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  2. PRIA Fees

Pesticide Registration Guidance and Related Links

The Pesticide Registration Improvement Act of 2022 (PRIA 5), enacted on December 29, 2022, specifies that not later than 180 days after enactment, the EPA shall post on a single webpage aggregated information on pesticide regulation under the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA), including:

  1. All guidance relating to risk assessment, risk mitigation, benefits assessments, and cost-benefit balancing;
  2. Hyperlinks to resources, including the Department of Agriculture's “national list of allowed and prohibited substances” for organic crop and livestock production;
  3. Biopesticides and pesticides exempt pursuant to section 25(b) of FIFRA; and
  4. Integrated pest management principles developed under section 28(c) of FIFRA, including technical assistance for implementation of those principles.

In response to this requirement, EPA is providing the following guidance documents and pesticide-related links.  EPA will continue to update this webpage with additional guidance as it becomes available.

Pesticide-related guidance:

This table displays a list of pesticide-related guidance documents issued by the Office of Chemical Safety and Pollution Prevention and addresses requirement 1 above.  EPA's guidance documents lack the force and effect of law, unless expressly authorized by statute or incorporated into a contract.

Document Name
(click on link to view)
Date Identifier Topic Description/Summary ID
Antimicrobial Pesticide Registration 2019-04-04 EPA 705-G-2020-0414 Pesticide Registration Resources for an individual or company wanting to register an antimicrobial pesticide. 11
Pesticide Registration Manual: Chapter 4 - Additional Considerations for Antimicrobial Products 2019-10-28 EPA 705-G-2020-0502 FIFRA, Antimicrobial This chapter provides additional guidance unique to antimicrobial pesticides that is not covered in the other chapters. 78
Methods and Guidance for Testing the Efficacy of Antimicrobial Products Against Spores of Clostridium difficile on Hard Non-Porous Surfaces (February 2018) 2019-02-25 EPA 705-G-2020-1261 FIFRA, Antimicrobial This document provides an update to the Agency’s interim guidance for the efficacy evaluation of antimicrobial pesticides that are labeled for treating hard non-porous surfaces in healthcare settings contaminated with spores of Clostridium difficile. 72
EPA Data Requirements for Registration of Antimicrobial Pesticides: Part 158W 2019-05-03 EPA 705-G-2020-1262 Pesticide Registration; FIFRA; Pesticides; Antimicrobial; This document gives the data requirements for antimicrobial products. 40
EPA Data Requirements for Registration of Antimicrobial Pesticides: 158W Implementation Letter 2017-05-05 EPA 705-G-2020-1264 Pesticide Registration This letter informs pesticide registrants how EPA has been implementing new data requirements under 40 CFR Part 158W. 39
Alternate Testing Framework for Classification of Eye Irritation Potential of EPA-Regulated Pesticide Products 2017-05-24 EPA 705-G-2020-1272 Pesticide Registration EPA has updated guidance on testing antimicrobial cleaning products for potential eye irritation. This guidance relies on non-animal testing and expands the use of certain tests. 9
How to Apply for the DfE Logo for Antimicrobial Pesticide Products 2019-05-21 EPA 705-G-2020-1297 FIFRA; Pesticides; Antimicrobial; This document explains how to apply for a designed for the environment logo on AD products. 65
Adding the NSF Logo to Antimicrobial Product Labels 2016-09-09 EPA 705-G-2020-1298 Pesticide Labels Upon receipt of certification from NSF, a registrant may submit a request to add the logo via the Agency’s notification process as described in PR Notice 98-10. 8
Use of the Term "Germs" on Antimicrobial Labels 2005-01-05 EPA 705-G-2020-1302 FIFRA; Pesticides; Antimicrobial; EPA response letter to CSPA providing guidance on when the term “germs” can be used on an antimicrobial label. 115
Indirect Dietary Residential Exposure Assessment Model (IDREAM) Implementation 2019-09-05 EPA 705-G-2020-1345 FIFRA, Antimicrobial The Indirect Dietary Residential Exposure Assessment Model (IDREAM) estimates indirect ingestion exposure to disinfectants used in residential settings on hard surfaces where there may be inadvertent transfer to edible items prepared on those surfaces. 66
Surface Safety Claims Guidance Letter 2016-03-24 EPA 705-G-2020-1455 FIFRA; Pesticides; Antimicrobial; This letter provides guidance on the use of surface safety claims on antimicrobial product labeling. 108
Protocol for Room Sterilization by Fogger Application 2016-09-26 EPA 705-G-2020-1457 FIFRA, Antimicrobial This protocol describes an end-use fogging application for sterilizing porous and non-porous surfaces within a sealed and enclosed space. 92
Efficacy Testing Standards for Antimicrobial Product Data Call-In Responses 2017-05-11 EPA 705-G-2020-1458 FIFRA, Antimicrobial One of the objectives of reregistration is for the Agency to ensure that antimicrobial pesticide products are supported by acceptable efficacy data. Find out about the standards data must meet for antimicrobial products subject to reregistration. 35
Guidance to Companies on Referring to Registered Disinfectant Products that Meet the CDC Criteria for Use Against the Ebola Virus 2017-10-13 EPA 705-G-2020-1459 FIFRA; Pesticides; Antimicrobial; There are no EPA-registered products with label claims against the Ebola virus, but enveloped viruses such as Ebola are susceptible to many hospital disinfectants used to disinfect hard, non-porous surfaces. CDC guidance addresses use of such products. 61
Guidance to Companies on Referring to Registered Disinfectant (Enterovirus D68) 2019-05-13 EPA 705-G-2020-1460 FIFRA, Antimicrobial EPA has worked closely with Center for Disease Control (CDC) to develop the CDC recommendations for environmental infection control in healthcare settings against Enterovirus D68 (EV-D68). 60
Fogger and Mister Final Signed Letter 2013-04-01 EPA 705-G-2020-1461 Pesticide Registration EPA has asked pesticide companies to provide data or amend registrations of products claiming to control public health microorganisms when applied by fogging and/or misting methods. The letter further describes the ways in which the company may respond. 42
Antimicrobials Used in the Fermentation of Fuel Ethanol – Clarification of Jurisdiction 2016-11-02 EPA 705-G-2020-1462 FIFRA; Pesticides; Antimicrobial; EPA has determined that antimicrobials applied to processed food or feed during fermentation of organic material to produce fuel ethanol are outside the scope of EPA’s regulatory authority under FIFRA. The Food and Drug Administration has jurisdiction. 18
Guidance for Use of Food-Grade Shell-Egg Sanitizers 2016-11-02 EPA 705-G-2020-1463 FIFRA; Pesticides; Antimicrobial; Formulations must be cleared under 21 CFR 178.1010 as sanitizing solutions for food contact surfaces or have a tolerance or exemption from the requirement of a tolerance in 40 CFR Part 180 that covers use as a sanitizing solution for food contact surfaces. 54
Protocols for Testing the Efficacy of Disinfectants Against Hepatitis B Virus (HBV) 2018-04-02 EPA 705-G-2020-1464 FIFRA, Antimicrobial EPA has endorsed the in vitro (test tube) duck assay as the appropriate and preferred alternative to animal testing. 93
Use of Disinfectants and Sanitizers in Heating, Ventilation, Air Conditioning, and Refrigeration Systems 2010-09-20 EPA 705-G-2020-1465 FIFRA; Pesticides; Antimicrobial; This document brings attention several concerns that the Agency has regarding the use of sanitizer and/or disinfectant products, and other types of antimicrobial products, to treat the surfaces of heating, ventilation 114
Consideration of Prions as a Pest under FIFRA 2003-09-10 EPA 705-G-2020-1467 FIFRA, Antimicrobial This is the record of decision regarding prions should be considered to be a “pest” the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA), as amended. It includes information about EPA regulation of pesticides based on this decision. 25
Protocol for Residual Self-Sanitizing Activity of Dried Chemical Residues on Hard, Non-Porous Surfaces 2016-09-26 EPA 705-G-2020-1471 FIFRA, Antimicrobial This protocol can be used to determine the residual sanitizing efficacy of antimicrobial products after application to inanimate, nonporous, non-food contact hard surfaces. 91
Updated Draft Protocol for the Evaluation of Bactericidal Activity of Hard, Non-porous Copper Containing Surface Products 2016-01-27 EPA 705-G-2020-1472 FIFRA, Antimicrobial This document describes the updated draft testing protocol recommended by the EPA to support the registration of copper-containing surface products (such as door knobs, or other items that are not intended for food contact) that bear sanitizer claims. 113
Guidance to Registrants: Process for Making Claims Against Emerging Viral Pathogens not on EPA-Registered Disinfectant Labels 2017-10-03 EPA 705-G-2020-1474 FIFRA, Antimicrobial This guidance proposes to use an organism hierarchy to identify effective products for use with emerging pathogens and to permit registrants to make limited statements against such pathogens. It provides general guidance to interested parties. 62
Guidance for Pre-Application Meetings on New Active Ingredients, Major New Uses and Other Registration Actions 2019-09-05 EPA 705-G-2020-1479 Pesticide Registration This is to provide guidance to OPP/AD staff concerning meetings with companies that are considering submitting an application involving a new active ingredient, new use, new technology. 47
Antimicrobial Policy and Guidance Documents 2017-09-26 EPA 705-G-2020-1486 Pesticide Registration These policies and guidance resources are intended to assist companies that want to register an antimicrobial pesticide. 13
Review Process for the Registration and Use Directions for Floor Wipe Towelette Products 2016-12-06 EPA 705-G-2020-1492 FIFRA, Antimicrobial This guidance provides Antimicrobials Division staff with guidance related to the registration requirements and use directions for presaturated/impregnated floor wipe towelette products. This document will be used for new and existing wipe registrations. 98
Emerging Viral Pathogen Guidance for Antimicrobial Pesticides 2017-07-31 EPA 705-G-2020-1519 Pesticide Registration The guidance outlines a voluntary, two stage process involving product label amendments and modified terms of registration and applies only to emerging viruses. 38
Mixtures Equation Pilot Program to Reduce Animal Testing 2017-05-10 EPA 705-G-2020-1639 FIFRA, Antimicrobial EPA is announcing the start of a pilot program to evaluate the usefulness and acceptability of a mathematical tool (the GHS Mixtures Equation), which is used in the Globally Harmonized System of Classification and Labeling of Chemicals (GHS). 73
Antimicrobial Testing Methods & Procedures: MB-35-00 2017-03-21 EPA 705-G-2020-1667 Pesticide Analytical Methods Information about ATMP - OECD Quantitative Method for Evaluating the Efficacy of Liquid Antimicrobials against Candida auris on Hard, Non-Porous Surfaces - MB-35-00 16
Interim Guidance for the Efficacy Evaluation of Products for Claims against Candida auris 2017-05-24 EPA 705-G-2020-1668 FIFRA, Antimicrobial EPA has developed two new test methods and associated testing guidance for evaluating the effectiveness of antimicrobial pesticides against Candida auris (C. auris). 67
Methods and Guidance for Testing the Efficacy of Antimicrobial Products Against Biofilms on Hard, Non-Porous Surfaces 2017-10-19 EPA 705-G-2020-1702 FIFRA, Antimicrobial Guidance document to assess the efficacy of antimicrobial pesticides hard non-porous surfaces. 71
Guidance on Disinfectant Products Intended to Treat Drinking Water 2017-10-17 EPA 705-G-2020-1712 FIFRA, Antimicrobial Guidance provides a basic overview of FIFRA product registration process and how FIFRA approval relates to the Safe Drinking Water Act, specifically for disinfectant products intended to treat. 58
New EPA Quick Guide for Registering Disinfectant Products for Drinking Water Use 2017-10-17 EPA 705-G-2020-1715 FIFRA, Antimicrobial Developed this Quick Guide for Disinfectant Products for Drinking Water Use in response to requests to help prospective pesticide registrants gain a basic understanding of the FIFRA. 74
Label Guidance for Antimicrobial Pesticides Used for Poultry House Disinfection 1980-01-17 EPA 705-G-2020-2342 FIFRA, Antimicrobial The purpose of this guidance is to outline the use directions for antimicrobial pesticides used in poultry houses. 69
875.1700 Product Use Information (Applicator) 1996-02-01 EPA 705-G-2020-2365 FIFRA, Pesticides, Antimicrobial This document explains pest use information. 3
875.2300 Indoor Surface Residue Dissipation 1998-02-10 EPA 705-G-2020-2366 FIFRA, Pesticides, Antimicrobial This document explains indoor surface residue test guidelines. 4
875.2700 Product Use Information (Post Application) 1998-02-10 EPA 705-G-2020-2367 FIFRA, Pesticides, Antimicrobial This document explains the guidelines for product use information. 5
875.2800 Descriptions of Human Activity.  2009-07-30 EPA 705-G-2020-2368 FIFRA, Pesticides, Antimicrobial This document explains the description of human activities testing guidelines. 6
Guidance for Waiving or Bridging of Mammalian Acute Toxicity Tests for Pesticides and Pesticide Products (Acute Oral, Acute Dermal, Acute Inhalation, Primary Eye, Primary Dermal, and Dermal Sensitization) 2012-03-01 EPA 705-G-2020-2376 FIFRA, Antimicrobial This document gives information on waiving or bridging acute tox data (master) 57
