Endocrine disrupting chemicals can interfere with the endocrine system and lead to problems with reproduction (i.e. egg and sperm production) and development (i.e. healthy fetal growth) in both humans and wildlife. EPA’s Endocrine Disruptor Screening Program is charged prioritizing and testing chemicals for potential endocrine disruption. EPA researchers develop and use innovative chemical screening technologies and other advanced scientific methods to help the program evaluate these chemicals for potential endocrine disruption.

Related Resources

• Human Health Research Related to Endocrine Disruption
  • Early Life Exposures and Lifetime Health
  • Research on the Reproductive Effects
  • Effects on Neurological Development
• Testing and Prioritizing Chemicals for Endocrine Disruption

  EPA researchers develop innovative methods to test and prioritize chemicals for potential endocrine disruption. Results from these methods are used by EPA’s Endocrine Disruption Screening Program to make better informed decisions about chemical safety. EPA's Endocrine Disruption Screening Program uses a two-tiered testing approach:

  • Tier 1 screens the thousands of chemicals that have the potential to interact with the endocrine system.
  • Tier 2 conducts more in-depth tests of select chemicals flagged in Tier 1 to determine the endocrine-related effects caused by each chemical at different levels of exposure.

  • Prioritizing Chemicals for Potential Endocrine Disruption
  • In-Depth Testing for Potential Endocrine Disruption
  • Testing for Potential Low-Dose Effects
• Ecosystems and Environment Research Related to Endocrine Disruption
  • Detecting Endocrine Disrupting Chemicals from Animal Feeding Operations
  • Evaluating Concentrations of Endocrine Disrupting Chemicals in Biosolids (Sewage Sludge)
  • Assessing Endocrine Disrupting Chemicals In Landfills, Solid Waste Sites and Wastewater
• Collaborations and Partnerships
  • EPA and National Institute of Environmental Health Sciences (NIEHS) Children’s Environmental Health and Disease Prevention Research Centers
  • EPA Funded External Endocrine Disrupting Chemicals Research Projects
  • Reports and Results from EPA Funded External Endocrine Disrupting Chemicals Research
  • Available and Awarded EPA Grants for Endocrine Disruption Research