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Causal Characteristics and Types of Evidence

The types of evidence and the characteristic of causation that they can represent are presented in Tables 5-3 and 5-4. Some types of evidence can support more than one characteristic, depending on how the study is designed.

The first set (Table 5-3) is based solely on evidence from the impaired site and associated comparison sites (i.e., sites that are part of the case). The second set (Table 5-4) uses knowledge gained from other studies to show that conditions at the impaired site could reasonably be expected to result in specific biological effects. Therefore, evidence for temporality and co-occurrence come only from the site. Evidence for coherence and sufficiency are more likely to come from other field and laboratory studies. Used together they make a stronger case that can help us identify probable causes of impairment in our environment.

Table 5-3. Characteristics of Causal Relationships Supported by Different Types of Evidence that Use Data from the Case
Type of Evidence Characteristic of Causal Relationships
Spatial/Temporal Co-occurrence Co-occurrence
Evidence of Exposure or Biological Mechanism Interaction
Alteration
Causal Pathway Antecedence
Stressor-Response Relationships from the Field Co-occurrence
Manipulation of Exposure Co-occurrence
Temporality
Laboratory Tests of Site Media Sufficiency
Temporal Sequence Temporality
Verified Prediction Alteration
Symptoms Alteration

Table 5-4. Characteristics of Causal Relationships Supported by Types of Evidence that Use Data from Elsewhere

Type of Evidence Characteristic of Causal Relationships
Stressor-Response Relationships from Other Field Studies Sufficiency
Stressor-Response Relationships from Laboratory Studies Sufficiency
Stressor-Response Relationships from Ecological Simulation Models Sufficiency
Mechanistically Plausible Cause Alteration
Manipulation of Exposure at Other Sites Sufficiency
Analogous Stressors Alteration

Causal Analysis/Diagnosis Decision Information System (CADDIS)

  • CADDIS Home
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  • Volume 1: Stressor Identification
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    • Step 1. Define the Case
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  • Volume 2: Sources, Stressors and Responses
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Last updated on February 7, 2025
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