Guidance for quantitative assessment of dermal sensitization risk for pesticide chemicals in the Office of Pesticide Programs 2019-09-04 EPA 705-G-2020-2377 FIFRA, Antimicrobial This document explains assessment of dermal sensitization. 48
Label Guidance for Antimicrobial Pesticides on Hard, Non-Porous Surfaces 1979-12-02 EPA 705-G-2020-2379 FIFRA, Antimicrobial This document provides information on products used on hard non-porous surfaces. 68
Guidance Document Label Claims for Products with ATP failures 2018-12-10 EPA 705-G-2020-2386 FIFRA, Antimicrobial Master, this document explains label guidance for ATP failures 45
Guidance for Reregistration of Pesticide Products Containing Chlorinated Isocyanurates as the Active Ingredient 1992-09-01 EPA 705-G-2020-2388 FIFRA, Antimicrobial This gives guidance for products containing chlorinated isocyanurates. 49
Guidance For The Reregistration Of Wood Preservative Pesticide Products Containing Chromated And Non-Chromated Arsenicals as the Active Ingredient, Case Number 0647 1986-09-10 EPA 705-G-2020-2391 FIFRA, Antimicrobial This document gives information for reregistration of chromated and non-chromated arsenicals. 53
Draft Guidance on Conducting an Ecological Exposure Assessment for Antifoulant Coatings & Paints— Saltwater Marinas. June 2016 2016-06-01 EPA 705-G-2020-2392 marinas, antifoulants, copper, FIFRA SOP for estimating exposures for antifoulant paints in coastal marinas. Master 32
E-FAST, Down the Drain Assessment Model 2007-10-01 EPA 705-G-2020-2394 down the drain, WWTP, wastewater, E-FAST, FIFRA Model developed by OPPT and used by AD to estimate aquatic exposures from pesticidal chemicals which are disposed of down the drain either in municipal or industrial waste water systems. Manual updated in 2015. Master 34
Reregistration Eligibility Document Sodium and Calcium Hypochlorite Salts 1992-02-01 EPA 705-G-2020-2395 FIFRA, Antimicrobial RED for Sodium and Calcium hypochlorite (aka bleach) 96
Guidance for Reregistration of Pesticides containing Sodium and Calcium Hypochlorite Salts as the Active Ingredient  1986-02-01 EPA 705-G-2020-2396 FIFRA, Antimicrobial The 1986 standard for Sodium and Calcium hypochlorite  50
Series 860 Residue Chemistry Guidelines 2016-08-25 EPA 705-G-2020-2563 FIFRA, Antimicrobial This document describes the residue chemistry guidelines for dietary analysis 102
870 Toxicology Guidelines 2019-12-12 EPA 705-G-2020-2564 FIFRA, Pesticides, Antimicrobial This document explains the toxicology guidelines. 1
875 Exposure Guidelines 2016-08-25 EPA 705-G-2020-2565 FIFRA, Pesticides, Antimicrobial This document explains the exposure guidelines. 2
Label Guidance for Antimicrobial Pesticides Used for Sanitation of Food Contact Surfaces 1979-12-02 EPA 705-G-2020-2581 FIFRA, Antimicrobial This document gives information on sanitizing food contact surfaces 70
Efficacy Testing Standards for Reregistration 2017-05-11 EPA 705-G-2020-2597 data-call-in; reregistration This document provides an overview of the 2014 efficacy data standards and identifies certain testing standards that differ from the 2012 Guidelines.  It is intended for registrants citing/submitting previously generated or new efficacy data in response to a reregistration data call-in 36
UDM Performance Standard Revision Document 2013-11-26 EPA 705-G-2020-2598 FIFRA, Antimicrobial Explanation of changes to Use Dilution Method (UDM) 112
Crosswalk Table for Non-Public Health Guidelines 2007-05-23 EPA 705-G-2020-2599 FIFRA, Antimicrobial Determination of non-public guidelines for organisms, archived page but still good 28
Fragrance Notification Programs 2015-12-01 EPA 705-G-2020-2600 FIFRA, Antimicrobial This document provides guidance for EPA's Office of Pesticide Programs (OPP) Fragrance Notification Program (PFNP) for registrants seeking to add or modify existing fragrances in new or currently registered pesticide products. 43
Guidelines for Voluntary Disclosure of Antimicrobial Ingredient Information on Company Websites and/or Labels 2019-03-28 EPA 705-G-2020-2601 FIFRA, Antimicrobial This document gives information on inert disclosure 64
Guidance for Testing and Labeling Claims against Pandemic 2009 H1N1 Influenza A Virus (formerly called Swine Flu) 2017-07-21 EPA 705-G-2020-2603 FIFRA, Antimicrobial This document gives information on claims about 2009 pandemic flu. 51
Response to questions concerning existing C. diff claims (vegetative form) on antimicrobial product labels 2008-09-22 EPA 705-G-2020-2605 FIFRA, Antimicrobial This document is a response to questions about C. diff claims 97
Barrier Products Clarification Document--Guidance for what is needed for an Agency barrier determination 2007-03-01 EPA 705-G-2020-2606 FIFRA, Antimicrobial This document provides information on what is considered a barrier 19
Use of the term "shock" on non-pesticide labeling 2008-07-24 EPA 705-G-2020-2607 FIFRA, Antimicrobial This document explains how the term shock is used on non-pesticidal labeling. 116
Antimicrobial Products Registered for Disinfection Use against Avian Influenza on Poultry Farms and Other Facilities 2019-12-18 EPA 705-G-2020-2608 FIFRA, Antimicrobial This document provides guidance on the avian on use of antimicrobial products in poultry farms and other facilities. 14
Draft Interim Guidance for Non-Residual Sanitizers on Hard, Inanimate Food Contact Surfaces Using Pre-Saturated Towelettes 2001-04-12 EPA 705-G-2020-2613 FIFRA, Antimicrobial This protocol can be used to conduct efficacy testing to support a pre-saturated towelette registration for use on food contact surfaces.   33
BISM JWOD & Skilkraft Letter 2004-07-26 EPA 705-G-2020-2614 FIFRA, Antimicrobial This letter explains the use of logos, the website is archived 20
Consumer Specialty Products Association (CSPA) Fruit Graphic Letter 2002-11-13 EPA 705-G-2020-2615 FIFRA, Antimicrobial This letter addressed to CSPA provides Guidance regarding the use of graphics depicting fruit on antimicrobial labels. 27
SC Johnson Biofilms Letter 2004-07-21 EPA 705-G-2020-2616 FIFRA, Antimicrobial This letter provides guidance on biofilm claims for products intended for use in the residential settings. 101
Shock Letter for swimming pools, hot tubs, and spa products 2007-06-21 EPA 705-G-2020-2617 FIFRA, Antimicrobial This is a letter that explains the term shock 103
Surface Safety Claims Guidance 2016-03-24 EPA 705-G-2020-2618 FIFRA; Pesticides; Antimicrobial; This is a guidance document on surface safety claims 107
Confirmatory Virucidal Effectiveness Test for Feline Calicivirus (FCV) 2017-12-27 EPA 705-G-2020-2620 FIFRA, Antimicrobial This document describes how to achieve efficacy of pre-saturated or impregnated towelettes for hard, non-porous surface disinfection against feline calicivirus (FCV), surrogate for norovirus. 24
Pre-Saturated or Impregnated Confirmatory Virucidal Effective Test against Norovirus 2017-12-27 EPA 705-G-2020-2622 FIFRA, Antimicrobial This document describes how to achieve virucidal effectiveness for a product used to disinfect hard, non-porous surfaces contaminated with Norovirus 80
Antimicrobial Science Policies: Disinfectant technical Science Section (DIS/TSS) 2006-05-02 EPA 705-G-2020-2625 FIFRA, Antimicrobial These documents provide a historical summary of current efficacy related requirements and/or policy for antimicrobial pesticide products, claims, and use patterns. 15
Acute Toxicity Templates for Antimicrobial Products 2017-04-25 EPA 705-G-2020-2626 FIFRA, Pesticides, Antimicrobial These templates are designed to guide registrants in required acute toxicity studies. 7
Determining If A Cleaning Product Is a Pesticide Under FIFRA 2019-07-03 EPA 705-G-2020-2628 FIFRA, Antimicrobial This fact sheet describes the Agency's longstanding interpretation of the statutory and regulatory language applicable to products marketed as cleaning products that claim, state or imply (by labeling or other means) that they mitigate a pest. 31
Test Method for the Continuous Reduction of Bacterial Contamination on Copper Alloy Surfaces 2016-01-29 EPA 705-G-2020-2629 FIFRA, Antimicrobial This document explains the test method for continuous reduction of bacterial contamination 110
Subdivision G 1982-11-01 EPA 705-G-2020-2631 FIFRA, Antimicrobial This subdivision of the pesticide registration guidelines concerns the effectiveness of pesticide products. These are efficacy of product guidelines. Primarily HED 106
Revisions to the Performance Standard for AOAC Use Dilution Methods for Staphylococcus aureus and Pseudomonas aeruginosa 2013-11-26 EPA 705-G-2020-2632 FIFRA, Antimicrobial Revisions to AOAC UDM to communication changes to performance standards for P. aeruginosa and S. aureus. 100
Guidance on Warranty Statements 2006-10-17 EPA 705-G-2020-2633 FIFRA, Antimicrobial This document contains information regarding acceptable warranty and disclaimer statements. 59
Guidance for Antimicrobial Pesticide Products with Mold-Related Label Claims 2012-12-12 EPA 705-G-2020-2636 FIFRA, Antimicrobial This document represents the Agency's guidance on product performance data and labeling for "mold-related" pesticide products. 46
Antimicrobial Testing Program 2018-12-10 EPA 705-G-2020-2637 FIFRA, ATP, antimicrobial Details of ATP including status table. 17
Consumer Products Treated with Pesticides 2018-05-29 EPA 705-G-2020-2638 FIFRA, Antimicrobial This explains the treated article exemption 26
Possible Product Chemistry Triggers for Confirmatory Efficacy Data 2017-02-21 EPA 705-G-2020-2641 FIFRA, Antimicrobial Chemical Modifications that may trigger additional data requirements 79
Pesticide Assessment Guidelines Subdivision F Hazard Evaluation:  Human and Domestic Animals 1984-11-01 EPA 705-G-2020-3389 FIFRA; pesticides; antimicrobials This document explains the hazard evaluation process for humans and domestic animals 76
Product Registration Batching Guidance for Quaternary Ammonium Compounds (Cases 03503 and 3003)--Acute Mammalian Toxicity Data Requirements 1988-02-26 EPA 705-G-2020-3390 acute, toxicity, DCI, quats This document identifies batches or groups of certain products which may rely on the same acute toxicity data to support product reregistration Data Call-In (DCI) requirements for quats. 90
Guidance for Waiving Acute Dermal Toxicity Tests for Pesticide Formulations & Supporting Retrospective Analysis 2016-11-09 EPA 705-G-2020-3391 acute, dermal, toxicity,  This document details the procedure for waiving acute dermal toxicity tests. 55
Conduct of Acute Toxicity Studies 1997-09-01 EPA 705-G-2020-3392 FIFRA; pesticides; antimicrobial This document details the procedure for conducting acute toxicity studies. 23
Clarification of Net Contents Declarations for Antimicrobial Wipe Products 2009-02-04 EPA 705-G-2020-3507 FIFRA; Pesticides; Antimicrobial; This document describes the net contents for wipe products, the website is archived. 22
CSPA Germs Letter 2005-01-05 EPA 705-G-2020-3508 FIFRA; Pesticides; Antimicrobial; This letter (addressed to the Consumer Specialty Products Association - CSPA) provides guidance on the use of the term "germs" on antimicrobial labeling. Superseded by 1302 29
Antimicrobial Pesticides 2016-11-15 EPA 705-G-2020-3509 FIFRA; Pesticides; Antimicrobial; Website detailing guidance documents for registration 12
Certification Statement for Design for the Environment Logo for Pesticide Products 2007-03-01 EPA 705-G-2020-3511 FIFRA; Pesticides; Antimicrobial; This document explains the certification process for designed for the environment products 21
Design for the Environment Logo for Antimicrobial Pesticide Products 2019-05-21 EPA 705-G-2020-3513 FIFRA; Pesticides; Antimicrobial; This document explains designed for the environment on antimicrobial products. 30
Guidance for the Efficacy Evaluation of Products with Sporicidal Claims Against 2014-06-01 EPA 705-G-2020-3515 FIFRA; Pesticides; Antimicrobial; This product reviews the evaluations for sporicidal claims. 52
Guidelines for Dental Issues 1999-03-31 EPA 705-G-2020-3516 FIFRA; Pesticides; Antimicrobial; This document describes examples of recent inquiries of antimicrobial dental uses, the website is archived. 63
NSF Logo Letter 2004-07-01 EPA 705-G-2020-3533 FIFRA; Pesticides; Antimicrobial; Letter describing the NSF logo that can be used on pesticide labels. Remove 75
Pesticide Label Statements:  Pilot Program to Help Promote Environmental Stability 2017-05-04 EPA 705-G-2020-3534 FIFRA; Pesticides; Antimicrobial; This document explains a pilot program to promote environmental stability 77
Questions about the DfE Logo for Antimicrobial Pesticide Products 2019-05-21 EPA 705-G-2020-3535 FIFRA; Pesticides; Antimicrobial; This document gives answers to common questions on DfE 94
Reregistration and Other Review Programs Predating Pesticide Registration Review 2017-05-24 EPA 705-G-2020-3537 FIFRA; Pesticides; Antimicrobial; This document gives information on reregistration 95
Timber Treatment Technologies TimberSil Products 2008-05-14 EPA 705-G-2020-3539 FIFRA; Pesticides; Antimicrobial; This letter is in response to a request for a barrier determination for TimberSil wood products the website is archived. 111
Wood Preservative Organic Memorandum Letter 2007-07-02 EPA 705-G-2020-3541 FIFRA; Pesticides; Antimicrobial; Memo explaining the use of the term organic with respect to pesticide products the website is archived 117
