January 2024 TSCA Fragrance Technical Expert Meeting
Under the Toxic Substances Control Act, EPA is required to conduct risk assessments for new and existing chemicals in U.S. commerce. EPA’s New Chemicals Program hosted a meeting on January 30-31, 2024, of technical experts on three different scientific topics related to the risk assessment of fragrances as new chemicals under TSCA. Some participants were in-person and others attended virtually. Information on this page provides the agenda, attendee list, and links to presentations made by EPA and various stakeholders.
The goal of the workshop was to advance the science in new chemical risk assessments for fragrance materials in the following areas:
- Quantifying the dermal sensitization endpoint for human health risk assessments for use in assessment of new chemical fragrances.
- Understanding the biodegradation of fragrances.
- Evaluating chronic aquatic toxicity endpoints for fragrances.
On this page:
- Meeting Agenda (pdf)
- Meeting Attendee List (pdf)
- Presentations from January 30, 2024, Meeting
- Presentations from January 31, 2024, Meeting
Presentations from January 30, 2024
Day 1 - Quantitative Evaluation of Dermal Sensitization
| Presentation | Speakers | Affiliation | Presentation Slides |
|---|---|---|---|
| Setting the Stage - Identifying Hazard and Risk for the Dermal Sensitization Endpoint | Louis (Gino) Scarano | U.S. EPA, Office of Pollution Prevention and Toxics | Louis (Gino) Scarano (pdf) |
| The Skin Allergy Risk Assessment (SARA) Model as a Quantitative Dermal Sensitization Method and its incorporation into the Integrated Chemical Environment (ICE) Platform | Emily Reinke, Joe Reynolds | NTP Interagency Center for the Evaluation of Alternative Toxicological Methods, Unilever | Emily Reinke, Joe Reynolds (pdf) |
| Quantitative Evaluation of Dermal Sensitization | Anna van der Zalm | PETA Science Consortium International e.V. | Anna van der Zalm (pdf) |
| Quantitative Risk Assessment (QRA) for Dermal Sensitization for Fragrance Ingredients: A Scientifically Rigorous Strategy for Dermal Sensitization | Anne Marie Api | Research Institute for Fragrance Materials | Anne Marie Api (pdf) |
| Benzyl Alcohol Classification as Sensitizing under EU CLP | John Piper | LANXESS | John Piper (pdf) |
| Three New Approach Methodologies for Skin Sensitization Potency Assessment Applied to Fragrance Ingredients | Isabelle Lee | Research Institute for Fragrance Materials | Isabelle Lee (pdf) |
| Gardskin Dose-Response Assay for POD Determination of Fragrance Materials and its Application in Conducting Quantitative Risk Assessment (QRA) | Shashikiran Donthamsetty | International Flavors & Fragrance Inc. | Shashikiran Donthamsetty (pdf) |
| The SENS-IS Assay | Malick Diop | MANE Flavor & Fragrance Manufacturer | Malick Diop (pdf) |
| Quantitative Evaluation of Dermal Sensitization - Stakeholder Comments | Kristie Sullivan | Institute for In Vitro Services | Kristie Sullivan (pdf) |
| Quantitative Evaluation of Dermal Sensitization | Vanessa Rocha, Nicholas Georges | Fragrance Science Advisory Council | Vanessa Rocha, Nicholas Georges (pdf) |
Presentations from January 31, 2024
Day Two - Understanding Biodegradation
| Presentation | Speakers | Affiliation | Presentation Slides |
|---|---|---|---|
| Setting the Stage - Evaluating Environmental Fate and Hazard of New Chemicals Under TSCA | Jeffrey Gallagher | U.S. EPA, Office of Pollution Prevention and Toxics | Jeffrey Gallagher (pdf) |
| Biodegradation of Fragrances | Danielle Johnson | U.S. EPA, Office of Pollution Prevention and Toxics | Danielle Johnson (pdf) |
| RIFM Biodegradation Data | Aurelia Lapczynski | Research Institute for Fragrance Materials | Aurelia Lapczynski (pdf) |
| Suitable Guidelines for Evaluating the Biodegradation of Fragrance Ingredients | Jared Bozich | International Flavor & Fragrance Inc. | Jared Bozich (pdf) |
| Biodegradation: Better Understand the Use of Biodegradation Information in the PMN Process & Linking This with Environmental Concern | Sylvia Gimeno | Firmenich | Sylvia Gimeno (pdf) |
| Chronic Aquatic Toxicity of Fragrance Ingredients: Deriving Chronic-CoC Values & Linking this with Environmental Concern | Gordon Sanders | Givaudan | Gordon Sanders (pdf) |
| Environmental Risk Assessment of Fragrance Material: RIFM Framework | Aurelia Lapczynski | Research Institute for Fragrance Materials | Aurelia Lapczynski 2 (pdf) |
| Implications and Evaluations of Chronic Aquatic Toxicity of Fragrances Using EPA Approaches | Ming Fan | Proctor & Gamble | Ming Fan (pdf) |
| Evaluating Chronic Aquatic Toxicity of Fragrance Ingredients | Chris Fassbender | PETA Science Consortium International e.V. | Chris Fassbender (pdf) |
| Activities in EPA/OPP to Reduce, Replace or Refine Acute Fish Testing | William Eckel | U.S. EPA, Office of Pesticide Programs | William Eckel (pdf) |
| Hazard Assessment of Fragrances Using Fish Cell Lines | Kristin Schirmir | Eawag | Kristin Schirmir (pdf) |