EPA New Approach Methods: Efforts to Reduce Use of Vertebrate Animals in Chemical Testing

EPA is prioritizing ongoing efforts to develop and use New Approach Methods (NAMs) to test chemicals for health effects. Using NAMs will help reduce the use of Vertebrate Animals in chemical testing while ensuring protection of human health and the environment.
The definition of NAMs has evolved over time. Currently, it is broadly descriptive reference to any non Vertebrate Animals technology, methodology, approach, or combination thereof that can be used to provide information on chemical hazard and risk assessment. NAMs are functionally equivalent to “alternatives" to mammal testing.
- New Approach Methods Work Plan for Reducing the Use of Vertebrate Animals in Chemical Testing
- Conferences on the State of the Science on Development and Use of New Approach Methods (NAMs) for Chemical Safety Testing
- List of NAMs per Section 4(h)(2)(C) of TSCA
Resources
News
- EPA's 3rd NAMs Conference (October 2022)
- New Chemicals Collaborative Research Program
- Updated NAMs Work Plan (December 2021)
- News Release: EPA Continues to Reduce Mammal Testing
- News Release: EPA Focuses on Reducing Mammal Testing, Awards $4.25 Million to Advance Research on Alternative Methods to Mammal Testing
- Research Grants Awarded for Advancing Actionable Alternatives to Vertebrate Mammal Testing for Chemical Safety Assessment
- Open for Public Comment: Availability of New Approach Methodologies in the Endocrine Disruptor Screening Program