Frequent Questions for the 2018 Series 810 – Product Performance Test Guidelines: Antimicrobial Efficacy Test Guidelines  2019-08-28 EPA 705-G-2020-3559 FIFRA, antimicrobial An FAQ for the 810 guidelines 44
Antimicrobial Performance Evaluation Program (APEP) 2019-11-21 EPA 705-G-2020-3561 FIFRA, Antimicrobial This document explains the APEP program, it supersedes the ATP guidance 10
Standard Evaluation Procedure (SEP) for Chemistry and Acute Toxicity Science Advisory Council (CATSAC) 2019-11-27 EPA 705-G-2020-3693 Pesticide Registration, FIFRA, Acute Toxicity The SEP generally describes the evaluation process for the determination of pesticide products claiming to be identical or substantially similar for the purposes of relying upon previously submitted product chemistry and/or acute toxicity data, or for bridging acute toxicity data. 104
Revised Temporary Amendment to Pesticide Registration (PR) Notice 98-10 - Notice to Manufacturers, Producers, Formulators and Registrants of Pesticides Products 2020-05-11 EPA 705-G-2020-3701 FIFRA, pesticides, disinfectants The temporary amendment to PRN 98-10, signed May 11, 2020, allows registrants to notify EPA of certain formulation and manufacturing facility changes and immediately release the product for sale without waiting for EPA approval. EPA has taken this action in order to address reports of shortages of active ingredients used in surface disinfectants on EPA’s List N: Disinfectants for Use Against SARS-CoV-2, the virus that causes COVID-19, and to address shortages of food-contact surface sanitizer products used on equipment for food manufacturing and food preparation. 99
Expedited Review of Emerging Viral Pathogens Claim Submissions 2020-03-09 EPA 705-G-2020-3702 FIFRA, pesticides, disinfectants EPA is expediting the review of emerging viral pathogen claims for EPA registered disinfectants that do not require review of new efficacy data. EPA is currently making every effort to expedite the review and make a regulatory decision for the submissions discussed in this document by at least one to two months faster than the normal PRIA timeframe, depending on the submission. 41
Standardized Efficacy Study Report and Efficacy Study Summary 2017-05-24 EPA 705-G-2020-3704 FIFRA, Pesticides, Antimicrobial The study report form contains all of the required elements of a study report as found in 40 CFR part 160, and meets the requirements of PR Notice 2011-3. The Efficacy Study Summary provides a form to create a summary of the important information and variables that are presented in detail in the final report. The summary may be inserted into the study report form. 105
Test Method for Efficacy of Antimicrobial Agents to Reduce Foodborne Pathogenic Bacteria in Processing Waters for Fruit and Vegetables 2008-06-01 EPA 705-G-2020-3707 FIFRA, pesticides This test method is used to determine If antimicrobial agents effectively reduce populations of foodborne pathogenic bacteria in fruit and vegetable processing waters. 109
Electrostatic Spray Applications / List N 2020-07-07 EPA 705-G-2020-3709 FIFRA, Antimicrobials This guidance outlines an expedited review process for adding directions for use for application using electrostatic spray for products intended for use against SARS-CoV-2, the cause of COVID-19 37
Guidance for Waiving Acute Dermal Toxicity Tests for Pesticide Technical Chemicals & Supporting Retrospective Analysis 2020-12-31 EPA 705-G-2020-3722 FIFRA, pesticides, data requirements This guidance document follows upon the final dermal waiver guidance published in November 2016 for pesticide formulations. This document expands the potential for data waivers for acute dermal studies to single active ingredient technical chemicals (technical chemicals) used to formulate end user products. 56
Product Performance Test Guidelines: Antimicrobial Efficacy Test Guidelines, 810.2300, Sanitizers for Use on Hard Surfaces--Efficacy Data Recommendations 2012-09-04 EPA 712-C-07-091 FIFRA, Antimicrobial This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 84
Product Performance Test Guidelines: Antimicrobial Efficacy Test Guidelines, 810.2700, Products with Prion-Related Claims 2012-12-01 EPA 712-C-13-001 FIFRA, Antimicrobial This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 88
Product Performance Test Guidelines: Antimicrobial Efficacy Test Guidelines, 810.2000, General Considerations for Testing Public Health Antimicrobial Pesticides 2018-02-01 EPA 712-C-17-002 FIFRA, Antimicrobial This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 81
Product Performance Test Guidelines: Antimicrobial Efficacy Test Guidelines, 810.2100, Sterilants, Sporicides, and Decontaminants 2018-02-01 EPA 712-C-17-003 FIFRA, Antimicrobial This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 82
Product Performance Test Guidelines: Antimicrobial Efficacy Test Guidelines, 810.2200, Disinfectants for Use on Environmental Surfaces 2018-02-01 EPA 712-C-17-004 FIFRA, Antimicrobial This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 83
Product Performance Test Guidelines: General, 810.1000, Overview, Definitions, and General Considerations 1998-03-01 EPA 712–C–98–001 FIFRA, Antimicrobial This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 89
Product Performance Test Guidelines: Antimicrobial Efficacy Test Guidelines, 810.2400, Disinfectants and Sanitizers for Use on Fabrics and Textiles 2012-12-21 EPA 730-C-11-003 FIFRA, Antimicrobial This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 85
Product Performance Test Guidelines: Antimicrobial Efficacy Test Guidelines, 810.2500, Air Sanitizers 2012-12-21 EPA 730-C-11-003 FIFRA, Antimicrobial This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 86
Product Performance Test Guidelines: Antimicrobial Efficacy Test Guidelines, 810.2600, Disinfectants for Use in Water 2012-12-21 EPA 730-C-11-003 FIFRA, Antimicrobial This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 87
The Role of Use-Related Information in Pesticide Risk Assessment and Risk Management 2000-10-11 EPA 705-G-2020-0041 FIFRA Provides an overview of the role of pesticide use-related information in the regulatory process for risk assessment and risk management for pesticides. 129
Use Dilution Method Performance Standard Revision Document 2013-11-26 EPA 705-G-2020-2518 Pesticide Analytical Methods The performance standard for the UDM was reassessed in 2013; the document provides the statistical analysis and data supporting the change. 130
Sporicidal Claims Against Clostridium difficile 2018-02-01 EPA 705-G-2020-2519 FIFRA The document provides criteria and references to test methods for developing efficacy data for antimicrobials against C. difficile. 127
Interim Guidance for the Efficacy Evaluation of Products for Claims Against Candida auris 2017-01-01 EPA 705-G-2020-2520 Pesticide Analytical Methods The document provides criteria and references to test methods for developing efficacy data for antimicrobials against C. auris. 118
Methods and Guidance for the Efficacy Evaluation of Antimicrobial Products Against Biofilms on Hard, Non-porous Surfaces 2017-01-01 EPA 705-G-2020-2521 Pesticide Analytical Methods The document provides criteria and references to test methods for developing efficacy data for antimicrobials against biofilm bacteria. 125
National Pesticide Standard Repository 2017-02-06 EPA 705-G-2020-3077 Pesticides Information on how to obtain analytical standards from the EPA National Pesticide Standard Repository, which distributes analytical standards to federal, state and tribal laboratories involved in performing environmental, food, or product monitoring for the enforcement of United States federal and state pesticide laws such as the Federal Food, Drug, and Cosmetic Act and the Federal Insecticide, Fungicide, and Rodenticide Act. 126
MB-19; Preparing a Pseudomonas aeruginosa or Staphylococcus aureus Biofilm using the CDC Biofilm Reactor 2019-11-25 EPA 705-G-2020-3094 Antimicrobial Testing Methods Provides the laboratory procedure for growing a biofilm for efficacy testing of disinfectants. 119
MB-20; Single Tube Method for Determining the Efficacy of Disinfectants Against Bacterial Biofilm 2019-12-02 EPA 705-G-2020-3097 Antimicrobial Testing Methods Provides a laboratory method for measuring the efficacy of disinfectants against bacterial biofilms. 120
MB-28; Procedure for the Production and Storage of Spores of Clostridium difficile for Use in the Efficacy Evaluation of Antimicrobial Agents  2017-12-08 EPA 705-G-2020-3105 Antimicrobial Testing Methods Provides a laboratory method for producing spores of Clostridium difficile. 121
MB-31; Quantitative Method for Testing Antimicrobial Products Against Spores of Clostridium difficile on Inanimate, Hard, Non-porous Surfaces 2019-12-21 EPA 705-G-2020-3107 Antimicrobial Testing Methods Provides a laboratory test method for evaluating antimicrobials for claims against clostridium difficile. 122
MB-35; OECD Quantitative Method for Evaluating the Efficacy of Liquid Antimicrobials Against Candida auris on Hard, Non-porous Surfaces  2018-01-09 EPA 705-G-2020-3108 Antimicrobial Testing Methods Provides a laboratory test method for testing disinfectants for efficacy against Candida auris. 123
MB-37; Neutralization Confirmation for Evaluating the Efficacy of Liquid Antimicrobials against Candida auris using the OECD Quantitative Method on Hard, Non-porous Surfaces 2018-01-09 EPA 705-G-2020-3109 Antimicrobial Testing Methods Provides a laboratory test method for determining the effectiveness of neutralizers in the Candida auris test method. 124
Suggestions for Applicants on Information Considered when Evaluating Benefits of New Conventional Active Ingredients/Significant New Use Site Requests 2018-09-01 EPA 705-G-2020-3140 Antimicrobial Testing Methods This memo describes the types of benefits related information that would be useful for registrants to submit in support of their applications to register new conventional active ingredients or for significant new use requests. 128
Biopesticide Registration 2017-04-12 EPA 705-G-2020-0415 Pesticide Registration; Biopesticides; Pre-Submission Meetings; Regulatory and Data Requirements; Guidance Documents; Work Plans Resources for an individual or company wanting to register a biopesticide product to include biochemical pesticides, microbial pesticides, or plant-incorporated protectants. 139
Biopesticides Confidential Statement of Formula 2010-01-05 EPA 705-G-2020-0466 Pesticide Registration; Confidential Statement of Formula; Form 8570-4; Microbial Pesticides; Biochemical Pesticides This document describes how to prepare a confidential statement of formula (CSF) for biochemical and microbial pesticides. 140
Pesticide Registration Manual: Chapter 3 - Additional Considerations for Biopesticide Products 2017-05-23 EPA 705-G-2020-0500 Pesticide Registration; Biopesticides; Biochemical Pesticides; Microbial Pesticides; Plant-Incorporated Protectants; Data Requirements; PRIA Review Phases; Genetically Modified Microbial Pesticides; Biotech Notifications Biopesticides are certain types of pesticides derived from such natural materials as animals, plants, bacteria, and certain minerals that fall into three major classes: microbial pesticides, plant-incorporated protectants, and biochemical pesticides. A separate chapter on biopesticides is included in this manual because there are different requirements for biopesticides that need to be explained in detail. This chapter should be referred to in conjunction with Chapter 2, “Registering a Pesticide Product.” 214
OECD Data Evaluation Record Templates 2011-11-18 EPA 705-G-2020-0516 Pesticide Registration; Joint Review; Canadian Pest Management Regulatory Agency; Data Templates; Microbial Pesticides See information about OECD templates used for writing data evaluation record for submitting studies for pesticide registrations. 211
How to Use OECD Data Evaluation Record Templates 2011-11-18 EPA 705-G-2020-0517 Pesticide Registration; Joint Review; Canadian Pest Management Regulatory Agency; Data Templates; Microbial Pesticides This document describes the process of development of the OECD data evaluation record templates and provides examples of how to use them. 153
Minimum Risk Pesticides 2019-04-30 EPA 705-G-2020-0557 Minimum Risk Pesticides; Exemption; 40 CFR 152.25(f); Composition; Label; Conditions; Enforcement The website provides information on the criteria that must be met for a product to qualify for the FIFRA exemption. 206
Conditions for Minimum Risk Pesticides 2018-03-14 EPA 705-G-2020-1090 Minimum Risk Pesticides; Exemption; 40 CFR 152.25(f); Composition; Label To qualify as minimum risk, a pesticide product must meet six conditions that relate to the ingredients in the product and claims that are made about the product on the label. Learn about these conditions. 145
State Regulation of Minimum Risk Pesticides 2016-11-01 EPA 705-G-2020-1091 Minimum Risk Pesticides; Exemption; 40 CFR 152.25(f); State Regulation The states are not required to permit the sale of an exempted product simply because it is exempted under federal pesticide law. 218
Need for Tolerances and Tolerance Exemptions for Minimum Risk Pesticides 2018-05-09 EPA 705-G-2020-1092 Minimum Risk Pesticides; Exemption; 40 CFR 152.25(f); Tolerances; Tolerance Exemptions; FFDCA The ingredients used in minimum risk products used on food, food crops, food contact surfaces, or animal feed commodities generally have a tolerance or tolerance exemption. Learn about tolerances and tolerance exemptions for minimum risk ingredients. 210
