Science & Technology
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Environmental Chemistry Methods Guidance for Pesticides
Describes EFED procedures and criteria related to requesting, reviewing, archiving, posting, and updating ECM reports and associated ILV reports.
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Additional Guidance for Reviewing Pesticide Environmental Fate Studies
Guidance for the review of environmental fate and related studies in support of drinking water exposure and ecological risk assessments.
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Supplemental Documents for November 19-22, 2019 SAP Meeting
Supporting documentation for FIFRA SAP on Approaches for Quantitative Use of Surface Water Monitoring Data in Pesticide Drinking Water Assessments.
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Human Health Issues Related to Pesticides
This web page discusses the potential health effects from pesticides.
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Framework for Conducting Pesticide Drinking Water Assessments for Surface Water
EPA developed this framework to document the long- standing practices that the Office of Pesticide Programs uses to conduct drinking water assessments for conventional pesticides in surface water.
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Models and Databases Used in Pesticide Risk Assessment
Collection of links to pesticide models and databases. Model topics include aquatic, terrestrial, atmospheric and health effects. Database topics include environmental effects, water, health effects and regulatory information.
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Documents on PCA/PCT and New Scenario Methods for Estimating Pesticide Concentration in Drinking Water
EPA is using percent cropped area (PCA) to better account for the amount of a crop grown within a watershed that drains to a drinking water intake
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Guidance for Identifying, Selecting and Evaluating Open Literature Studies
This guidance for Office of Pesticide Program staff will assist in their evaluation of open literature studies of pesticides. It also describes how we identify, select, and ensure that data we use in risk assessments is of sufficient scientific quality.
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Summary of September 2025 Updates to Aquatic Life Benchmarks Table
Summary of updates to aquatic life benchmarks table for new registrations and updated registrations.
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How to Submit via e-PMN
This page explains the requirements and how to use the electronic premanufacture notice (e-PMN) software and central data exchange (CDX) to submit a premanufacture notice (PMN).
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Reviewing New Chemicals under the Toxic Substances Control Act (TSCA)
This microsite will provide information on how EPA’s new chemicals review program works, on the assessment tools and policies EPA uses in this program, and on the regulatory outcomes of EPA’s review of new chemicals notifications.
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EPA Seeking Nominations for Peer Review of the 2023 Draft Risk Evaluation for TCEP
The Environmental Protection Agency (EPA) is seeking public nominations of scientific and technical experts to review the 2023 Draft Risk Evaluation for Tris(2-chloroethyl) Phosphate (TCEP). Nominations are due October 30, 2023.
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EPA Updates Safer Chemical Ingredients List
The US EPA is adding 10 chemicals to the Safer Chemical Ingredients List (SCIL), bringing the total to 1,071. The SCIL is a living list of chemicals that EPA’s Safer Choice program has evaluated and determined meet Safer Choice criteria.
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EPA Requests Nominations of Peer Reviewers for TSCA Risk Evaluation of D4
EPA is seeking nominations of scientific and technical experts to be considered as ad hoc reviewers assisting the SACC with the peer review of the draft risk evaluation of D4 under TSCA.
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Examples of Sustainable Futures Benefits
Real-life examples of benefits of utilizing Sustainable Futures concepts by participating companies
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Sustainable Futures: US/OECD Minimum Pre-Market Data/Structure Activity Relationships Study - Annexes 1-15
US/OECD Minimum Pre-Market Data/Structure Activity Relationships Study - Annexes 1-15
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Sustainable Futures
Sustainable Futures is a voluntary program that encourages industry to use predictive models to screen new chemicals early in the development process and offers incentives to companies subject to TSCA section 5.