (P-16-0192): Silanized amorphous silica | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C))* | *In EPA’s original screening analysis for this PMN in 2016, EPA identified potential for risk for lung effects for reasonably foreseen conditions of use, which resulted in the interim finding. EPA's final determination that the chemical substance is not likely to present unreasonable risk is based on EPA's risk assessment for the chemical substance under the intended conditions of use described in the PMN where the substance is manufactured in an amorphous form and EPA's issuance of a proposed SNUR to address certain reasonably foreseen uses. Conditions of use that fall under the restrictions of the proposed SNUR are not likely to present unreasonable risk of injury to health or the environment because (1) those conditions of use are not likely to be commenced during the pendency of proposed SNUR and (2) upon finalization of the SNUR those conditions of use would be prohibited unless and until EPA makes an affirmative determination that the significant new use is not likely to present an unreasonable risk or takes appropriate action under section 5(e) or 5(f). View the determination document and the terms of the SNUR. | 06/22/2016 | 10/09/2018 |
| P-18-0070 | Generic: Waste plastics, polyester, depolymd. with glycols, polymers with dicarboxylic acids | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 01/04/2018 | 10/05/2018 |
| P-18-0100 | Generic: Substituted alkanoic acid polymer with alkylcarbonate, alkanediols and isocyanate substituted carbomonocycles, sodium salt, alkenoic acid substituted polyol reaction products-blocked. | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 01/26/2018 | 10/05/2018 |
| P-18-0102 | Generic: Alkenoic acid, ester with [oxybis(alkylene)]bis[alkyl-substituted alkanediol], polymer with alkylcarbonate, alkanediols, substituted alkanoic acid and isocyanate and alkyl substituted carbomonocycle, sodium salt. | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 01/26/2018 | 10/05/2018 |
| P-18-0116 | Generic: Fatty acid oil reaction product with fatty acid oil | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 02/26/2018 | 10/05/2018 |
| P-18-0137 | Generic: Alkylsilsesquioxane, ethoxy-terminated | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 03/23/2018 | 10/05/2018 |
| P-18-0227 | Specific: D-Glucaric acid (CASRN: 87-73-0) | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 06/29/2018 | 10/05/2018 |
| P-18-0231 | Generic: Alkanoic acid, substituted alkyl-, polymer with isocyanatoalkane, alkyl carbonate, alkanediol and polyalkylene glycol ether with alkyl(substituted alkyl) alkanediol alkenoate, glycerol monoacrylate alkanoate-blocked | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 06/29/2018 | 09/26/2018 |
| J-18-0022 J-18-0023 J-18-0024 J-18-0025 | Generic: Modified Saccharomyces cerevisiae | The microorganisms are not likely to present an unreasonable risk (5(a)(3)(C)) | The microorganisms are not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganisms and introduced genetic material. S. cerevisiae is not pathogenic to humans or animals and has an extensive history of safe use in food processing. The introduced genetic modifications pose low concern for health and environmental hazard and do not include antibiotic resistance markers. View the determination document. | 07/13/2018 | 09/27/2018 |
| P-18-0230 | Specific: Waxes and Waxy substances, rice bran, oxidized, calcium salts (CASRN 1850357-57-1) | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document. | 06/29/2018 | 09/18/2018 |
| P-17-0332 | Generic: Benzenesulfonic acid, (alkenediyl)bis[[[(hydroxyalkyl)amino]-(phenylamino)-triazin-2- yl]amino]-, N-(hydroxyalkyl) derivs., salts | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented below. Although EPA estimated that the new chemical substance could be very persistent, the chemical substance has low potential for bioaccumulation, such that repeated exposures are not expected to be cumulative. Based on test data on the new chemical substance and analogous chemical substances, EPA estimates that the chemical substance has moderate environmental hazard and low human health hazard. EPA determines that the new chemical substance is not likely to present an unreasonable risk under the conditions of use. View the determination document. | 06/19/2017 | 09/18/2018 |
| J-18-0028 J-18-0029 J-18-0030 | Generic: Saccharomyces cerevisiae modified | The microorganisms are not likely to present an unreasonable risk (5(a)(3)(C)) | The microorganisms are not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. S. cerevisiae is not pathogenic to humans or animals and has an extensive history of safe use in food processing. View the determination document. | 07/03/2018 | 09/14/2018 |
| P-16-0532 | Generic: Substituted heteromonocycle | Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental concerns. View the determination document. | 08/25/2018 | 09/06/2018 |
| J-18-0004 J-18-0005 J-18-0006 J-18-0007 J-18-0008 J-18-0009 | Generic: Biofuel-producing modified microorganisms, with chromosomally-borne modifications | The microorganisms are not likely to present an unreasonable risk (5(a)(3)(C)) | The microorganisms are not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document. | 06/14/2018 | 09/06/2018 |