Enforcement Related to Minimum Risk Pesticides 2016-11-01 EPA 705-G-2020-1093 Minimum Risk Pesticides; Exemption; 40 CFR 152.25(f); Federal Enforcement; State Enforcement If a product does not meet all the requirements of the minimum risk exemption, it must be registered unless eligible for some other exemption. Learn about enforcement actions EPA can take where unregistered products make pesticidal claims. 150
Personal Insect Repellents and Minimum Risk Pesticides 2019-07-23 EPA 705-G-2020-1094 Minimum Risk Pesticides; Exemption; 40 CFR 152.25(f); Insect Repellents; Sunscreen Components; FDA; Public Health Pests An exempt pesticide product may not bear claims to control rodent, insect or microbial pests in a way that links the pests with specific disease. We are considering a proposal to remove personal mosquito and tick repellents from the minimum risk exemption. 213
Consumer Specialty Products Association Letter and EPA Response re: Minimum Risk Pesticide Exemption Petition 2017-03-27 EPA 705-G-2020-1095 Minimum Risk Pesticides; Exemption; 40 CFR 152.25(f); Public Health Pests; Consumer Specialty Products Association Petition The Consumer Specialty Products Association petitioned EPA to exclude from the minimum risk pesticide exemption pesticides claiming to control “pests of significant public health importance” and require registration. View the petition and EPA's response. 146
Commonly Consumed Food Commodities 2019-07-23 EPA 705-G-2020-1096 Minimum Risk Pesticides; Exemption; 40 CFR 152.25(f); Inert Ingredients; Commonly Consumed Food Commodities; Animal Feed Items; Edible Fats and Oils; 40 CFR 180.950  Commonly consumed foods are those ingested for their nutrient properties. Food commodities can be either raw agricultural commodities or processed commodities, provided that they are the forms that are sold or distributed for human consumption. Learn more about commonly consumed food commodities, as well as other items from 40 CFR 180.950 (e.g., animal feed items and edible fats and oils), and how they relate to minimum risk pesticides. 144
Determining If Insect Repellent Skin Patch Products Must Be Registered Under FIFRA 2018-04-02 EPA 705-G-2020-1257 Pesticide Registration; Vitamin B; Biochemical Pesticides; Insect Repellent; Skin Patch; Minimum Risk Pesticides; 40 CFR 152.25(f); Enforcement Certain skin patch products that claim to repel insects are required to be registered under the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA), while others are exempt. Learn more about this issue. 148
How to Apply for the DfE Logo for Biopesticide Products 2019-05-06 EPA 705-G-2020-1296 Pesticide Labels; Design for the Environment; Logo; Biopesticides; Safer Choice This page lists the criteria a product must meet and provides instructions to apply for the DfE logo on biopesticide product labels. 152
Labeling of Pesticide Products under the National Organic Program 2017-05-24 EPA 705-G-2020-1305 Pesticide Labels; National Organic Program; Logo This notice describes how registrants can obtain EPA approval of label language indicating that all ingredients in a pesticide product and all uses of that pesticide meet the criteria defined in the USDA National Organic Program Rule. 157
Tips for Plant-Incorporated Protectant (PIP) Experimental Use Permit (EUP) Program Submission 2017-06-06 EPA 705-G-2020-1410 Experimental Use Permits; Biotechnology; Plant-Incorporated Protectants; Acreage; Test Protocols; Objectives; Locations; Seed Increase Includes information to include in the program description and final program report, recommendations for calculating acreage, use of seed produced under PIP EUPs, and consultation with Biopesticides and Pollution Prevention Division. 221
Biotech Information - Sharing Memorandum of Understanding 2000-02-02 EPA 705-G-2020-1412 Biotechnology; Plant-Incorporated Protectants; Regulatory Oversight; Information Sharing; Memorandum of Understanding; FDA; USDA EPA, FDA, and the U.S. Department of Agriculture's Animal and Plant Health Inspection Service/Biotechnology Regulatory Services share the regulatory oversight over genetically engineered plants and the foods derived from such plants. 141
EPA’s National Organic Program Guidance 2017-05-24 EPA 705-G-2020-1417 Pesticide Registration; National Organic Program; Ingredients  The National Organic Program is a USDA program, including concerning the eligibility of inert ingredients for use in the NOP. EPA’s role is to assist USDA by assuring that USDA’s policies are implemented for organic claims by registered pesticide products. 151
NAFTA Revised Procedures for Joint Review of Microbials and Semiochemicals 2002-07-17 EPA 705-G-2020-1418 Biopesticides; Joint Review; Canadian Pest Management Regulatory Agency; Microbial Pesticides; Arthropod Semiochemicals; Pre-Submission Consultations; Time Frames; Data Requirements The Canadian Pest Management Regulatory Agency and EPA have established a process for the joint review of pest control products in which the new active ingredient is a microbial or an arthropod semiochemical (including pheromones). 208
National Strategy for Modernizing the Regulatory System for Biotechnology Products 2016-09-01 EPA 705-G-2020-1646 Biotechnology; Plant-Incorporated Protectants; Genetically Engineered Microbial Pesticides; Biotechnology Working Group; Coordinated Framework; FDA; USDA; Transparency; Predictability; Efficiency; Best Available Science; Strategy This National Strategy for Modernizing the Regulatory System for Biotechnology Products sets forth a vision for ensuring that the federal regulatory system is prepared to efficiently assess the risks, if any, of the future products of biotechnology. 209
Memorandum on Modernizing the Regulatory System for Biotechnology Products 2015-07-02 EPA 705-G-2020-1647 Biotechnology; Plant-Incorporated Protectants; Genetically Engineered Microbial Pesticides; Biotechnology Working Group; Coordinated Framework; FDA; USDA; Transparency; Predictability; Efficiency; Best Available Science; Strategy This July 2, 2015 memorandum initiated a process to modernize the federal regulatory system for the products of biotechnology and to establish mechanisms for periodic updates of that system. 158
Plant-Incorporated Protectants Data Symposium 2016-10-19 EPA 705-G-2020-2545 Pesticide Registration; Data; Biotechnology; Plant-Incorporated Protectants; Human Health Risk Assessment; Environmental Risk Assessment; Insect Resistance Management; Coordinated Framework; FDA; USDA The symposium provided a forum for PIP developers, the agricultural sector and the general public to receive information firsthand on the scope of the scientific review process that determines the safety of PIPs and on the pesticide registration process as a whole. EPA, FDA and USDA representatives gave an overview of the regulatory system that applies to biotechnology in the United States in the context of the Coordinated Framework for Regulation of Biotechnology. 215
Overview of Plant Incorporated Protectants 2019-05-20 EPA 705-G-2020-2546 Pesticide Registration; Biotechnology; Plant-Incorporated Protectants; Data; Regulation History; Scientific Advisory Panels; Risk Assessment Plant-incorporated protectants are pesticidal substances produced by plants and the genetic material necessary for the plant to produce the substance. For example, scientists can take the gene for a specific Bt pesticidal protein and introduce the gene into the plant's genetic material. Then the plant manufactures the pesticidal protein that controls the pest when it feeds on the plant. Both the protein and its genetic material are regulated by EPA; the plant itself is not regulated. 212
Insect Resistance Management for Bt Plant-Incorporated Protectants 2017-08-22 EPA 705-G-2020-2547 Pesticide Registration; Biotechnology; Plant-Incorporated Protectants; Insect Resistance Management; Pyramids; Stacks; Refuge; Mitigation Strategies; Compliance Assurance Plans; Resistance Monitoring; Scientific Advisory Panels EPA places a high value on the efficacy of Bt PIPs and on preserving their significant agricultural and environmental benefits. Therefore, the Agency is committed to maintaining effective oversight of these products to mitigate the development of resistance in the target pests. To counter the threat of resistance, EPA has mandated the implementation of an Insect Resistance Management (IRM) plan for each commercially registered Bt PIP. The goal of IRM is to delay the onset of resistance for as long as possible, though it is important to note that it may not be possible to entirely prevent resistance from evolving.   155
Tier-Based Testing for the Effects of Proteinaceous Insecticidal Plant-Incorporated Protectants 2007-04-06 EPA 705-G-2020-2548 Pesticide Registration; Biotechnology; Plant-Incorporated Protectants; Nontarget Invertebrates; Environmental Risk Assessment; Data The purpose of this paper is to summarize scientific and regulatory information on nontarget invertebrate testing and evaluation of new products expressing insecticidal proteins in an ecological risk assessment. The information included provides a general discussion for conducting non-target invertebrate ecological risk assessments for crops expressing insecticidal proteins. 219
Tips for Avoiding Confidential Statement of Formula or Product Chemistry Issues with Biopesticides 2019-08-02 EPA 705-G-2020-2549 Pesticide Registration; Confidential Statement of Formula; Form 8570-4; Microbial Pesticides; Biochemical Pesticides; Product Chemistry; Biochemical Classification Committee; Plant-Incorporated Protectants; Pre-Registration Meeting These recommendations may assist registrants in avoiding common mistakes when preparing and submitting biopesticide product chemistry data and the Confidential Statement of Formula (CSF). 220
Clarification of the Information Necessary to Determine the Formation of Unintended Ingredients in Microbial Pesticide Products 2019-05-06 EPA 705-G-2020-2550 Unintentional Ingredients; Manufacturing Process; Microbial Pesticides; Critical Control Points; Quality Assurance; Quality Control; Contamination; Contaminants Data and information needed to satisfy the OCSPP Guidelines 885.1200 (manufacturing process) and 885.1300 (formation of unintentional ingredients) for new microbial active ingredients must be accompanied by a full description of the production process, ingredients used, and quality assurance (QA) and quality control (QC) measures. The intent of this document is to provide additional clarification to applicants of novel microbial pesticides and facilitate the development of complete submission packages.  143
Draft Guidance for Plant Regulator Label Claims, Including Plant Biostimulants 2019-03-25 EPA 705-G-2020-2558 Plant Regulators; Claims; Plant Biostimulants; Plant Nutrients; Plant Inoculants; Soil Amendments; Vitamin-Hormone Products; Exclusions In recognition of the growing categories of products generally known as plant biostimulants, this document is intended to provide guidance on identifying product label claims that are considered to be plant regulator claims by the Agency, thereby subjecting the products to regulation as pesticides under FIFRA. 149
Sample Request for Additional Information to Support a FIFRA Determination Request 2020-01-27 EPA 705-G-2020-2559 Microbial Products; Pesticide Determination Information sent to stakeholders, who ask EPA to make determinations as to whether their microbial products are pesticides. As these types of requests need to now be submitted under PRIA (as an M009), EPA does its best to provide guidance as to what needs to be submitted for a successful application: (1) complete composition of the product, (2) label and advertising associated with the product, (3) information that shows the microorganism(s) in the product has/have non-pesticidal activity, and (4) confirmation as to whether the microorganism(s) in the product is/are intergeneric or naturally occurring. 217
EPA's Regulation of Biotechnology for Use in Pest Management 2019-12-23 EPA 705-G-2020-2647 Pesticide Registration; Biotechnology; Plant-Incorporated Protectants; Genetically Modified Microbial Pesticides; Herbicide-Tolerant Crops; Risk Assessment; Gene Flow; Insect Resistance Management; USDA; FDA; Tolerance Exemptions; Data Requirements; FIFRA To address the challenges of biotechnology, the Environmental Protection Agency (EPA), the U.S. Department of Agriculture (USDA), and the Food and Drug Administration (FDA) have shared responsibility for regulating agricultural biotechnology in the United States. In particular, EPA regulates pesticides created through biotechnology as a part of its regulatory jurisdiction over all pesticides marketed and used in the United States. As such, EPA has tailored its basic regulatory framework to fit the distinctive characteristics of these genetically engineered biological pesticides. A description of this framework is provided below. 1009
Introduction to Biotechnology Regulation for Pesticides 2017-06-06 EPA 705-G-2020-2653 Pesticide Registration; Data; Biotechnology; Plant-Incorporated Protectants; Genetically Engineered Microbial Pesticides; Herbicide-Tolerant Plants; Gene Flow; Risk Assessments; Insect Resistance Management This document provides an overview of what biotechnology pesticide products are and how EPA evaluates them during the registration process. 156
Inert Ingredients Eligible for FIFRA 25(b) Pesticide Products 2016-11-16 EPA 705-G-2020-3380 Minimum Risk Pesticide; 40 CFR 152.25(f); Inert Ingredient; Composition; Tolerance Exemption Status This list includes the inert ingredients that can be used in minimum risk pesticide products. 154
