Electronic signature capabilities can be integrated into EPA applications, electronic workflow tools, and other business processes. EPA systems/applications may use any valid electronic signature solution that meets its business requirements so long as it complies with Federal Information Security Modernization Act, Federal Information Processing Standards and the Privacy Act for its implementation. Refer to EPA's Electronic Signature Directives for more information. The federal project lead will advise development teams of any project-specific requirements.

EPA collects regulatory data through Central Data Exchange which has further requirements around electronic signatures of submissions based on the Cross Media Electronic Reporting Rule.