Human Health Toxicity Assessments for GenX Chemicals

EPA has finalized the human health toxicity assessment for Hexafluoropropylene Oxide (HFPO) Dimer Acid and its Ammonium Salt. HFPO dimer acid and its ammonium salt are also known as “GenX chemicals” because they are the two major chemicals associated with the GenX processing aid technology. GenX is a trade name for a processing aid technology used to make high-performance fluoropolymers without the use of perfluorooctanoic acid (PFOA).

The GenX chemicals toxicity assessment provides hazard identification, dose-response information, and derives toxicity values called oral reference doses (RfDs) for chronic and subchronic exposures. The assessment underwent external peer review and public comment. Policy makers can use the GenX chemicals toxicity assessment along with exposure information and other important considerations to determine if, and when, it is appropriate to take action to reduce exposure to GenX chemicals.

Previously released public draft assessment materials from November 2018 include:

Human Health Toxicity Assessments for GenX Chemicals

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