Risk Evaluation for 1,2-Dichloropropane
In July 2026, EPA released the draft chemistry, fate, release, and exposure assessment for 1,2-dichloropropane. EPA designated 1,2-dichloropropane as a high priority chemical in December 2019 and the chemical is currently undergoing risk evaluation.
Find other information about other chemicals undergoing risk evaluations under TSCA.
On this page:
- What is 1,2-Dichloropropane?
- Uses of 1,2-Dichloropropane
- Recent Activities and Opportunities for Public Comment
- Draft Supporting Documents
What is 1,2-Dichloropropane?
1,2-dichloropropane (CASRN 78-87-5) is a colorless liquid with a chloroform-like odor, and it is highly flammable. The primary use of 1,2-dichloropropane is in organic chemical manufacturing. Information from the 2016 Chemical Data Reporting (CDR) for 1,2-dichloropropane indicates the reported production volume is between 100 million and one billion lbs/year.
Uses of 1,2-Dichloropropane
In the final scope, EPA identified conditions of use associated with the manufacturing (including importing); processing; distribution in commerce; industrial, commercial and consumer uses; and disposal of 1,2-dichloropropane, for example:
- As an intermediate in basic organic chemical manufacturing and other chemical product and preparation manufacturing;
- As an industrial processing aid for paper sizing agents;
- As a laboratory chemical; and
- In cleaning and furnishing care products.
The above listed conditions of use are ways that a person or the environment could be potentially exposed to this chemical. However, when conducting a risk evaluation, EPA also considers the hazards (i.e. health effects or environmental impacts) that could occur from coming in contact with a chemical.
Recent Activities and Opportunities for Public Comment
In July 2026, EPA released the draft chemistry, fate, release, and exposure assessment technical support document. The document will be available for public comment on the TSCA docket at a later date once the draft risk evaluation has been released (EPA-HQ-OPPT-2018-0428).
In June 2026, EPA released the draft human health and environmental hazard assessment for peer review by the Science Advisory Committee on Chemicals (SACC).
In August 2020, EPA published a final scope document outlining the hazards, exposures, conditions of use, and the potentially exposed or susceptible subpopulations the agency expects to consider in its risk evaluation. The agency released the draft scope in April 2020 and took public comments on the draft document.
- Read the final scope of the risk evaluation for this chemical and EPA’s response to comments on the draft scope.
- View the docket for this chemical, EPA-HQ-OPPT-2018-0428 on www.regulations.gov.
As EPA continues to move through the risk evaluation process there will be additional opportunities for public comment, including a public comment period on the draft risk evaluation. In addition to public comment periods, EPA will continue to engage with stakeholders as it refines the risk evaluation and stakeholders should reach out to EPA via the staff contact to engage with the agency.
Draft Supporting Documents
- Draft Chemistry, Fate, Release, and Exposure Assessment for 1,2-Dichloropropane (pdf)
- Draft Data Quality Evaluation and Data Extraction Information for Physical and Chemical Properties for 1,2-Dichloropropane (pdf)
- Draft Data Quality Evaluation and Data Extraction Information for Environmental Fate and Transport for 1,2-Dichloropropane (pdf)
- Draft Data Quality Evaluation and Data Extraction Information for Environmental Release and Occupational Exposure for 1,2-Dichloropropane (pdf)
- Draft Data Quality Evaluation Information for Dermal Absorption for 1,2-Dichloropropane (pdf)
- Draft Data Quality Evaluation Information for General Population, Consumer, and Environmental Exposure for 1,2-Dichloropropane (pdf)
- Draft Data Extraction Information for General Population, Consumer, and Environmental Exposure for 1,2-Dichloropropane (pdf)
- Draft Integrated Indoor Outdoor Air Calculator (IIOAC) Generic Releases Exposure and Risk Analysis for 1,2-Dichloropropane (xlsx)
- Draft AMTIC Monitoring Data for 1,2-Dichloropropane (xlsx)
- Draft Supplemental Information on HEM TRI Exposure and Risk Analysis for 1,2-Dichloropropane (xlsx)
- Draft Supplemental Information on HEM NEI Exposure and Risk Analysis for 1,2-Dichloropropane (xlsx)
- Draft Surface Water Concentration Modeling and Environmental Exposure for 1,2-Dichloropropane (xlsx)
- Draft General Population Surface Water Pathway Exposure Estimates for 1,2-Dichloropropane (xlsx)
- Draft Surface Water and Sediment Monitoring Data for 1,2-Dichloropropane (xlsx)
- Draft OECD 428 Dermal Absorption Study Calculations (xlsx)
- Draft Air Releases for 1,2-Dichloropropane (xlsx)
- Draft Land Releases for 1,2-Dichloropropane (xlsx)
- Draft Water Releases for 1,2-Dichloropropane (xlsx)
- Draft Number of Sites for 1,2-Dichloropropane (xlsx)
- Draft Use of Laboratory Chemicals Environmental Release Model for 1,2-Dichloropropane (xlsm)
- Draft Occupational Risk Calculator for 1,2-Dichloropropane (xlsx)
- Draft Estimates of Number of Workers and ONUs for 1,2-Dichloropropane (xlsx)
- Draft Dermal Monte Carlo Exposure Model for 1,2-Dichloropropane (xlsx)
- Draft Consumer Exposure Analysis and Risk Calculator (xlsx)
- Draft General Population Fish Ingestion Estimates for 1,2-Dichloropropane (xlsx)
- Draft HEM Input and Output Files for 1,2-Dichloropropane (pdf)
- Draft TRI HEM Input Files for 1,2-Dichloropropane (xlsx)
- Draft NEI HEM Input Files for 1,2-Dichloropropane (xlsx)
- Draft Human Health and Environmental Hazard Assessment for 1,2-Dichloropropane (pdf)
- Draft Data Quality Evaluation Information for Human Health Hazard Animal Toxicology for 1,2-Dichloropropane (pdf)
- Draft Data Quality Evaluation Information for Human Health Hazard Epidemiology for 1,2-Dichloropropane (pdf)
- Draft Data Quality Evaluation Information for Environmental Hazard for 1,2-Dichloropropane (pdf)
- Draft Data Extraction Information for Environmental Hazard and Human Health Hazard Animal Toxicology and Epidemiology for 1,2-Dichloropropane (pdf)
- Draft Tool Settings and Analog List for Environmental Hazard Assessment for 1,2-Dichloropropane (xlsx)
- Draft Benchmark Dose Modeling for 1,2-Dichloropropane (pdf)
- Draft Data Quality Evaluation Information for Dermal Absorption for 1,2-Dichloropropane (pdf)