| J-18-0012 | Generic: Genetically modified yeast | Microorganism not likely to present an unreasonable risk (5(a)(3)(C)) | The microorganism is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document. | 06/06/2018 | 08/27/2018 |
| J-18-0001 | Generic: Modified Corynebacterium glutamicum | Microorganism not likely to present an unreasonable risk (5(a)(3)(C)) | The microorganism is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document. | 12/08/2017 | 08/02/2018 |
| P-16-0510 | Specific: Oxirane, 2-methyl-, polymer with oxirane, bis[2-[(1-oxo-2-propen-1-yl)amino]propyl] ether (CASRN: 1792208-65-1) | Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment. Although EPA estimated that the new chemical substance could be very persistent, the chemical substance has low potential for bioaccumulation, such that repeated exposures are not expected to be cumulative. Based on EPA’s TSCA New Chemicals Program Chemical Categories for Acrylates and Acrylamides and test data on analogous chemical substances, EPA estimates that the chemical substance has low to moderate environmental hazard and the potential for the following human health hazards: irritation, mutagenicity, developmental/reproductive toxicity, neurotoxicity, and carcinogenicity. Based on test data on structural analogues to the low molecular weight components of the PMN substance, systemic effects were used as the endpoint for evaluation. EPA determines that the conditions of use would not produce these potential unreasonable risks because the PMN submitter would import the chemical substance in solution at a concentration of 50% or less for processing which would result in a deodorizer for use at a concentration of 2% by weight in the formulation of the final product. View the determination document. | 08/05/2016 | 07/30/2018 |
| P-18-0142 | Generic: Alkanoic acid, alkyl-, alkyl ester, polymer with substituted alkenoates, alkenoic acid, alkyl peroxoate-initiated; polymer exemption flag. Polymer exemption flag: The chemical must be manufactured such that it meets the polymer exemption criteria as described under 40 CFR §723.250(e)(1), in addition to meeting the definition of polymer at 40 CFR §723.250(b). | Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental concerns. View the determination document. | 03/27/2018 | 07/27/2018 |
| J-18-0002 J-18-0003 | Generic: Saccharomyces cerevisiae modified | Microorganisms not likely to present an unreasonable risk (5(a)(3)(C)) | The microorganisms are not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganisms and introduced genetic material. View the determination document. | 02/12/2018 | 06/12/2018 |
| P-18-0083 | Specific: 2-Propenoic acid, telomers with Bu alc.-2-[(2-propen-1-yloxy) methyl]oxirane reaction products, sodium bisulfite and sodium 2- hydroxy-3-(2-propen-1-yloxy)-1-propanesulfonate(1:1), sodium salts, peroxydisulfuric acid ([(HO)S(O)2]2O2) sodium salt (1:2)- initiated. (CASRN: 2118944-42-4) | Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental concerns. View the determination document. | 01/03/2018 | 03/23/2018 |
| P-18-0044 P-18-0045 | Generic (P-18-0044): Fatty acids Generic (P-18-0045): Fatty acids, alkyl esters | Chemical substances not likely to present an unreasonable risk (5(a)(3)(C)) | These chemical substances are not likely to present an unreasonable risk based on low/moderate human health hazard and low environmental hazard. View the determination document. | 11/07/2017 | 03/23/2018 |
| P-18-0021 | Generic: Dicarboxylic acids, polymers with substituted poly( substituted alkendiyl) ,3-hydroxy-2-(hydroxyalkyl)-2-alkylalkenoic acid, 5-substituted-1-(substituted alkyl)- 1,3,3-trialkyl carbomonocyle, alkanediol, alkane-triol, alcohol blocked compounds with aminoalcohol; polymer exemption flag. | Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. | 10/16/2017 | 03/23/2018 |
| P-18-0002 | Generic: Phosphinic acid, P,P-alkyl-, salt | Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk of injury to health or the environment. View the determination document. | 10/02/2017 | 03/19/2018 |
| P-16-0415 | Generic: Polyurethane; polymer exemption flag. | Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk based on low human health concern and low environmental hazard when made in accordance with the polymer exemption. View the determination document. | 06/22/2016 | 03/19/2018 |
| J-17-0028 | Generic: Biofuel producing Saccharomyces cerevisiae modified, genetically stable | Microorganism not likely to present an unreasonable risk (5(a)(3)(C)) | The microorganism is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document. | 09/28/2017 | 01/04/2018 |
| J-17-0022 | Generic: Modified Trichoderma reesei | Microorganism not likely to present an unreasonable risk (5(a)(3)(C)) | The microorganism is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document. | 10/09/2017 | 01/04/2018 |
| J-17-0021 | Generic: Modified Saccharomyces cerevisiae | Microorganism not likely to present an unreasonable risk (5(a)(3)(C)) | The microorganism is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document. | 10/06/2017 | 01/04/2018 |
| J-17-0015 J-17-0016 J-17-0017 J-17-0018 J-17-0019 | Generic: Saccharomyces cerevisiae modified | Microorganisms not likely to present an unreasonable risk (5(a)(3)(C)) | The microorganisms are not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document. | 08/07/2017 | 01/04/2018 |
