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Tools and Databases to Support Children’s Health Protective Decisions

EPA researchers have released or are developing a suite of decision support tools to help public health officials, state, tribal, and local governments, and others make sound decisions that advance healthy, prosperous, and sustainable communities. Many of these tools can be used to ensure that children’s environmental health is an explicit part of such decision-making. These include the following:

Name and Type Acronym Description
Consolidated Human Activity Database CHAD Compiled, detailed data on human behavior from 19 separate studies
Exposure Forecaster Database ExpoCast Automated model to predict exposures for thousands of chemicals
Aggregated Computational Toxicology Resource ACToR Data warehouse of all publicly available chemical toxicity data, including chemical structure, physico- chemical values, in vitro assay data and in vivo toxicology data.
Physiological Parameters Database for PBPK Modeling - Includes physiological parameters such as alveolar ventilation, blood flow, tissue volumes, and glomerular filtration rate used for Physiologically- Based Pharmacokinetic (PBPK) modeling
Chemical and Product Categories Database CPCat Database containing information on the uses of chemicals, products that contain chemicals and manufacturers of the products
Ontogeny Database on Enzymes - Database that can be used as a screening tool to explore metabolism-based variability, based on enzyme differences, during early lifestages
Toxicity Forecaster Database ToxCast Builds computational models from HTS data to forecast the potential human toxicity of chemicals
Toxicity Reference Database ToxRef Captures thousands of in vivo animal toxicity studies on hundreds of chemicals
Adverse Outcome Pathway Wiki AOP Wiki Provides an open-source interface for rapid and collaborative sharing of established AOPs and building new AOPs
Virtual Tissues Knowledgebase VT-KB A human and machine readable knowledgebase developed by extracting and organizing relevant facts from the scientific literature and other sources of information in to central database
Exposure Toolbox Expo-Box Web-based compendium of over 800 exposure assessment tools that provides links to exposure assessment databases, models, and references
Exposure Factors Handbook EFH Summary of the available statistical data on various factors used in assessing human exposure
Stochastic Human Exposure and Dose Simulations– HT Model SHEDS-HT A probabilistic human exposure model that produces population-level distributions of exposures by the dermal, inhalation, and ingestion routes
Stochastic Human Exposure and Dose Simulation Model for Multimedia SHEDS-Multimedia A physically-based, probabilistic model, that can simulate multiple- or single-chemical exposures over time for a population via residential and dietary exposure routes for a variety of multimedia, multipathway environmental chemicals
Community-Focused Exposure and Risk Screening Tool C-FERST A community mapping, information access, and assessment tool designed to help assess risk and assist in decision making with communities
EnviroAtlas - Collection of tools and resources that provides geospatial data, maps, research, and analysis on the relationships between nature, people, health, and the economy
Eco-Health Relationship Browser - Interactive tool that illustrates scientific evidence for linkages between human health and ecosystem services
Environmental Quality Index EQI Estimates environmental quality at the county level used to assess effects on health outcomes
CompTox Dashboard - Provides access to data associated with over 700,000 chemicals. Features mapping of curated physiocochemical property data associated with chemical substances to their corresponding chemical structures

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