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Assessing and Managing Chemicals under TSCA

Application of Systematic Review in TSCA Risk Evaluations

In 2018, EPA released the first document below, the Application of Systematic Review in TSCA Risk Evaluations, to guide the agency’s selection and review of the scientific studies that are used to inform Toxic Substances Control Act (TSCA) chemical risk evaluations. In February 2021, EPA announced that it will refine its approach to systematic review. EPA is not using, and will not again use, the systematic review approach document found below. 

EPA contracted with the National Academies of Science, Engineering, and Medicine in December 2019 to conduct a peer review of EPA’s 2018 Application of Systematic Review in TSCA Risk Evaluations. The agency has received the report from the AcademiesExit and is committed to addressing their recommendations and ensuring strong science is the basis for all chemical risk evaluations. To that end, EPA has already begun to develop a TSCA systematic review protocol in collaboration with the agency’s Office of Research and Development to incorporate approaches from the Integrated Risk Information System (IRIS) Program, which the Academies’ report strongly recommends.

EPA is committed to following an open and transparent process to review and update the agency’s systematic review approach. EPA expects to publish and take public comment on a TSCA systematic review protocol that will adopt many of the recommendations in the Academies’ report later this year.

EPA’s initial work on systematic review was described in the supplemental files for each TSCA scope document, which included the Strategy for Conducting Literature Searches and the Bibliography for each chemical. The second document below contains the agency’s response to the comments received on these supplemental documents.

Learn more about risk evaluations for existing chemicals under TSCA.

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