| P-18-0026 | Specific: Silsesquioxanes, 2,4,4- trimethylpentyl, hydroxy-terminated. (CASRN: 217654-68-7) | Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. | 10/17/2017 | 12/12/2017 |
| P-18-0032 | Generic: Alkyl alkenoic acid, alkyl ester, polymer with alkyl alkenoate, dialkyl alkanediol, substituted carbomonocycle, disubstituted heteromonocycle,disubstituted heteropolycyclic, alkanediol, substituted alkyl alkyl alkenoate and substituted heteromonocycle, dialkyl peroxide initiated. | Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. | 10/27/2017 | 12/12/2017 |
| P-17-0153 | Specific: D-Glucitol, 1-deoxy-1-(dimethylamino)-. (CASRN: 76326-99-3) | Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. | 11/23/2016 | 12/12/2017 |
| P-17-0390 | Generic: Carbomonocyclic dicarboxylic acid, polymer with alkenedioic acid, substituted heteropolycycle, substituted heteromonocycle, alkanediol, alkanedioic acid, alkoxylated substituted dicarbomonocycle, alkoxylated substituted dicarbomonocycle and alkanetriol, carbomonocyclic carboxylate alkanoate | Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. | 09/06/2017 | 11/02/2017 |
| P-17-0190 | Generic: Butanoic acid, 3-oxo-, 2-[(2- methyl-1-oxo-2-propen-1-yl)oxy]ethyl ester, polymer with cycloalkyl 2-methyl-2-propenoate, ethenylbenzene, 2- ethylhexyl 2- propenoate, methyl 2- methyl-2-propenoate and 2- methylpropyl 2-methyl-2- propenoate | Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. | 12/26/2016 | 09/06/2017 |
| J-17-0014 | Generic: organic acid producing yeast, modified, genetically stable | Microorganism not likely to present an unreasonable risk (5(a)(3)(C)) | The microorganism is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document. | 07/10/2017 | 10/05/2017 |
| P-16-0508 | Generic: Terephthalic acid and alcohol ester polymer hydroxy glycol and 2- Ethylhexyl alcohol; polymer exemption flag. | Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. | 10/04/2016 | 09/26/2017 |
| P-14-0314 | Generic: Poly aliphatic phosphate | Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. | 06/22/2016 | 07/31/2017 |
| J-17-0008 J-17-0009 J-17-0010 J-17-0011 J-17-0012 J-17-0013 | Generic: Modified microorganism | Microorganism not likely to present an unreasonable risk (§5(a)(3)(C)) | The microorganisms are not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganisms and introduced genetic material. The introduced genetic modifications pose low concern for health and environmental hazard and do not include antibiotic resistance markers. View the determination document. | 05/08/2017 | 07/27/2017 |
| P-17-0117 P-17-0118 | Specific (P-17-0117): 1,6,10- Dodecatriene, 7,11-dimethyl-3-methylene-, (6E)-, homopolymer, 2-hydroxypropyl-terminated (CASRN: 1898242-86-8); polymer exemption flag. Specific (P-17-0118): 1,6,10- Dodecatriene, 7,11-dimethyl-3- methylene-, (6E)-, homopolymer, 2-hydroxyethyl-terminated (CASRN: 2007163-32-6); polymer exemption flag Polymer exemption flag: The chemical must be manufactured such that it meets the polymer exemption criteria as described under 40 CFR §723.250(e)(1), in addition to meeting the definition of polymer at 40 CFR §723.250(b). | Chemical substances are not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substances are not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. | 11/17/2016 | 07/24/2017 |
| P-17-0293 | Generic: Substituted carbomonocycle, polymer with substituted carbonomoncycles, alkyl substituted- alkanediols, alkanediol, alkanedioic acid, and dialkylene glycol; polymer exemption flag. Polymer exemption flag: The chemical must be manufactured such that it meets the polymer exemption criteria as described under 40 CFR §723.250(e)(1), in addition to meeting the definition of polymer at 40 CFR §723.250(b). | Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. | 04/24/2017 | 07/21/2017 |
| P-17-0266 | Specific: Alcohols, C12-13-branched and linear, dimerized (CASRN: 2041102-78-5). | Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. | 03/22/2017 | 07/27/2017 |
| P-17-0219 | Generic: Polyester of aliphatic glycols and aromatic diacids; polymer exemption flag. Polymer exemption flag: The chemical must be manufactured such that it meets the polymer exemption criteria as described under 40 CFR §723.250(e)(1), in addition to meeting the definition of polymer at 40 CFR §723.250(b). | Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. | 01/25/2017 | 07/14/2017 |
| P-17-0112 | Specific: 1,4-Benzenedicarboxylic acid, polymer with hexanedioic acid and 1,6-hexanediol (CASRN: 84191-80-0); polymer exemption flag. Polymer exemption flag: The chemical must be manufactured such that it meets the polymer exemption criteria as described under 40 CFR §723.250(e)(1), in addition to meeting the definition of polymer at 40 CFR §723.250(b). | Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. | 11/16/2016 | 07/06/2017 |
| P-17-0264 | Generic: Alkanoic acid, 2-alkyl-, substituted alkyl ester, polymer with alkyl alkenoate, substituted carbomonocycle, substituted alkyl alkenoate and alkyl substituted alkenoate, substituted alkanenitrile- initiated; polymer exemption flag. Polymer exemption flag: The chemical must be manufactured such that it meets the polymer exemption criteria as described under 40 CFR §723.250(e)(1), in addition to meeting the definition of polymer at 40 CFR §723.250(b). | Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. | 03/22/2017 | 06/29/2017 |