Design for the Environment Logo for Biopesticide Products  2019-05-21 EPA 705-G-2020-3381 Pesticide Registration; Design for the Environment; Logo; Biopesticides Brief description of how to obtain the Design for the Environment (DoE) logo, what the DoE logo means on biopesticide product labels, and when the DoE logo can be used. 147
Minimum Risk - Addition of an Inert Ingredient or Active Ingredient to the Exemption 2017-06-16 EPA 705-G-2020-3382 Minimum Risk Pesticide; 40 CFR 152.25(f); Exemption; Adding Active or Inert Ingredients; Petition This information describes that EPA is looking to set up a streamlined process for adding ingredients to the minimum risk pesticide active or inert lists and how parties interested in adding a substance to the two lists can proceed in the meantime. 204
Minimum Risk Pesticide: Definition and Product Confirmation 2018-04-02 EPA 705-G-2020-3383 Minimum Risk Pesticide; 40 CFR 152.25(f); Exemption Description of what a minimum risk pesticide is and a statement as to whether EPA will confirm minimum risk pesticide status. 205
Active Ingredients Allowed in Minimum Risk Pesticide Products 2017-05-24 EPA 705-G-2020-3384 Minimum Risk Pesticide; 40 CFR 152.25(f); Exemption; Active Ingredient; Composition; FFDCA; Tolerance Exemption Status The following active ingredients can be used in pesticide products that are exempt from the requirements of the Federal Insecticide, Fungicide, and Rodenticide Act under the minimum risk exemption regulations in 40 CFR 152.25(f). They can be used alone or in combination with other substances listed in this paragraph, provided that all of the criteria for minimum risk exemption are met. 131
Minimum Risk Pesticides - Inert Ingredient and Active Ingredient Eligibility under 40 CFR 152.25(f) 2018-03-19 EPA 705-G-2020-3385 Minimum Risk Pesticide; 40 CFR 152.25(f); Exemption; Active Ingredient; Inert Ingredient; Eligibility; Composition Ingredients that are included on both the Minimum Risk Active Ingredient list and the Minimum Risk Inert Ingredients list may be used either as an active ingredient or an inert ingredient. However, the active ingredient and inert ingredient lists are not interchangeable. Unless the ingredient appears on both lists, it can only be used based on the list it appears on. 207
Risk Assessment and Weight-of-the Evidence (WOE): Outcome from Meeting Between the Biopesticide Industry Alliance (BPIA) and EPA’s Office of Pesticide Programs (OPP) 2020-02-13 EPA 705-G-2020-3386 Risk Assessment; Weight-of-the-Evidence; Data; Rationale; I-DEEM; Tolerance; Tolerance Exemption; Nonfood Determination; FFDCA Outcome from meeting between BPIA and OPP to discuss what data are needed for a risk assessment, what BioDEEM is and when is it triggered, possibility of demonstrating an adequate margin of safety between actual exposure and an effect level, possible regulatory tools to implement a determination of safety, and how much data to present to EPA before an application is submitted. 216
Information Needed to Support a Biochemical Classification Determination 2020-01-16 EPA 705-G-2020-3387 Biochemical Pesticide; Biochemical Classification Committee; Criteria; Naturally Occurring Compound; Structurally Similar and Functionally Identical to Naturally Occurring Compound; Non-Toxic Mode of Action; History of Safe Exposure; Other Supporting Info Describes the information a prospective pesticide applicant needs to provide to EPA to allow it to make a determination whether a particular substance is a biochemical pesticide. 1010
BPPD’s Risk Assessment Elements “Cheat Sheet” for Applicants 2019-09-01 EPA 705-G-2020-3388 Risk Assessment; Product Uses; Use Rates; Toxic Effects; Open Scientific Literature Information; Qualitative; Quantitative; Aggregate When submitting a pesticide product registration application to EPA/OPP/BPPD, it is essential that you (applicant) address all applicable data requirements per the Code of Federal Regulations (CFR), part 158. However, it is also imperative that you (applicant) characterize your use sites, use patterns, rates and generally summarize your toxicity data so that a comprehensive risk assessment, taking into account all aspects of your product, can be performed by EPA. Often, when one or more of these pieces of information is missing from an application, the applicant is unsatisfied with the unavoidably conservative assessment that is performed. Further, presenting this information to EPA upfront can alleviate some unnecessary back-and-forth exchanges between EPA and the applicant and subsequent review time lost. EPA/BPPD highly recommends that applicants answer the following questions in writing in either a cover letter, data volume, or both when submitting their new product application. 142
Microbial Pesticide Test Guidelines: OCSPP 885.1250: Deposition of a Sample in a Nationally Recognized Culture Collection 2012-04-01 EPA 712-C-12-027 Test Guideline; Microbial Pesticide; Culture Collection Deposition; 885.1250 This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 159
Microbial Pesticide Test Guidelines: OPPTS 885.5000 Background for Microbial Pesticides Testing 1996-02-01 EPA 712-C-96-056 Test Guideline; Microbial Pesticide; Environmental Expression Testing Background; Tier II Testing; 885.5000 This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 200
Biochemicals Test Guidelines: OPPTS 880.1100 Product Identity and Composition 1996-02-01 EPA 712-C-96-273 Test Guideline; Biochemical Pesticide; Product Identity; Composition; 880.1000 The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 132
Microbial Pesticide Test Guidelines: OPPTS 885.1100 Product Identity 1996-02-01 EPA 712-C-96-273 Test Guideline; Microbial Pesticide; Product Identity; 885.1100 This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 161
Biochemicals Test Guidelines: OPPTS 880.1200 Description of Starting Materials, Production, and Formulation Process 1996-02-01 EPA 712-C-96-274 Test Guideline; Biochemical Pesticide; Starting Materials; Production; Formulation Process; 880.1200 The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 133
Biochemicals Test Guidelines: OPPTS 880.1400 Discussion of Formation of Impurities 1996-02-01 EPA 712-C-96-275 Test Guideline; Biochemical Pesticide; Impurities; 880.1400 The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 134
Biochemicals Test Guidelines: OPPTS 880.3550 Immunotoxicity 1996-02-01 EPA 712-C-96-280 Test Guideline; Biochemical Pesticide; Immunotoxicity; 880.3550 The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 135
Microbial Pesticide Test Guidelines: OPPTS 885.0001 Overview for Microbial Pest Control Agents 1996-02-01 EPA 712-C-96-280 Test Guideline; Microbial Pesticide; Microbial Pesticide Testing Overview; 885.0001 This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 160
Biochemicals Test Guidelines: OPPTS 880.3800 Immune Response 1996-02-01 EPA 712-C-96-281 Test Guideline; Biochemical Pesticide; Immune Response; 880.3800 The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 136
Biochemicals Test Guidelines: OPPTS 880.4350 Nontarget Insect Testing 1996-02-01 EPA 712-C-96-285 Test Guideline; Biochemical Pesticide; Nontarget Insect Testing; 880.4350 The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 137
Biochemicals Test Guidelines: OPPTS 880.4425 Dispenser Water Leaching 1996-02-01 EPA 712-C-96-286 Test Guideline; Biochemical Pesticide; Dispenser Water Leaching; 880.4425 The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 138
Microbial Pesticide Test Guidelines: OPPTS 885.1200 Manufacturing Process 1996-02-01 EPA 712-C-96-293 Test Guideline; Microbial Pesticide; Manufacturing Process; 885.1200 This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 162
Microbial Pesticide Test Guidelines: OPPTS 885.1300 Discussion of Formation of Unintentional Ingredients 1996-02-01 EPA 712-C-96-294 Test Guideline; Microbial Pesticide; Unintentional Ingredients; 885.1300 This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 163
Microbial Pesticide Test Guidelines: OPPTS 885.1400 Analysis of Samples 1996-02-01 EPA 712-C-96-295 Test Guideline; Microbial Pesticide; Analysis of Samples; 885.1400 This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 164
Microbial Pesticide Test Guidelines: OPPTS 885.1500 Certification of Limits 1996-02-01 EPA 712-C-96-296 Test Guideline; Microbial Pesticide; Certification of Limits; 885.1500 This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 165
Microbial Pesticide Test Guidelines: OPPTS 885.2000 Background for Residue Analysis of Microbial Pest Control Agents 1996-02-01 EPA 712-C-96-299 Test Guideline; Microbial Pesticide; Residue Analysis Background; 885.2000 This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 166
Microbial Pesticide Test Guidelines: OPPTS 885.2100 Chemical Identity 1996-02-01 EPA 712-C-96-300 Test Guideline; Microbial Pesticide; Chemical Identity; Residues; 885.2100 This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 167
Microbial Pesticide Test Guidelines: OPPTS 885.2200 Nature of the Residue in Plants 1996-02-01 EPA 712-C-96-302 Test Guideline; Microbial Pesticide; Residue Nature in Plants; 885.2200 This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 168
Microbial Pesticide Test Guidelines: OPPTS 885.2250 Nature of the Residue in Animals 1996-02-01 EPA 712-C-96-303 Test Guideline; Microbial Pesticide; Residue Nature in Animals; 885.2250 This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 169
Microbial Pesticide Test Guidelines: OPPTS 885.2300 Analytical Methods—Plants 1996-02-01 EPA 712-C-96-304 Test Guideline; Microbial Pesticide; Residue; Analytical Methods; Plants; 885.2300 This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 170
Microbial Pesticide Test Guidelines: OPPTS 885.2350 Analytical Methods—Animals 1996-02-01 EPA 712-C-96-305 Test Guideline; Microbial Pesticide; Residue; Analytical Methods; Animals; 885.2350 This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 171
Microbial Pesticide Test Guidelines: OPPTS 885.2400 Storage Stability 1996-02-01 EPA 712-C-96-306 Test Guideline; Microbial Pesticide; Residue; Storage Stability; 885.2400 This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 172
Microbial Pesticide Test Guidelines: OPPTS 885.2500 Magnitude of Residues in Plants 1996-02-01 EPA 712-C-96-307 Test Guideline; Microbial Pesticide; Magnitude of Residues; Plants; 885.2500 This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 173
Microbial Pesticide Test Guidelines: OPPTS 885.2550 Magnitude of Residues in Meat, Milk, Poultry, and Eggs 1996-02-01 EPA 712-C-96-308 Test Guideline; Microbial Pesticide; Magnitude of Residues; Meat; Milk; Poultry; Eggs; 885.2550 This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 174
Microbial Pesticide Test Guidelines: OPPTS 885.2600 Magnitude of Residues in Potable Water, Fish, and Irrigated Crops 1996-02-01 EPA 712-C-96-309 Test Guideline; Microbial Pesticide; Magnitude of Residues; Potable Water; Fish; Irrigated Crops; 885.2600 This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 175
Microbial Pesticide Test Guidelines: OPPTS 885.5400 Expression in a Marine or Estuarine Environment 1996-02-01 EPA 712-C-96-312 Test Guideline; Microbial Pesticide; Marine or Estuarine Environment Expression; Tier II Testing; 885.5400 This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 203
Microbial Pesticide Test Guidelines: OPPTS 885.3000 Background-Mammalian Toxicity/Pathogenicity/Infectivity 1996-02-01 EPA 712-C-96-314 Test Guideline; Microbial Pesticide; Background; Toxicity; Pathogenicity; Infectivity; Mammals; 885.3000 The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 176
Microbial Pesticide Test Guidelines: OPPTS 885.3050 Acute Oral Toxicity/Pathogenicity 1996-02-01 EPA 712-C-96-315 Test Guideline; Microbial Pesticide; Acute Oral Toxicity and Pathogenicity; Mammals; 885.3050 The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 177
Microbial Pesticide Test Guidelines: OPPTS 885.3100 Acute Dermal Toxicity/Pathology 1996-02-01 EPA 712-C-96-316 Test Guideline; Microbial Pesticide; Acute Dermal Toxicity and Pathology; Mammals; 885.3100 This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 178
Microbial Pesticide Test Guidelines: OPPTS 885.3150 Acute Pulmonary Toxicity/Pathogenicity 1996-02-01 EPA 712-C-96-317 Test Guideline; Microbial Pesticide; Acute Pulmonary Toxicity and Pathogenicity; Mammals; 885.3150 This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 179
Microbial Pesticide Test Guidelines: OPPTS 885.3200 Acute Injection Toxicity/Pathogenicity 1996-02-01 EPA 712-C-96-318 Test Guideline; Microbial Pesticide; Acute Injection Toxicity and Pathogenicity; Mammals; 885.3200 This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 180
Microbial Pesticide Test Guidelines: OPPTS 885.3400 Hypersensitivity Incidents 1996-02-01 EPA 712-C-96-320 Test Guideline; Microbial Pesticide; Hypersensitivity Incidents; 885.3400 This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 181
Microbial Pesticide Test Guidelines: OPPTS 885.3500 Cell Culture 1996-02-01 EPA 712-C-96-321 Test Guideline; Microbial Pesticide; Cell Culture; Mammals; 885.3500 This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 182
Microbial Pesticide Test Guidelines: OPPTS 885.3550 Acute Toxicology, Tier II 1996-02-01 EPA 712-C-96-322 Test Guideline; Microbial Pesticide; Mammals; Acute Toxicology; Tier II Testing; 885.3550 This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 183
