Skip to main content
U.S. flag

An official website of the United States government

Here’s how you know

Dot gov

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

HTTPS

Secure .gov websites use HTTPS
A lock (LockA locked padlock) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

    • Environmental Topics
    • Air
    • Bed Bugs
    • Cancer
    • Chemicals, Toxics, and Pesticide
    • Emergency Response
    • Environmental Information by Location
    • Health
    • Land, Waste, and Cleanup
    • Lead
    • Mold
    • Radon
    • Research
    • Science Topics
    • Water Topics
    • A-Z Topic Index
    • Laws & Regulations
    • By Business Sector
    • By Topic
    • Compliance
    • Enforcement
    • Laws and Executive Orders
    • Regulations
    • Report a Violation
    • Environmental Violations
    • Fraud, Waste or Abuse
    • About EPA
    • Our Mission and What We Do
    • Headquarters Offices
    • Regional Offices
    • Labs and Research Centers
    • Planning, Budget, and Results
    • Organization Chart
    • EPA History

Breadcrumb

  1. Home
  2. Pesticide Registration

E-Submission Chronic Toxicology Study Supplemental Files

The formats and instructions in these documents are designed to be used as an example or guide for registrants to format electronic files for submission of animal toxicology data to the EPA's Office of Pesticide Programs for review in support of registration and reevaluation of pesticides. They are based upon, and are intended to be consistent with, similar guidance published by the Food and Drug Administration (FDA). 

  • Chronic subchronic toxicity studies (pdf) (346.52 KB)
  • Developmental neurotoxicity studies (pdf) (567.26 KB)
  • Prenatal developmental toxicity studies (pdf) (329.2 KB)
  • Multi-generation reproduction studies (pdf) (469.89 KB)

Pesticide Registration

  • About Pesticide Registration
  • Electronic Submission of Applications
  • Pesticide Registration Manual
  • Fees and Waivers
  • Registration Information by Type of Pesticide
  • — Antimicrobial Registration
  • — Biopesticide Registration
  • — Conventional Registration
  • — Inert Ingredient Regulation
  • Requirements and Guidance
  • — Data
  • — Forms
  • — Labeling
Contact Us about Pesticide Registration
Contact Us to ask a question, provide feedback, or report a problem.
Last updated on January 16, 2025
  • Assistance
  • Spanish
  • Arabic
  • Chinese (simplified)
  • Chinese (traditional)
  • French
  • Haitian Creole
  • Korean
  • Portuguese
  • Russian
  • Tagalog
  • Vietnamese
United States Environmental Protection Agency

Discover.

  • Accessibility Statement
  • Budget & Performance
  • Contracting
  • EPA www Web Snapshot
  • Grants
  • No FEAR Act Data
  • Plain Writing
  • Privacy
  • Privacy and Security Notice

Connect.

  • Data
  • Inspector General
  • Jobs
  • Newsroom
  • Regulations.gov
  • Subscribe
  • USA.gov
  • White House

Ask.

  • Contact EPA
  • EPA Disclaimers
  • Hotlines
  • FOIA Requests
  • Frequent Questions
  • Site Feedback

Follow.