| P-16-0426 | Generic: Alkenyl bis-succinimide | Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. | 06/30/2016 | 06/28/2017 |
| P-17-0255 | Generic: Carbomonocyclic dicarboxylic acid, polymer with carbomonocyclic dicarboxylic acid, alkanedioic acid, alkenedioic acid, substituted dioxoheteropolycyclic, substituted dioxoheteropolycyclic, alkanedioic acid, alkoxylated alkylidene dicarbomonocycle and alkoxylated alkylidene dicarbomonocycle, ester. | Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. | 03/14/2017 | 06/07/2017 |
| P-16-0587 | Specific: Galactoarabinoxylan (CASRN: 37324-70-2). | Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. | 09/22/2016 | 06/15/2017 |
| P-16-0401 | Generic: Alkyl acrylate polymer; polymer exemption flag. Polymer exemption flag: The chemical must be manufactured such that it meets the polymer exemption criteria as described under 40 CFR §723.250(e)(1), in addition to meeting the definition of polymer at 40 CFR §723.250(b). | Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. | 06/22/2016 | 06/15/2017 |
| P-16-0588 | Generic: Alkyl methacrylate, polymer with alkyl acrylate and polyesters; polymer exemption flag. Polymer exemption flag: The chemical must be manufactured such that it meets the polymer exemption criteria as described under 40 CFR §723.250(e)(1), in addition to meeting the definition of polymer at 40 CFR §723.250(b). | Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. | 09/22/2016 | 05/30/2017 |
| P-16-0303 | Generic: Alkyl methyacrylate polymer with styrene, amino acrylate and acrylic acid, ammonium salt; polymer exemption flag. Polymer exemption flag: The chemical must be manufactured such that it meets the polymer exemption criteria as described under 40 CFR §723.250(e)(1), in addition to meeting the definition of polymer at 40 CFR §723.250(b). | Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. | 06/22/2016 | 05/30/2017 |
| P-17-0237 P-17-0238 | Specific (P-17-0237): 1,6,10- Dodecatriene, 7,11-dimethyl-3- methylene-, (6E)-, homopolymer, hydrogenated, 2-hydroxyethyl- terminated (CASRN: 2007163-33-7). Specific (P-17-0238): 1,6,10- Dodecatriene, 7,11-dimethyl-3- methylene-, (6E)-, homopolymer, 2-hydroxypropyl-terminated, hydrogenated (CASRN: 1912453-88-3). | Chemical substances are not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substances are not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. | 02/23/2017 | 05/19/2017 |
| P-17-0256 | Generic: Carbopolycyclic dicarboxylic acid, dialkyl ester, polymer with dialkyl carbomonocyclic diester, dialkyl substituted carbomonocyclic diester alkali metal salt and alkanediol; polymer exemption flag. Polymer exemption flag: The chemical must be manufactured such that it meets the polymer exemption criteria as described under 40 CFR §723.250(e)(1), in addition to meeting the definition of polymer at 40 CFR §723.250(b). | Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. | 03/14/2017 | 05/18/2017 |
| P-17-0207 | Generic: 2-alkenoic acid, 2 alkyl, 2 alkyl ester, polymer with alkyl alkenoate, carbomonocyle, alkyl alkenoate and alkyl alkenoate, alkyl peroxide initiated; polymer exemption flag. Polymer exemption flag: The chemical must be manufactured such that it meets the polymer exemption criteria as described under 40 CFR §723.250(e)(1), in addition to meeting the definition of polymer at 40 CFR §723.250(b). | Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. | 01/23/2017 | 05/18/2017 |
| P-17-0246 | Generic: Polycarbonate polyol. | Chemical substance not likely to present an unreasonable risk (5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. | 02/28/2017 | 05/11/2017 |
| P-16-0578 | Generic: Alkenoic acid, alkyester, polymer with N-(dialkyl-oxoalkyl)- alkenamide, alkenylbenzene, alkyl alkenoate and alkenoic acid; polymer exemption flag. | Chemical substance not likely to present an unreasonable risk (§5(a)(3)(C))., Polymer exemption flag: The chemical must be manufactured such that it meets the polymer exemption criteria as described under 40 CFR §723.250(e)(1), in addition to meeting the definition of polymer at 40 CFR §723.250(b). | The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. | 09/18/2016 | 05/15/2017 |
| J-17-0007 | Generic: Biofuel producing Saccharomyces cerevisiae modified, genetically stable | Microorganism not likely to present an unreasonable risk (§5(a)(3)(C)) | The microorganism is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document. | 02/01/2017 | 04/27/2017 |
| P-17-0227 | Generic: 2-Alkenoic acid, 2-alkyl-, alkyl ester, polymer with 2-alkyl 2- propenoate and -(2-alkyl-1-oxo-2- alken-1-yl--alkoxypoly(oxy-1,2- alkanediyl), ester with -2-alken-1-yl--hydroxypoly(oxy-1,2-alkanediyl); polymer exemption flag. | Chemical substance not likely to present an unreasonable risk (§5(a)(3)(C))., Polymer exemption flag: The chemical must be manufactured such that it meets the polymer exemption criteria as described under 40 CFR §723.250(e)(1), in addition to meeting the definition of polymer at 40 CFR §723.250(b). | The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. | 02/01/2017 | 04/27/2017 |
