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Past Conferences on the State of the Science on Development and Use of New Approach Methods (NAMs) for Chemical Safety Testing

In 2019, EPA committed to developing and implementing a work plan to reduce the use of animals in chemical testing and to prioritize ongoing efforts, and to direct existing resources, toward additional activities that will demonstrate measurable impacts in the reduction of animal testing while ensuring protection of human health and the environment. To report progress on these activities, EPA hosts regular conferences to provide updates and solicit input from interested stakeholders.

Directive to Prioritize Efforts to Reduce Animal Testing

On this page:

  • First NAMs Conference
  • Second NAMs Conference

First NAMs Conference

Location 

The Conference was held on December 17, 2019 in EPA’s William Jefferson Clinton East Building at Headquarters in Washington, D.C. and made available by webinar.

Conference Agenda and Materials 

2019 Agenda 

  Presentation Presenter Affiliation
1. Retrospective analysis of the statutory requirements, study requests, and research utilization in OCSPP and ORD Anna Lowit EPA
2.

Variability of animal studies for acute toxicity, skin sensitization, and mechanistic responses

Nicole Kleinstreuer

NICEATM
3.

Qualitative and quantitative variability of repeat dose animal toxicity studies

Katie Paul Friedman EPA
4.

Development of NAMs to predict acute toxicological responses

Dave Allen

Integrated Laboratory Systems

5. Application of NAMs for quantitative screening level risk decisions Tara Barton-Maclaren Health Canada
6.

State of the science for predicting developmental toxicity using NAMs

George Daston

Proctor & Gamble

7.

Advances in the development of organotypic and tissue chip technologies for toxicity testing

Dan Tagle

National Institutes of Health

8.

Development and application of in vitro methods for evaluating respiratory irritants

Doug Wolf Syngenta
9.

Identifying endocrine disrupting chemicals using in vitro and computational approaches

Maureen Gwinn EPA
10.

New Approaches to Validation and Characterizing Performance of NAMs

Warren Casey NICEATM

Second NAMs Conference

EPA hosted the Second Conference on the State of the Science on Development and Use of New Approach Methods (NAMs) for Chemical Safety Testing virtually on October 19 & 20, 2020.

Date

The conference was held virtually October 19-20, 2020

Conference Agenda, Presentations, Recordings and Materials

2020 Agenda
Conference Summary
Recording of Day One
Recording of Day Two

Presentation

Presenter

Affiliation

Overview of EPA NAMs Work Plan

Russell Thomas

EPA

Progress on Implementing the TSCA Alternatives Strategic Plan 

Gino Scarano

EPA

Using Chemical, Biological, and In Vivo Data for NAMs: Which data do we have, and what can we do with it?

Andreas Bender

Cambridge

Transcriptome-Based Derivation of an In Vivo POD: Current and Future Utility

Kamin Johnson

Corteva

“Fit for Purpose” for Organotypic Models in Environmental Health Protection

Ivan Rusyn

Texas A&M

Retrofitting an Estrogen Receptor Transactivation Assay with Metabolic Competence

Chad Deisenroth

EPA

In Vitro Disposition of Tox21 Chemicals: Initial Results and Next Steps

David Crizer

NTP6

An OECD Harmonized Template (OHT) to Report NAM Results in Regulatory Environments: Principles and Practical Use

Clemens Wittwehr

JRC

Case Study #1: Integration of NAM Data for Evaluating Potential Developmental Neurotoxicity

Monique Perron

EPA

Case Study #2: Integration of NAM Data in a Next Generation Risk Assessment for Cosmetic Ingredients

Andrew White

Unilever

Case Study #3: Incorporating the Threshold of Toxicological Concern into Regulatory Decisions under the Amended Toxic Substances Control Act

Todd Stedeford

EPA

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Last updated on June 10, 2022
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