Microbial Pesticide Test Guidelines: OPPTS 885.3600 Subchronic Toxicity/Pathogenicity 1996-02-01 EPA 712-C-96-323 Test Guideline; Microbial Pesticide; Mammals; Subchronic Toxicity and Pathogenicity; Tier II Testing; 885.3600 This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 184
Microbial Pesticide Test Guidelines: OPPTS 885.3650 Reproductive/Fertility Effects 1996-02-01 EPA 712-C-96-324 Test Guideline; Microbial Pesticide; Mammals; Reproductive and Fertility Effects; Tier III Testing; 885.3650 This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 185
Microbial Pesticide Test Guidelines: OPPTS 885.4000 Background for Nontarget Organism Testing of Microbial Pest Control Agents 1996-02-01 EPA 712-C-96-328 Test Guideline; Microbial Pesticide; Nontarget Organism Testing Background; 885.4000 This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 186
Microbial Pesticide Test Guidelines: OPPTS 885.4050 Avian Oral, Tier I 1996-02-01 EPA 712-C-96-329 Test Guideline; Microbial Pesticide; Avian Oral Toxicity and Pathogenicity; 885.4050 This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 187
Microbial Pesticide Test Guidelines: OPPTS 885.4100 Avian Inhalation Test, Tier I 1996-02-01 EPA 712-C-96-330 Test Guideline; Microbial Pesticide; Avian Inhalation Toxicity and Pathogenicity; 885.4100 This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 188
Microbial Pesticide Test Guidelines: OPPTS 885.4150 Wild Mammal Testing, Tier I 1996-02-01 EPA 712-C-96-331 Test Guideline; Microbial Pesticide; Wild Mammal Toxicity and Pathogenicity; 885.4150 This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 189
Microbial Pesticide Test Guidelines: OPPTS 885.4200 Freshwater Fish Testing, Tier I 1996-02-01 EPA 712-C-96-332 Test Guideline; Microbial Pesticide; Freshwater Fish Toxicity and Pathogenicity; 885.4200 This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 190
Microbial Pesticide Test Guidelines: OPPTS 885.4240 Freshwater Aquatic Invertebrate Testing, Tier I 1996-02-01 EPA 712-C-96-333 Test Guideline; Microbial Pesticide; Freshwater Invertebrate Toxicity and Pathogenicity; 885.4240 This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 191
Microbial Pesticide Test Guidelines: OPPTS 885.4280 Estuarine and Marine Animal Testing, Tier I 1996-02-01 EPA 712-C-96-334 Test Guideline; Microbial Pesticide; Estuarine and Marine Animal Toxicity and Pathogenicity; 885.4280 This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 192
Microbial Pesticide Test Guidelines: OPPTS 885.4300 Nontarget Plant Studies, Tier I 1996-02-01 EPA 712-C-96-335 Test Guideline; Microbial Pesticide; Nontarget Plant Testing; 885.4300 This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 193
Microbial Pesticide Test Guidelines: OPPTS 885.4340 Nontarget Insect Testing, Tier I 1996-02-01 EPA 712-C-96-336 Test Guideline; Microbial Pesticide; Nontarget Insect Toxicity and Pathogenicity; 885.4340 This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 194
Microbial Pesticide Test Guidelines: OPPTS 885.4380 Honey Bee Testing, Tier I 1996-02-01 EPA 712-C-96-337 Test Guideline; Microbial Pesticide; Honey Bee Toxicity and Pathogenicity; 885.4380 This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 195
Microbial Pesticide Test Guidelines: OPPTS 885.5200 Expression in a Terrestrial Environment 1996-02-01 EPA 712-C-96-338 Test Guideline; Microbial Pesticide; Terrestrial Environment Expression; Tier II Testing; 885.5200 This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 201
Microbial Pesticide Test Guidelines: OPPTS 885.5300 Expression in a Freshwater Environment 1996-02-01 EPA 712-C-96-339 Test Guideline; Microbial Pesticide; Freshwater Environment Expression; Tier II Testing; 885.5300 This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 202
Microbial Pesticide Test Guidelines: OPPTS 885.4600 Avian Chronic Pathogenicity and Reproduction Test, Tier III 1996-02-01 EPA 712-C-96-342 Test Guideline; Microbial Pesticide; Avian Chronic Pathogenicity and Reproduction; Tier III Testing; 885.4600 This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 196
Microbial Pesticide Test Guidelines: OPPTS 885.4650 Aquatic Invertebrate Range Testing, Tier III 1996-02-01 EPA 712-C-96-343 Test Guideline; Microbial Pesticide; Aquatic Invertebrate Range Testing; Tier III Testing; 885.4650 This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 197
Microbial Pesticide Test Guidelines: OPPTS 885.4700 Fish Life Cycle Studies, Tier III 1996-02-01 EPA 712-C-96-344 Test Guideline; Microbial Pesticide; Fish Life Cycle Studies; Tier III Testing; 885.4700 This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 198
Microbial Pesticide Test Guidelines: OPPTS 885.4750 Aquatic Ecosystem Test 1996-02-01 EPA 712-C-96-345 Test Guideline; Microbial Pesticide; Aquatic Ecosystem Test; Tier III Testing; 885.4750 This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 199
Ecological Effects Test Guidelines: Aquatic and Sediment-Dwelling Fauna, Aquatic Microcosm and Field Testing Test Guidelines, 850.1350, [Reserved] 2015-07-01 EPA 705-G-2020-0162 Test Guideline; Ecological Effects Draft guideline. FINAL Guideline has not yet been published. 260
Ecological Effects Test Guidelines: Aquatic and Sediment-Dwelling Fauna, Aquatic Microcosm and Field Testing Test Guidelines, 850.1500, [Reserved] 2015-07-01 EPA 705-G-2020-0165 Test Guideline; Ecological Effects Draft guideline. FINAL Guideline has not yet been published. 262
Ecological Effects Test Guidelines: Aquatic and Sediment-Dwelling Fauna, Aquatic Microcosm and Field Testing Test Guidelines, 850.1790, [Reserved] 2015-07-01 EPA 705-G-2020-0171 Test Guideline; Ecological Effects Draft guideline. FINAL Guideline has not yet been published. 267
E-Submission Environmental Study Supplemental Files 2002-06-27 EPA 705-G-2020-0490 Pesticide Registration; E-submission; Environmental Study Supplemental; Aquatic Toxicity Study This document provides standard format for electronic submission of supplemental data files in support of aquatic toxicity studies. 247
E-submission for avian reproduction studies 2002-06-01 EPA 705-G-2020-0495 Pesticide Registration; E-submission Avian Reproduction Studies Guidance information about electronic submission for avian reproduction studies. 248
E-Submission for Terrestrial and Aquatic Plant Studies 2001-02-01 EPA 705-G-2020-0496 Pesticide Registration; E-submission Terrestrial and Aquatic Plant Studies Guidance information about electronic submissions for terrestrial and aquatic plant studies. 250
E-submission for surface water and groundwater field studies and monitoring data 2001-02-01 EPA 705-G-2020-0497 Pesticide Registration; E-submission Surface Water Ground Water Monitoring Data Guidance information about electronic submission for surface water and groundwater field studies and monitoring data. 249
Draft Test Guideline: Fish Acute Toxicity Mitigated By Humic Acid 2017-01-01 EPA 705-G-2020-1330 Test Guidelines for Pesticides and Toxic Substances The following draft test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 240
Draft Test Guideline: Mysid Chronic Toxicity Test 2017-01-01 EPA 705-G-2020-1334 Test Guidelines for Pesticides and Toxic Substances The following draft test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 243
Draft Test Guideline: Fish Life Cycle Toxicity 2017-01-01 EPA 705-G-2020-1335 Test Guidelines for Pesticides and Toxic Substances The following draft test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 241
Draft Test Guideline: Whole Sediment Acute Toxicity Invertebrates, Marine 2015-07-01 EPA 705-G-2020-1336 Test Guidelines for Pesticides and Toxic Substances The following draft test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 246
Draft Test Guideline: Chironomid Sediment Toxicity Test 2017-01-01 EPA 705-G-2020-1337 Test Guidelines for Pesticides and Toxic Substances The following draft test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 238
Draft Test Guideline: Tadpole/Sediment Subchronic Toxicity Test 2017-01-01 EPA 705-G-2020-1338 Test Guidelines for Pesticides and Toxic Substances The following draft test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 245
Draft Test Guideline: Aquatic Food Chain Transfer 2017-01-01 EPA 705-G-2020-1339 Test Guidelines for Pesticides and Toxic Substances The following draft test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 237
Draft Test Guideline: Generic Freshwater Microcosm Test, Laboratory 2017-01-01 EPA 705-G-2020-1340 Test Guidelines for Pesticides and Toxic Substances The following draft test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 242
Draft Test Guideline: Site-Specific Aquatic Microcosm Test, Laboratory 2017-01-01 EPA 705-G-2020-1341 Test Guidelines for Pesticides and Toxic Substances The following draft test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 244
Draft Test Guideline: Field Testing For Aquatic Organisms 2017-01-01 EPA 705-G-2020-1342 Test Guidelines for Pesticides and Toxic Substances The following draft test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 239
Guidance for Use When Regurgitation is Observed in Avian Acute Toxicity Studies with Passerine Species 2012-04-09 EPA 705-G-2020-1379 Pesticide Science and Assessing Pesticide Risks Guidance based on comparison of results from the TG223 validation studies to results from avian acute oral studies previously submitted to EPA for two test chemicals following EPA's 850.2100 (public draft) guidelines. 341
Toxicity Testing and Ecological Risk Assessment Guidance for Benthic Invertebrates 2014-04-10 EPA 705-G-2020-1384 Pesticide Science and Assessing Pesticide Risks Guidance for when to require whole sediment toxicity tests and how to integrate sediment toxicity tests results into EFED ecological risk assessments. 355
NAFTA Guidance Document for Conducting Terrestrial Field Dissipation Studies 2006-03-31 EPA 705-G-2020-1404 Pesticide Science and Assessing Pesticide Risks Harmonized guidance for TFD studies that demonstrate transformation, transport and fate of pesticides under representative actual use conditions. Field studies substantiate physicochemical, mobility and biotransformation data from laboratory studies. 345
Guidance for Use When Regurgitation is Observed in Avian Acute Toxicity 2012-01-01 EPA 705-G-2020-3254 Acute oral avian toxicity, Test guidelines Recommends an alternative testing option when regurgitation is observed in passerine studies. 340
Label Review Manual (Chapter 8_Env Hazards) 2012-01-01 EPA 705-G-2020-3262 Label statements This guidance provides the language informing users of the potential hazards to the environment from transport, use, storage, or spill of the product and indicates in what circumstances given statements are required. 343
SOP: Evaluation of Patent Assertion Claims of Greater Than Additive (GTA) Effects 2020-01-01 EPA 705-G-2020-3288 Synergy, Patent claims Addresses risk estimate uncertainties associated with U.S. patent assertions of greater than additive effects in mixtures of pesticide active ingredients for controlling pests (often referred to as “synergy”). 353
Adsorption and desorption of test compound in soils or sediments 2012-05-01 EPA 705-G-2020-3294 Study Template The following study template, in conjunction with the associated test guideline, has been developed by EPA to provide a consistent format for submission of test data to the Agency for review. 231
Laboratory Volatility of [test compound] 2012-12-01 EPA 705-G-2020-3295 Study Template The following study template, in conjunction with the associated test guideline, has been developed by EPA to provide a consistent format for submission of test data to the Agency for review. 344
Hydrolysis of [test compound] at pH [4,7, and 9, or other values studied] 2012-05-01 EPA 705-G-2020-3296 Study Template The following study template, in conjunction with the associated test guideline, has been developed by EPA to provide a consistent format for submission of test data to the Agency for review. 342
Aqueous Photolysis of [test compound] 2012-05-01 EPA 705-G-2020-3297 Study Template The following study template, in conjunction with the associated test guideline, has been developed by EPA to provide a consistent format for submission of test data to the Agency for review. 235
Soil Photolysis of [test compound] 2012-05-01 EPA 705-G-2020-3298 Study Template The following study template, in conjunction with the associated test guideline, has been developed by EPA to provide a consistent format for submission of test data to the Agency for review. 352
Aerobic (or Anaerobic) Degradation in Soil of [test compound] 2012-05-01 EPA 705-G-2020-3299 Study Template The following study template, in conjunction with the associated test guideline, has been developed by EPA to provide a consistent format for submission of test data to the Agency for review. 233
Aerobic (or Anaerobic) Degradation in Aquatic Systems 2012-05-01 EPA 705-G-2020-3300 Study Template The following study template, in conjunction with the associated test guideline, has been developed by EPA to provide a consistent format for submission of test data to the Agency for review. 232
Field Dissipation of [test compound] 2012-05-01 EPA 705-G-2020-3301 Study Template The following study template, in conjunction with the associated test guideline, has been developed by EPA to provide a consistent format for submission of test data to the Agency for review. 337