| P-17-0194 | Generic: Hydrogenated dihalo dialkyl diindolotriphenodioxazine, dihydrodisubstituted isoindolyl alkyl derivs. | Chemical substance not likely to present an unreasonable risk (§5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. | 01/04/2017 | 03/13/2017 |
| P-17-0215 | Generic: Copolymer of alpha-olefin and dibutyl maleate. | Chemical substance not likely to present an unreasonable risk (§5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. | 01/16/2017 | 03/13/2017 |
| P-17-0214 | Generic: 2-Propenoic acid, polymer with alkene and alkenyl acetate, alkyl 2-alkyl isoalkyl esters. | Chemical substance not likely to present an unreasonable risk (§5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. | 01/16/2017 | 03/13/2017 |
| P-17-0014 | Specific: Fatty acids, C8-10, mixed esters with C18-unsatd. fatty acid dimers and .alpha.-hydro-.omega.-hydroxypoly(oxy-1,4-butanediyl) (CASRN: None). | Chemical substance not likely to present an unreasonable risk (§5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. | 02/06/2017 | 03/13/2017 |
| P-17-0008 | Generic: Modified 1,3- isobenzofurandione, polymer with 1,2-ethanediol, 2-ethyl-2-(alkoxyalkyl)-1,3-propanediol and 1,3- Isobenzofurandione, alkanoate | Chemical substance not likely to present an unreasonable risk (§5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. | 11/02/2016 | 03/30/2017 |
| P-16-0592 | Specific: Fatty acids, C8-10, diesters with .alpha.-hydro-.omega.- hydroxypoly(oxy-1,4-butanediyl) (CASRN: None) | Chemical substance not likely to present an unreasonable risk (§5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. | 01/23/2017 | 03/13/2017 |
| P-17-0185 | Generic: Fatty acids, C18-unsatd., dimers, hydrogenated, polymers with C18-unsatd. fatty acid trimers, alkylenediamine and hydroxyalkanoic acid. | Chemical substance not likely to present an unreasonable risk (§5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. | 12/30/2016 | 02/13/2017 |
| P-17-0182 | Generic: Alkyldioic acid, polymer with 2,2-dimethyl-1,3-propanediol, heteropolycyclic carboxy acid anhydride and 1,3-propanediol. | Chemical substance not likely to present an unreasonable risk (§5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. | 12/30/2016 | 02/13/2017 |
| P-17-0160 P-17-0161 | Generic: 2-Propenoic acid, alkyl-, alkyl ester, polymer with alkyl 2- propenoate, dialkyloxoalkyl-2- propenamide and alkyl 2-propenoate. Generic: 2-Propenoic acid, alkyl-, alkyl ester, polymer with alkyl 2- propenoate, dialkyloxoalkyl-2- propenamide, ethenylbenzene and alkyl 2-propenoate. | Chemical substances are not likely to present an unreasonable risk (§5(a)(3)(C)) | The chemical substances are not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. | 11/30/2016 | 02/13/2017 |
| P-17-0158 | Generic: Perylene bisimide | Chemical substance not likely to present an unreasonable risk (§5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. | 11/30/2016 | 02/13/2017 |
| J-17-0006 | Generic: Saccharomyces cerevisiae modified | Microorganism not likely to present an unreasonable risk (§5(a)(3)(C)) | The microorganism is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document. | 11/23/2016 | 02/13/2017 |
| P-17-0144 | Specific: Amines, C36-alkylenedi-, polymers with octahydro-4,7- methano-1H- indenedimethanamine and pyromellitic dianhydride, maleated (CASRN: 2020378-57-6). | Chemical substance not likely to present an unreasonable risk (§5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. | 11/18/2016 | 01/18/2017 |
| J-17-0001 J-17-0002 J-17-0003 J-17-0004 J-17-0005 | Generic: Saccharomyces cerevisiae modified | Microorganisms are not likely to present an unreasonable risk (§5(a)(3)(C)) | The microorganisms are not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document. | 10/24/2016 | 01/18/2017 |
| P-17-0016 P-17-0017 P-17-0018 P-17-0019 P-17-0020 P-17-0021 | Generic: (P-17-0016): Hydroxyl alkyl acrylate ester, polymer with acrylates, aromatic vinyl monomer, cycloaliphatic lactone, and alkyl carboxylic acid, peroxide initiated Generic (P-17-0017): Hydroxyl alkyl acrylate ester, polymer with acrylates, aromatic vinyl monomer, cycloaliphatic lactone, and alkyl carboxylic acid, peroxide initiated. Generic (P-17-0018): Hydroxyl alkyl acrylate ester, polymer with acrylates, aromatic vinyl monomer, cycloaliphatic lactone, and alkyl carboxylic acid, Azobis[aliphatic nitrile] initiated Generic (P-17-0019): Hydroxyl alkyl acrylate ester, polymer with acrylates, aromatic vinyl monomer, cycloaliphatic lactone, and alkyl carboxylic acid, peroxide initiated Generic (P-17-0020): Hydroxyl alkyl acrylate ester, polymer with acrylates, aromatic vinyl monomer, cycloaliphatic lactone, and alkyl carboxylic acid, peroxide initiated Generic (P-17-0021): Hydroxyl alkyl acrylate ester, polymer with acrylates, aromatic vinyl monomer, cycloaliphatic lactone, and alkyl carboxylic acid, Azobis[aliphatic nitrile] initiated | Chemical substances are not likely to present an unreasonable risk (§5(a)(3)(C)) | The chemical substances are not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. | 10/25/2016 | 12/19/2016 |
| P-17-0009 | Generic: Depolymerized waste plastics | Chemical substance not likely to present an unreasonable risk (§5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. | 10/13/2016 | 12/01/2016 |
| J-16-0033 | Generic: Saccharomyces cerevisiae modified to express glucoamylase activity | Microorganism not likely to present an unreasonable risk (§5(a)(3)(C)) | The microorganism is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document. | 08/22/2016 | 12/01/2016 |
