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Reviewing New Chemicals under the Toxic Substances Control Act (TSCA)

  • EPA Reforms New Chemicals Review Process

    EPA finalized amendments to the regulations that govern the Agency’s review of new chemicals under TSCA to protect public health and promote efficiency and consistency. Learn more.

  • New Chemicals Division Reference Library

    EPA has created a new reference library so you can find all our new chemicals program materials in one place. It includes guidance documents, compliance advisories, templates, manuals and more. Visit the NCD Reference Library.

  • Framework for Addressing New PFAS and New Uses of PFAS

    EPA released a Framework for Addressing New PFAS and New Uses of PFAS, which outlines EPA’s planned approach when reviewing new PFAS and new uses of existing PFAS to ensure that, if allowed to enter into commerce, they will not be harmful to human health and the environment.  Learn More.

  • Greater Transparency in Tracking Active New Chemical Cases

    EPA launched a tool to allow companies and the public to see where cases are in the EPA review process. Learn more.

Basic information

  • What is the TSCA New Chemicals Review Program?
  • What is a "new chemical?"
  • Who must submit a premanufacture notice (PMN) to EPA?
  • Start the PMN process with the TSCA Inventory
  • New Chemicals Division Reference Library
  • Legislative and regulatory authority

EPA's review process

  • Track active cases and view program statistics
  • New chemical notices received by EPA
  • How EPA reviews new chemicals
    • Chemical categories used in EPA's review
    • Predictive tools and models 
    • Policies, frameworks and guidance
  • Sustainable Futures
  • Integrated approach for biofuel PMNs
  • Integrated approach for mixed metal oxides new chemicals review
  • New chemicals collaborative research program

Filing a Premanufacture Notice with EPA

  • Learn about Premanufacture Notices (PMNs)
  • Submitting a PMN
    • How to submit via e-PMN
  • After you submit a notice
    • What's the final status of my new chemical case?
    • View the “Not likely to present risk” determinations

EPA regulatory actions

  • Actions under TSCA section 5
    • TSCA section 5(e) Consent Orders 
    • Significant New Use Rules
    • Is my chemical subject to a SNUR 
  • Chlorinated paraffins PMNs

Related information

  • Recent activities for New Chemicals
  • ChemView
  • Substantiating CBI
  • Control of Nanoscale Materials under TSCA
  • Regulation of Biotechnology under TSCA and FIFRA
  • Test guidelines for Pesticides and Toxic Substances
  • Assessing and Managing Chemicals under TSCA
  • The Frank R. Lautenberg Chemical Safety for the 21st Century Act
  • Pollution Prevention Efforts in the New Chemicals Program
  • OECD Clearing House on New Chemicals
  • Chemicals Subject to TSCA Section 12(b) Export Notification Requirements

Important information

  • WARNING - Do not e-mail any Confidential Business Information (CBI) to EPA. EPA's e-mail system is not secured to protect CBI.

  • Need Help?
    • TSCA Hotline at 202-554-1404
    • TSCA Hotline e-mail
    • CDX Help Desk at 1-888-890-1995
    • Central Data Exchange (CDX) Hotline
Contact Us to ask a question, provide feedback, or report a problem.
Last updated on April 21, 2025
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