Prospective Ground Water Monitoring of [test compound] 2012-12-01 EPA 705-G-2020-3302 Study Template The following study template, in conjunction with the associated test guideline, has been developed by EPA to provide a consistent format for submission of test data to the Agency for review. 349
Field volatility of [test compound] 2012-12-01 EPA 705-G-2020-3303 Study Template The following study template, in conjunction with the associated test guideline, has been developed by EPA to provide a consistent format for submission of test data to the Agency for review. 338
Sample storage stability of [test compound(s)] in [frozen soil, water, etc.] 2012-12-01 EPA 705-G-2020-3304 Study Template The following study template, in conjunction with the associated test guideline, has been developed by EPA to provide a consistent format for submission of test data to the Agency for review. 351
Acute Toxicity Effects of {TAI or EUP} on Earthworms 2004-05-01 EPA 705-G-2020-3305 Study Template The following study template, in conjunction with the associated test guideline, has been developed by EPA to provide a consistent format for submission of test data to the Agency for review. 225
Acute Toxicity of {TAI or EUP} to Freshwater Invertebrates - [Daphnia sp.] 2004-05-01 EPA 705-G-2020-3306 Study Template The following study template, in conjunction with the associated test guideline, has been developed by EPA to provide a consistent format for submission of test data to the Agency for review. 229
Acute Toxicity of {TAI or EUP} to Fish - [name of species] 2004-05-01 EPA 705-G-2020-3307 Study Template The following study template, in conjunction with the associated test guideline, has been developed by EPA to provide a consistent format for submission of test data to the Agency for review. 228
Chronic Toxicity of {TAI or EUP} to Fresh Water Invertebrates - [Daphnia sp.] 2004-05-01 EPA 705-G-2020-3308 Study Template The following study template, in conjunction with the associated test guideline, has been developed by EPA to provide a consistent format for submission of test data to the Agency for review. 236
Toxicity of {TAI or EUP} to Fish Early Life-Stage 2004-05-01 EPA 705-G-2020-3309 Study Template The following study template, in conjunction with the associated test guideline, has been developed by EPA to provide a consistent format for submission of test data to the Agency for review. 354
[Fish or Oyster] Bioconcentration Factor (BCF) of [Test Compound] 2012-12-01 EPA 705-G-2020-3310 Study Template The following study template, in conjunction with the associated test guideline, has been developed by EPA to provide a consistent format for submission of test data to the Agency for review. 222
Acute Oral Toxicity of {TAI or EUP} to Avian Species - [name of species] 2004-05-01 EPA 705-G-2020-3311 Study Template The following study template, in conjunction with the associated test guideline, has been developed by EPA to provide a consistent format for submission of test data to the Agency for review. 224
Acute Dietary Toxicity of {TAI or EUP} to Avian Species - [name of species] 2004-05-01 EPA 705-G-2020-3312 Study Template The following study template, in conjunction with the associated test guideline, has been developed by EPA to provide a consistent format for submission of test data to the Agency for review. 223
Reproductive Effects of {TAI or EUP} on Avian Species - [name of species] 2004-05-01 EPA 705-G-2020-3313 Study Template The following study template, in conjunction with the associated test guideline, has been developed by EPA to provide a consistent format for submission of test data to the Agency for review. 350
Acute Toxicity of {TAI or EUP} to Terrestrial Vascular Plant - [name of species - seed germination-root elongation/seedling emergence/vegetative vigour] 2004-05-01 EPA 705-G-2020-3314 Study Template The following study template, in conjunction with the associated test guideline, has been developed by EPA to provide a consistent format for submission of test data to the Agency for review. 230
Acute Toxicity of {TAI or EUP} to Aquatic Vascular Plants - [name of species] 2004-05-01 EPA 705-G-2020-3315 Study Template The following study template, in conjunction with the associated test guideline, has been developed by EPA to provide a consistent format for submission of test data to the Agency for review. 227
Acute Toxicity of {TAI or EUP} to Algae - [name of species] 2004-05-01 EPA 705-G-2020-3316 Study Template The following study template, in conjunction with the associated test guideline, has been developed by EPA to provide a consistent format for submission of test data to the Agency for review. 226
Analytical method for [analyte(s)] in [soil, water, air, or other environmental medium] 2012-12-01 EPA 705-G-2020-3317 Study Template The following study template, in conjunction with the associated test guideline, has been developed by EPA to provide a consistent format for submission of test data to the Agency for review. 234
Process for Requiring Exposure and Effects Testing for Assessing Risks to Bees during Registration and Registration Review 2016-01-01 EPA 705-G-2020-3627 Pollinators, Honey Bees The intent of this document is to provide interim guidance to the public and staff within EPA OPP for determining when honey bee exposure and effects data identified in the EPA’s 2014 risk assessment framework Guidance for Assessing Pesticide Risks to Bees and the 2016 Guidance on Exposure and Effects Testing for Assessing Risks To Bees are required. 348
Fish Bioconcentration Data Requirement: Guidance for Selection of Number of Treatment Concentration 2020-07-18 EPA 705-G-2020-3708 Pesticide data requirement, Testing Guidance Clarify EPA recommendations for the number of treatment concentrations needed to result in acceptable fish bioconcentration factor (BCF) studies for pesticide registration (supplements OCSPP Test Guideline 850.1730).​​​​ 339
Fate, Transport and Transformation Test Guidelines: Ground Water Monitoring Test Guidelines, 835.7100, Guidance for Prospective Ground-Water Monitoring Studies 2008-08-01 EPA 712-B-10-001 Test Guideline; Fate, Transport and Transformation The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 299
OCSPP 850.4000: Background and Special Considerations- Tests with Terrestrial and Aquatic Plants, Cyanobacteria, and Terrestrial Soil-Core Microcosms [EPA 712-C-013] 2012-01-01 EPA 712-C-013 Test Guideline; Ecological Effects The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 347
OCSPP 850.3000: Background and Special Considerations- Tests with Terrestrial Beneficial Insects, Invertebrates and Microorganisms [EPA 712-C-020] 2012-01-01 EPA 712-C-020 Test Guideline; Ecological Effects The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 346
Fate, Transport and Transformation Test Guidelines: Laboratory Biological Transformation Test Guidelines, 835.3140, Ready Biodegradability - CO2 in Sealed Vessels (Headspace Test) [SUPERSEDES 835.3120] 2008-10-01 EPA 712-C-08-001 Test Guideline; Fate, Transport and Transformation The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 309
Fate, Transport and Transformation Test Guidelines: Laboratory Biological Transformation Test Guidelines, 835.3190, Aerobic Mineralization in Surface Water - Simulation Biodegradation Test 2008-10-01 EPA 712-C-08-002 Test Guideline; Fate, Transport and Transformation The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 312
Fate, Transport and Transformation Test Guidelines: Laboratory Biological Transformation Test Guidelines, 835.3215, Inherent Biodegradability - Concawe Test 2008-10-01 EPA 712-C-08-003 Test Guideline; Fate, Transport and Transformation The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 315
Fate, Transport and Transformation Test Guidelines: Laboratory Biological Transformation Test Guidelines, 835.3240, Simulation Test—Aerobic Sewage Treatment: A. Activated Sludge Units 2008-10-01 EPA 712-C-08-004 Test Guideline; Fate, Transport and Transformation The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 317
Fate, Transport and Transformation Test Guidelines: Laboratory Biological Transformation Test Guidelines, 835.3260, Simulation Test—Aerobic Sewage Treatment: B. Biofilms 2008-10-01 EPA 712-C-08-005 Test Guideline; Fate, Transport and Transformation The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 318
Fate, Transport and Transformation Test Guidelines: Laboratory Biological Transformation Test Guidelines, 835.3280, Simulation Tests to Assess the Primary and Ultimate Biodegradability of Chemicals Discharged to Wastewater 2008-10-01 EPA 712-C-08-006 Test Guideline; Fate, Transport and Transformation The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 319
Fate, Transport and Transformation Test Guidelines: Laboratory Biological Transformation Test Guidelines, 835.3420, Anaerobic Biodegradability of Organic Compounds in Digested Sludge: By Measurement of Gas Production 2008-10-01 EPA 712-C-08-007 Test Guideline; Fate, Transport and Transformation The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 322
Fate, Transport and Transformation Test Guidelines: Laboratory Transport Test Guidelines, 835.1230, Adsorption/Desorption (Batch Equilibrium) 2008-10-01 EPA 712-C-08-009 Test Guideline; Fate, Transport and Transformation The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 326
Fate, Transport and Transformation Test Guidelines: Laboratory Transport Test Guidelines, 835.1240, Leaching Studies 2008-10-01 EPA 712-C-08-010 Test Guideline; Fate, Transport and Transformation The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 327
Fate, Transport and Transformation Test Guidelines: Laboratory Transport Test Guidelines, 835.1410, Laboratory Volatility 2008-10-01 EPA 712-C-08-011 Test Guideline; Fate, Transport and Transformation The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 328
Fate, Transport and Transformation Test Guidelines: Laboratory Abiotic Transformation Test Guidelines, 835.2120, Hydrolysis [SUPERSEDES 835.2110] 2008-10-01 EPA 712-C-08-012 Test Guideline; Fate, Transport and Transformation The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 300
Fate, Transport and Transformation Test Guidelines: Laboratory Abiotic Transformation Test Guidelines, 835.2240, Photodegradation in Water 2008-10-01 EPA 712-C-08-013 Test Guideline; Fate, Transport and Transformation The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 303
Fate, Transport and Transformation Test Guidelines: Laboratory Abiotic Transformation Test Guidelines, 835.2370, Photodegradation in Air 2008-10-01 EPA 712-C-08-014 Test Guideline; Fate, Transport and Transformation The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 305
Fate, Transport and Transformation Test Guidelines: Laboratory Abiotic Transformation Test Guidelines, 835.2410, Photodegradation in Soil 2008-10-01 EPA 712-C-08-015 Test Guideline; Fate, Transport and Transformation The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 306
Fate, Transport and Transformation Test Guidelines: Transformation in Water and Soil Test Guidelines, 835.4100, Aerobic Soil Metabolism 2008-10-01 EPA 712-C-08-016 Test Guideline; Fate, Transport and Transformation The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 332
Fate, Transport and Transformation Test Guidelines: Transformation in Water and Soil Test Guidelines, 835.4200, Anaerobic Soil Metabolism 2008-10-01 EPA 712-C-08-017 Test Guideline; Fate, Transport and Transformation The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 333
Fate, Transport and Transformation Test Guidelines: Transformation in Water and Soil Test Guidelines, 835.4300, Aerobic Aquatic Metabolism 2008-10-01 EPA 712-C-08-018 Test Guideline; Fate, Transport and Transformation The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 334
Fate, Transport and Transformation Test Guidelines: Transformation in Water and Soil Test Guidelines, 835.4400, Anaerobic Aquatic Metabolism 2008-10-01 EPA 712-C-08-019 Test Guideline; Fate, Transport and Transformation The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 335
Fate, Transport and Transformation Test Guidelines: Volatility from Soil Test Guidelines, 835.8100, Field Volatility 2008-10-01 EPA 712-C-08-024 Test Guideline; Fate, Transport and Transformation The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 336
Fate, Transport and Transformation Test Guidelines: Field Dissipation Test Guidelines, 835.6100, Terrestrial Field Dissipation 2008-10-01 EPA 712-C-08-20 Test Guideline; Fate, Transport and Transformation The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 295
Fate, Transport and Transformation Test Guidelines: Field Dissipation Test Guidelines, 835.6200, Aquatic (Sediment) Field Dissipation 2008-10-01 EPA 712-C-08-21 Test Guideline; Fate, Transport and Transformation The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 296
Fate, Transport and Transformation Test Guidelines: Field Dissipation Test Guidelines, 835.6300, Forestry Dissipation 2008-10-01 EPA 712-C-08-22 Test Guideline; Fate, Transport and Transformation The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 297
Fate, Transport and Transformation Test Guidelines: Field Dissipation Test Guidelines, 835.6400, Combination and Tank Mixes Field Dissipation 2008-10-01 EPA 712-C-08-23 Test Guideline; Fate, Transport and Transformation The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 298
Ecological Effects Test Guidelines: Field Test Data Reporting Guidelines, 850.6100, Environmental Chemistry Methods and Associated Independent Laboratory Validation  (Public draft was numbered 850.7100) 2012-01-01 EPA 712-C-12-001 Test Guideline; Ecological Effects The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 271