| J-16-0034 | Generic: Saccharomyces cerevisiae modified | Microorganism not likely to present an unreasonable risk (§5(a)(3)(C)) | The microorganism is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document. | 08/23/2016 | 12/01/2016 |
| J-16-0036 J-16-0037 J-16-0038 J-16-0039 J-16-0040 J-16-0041 | Generic: Biofuel producing modified microorganism(s), with chromosomally-borne modifications | Microorganisms are not likely to present an unreasonable risk (§5(a)(3)(C)) | The microorganisms are not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document. | 09/07/2016 | 12/01/2016 |
| J-16-0035 | Generic: Saccharomyces cerevisiae modified | Microorganism not likely to present an unreasonable risk (§5(a)(3)(C)) | The microorganism is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document. | 08/23/2016 | 12/01/2016 |
| P-16-0580 | Generic: Trimethylolpropane ester of mixed linear and branched carboxylic acids | Chemical substance not likely to present an unreasonable risk (§5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. | 09/19/2016 | 11/10/2016 |
| J-16-0025 | Generic: Trichoderma reesei modified | Microorganism not likely to present an unreasonable risk (§5(a)(3)(C)) | The microorganism is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document. | 07/29/2016 | 11/14/2016 |
| J-16-0024 | Generic: Trichoderma reesei modified | Microorganism not likely to present an unreasonable risk (§5(a)(3)(C)) | The microorganism is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document. | 07/28/2016 | 11/14/2016 |
| P-16-0519 | Generic: Polyalkylether polyester | Chemical substances not likely to present an unreasonable risk (§5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. | 08/12/2016 | 11/17/2016 |
| P-16-0518 | Generic: Polyalkylether polyester | Chemical substances not likely to present an unreasonable risk (§5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. | 08/12/2016 | 11/17/2016 |
| P-16-0403 | Generic: Heteropolycyclic carboxylic acid, polymer with 2-ethyl-2-(hydroxymethyl)-1, 3-propanediol and 4- substitutedbenzene, substituted carbomonocycle- and alkyl-substituted carbomonocycle-blocked | Chemical substances not likely to present an unreasonable risk (§5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. | 06/22/2016 | 11/17/2016 |
| P-16-0545 | Generic: substituted siloxane polymer | Chemical substances not likely to present an unreasonable risk (§5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard.View the determination document. | 09/02/2016 | 11/10/2016 |
| P-16-0515 | Generic: Diamine substituted arylimidazole | Chemical substances not likely to present an unreasonable risk (§5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. | 08/09/2016 | 11/10/2016 |
| P-16-0492 | Generic: Polyester-amide polymer of 'isophthalic acid' with diamino-alkane, cyclohexanedialcohol, alkanetriol, di-isocyanate and acrylic acid-ethylene copolymer | Chemical substances not likely to present an unreasonable risk (§5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. | 07/25/2016 | 11/10/2016 |
| J-16-0023 | Generic: Trichoderma reesei modified | Microorganism not likely to present an unreasonable risk (§5(a)(3)(C)) | The microorganism is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document. | 07/16/2016 | 10/19/2016 |
| J-16-0022 | Generic: Trichoderma reesei modified | Microorganism not likely to present an unreasonable risk (§5(a)(3)(C)) | The microorganism is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document. | 07/15/2016 | 10/19/2016 |
| J-16-0021 | Generic: Trichoderma reesei modified | Microorganism not likely to present an unreasonable risk (§5(a)(3)(C)) | The microorganism is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document. | 07/15/2016 | 10/19/2016 |
| J-16-0020 | Generic: Trichoderma reesei modified | Microorganism not likely to present an unreasonable risk (§5(a)(3)(C)) | The microorganism is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document. | 06/29/2016 | 10/04/2016 |
| J-16-0019 | Generic: Trichoderma reesei modified | Microorganism not likely to present an unreasonable risk (§5(a)(3)(C)) | The microorganism is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. View the determination document. | 06/29/2016 | 10/04/2016 |
| P-16-0459 | Generic: Carbomonocyclic dicarboxylic acid, polymer with alkanedioic acid, substituted heteropolycycle, substituted carbomonocycle, alkyl alkenoate, alkanedioic acid, alkoxylated substituted dicarbomonocycle, alkoxylated substituted dicarbomonocycle, alkenoic acid, oxo alkyl initiated. | Chemical substances not likely to present an unreasonable risk (§5(a)(3)(C)) | The chemical substances are not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. Although EPA estimated that the new chemical substances would be very persistent, this did not indicate a likelihood that the chemical substances would present an unreasonable risk, given that the chemical substances have low potential for bioaccumulation, low human health hazard, and low environmental hazard. View the determination document. | 07/08/2016 | 10/04/2016 |
