Risk Evaluation for 1,2-Dichloropropane
In September 2026, EPA released the draft risk evaluation and supporting documents for 1,2-dichloropropane.
EPA will accept public comments on the draft risk evaluation for 60 days in the 1,2-dichloropropane TSCA docket (EPA-HQ-OPPT-2018-0428) at www.regulations.gov.
EPA designated 1,2-dichloropropane as a high priority chemical in December 2019 and the chemical is currently undergoing risk evaluation.
Find other information about other chemicals undergoing risk evaluations under TSCA.
On this page:
- What is 1,2-Dichloropropane?
- Draft Risk Evaluation for 1,2-Dichloropropane
- Draft Risk Evaluation and Supporting Documents
What is 1,2-Dichloropropane?
1,2-dichloropropane (CASRN 78-87-5) is a colorless liquid with a chloroform-like odor, and it is highly flammable. The primary use of 1,2-dichloropropane is in organic chemical manufacturing. Information from the 2024 Chemical Data Reporting (CDR) for 1,2-dichloropropane indicates the reported production volume is between 100 and 250 million lbs/year.
Draft Risk Evaluation for 1,2-Dichloropropane
Based on the best available science and weight of scientific evidence, EPA preliminarily determined that 14 of the 15 conditions of use assessed significantly contribute to unreasonable risk of injury to human health. Eleven conditions of use contribute to the preliminary unreasonable risk determination for workers, including four that also contribute to unreasonable risk for ONUs. All three consumer conditions of use assessed contribute to the preliminary unreasonable risk determination for consumers and/or bystanders.
EPA preliminarily determined that distribution in commerce does not significantly contribute to unreasonable risk to human health. EPA also preliminarily determined that no conditions of use significantly contribute to unreasonable risk to the general population, including fenceline communities, or the environment.
EPA will move quickly under TSCA, after public comment, to finalize the risk evaluation. Should the Agency continue to find unreasonable risk, EPA will then propose risk management actions under TSCA to address these unsafe workplace exposures.
EPA emphasizes that this evaluation is draft and does not represent a final Agency determination regarding the risks posed by 1,2-dichloropropane. The preliminary findings and conclusions may change based on feedback received during the public comment period. Additionally, the release of a draft risk evaluation does not alter or impact any existing protections, regulations, or risk management measures currently in place for 1,2-dichloropropane. All current safeguards remain in place.
Draft Risk Evaluation and Supporting Documents
View a pre-publication of the Federal Register Notice and supporting documents in docket EPA-HQ-OPPT-2018-0428 at regulations.gov.
- Draft Risk Evaluation for 1,2-Dichloropropane (pdf)
- Draft Human Health and Environmental Hazard Assessment for 1,2-Dichloropropane (pdf)
- Draft Chemistry, Fate, Release, and Exposure Assessment for 1,2-Dichloropropane (pdf)
- Draft Systematic Review Protocol for 1,2-Dichloropropane (pdf)
- Draft Benchmark Dose Modeling for the Draft Risk Evaluation for 1,2-Dichloropropane (pdf)
- Draft Data Quality Evaluation and Data Extraction Information for Physical and Chemical Properties for 1,2-Dichloropropane (pdf)
- Draft Data Quality Evaluation and Data Extraction Information for Environmental Fate and Transport for 1,2-Dichloropropane (pdf)
- Draft Data Quality Evaluation and Data Extraction Information for Environmental Release and Occupational Exposure for 1,2-Dichloropropane (pdf)
- Draft Data Quality Evaluation Information for Dermal Absorption for 1,2-Dichloropropane (pdf)
- Draft Data Quality Evaluation Information for General Population, Consumer, and Environmental Exposure for 1,2-Dichloropropane (pdf)
- Draft Data Extraction Information for General Population, Consumer, and Environmental Exposure for 1,2-Dichloropropane (pdf)
- Draft Data Quality Evaluation Information for Human Health Hazard Epidemiology for 1,2-Dichloropropane (pdf)
- Draft Data Quality Evaluation Information for Human Health Hazard Animal Toxicology for 1,2-Dichloropropane (pdf)
- Draft Data Quality Evaluation Information for Environmental Hazard for 1,2-Dichloropropane (pdf)
- Draft Data Extraction Information for Environmental Hazard and Human Health Hazard Animal Toxicology and Epidemiology for 1,2-Dichloropropane (pdf)
- Draft Integrated Indoor Outdoor Air Calculator (IIOAC) Generic Releases Exposure and Risk Analysis for 1,2-Dichloropropane (xlsx)
- Draft AMTIC Monitoring Data for 1,2-Dichloropropane (xlsx)
- Draft Supplemental Information on HEM TRI Exposure and Risk Analysis for 1,2-Dichloropropane (xlsx)
- Draft Supplemental Information on HEM NEI Exposure and Risk Analysis for 1,2-Dichloropropane (xlsx)
- Draft Surface Water Concentration Modeling and Environmental Exposure for 1,2-Dichloropropane (xlsx)
- Draft General Population Surface Water Pathway Exposure Estimates for 1,2-Dichloropropane (xlsx)
- Draft Surface Water and Sediment Monitoring Data for 1,2-Dichloropropane (xlsx)
- Draft OECD 428 Dermal Absorption Study Calculations (xlsx)
- Draft Air Releases for 1,2-Dichloropropane (xlsx)
- Draft Land Releases for 1,2-Dichloropropane (xlsx)
- Draft Water Releases for 1,2-Dichloropropane (xlsx)
- Draft Number of Sites for 1,2-Dichloropropane (xlsx)
- Draft Use of Laboratory Chemicals Environmental Release Model for 1,2-Dichloropropane (xlsm)
- Draft Occupational Risk Calculator for 1,2-Dichloropropane (xlsx)