Evaluating the Effects of Chemicals on Nervous System Development
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Why are we researching this?
About 1 in 6 children in the United States are affected by a neurodevelopmental disability such as a lower IQ, learning deficits, and abnormal behavior such as hyperactivity or autism (CDC, 2018). Exposure to toxic chemicals during early life may produce adverse effects on the nervous system throughout life. Since environmental contaminants can affect children differently than adults, EPA is conducting research to identify chemicals that have the potential to contribute to neurodevelopmental disorders and understand child-specific vulnerabilities.
Why is this important?
The developing nervous system can be particularly sensitive to exposure to environmental chemicals. As a result of slow and expensive testing, less than 1% of chemicals in the environment have been evaluated for their potential to cause developmental neurotoxicity, or the impact of the chemical on the developing nervous system. In the absence of these critical data, it is not possible to understand the extent or potential contribution of environmental chemicals in neurodevelopmental disease, nor predict the potential developmental neurotoxicity risk for individual chemicals.
What is EPA doing?
EPA is developing new approach methods, or techniques used to provide data or information for regulatory decision making, to evaluate thousands of chemicals for developmental neurotoxicity hazard. These methods involve cell (in vitro), computational (in silico) or chemical (in chemico) evaluation based techniques.
High-Throughput Screening
Virtual Tissue Models
Alternative Animal Models
Adverse Outcome Pathways (AOPs)
Adverse outcome pathways are frameworks that assemble knowledge about biological events that can be used to help interpret how a stressor (e.g. a chemical) can lead to an adverse health effect in an organism. EPA scientists are starting to use these powerful tools to organize data from in vitro and higher throughput methods, coupled with existing biological data and information from animal tests, to predict changes in biological pathways and the potential effects of chemicals on the developing nervous system. Learn more.