| P-16-0343 P-16-0344 | Generic: Modified urethane polymer. | Chemical substances are not likely to present an unreasonable risk (§5(a)(3)(C)) | The chemical substances are not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. Although EPA estimated that the new chemical substances would be very persistent, this did not indicate a likelihood that the chemical substances would present an unreasonable risk, given that the chemical substances have low potential for bioaccumulation, low human health hazard, and low environmental hazard. View the determination document. | 06/22/2016 | 09/16/2016 |
| P-16-0391 | Generic: Polyester polyol polymer with aliphatic isocyanate and phenol derivates | Chemical substance not likely to present an unreasonable risk (§5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. Although EPA estimated that the new chemical substance would be very persistent, this did not indicate a likelihood that the chemical substance would present an unreasonable risk, given that the chemical substance has low potential for bioaccumulation, low human health hazard, and low environmental hazard. View the determination document. | 06/22/2016 | 09/14/2016 |
| J-16-0010 | Generic: Saccharomyces cerevisiae modified | Microorganism not likely to present an unreasonable risk (§5(a)(3)(C)) | The microorganism is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. S. cerevisiae is not pathogenic to humans or animals and has an extensive history of safe use in food processing. The introduced genetic modifications pose low concern for health and environmental hazard and do not include antibiotic resistance markers. View the determination document. | 06/22/2016 | 09/14/2016 |
| J-16-0011 J-16-0012 J-16-0013 J-16-0014 J-16-0015 J-16-0016 | Generic: Biofuel Producing Organism | Microorganisms are not likely to present an unreasonable risk (§5(a)(3)(C)) | The microorganisms are not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. The recipient microorganism is not pathogenic to humans or animals and has an extensive history of safe use. The introduced genetic modifications pose low concern for health and environmental hazard and do not include antibiotic resistance markers. View the determination document. | 06/22/2016 | 09/14/2016 |
| J-16-0017 | Generic: Saccharomyces cerevisiae modified | Microorganism not likely to present an unreasonable risk (§5(a)(3)(C)) | The microorganism is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. S. cerevisiae is not pathogenic to humans or animals and has an extensive history of safe use in food processing. The introduced genetic modifications pose low concern for health and environmental hazard and do not include antibiotic resistance markers. View the determination document. | 06/22/2016 | 09/14/2016 |
| J-16-0018 | Generic: Saccharomyces cerevisiae modified | Microorganism not likely to present an unreasonable risk (§5(a)(3)(C)) | The microorganism is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. S. cerevisiae is not pathogenic to humans or animals and has an extensive history of safe use in food processing. The introduced genetic modifications pose low concern for health and environmental hazard and do not include antibiotic resistance markers. View the determination document. | 06/22/2016 | 09/14/2016 |
| P-16-0366 | Generic: Blocked polyisocyanate | Chemical substance not likely to present an unreasonable risk (§5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. Although EPA estimated that the new chemical substance would be very persistent, this did not indicate a likelihood that the chemical substance would present an unreasonable risk, given that the chemical substance has low potential for bioaccumulation, low human health hazard, and low environmental hazard. View the determination document. | 06/22/2016 | 09/12/2016 |
| P-16-0373 | Generic: Tris(alkyloxyphenyl)triazine compounds | Chemical substance not likely to present an unreasonable risk (§5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. Although EPA estimated that the new chemical substance would be very persistent, this did not indicate a likelihood that the chemical substance would present an unreasonable risk, given that the chemical substance has low potential for bioaccumulation, low human health hazard, and low environmental hazard. View the determination document. | 06/22/2016 | 09/12/2016 |
| P-16-0466 | Generic: 2,5-Furandione, telomer with ethenylbenzene and (alkylethyl)benzene, amides with polyethylene-polypropylene glycol aminoalkyl Me ether, alkali salts | Chemical substance not likely to present an unreasonable risk (§5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental toxicity. Although EPA estimated that the new chemical substance would be very persistent, this did not indicate a likelihood that the chemical substance would present an unreasonable risk, given that the chemical substance has low potential for bioaccumulation, low human health hazard, and low environmental hazard. View the determination document. | 07/11/2016 | 09/02/2016 |
| J-16-0006 | Generic: Trichoderma reesei modified | Microorganism not likely to present an unreasonable risk (§5(a)(3)(C)) | The microorganism is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard associated with the recipient microorganism and introduced genetic material. T. reesei is not pathogenic to humans or animals and has a long history of safe use for production of enzymes. The introduced genetic modifications pose low concern for health and environmental hazard, do not include antibiotic resistance markers, and do not provide a growth advantage over the parental strain. View the determination document. | 06/22/2016 | 09/02/2016 |
