Past Conferences on the State of the Science on Development and Use of New Approach Methods (NAMs) for Chemical Safety Testing

In 2019, EPA committed to developing and implementing a work plan to reduce the use of animals in chemical testing and to prioritize ongoing efforts, and to direct existing resources, toward additional activities that will demonstrate measurable impacts in the reduction of animal testing while ensuring protection of human health and the environment. To report progress on these activities, EPA hosts regular conferences to provide updates and solicit input from interested stakeholders.

Directive to Prioritize Efforts to Reduce Animal Testing

First NAMs Conference

Location

The Conference was held on December 17, 2019 in EPA’s William Jefferson Clinton East Building at Headquarters in Washington, D.C. and made available by webinar.

Conference Agenda and Materials

2019 Agenda

	Presentation	Presenter	Affiliation
1.	Retrospective analysis of the statutory requirements, study requests, and research utilization in OCSPP and ORD	Anna Lowit	EPA
2.	Variability of animal studies for acute toxicity, skin sensitization, and mechanistic responses	Nicole Kleinstreuer	NICEATM
3.	Qualitative and quantitative variability of repeat dose animal toxicity studies	Katie Paul Friedman	EPA
4.	Development of NAMs to predict acute toxicological responses	Dave Allen	Integrated Laboratory Systems
5.	Application of NAMs for quantitative screening level risk decisions	Tara Barton-Maclaren	Health Canada
6.	State of the science for predicting developmental toxicity using NAMs	George Daston	Proctor & Gamble
7.	Advances in the development of organotypic and tissue chip technologies for toxicity testing	Dan Tagle	National Institutes of Health
8.	Development and application of in vitro methods for evaluating respiratory irritants	Doug Wolf	Syngenta
9.	Identifying endocrine disrupting chemicals using in vitro and computational approaches	Maureen Gwinn	EPA
10.	New Approaches to Validation and Characterizing Performance of NAMs	Warren Casey	NICEATM

Second NAMs Conference

EPA hosted the Second Conference on the State of the Science on Development and Use of New Approach Methods (NAMs) for Chemical Safety Testing virtually on October 19 & 20, 2020.

Date

The conference was held virtually October 19-20, 2020

Conference Agenda, Presentations, Recordings and Materials

2020 Agenda
Conference Summary
Recording of Day One
Recording of Day Two

Presentation	Presenter	Affiliation
Overview of EPA NAMs Work Plan	Russell Thomas	EPA
Progress on Implementing the TSCA Alternatives Strategic Plan	Gino Scarano	EPA
Using Chemical, Biological, and In Vivo Data for NAMs: Which data do we have, and what can we do with it?	Andreas Bender	Cambridge
Transcriptome-Based Derivation of an In Vivo POD: Current and Future Utility	Kamin Johnson	Corteva
“Fit for Purpose” for Organotypic Models in Environmental Health Protection	Ivan Rusyn	Texas A&M
Retrofitting an Estrogen Receptor Transactivation Assay with Metabolic Competence	Chad Deisenroth	EPA
In Vitro Disposition of Tox21 Chemicals: Initial Results and Next Steps	David Crizer	NTP6
An OECD Harmonized Template (OHT) to Report NAM Results in Regulatory Environments: Principles and Practical Use	Clemens Wittwehr	JRC
Case Study #1: Integration of NAM Data for Evaluating Potential Developmental Neurotoxicity	Monique Perron	EPA
Case Study #2: Integration of NAM Data in a Next Generation Risk Assessment for Cosmetic Ingredients	Andrew White	Unilever
Case Study #3: Incorporating the Threshold of Toxicological Concern into Regulatory Decisions under the Amended Toxic Substances Control Act	Todd Stedeford	EPA