Toxicity Forecasting

Advancing the Next Generation of Chemical Evaluation

EPA needs rapid and efficient methods to prioritize, screen and evaluate thousands of chemicals. EPA's Toxicity Forecaster (ToxCast) generates data and predictive models on thousands of chemicals of interest to the EPA. ToxCast uses high-throughput screening methods and computational toxicology approaches to rank and prioritize chemicals. In fact, EPA's Endocrine Disruption Screening Program (EDSP) is working to use ToxCast to identify priority chemicals.

• ToxCast has data for approximately 1,800 chemicals from a broad range of sources including industrial and consumer products, food additives, and potentially green chemicals that could be safer alternatives to existing chemicals.
• ToxCast screens chemicals in more than 700 high-throughput assay endpoints that cover a range of high-level cell responses.
• Part of EPA's contribution to the Toxicology in the 21^st Century federal agency collaboration is some of the ToxCast data. 

As part of EPA’s commitment to gather and share its chemical data in open and transparent ways, all ToxCast chemical data is publicly available.

• ToxCast Owner's Manual - (Start here to explore the data!)
• What is the Toxicology in the 21st Century collaboration and how does it relate to ToxCast?