| P-16-0348 | Generic: Polypentaerythritol, mixed esters with linear and branched monoacids | Chemical substance not likely to present an unreasonable risk (§5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. Although EPA estimated that the new chemical substance would be very persistent, this did not indicate a likelihood that the chemical substance would present an unreasonable risk, given that the chemical substance has low potential for bioaccumulation, low human health hazard, and low environmental hazard. View the determination document. | 06/22/2016 | 09/02/2016 |
| P-16-0392 | Generic: Modified vegetable oil | Not likely to present an unreasonable risk (§5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental toxicity. Although EPA estimated that the new chemical substance would be very persistent, this did not indicate a likelihood that the chemical substance would present an unreasonable risk, given that the chemical substance has low potential for bioaccumulation, low human health hazard, and low environmental hazard. View the determination document. | 06/22/2016 | 07/29/2016 |
| P-16-0351 | Generic: Glycerides, C14-18 and C16-C18 unsaturated, from fermentation | Not likely to present an unreasonable risk (§5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental toxicity. Although EPA estimated that the new chemical substance would be persistent, this did not indicate a likelihood that the chemical substance would present an unreasonable risk, given that the chemical substance has low potential for bioaccumulation, low human health hazard, and low environmental hazard. View the determination document. | 06/22/2016 | 07/29/2016 |
| P-16-0340 | Generic: Glycerides, C8-18 and C18 unsaturated, from fermentation | Not likely to present an unreasonable risk (§5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental toxicity. Although EPA estimated that the new chemical substance would be persistent, this did not indicate a likelihood that the chemical substance would present an unreasonable risk, given that the chemical substance has low potential for bioaccumulation, low human health hazard, and low environmental hazard. View the determination document. | 06/22/2016 | 07/29/2016 |
| P-16-0302 | Generic: Organic modified propyl silsesquioxane | Not likely to present an unreasonable risk (§5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental toxicity. Although EPA estimated that the new chemical substance would be very persistent, this did not indicate likelihood that the chemical substance would present an unreasonable risk, given that the chemical substance has low potential for bioaccumulation, low human health hazard, and low environmental hazard. View the determination document. | 06/22/2016 | 07/20/2016 |
| P-16-0301 | Generic: Propyl silsesquioxanes, hydrogen-terminated | Not likely to present an unreasonable risk (§5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. View the determination document. | 06/22/2016 | 07/20/2016 |
| P-16-0292 | Generic: Depolymerized waste plastics. | Not likely to present an unreasonable risk (§5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk based on low human health hazard and low environmental hazard. Although EPA estimated that the new chemical substance would be very persistent, this did not indicate a likelihood that the chemical substance would present an unreasonable risk, given that the chemical substance has low potential for bioaccumulation, low human health hazard, and low environmental hazard. View the determination document. | 06/22/2016 | 07/20/2016 |
| P-16-0281 | Generic: Fatty alcohols-dimers, trimers, polymers | Not likely to present an unreasonable risk (§5(a)(3)(C)) | The chemical substance is not likely to present an unreasonable risk based on low health hazard concern and low environmental toxicity. View the determination document. | 06/22/2016 | 07/15/2016 |
| P-24-0110 | Generic: Alkyl fatty acids, polymers with substituted heteropolycyclic, substituted carbomonocycle, carbomonocyclic dicarboxylic acid and trisubstituted alkyl, substituted alkyl alkenoate-blocked, polymers with substituted alkene, substituted bis alkylalkanenitrile-initiated heteromonocyclic alkenoate-substituted alkanoic acid-alkyl alkenoate polymer alkenoate, heteromonocyclic alkenoate, substituted alkyl alkenoate, alkyl alkenoate, alkyl alkenoate, alkenoic acid and substituted carbomonocycle, alkyl substituted alkyl alkanoate initiated,- and substituted bis alkylalkanenitrile-initiated | The chemical substance is not likely to present an unreasonable risk (5(a)(3)(C)). | ‘Not likely to present an unreasonable risk' section 5(a)(3)(C) determination. The chemical substance is not likely to present an unreasonable risk of injury to health or the environment, without consideration of costs or other nonrisk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant by the Administrator under the conditions of use, based on the risk assessment presented. View the determination document: TSCA Section 5(a)(3) Determination for Premanufacture Notice (PMN) P-24-0110 (pdf) . | 05/31/2024 | 06/27/2025 |