Past Conferences on the State of Science on Development and Use of New Approach Methods (NAMs) for Chemical Safety Testing

In 2019, EPA committed to developing and implementing a work plan to reduce the use of animals in chemical testing and to prioritize ongoing efforts, and to direct existing resources, toward additional activities that will demonstrate measurable impacts in the reduction of animal testing while ensuring protection of human health and the environment. To report progress on these activities, EPA hosts regular conferences to provide updates and solicit input from interested stakeholders.

• Fourth NAMs Conference
• Third NAMs Conference
• Second NAMs Conference
• First NAMs Conference

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Fourth EPA NAMs Conference (November 5^th & 6^th, 2024)

EPA hosted its 4^th NAMs Conference on November 5th & 6th, 2024. The conference consisted of presentations by scientific experts from inside and outside of the Agency to inform attendees on advances in the NAMs field. EPA presenters also provided an update on the deliverables outlined in the EPA NAMs Work Plan. Speakers presented on the state of the science in NAMs related to exposure NAMs, ‘omics, and in vitro to in vivo extrapolation (IVIVE). There were 130 in-person participants and 818 virtual participants at the two-day conference. The participants were from various sectors, including academia, government, and industry. Conference topics included:

• NAMs Work Plan Implementation and Validation Update
• Exposure NAMs
• ‘Omics
• In Vitro - In Vivo Extrapolation

For questions, please contact us at NAM@epa.gov.

Agenda and Conference Materials

4th NAMs Conference Agenda (pdf) (60.05 KB, 11/4/24)

2024 New Approach Methods Conference Presentations (pdf) (70.43 MB, 01/06/2024)

2024 New Approach Methods Conference Summary Report (pdf) (633.83 KB, 03/24/2025)

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Third EPA NAMs Conference (October 12^th & 13^th, 2022)

EPA hosted its 3^rd NAMs Conference on October 12-13^th, 2022. At the conference, attendees heard from representatives from EPA, other federal agencies, industry, universities, and international organizations on the state of the science on the development and use of NAMs for chemical safety testing. There were more than 600 participants for Day 1 and roughly 400 for Day 2, with approximately 50 in-person participants each day. Conference topics included:

• Variability and Relevance of Traditional Toxicity Tests
• Evolution of Validation and Scientific Confidence Frameworks to Incorporate 21^st Century Science
• Breakout groups discussing Variability of Traditional Toxicity Tests, Relevance of Traditional Toxicity Tests, and Feedback on EPA Scientific Confidence Framework

For questions, please contact us at NAM@epa.gov.

Agenda and Conference Materials

New Approach Methods Conference 2022 Agenda (pdf) (78.53 KB)

New Approach Methods Conference 2022 Slides (pdf) (24.89 MB)

Summary Report: U.S. EPA New Approach Methods (NAMs) Conference 2022 (pdf) (662.24 KB, 4/21/2023)

2022 NAMs Conference Recording: Day 1 

2022 NAMs Conference Recording: Day 2

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Second EPA NAMs Conference (October 19^th & 20^th, 2020)

EPA hosted the Second Conference on the State of the Science on Development and Use of New Approach Methods (NAMs) for Chemical Safety Testing virtually.

Agenda and Conference Materials

Second NAMs Conference (2020) (pdf) (105.93 KB)

Transcript of Administrator Wheeler's Remarks for Second Conference on the State of Science on Development and Use of NAMs for Chemical Safety Testing (pdf) (122.28 KB)
Second NAMs Conference Summary Report (pdf) (504.84 KB)
Recording of Day One   |   Recording of Day Two

Presentation	Presenter	Affiliation
Overview of EPA NAMs Work Plan (pdf) (620.65 KB)	Russell Thomas	EPA
Progress on Implementing the TSCA Alternatives Strategic Plan Slides (pdf) (740.35 KB)	Gino Scarano	EPA
Using Chemical, Biological, and In Vivo Data for NAMs: Which data do we have, and what can we do with it? Slides (pdf) (1.17 MB)	Andreas Bender	Cambridge
Transcriptome-Based Derivation of an In Vivo POD: Current and Future Utility Slides (pdf) (1.03 MB)	Kamin Johnson	Corteva
“Fit for Purpose” for Organotypic Models in Environmental Health Protection Slides (pdf) (4.36 MB)	Ivan Rusyn	Texas A&M
Retrofitting an Estrogen Receptor Transactivation Assay with Metabolic Competence Slides (pdf) (3.77 MB)	Chad Deisenroth	EPA
In Vitro Disposition of Tox21 Chemicals: Initial Results and Next Steps (pdf) (1010.66 KB)	David Crizer	NTP
An OECD Harmonized Template (OHT) to Report NAM Results in Regulatory Environments: Principles and Practical Use (pdf) (2.11 MB)	Clemens Wittwehr	JRC
Case Study #1: Integration of NAM Data for Evaluating Potential Developmental Neurotoxicity (pdf) (2 MB)	Monique Perron	EPA
Case Study #2: Integration of NAM Data in a Next Generation Risk Assessment for Cosmetic Ingredients Slides (pdf) (3.44 MB)	Andrew White	Unilever
Case Study #3: Incorporating the Threshold of Toxicological Concern into Regulatory Decisions under the Amended Toxic Substances Control Act Slides (pdf) (288.52 KB)	Todd Stedeford	EPA

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First EPA NAMs Conference (December 17^th, 2019)

EPA hosted the first NAMs Conference in EPA’s William Jefferson Clinton East Building at Headquarters in Washington, D.C. and made available by webinar.

Agenda and Conference Materials

  NAMs Conference Agenda 2019 (pdf) (159.33 KB, 2019)

First NAMs Conference Summary Report.pdf (pdf) (241.03 KB)

Presentation	Presenter	Affiliation
Retrospective analysis of the statutory requirements, study requests, and research utilization in OCSPP and ORD (pdf) (198.93 KB)	Anna Lowit	EPA
Variability of animal studies for acute toxicity, skin sensitization, and mechanistic responses (pdf) (3.19 MB)	Nicole Kleinstreuer	NICEATM
Qualitative and quantitative variability of repeat dose animal toxicity studies (pdf) (1.03 MB)	Katie Paul Friedman	EPA
Development of NAMs to predict acute toxicological responses (pdf) (4.79 MB)	Dave Allen	Integrated Laboratory Systems
Application of NAMs for quantitative screening level risk decisions (pdf) (2.56 MB, 2019)	Tara Barton-Maclaren	Health Canada
State of the science for predicting developmental toxicity using NAMs (pdf) (447.9 KB, 2019)	George Daston	Proctor & Gamble
Advances in the development of organotypic and tissue chip technologies for toxicity testing (pdf) (2.35 MB, 2019)	Dan Tagle	National Institutes of Health
Development and application of in vitro methods for evaluating respiratory irritants (pdf) (1.86 MB, 2019)	Doug Wolf	Syngenta
Identifying endocrine disrupting chemicals using in vitro and computational approaches (pdf) (2.27 MB, 2019)	Maureen Gwinn	EPA
New Approaches to Validation and Characterizing Performance of NAMs (pdf) (333.09 KB, 2019)	Warren Casey	NICEATM