Ecological Effects Test Guidelines: Terrestrial and Aquatic Plants, Cyanobacteria, and Terrestrial Soil Core Microcosm Test Guidelines, 850.4800, Plant Uptake and Translocation Test 2012-01-01 EPA 712-C-12-002 Test Guideline; Ecological Effects The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 281
Ecological Effects Test Guidelines: Terrestrial and Aquatic Plants, Cyanobacteria, and Terrestrial Soil Core Microcosm Test Guidelines, 850.4900, Terrestrial Soil-Core Microcosm Test 2012-01-01 EPA 712-C-12-003 Test Guideline; Ecological Effects The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 282
Ecological Effects Test Guidelines: Terrestrial and Aquatic Plants, Cyanobacteria, and Terrestrial Soil Core Microcosm Test Guidelines, 850.4600, Rhizobium-Legume Toxicity 2012-01-01 EPA 712-C-12-004 Test Guideline; Ecological Effects The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 280
Ecological Effects Test Guidelines: Terrestrial and Aquatic Plants, Cyanobacteria, and Terrestrial Soil Core Microcosm Test Guidelines, 850.4550, Cyanobacteria (Anabaena flos-aquae) Toxicity 2012-01-01 EPA 712-C-12-005 Test Guideline; Ecological Effects The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 279
Ecological Effects Test Guidelines: Terrestrial and Aquatic Plants, Cyanobacteria, and Terrestrial Soil Core Microcosm Test Guidelines, 850.4500, Algal Toxicity 2012-01-01 EPA 712-C-12-006 Test Guideline; Ecological Effects The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 278
Ecological Effects Test Guidelines: Terrestrial and Aquatic Plants, Cyanobacteria, and Terrestrial Soil Core Microcosm Test Guidelines, 850.4450, Aquatic Plants Field Study 2012-01-01 EPA 712-C-12-007 Test Guideline; Ecological Effects The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 277
Ecological Effects Test Guidelines: Terrestrial and Aquatic Plants, Cyanobacteria, and Terrestrial Soil Core Microcosm Test Guidelines, 850.4400, Aquatic Plant Toxicity Test Using Lemna spp. 2012-01-01 EPA 712-C-12-008 Test Guideline; Ecological Effects The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 276
Ecological Effects Test Guidelines: Terrestrial and Aquatic Plants, Cyanobacteria, and Terrestrial Soil Core Microcosm Test Guidelines, 850.4300, Terrestrial Plants Field Study 2012-01-01 EPA 712-C-12-009 Test Guideline; Ecological Effects The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 275
Ecological Effects Test Guidelines: Terrestrial and Aquatic Plants, Cyanobacteria, and Terrestrial Soil Core Microcosm Test Guidelines, 850.4230, Early Seedling Growth Toxicity Test 2012-01-01 EPA 712-C-12-010 Test Guideline; Ecological Effects The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 274
Ecological Effects Test Guidelines: Terrestrial and Aquatic Plants, Cyanobacteria, and Terrestrial Soil Core Microcosm Test Guidelines, 850.4150, Vegetative Vigor 2012-01-01 EPA 712-C-12-011 Test Guideline; Ecological Effects The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 273
Ecological Effects Test Guidelines: Terrestrial and Aquatic Plants, Cyanobacteria, and Terrestrial Soil Core Microcosm Test Guidelines, 850.4100, Seedling Emergence and Seedling Growth 2012-01-01 EPA 712-C-12-012 Test Guideline; Ecological Effects The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 272
Ecological Effects Test Guidelines: Terrestrial Beneficial Insects, Invertebrates, and Soil and Wastewater Microorganisms Test Guidelines, 850.3300, Modified Activated Sludge, Respiration Inhibition Test 2012-01-01 EPA 712-C-12-014 Test Guideline; Ecological Effects The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 288
Ecological Effects Test Guidelines: Terrestrial Beneficial Insects, Invertebrates, and Soil and Wastewater Microorganisms Test Guidelines, 850.3200, Soil Microbial Community Toxicity Test 2012-01-01 EPA 712-C-12-015 Test Guideline; Ecological Effects The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 287
Ecological Effects Test Guidelines: Terrestrial Beneficial Insects, Invertebrates, and Soil and Wastewater Microorganisms Test Guidelines, 850.3100, Earthworm Subchronic Toxicity Test 2012-01-01 EPA 712-C-12-016 Test Guideline; Ecological Effects The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 286
Ecological Effects Test Guidelines: Terrestrial Beneficial Insects, Invertebrates, and Soil and Wastewater Microorganisms Test Guidelines, 850.3040, Field Testing for Pollinators 2012-01-01 EPA 712-C-12-017 Test Guideline; Ecological Effects The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 285
Ecological Effects Test Guidelines: Terrestrial Beneficial Insects, Invertebrates, and Soil and Wastewater Microorganisms Test Guidelines, 850.3030, Honey Bee Toxicity of Residues on Foliage 2012-01-01 EPA 712-C-12-018 Test Guideline; Ecological Effects The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 284
Ecological Effects Test Guidelines: Terrestrial Beneficial Insects, Invertebrates, and Soil and Wastewater Microorganisms Test Guidelines, 850.3020, Honey Bee Acute Contact Toxicity Test 2012-01-01 EPA 712-C-12-019 Test Guideline; Ecological Effects The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 283
Ecological Effects Test Guidelines: Terrestrial Wildlife Test Guidelines, 850.2500, Field Testing for Terrestrial Wildlife 2012-01-01 EPA 712-C-12-021 Test Guideline; Ecological Effects The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 294
Ecological Effects Test Guidelines: Terrestrial Wildlife Test Guidelines, 850.2400, Wild Mammal Toxicity Testing 2012-01-01 EPA 712-C-12-022 Test Guideline; Ecological Effects The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 293
Ecological Effects Test Guidelines: Terrestrial Wildlife Test Guidelines, 850.2300, Avian Reproduction Test 2012-01-01 EPA 712-C-12-023 Test Guideline; Ecological Effects The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 292
Ecological Effects Test Guidelines: Terrestrial Wildlife Test Guidelines, 850.2200, Avian Dietary Toxicity Test 2012-01-01 EPA 712-C-12-024 Test Guideline; Ecological Effects The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 291
Ecological Effects Test Guidelines: Terrestrial Wildlife Test Guidelines, 850.2100, Avian Acute Oral Toxicity Test 2012-01-01 EPA 712-C-12-025 Test Guideline; Ecological Effects The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 290
Ecological Effects Test Guidelines: Terrestrial Wildlife Test Guidelines, 850.2000, Background and Special Considerations- Tests with Terrestrial Wildlife 2012-01-01 EPA 712-C-12-026 Test Guideline; Ecological Effects The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 289
Ecological Effects Test Guidelines: Aquatic and Sediment-Dwelling Fauna, Aquatic Microcosm and Field Testing Test Guidelines, 850.1740, Spiked Whole Sediment 10-Day Toxicity Test, Saltwater Invertebrates 2016-10-01 EPA 712-C-16-001 Test Guideline; Ecological Effects The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 266
Ecological Effects Test Guidelines: Aquatic and Sediment-Dwelling Fauna, Aquatic Microcosm and Field Testing Test Guidelines, 850.1735, Spiked Whole Sediment 10-Day Toxicity Test, Freshwater Invertebrates 2016-10-01 EPA 712-C-16-002 Test Guideline; Ecological Effects The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 265
Ecological Effects Test Guidelines: Aquatic and Sediment-Dwelling Fauna, Aquatic Microcosm and Field Testing Test Guidelines, 850.1730, Fish Bioconcentration Factor (BCF) 2016-10-01 EPA 712-C-16-003 Test Guideline; Ecological Effects The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 264
Ecological Effects Test Guidelines: Aquatic and Sediment-Dwelling Fauna, Aquatic Microcosm and Field Testing Test Guidelines, 850.1710, Oyster Bioconcentration Factor (BCF) 2016-10-01 EPA 712-C-16-004 Test Guideline; Ecological Effects The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 263
Ecological Effects Test Guidelines: Aquatic and Sediment-Dwelling Fauna, Aquatic Microcosm and Field Testing Test Guidelines, 850.1300, Daphnid Chronic Toxicity Test 2016-10-01 EPA 712-C-16-005 Test Guideline; Ecological Effects The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 259
Ecological Effects Test Guidelines: Aquatic and Sediment-Dwelling Fauna, Aquatic Microcosm and Field Testing Test Guidelines, 850.1055, Bivalve Acute Toxicity Test 2016-10-01 EPA 712-C-16-006 Test Guideline; Ecological Effects The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 257
Ecological Effects Test Guidelines: Aquatic and Sediment-Dwelling Fauna, Aquatic Microcosm and Field Testing Test Guidelines, 850.1075, Freshwater and Saltwater Fish Acute Toxicity Test 2016-10-01 EPA 712-C-16-007 Test Guideline; Ecological Effects The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 258
Ecological Effects Test Guidelines: Aquatic and Sediment-Dwelling Fauna, Aquatic Microcosm and Field Testing Test Guidelines, 850.1400, Fish Early Life Stage Toxicity Test 2016-10-01 EPA 712-C-16-008 Test Guideline; Ecological Effects The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 261
Ecological Effects Test Guidelines: Aquatic and Sediment-Dwelling Fauna, Aquatic Microcosm and Field Testing Test Guidelines, 850.1045, Penaeid Acute Toxicity Test 2016-10-01 EPA 712-C-16-009 Test Guideline; Ecological Effects The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 256
Ecological Effects Test Guidelines: Aquatic and Sediment-Dwelling Fauna, Aquatic Microcosm and Field Testing Test Guidelines, 850.1025, Oyster Acute Toxicity Test 2016-10-01 EPA 712-C-16-010 Test Guideline; Ecological Effects The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 254
Ecological Effects Test Guidelines: Aquatic and Sediment-Dwelling Fauna, Aquatic Microcosm and Field Testing Test Guidelines, 850.1035, Mysid Acute Toxicity Test 2016-10-01 EPA 712-C-16-011 Test Guideline; Ecological Effects The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 255
Ecological Effects Test Guidelines: Aquatic and Sediment-Dwelling Fauna, Aquatic Microcosm and Field Testing Test Guidelines, 850.1020, Gammarid Amphipod Acute Toxicity Test 2016-10-01 EPA 712-C-16-012 Test Guideline; Ecological Effects The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 253
Ecological Effects Test Guidelines: Aquatic and Sediment-Dwelling Fauna, Aquatic Microcosm and Field Testing Test Guidelines, 850.1010, Aquatic Invertebrate Acute Toxicity Test, Freshwater Daphnids 2016-10-01 EPA 712-C-16-013 Test Guideline; Ecological Effects The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 252
Ecological Effects Test Guidelines: 850.1000, Background and Special Considerations - Tests with Aquatic and Sediment-Dwelling Fauna and Aquatic Microcosms 2016-10-01 EPA 712-C-16-014 Test Guideline; Ecological Effects The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 251
Ecological Effects Test Guidelines: Aquatic Fauna Test Guidelines, 850.1500, Fish Life Cycle Toxicity 1996-04-01 EPA 712-C-96-122 Public Draft; Test Guideline; Ecological Effects The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 269
Ecological Effects Test Guidelines: Aquatic Fauna Test Guidelines, 850.1350, Mysid Chronic Toxicity Test 1996-04-01 EPA 712-C-96-166 Public Draft; Test Guideline; Ecological Effects The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 268
Ecological Effects Test Guidelines: Aquatic Fauna Test Guidelines, 850.1790, Chironomid Sediment Toxicity Test 1996-04-01 EPA 712-C-96-313 Public Draft; Test Guideline; Ecological Effects The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 270
Fate, Transport and Transformation Test Guidelines: Laboratory Transport Test Guidelines, 835.1210, Soil Thin Layer Chromatography 1998-01-01 EPA 712-C-98-047 Test Guideline; Fate, Transport and Transformation The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 324
Fate, Transport and Transformation Test Guidelines: Laboratory Transport Test Guidelines, 835.1220, Sediment and Soil Adsorption/Desorption Isotherm 1998-01-01 EPA 712-C-98-048 Test Guideline; Fate, Transport and Transformation The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 325
Fate, Transport and Transformation Test Guidelines: Laboratory Abiotic Transformation Test Guidelines, 835.2130, Hydrolysis as a Function of pH and Temperature 1998-01-01 EPA 712-C-98-059 Test Guideline; Fate, Transport and Transformation The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 301
Fate, Transport and Transformation Test Guidelines: Laboratory Abiotic Transformation Test Guidelines, 835.2210, Direct Photolysis Rate in Water by Sunlight 1998-01-01 EPA 712-C-98-060 Test Guideline; Fate, Transport and Transformation The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 302
Fate, Transport and Transformation Test Guidelines: Laboratory Abiotic Transformation Test Guidelines, 835.2310, Maximum Direct Photolysis Rate in Air from UV/Visible Spectroscopy 1998-01-01 EPA 712-C-98-066 Test Guideline; Fate, Transport and Transformation The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 304
Fate, Transport and Transformation Test Guidelines: Laboratory Biological Transformation Test Guidelines, 835.3100, Aerobic Aquatic Biodegradation 1998-01-01 EPA 712-C-98-075 Test Guideline; Fate, Transport and Transformation The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 307
Fate, Transport and Transformation Test Guidelines: Laboratory Biological Transformation Test Guidelines, 835.3110, Ready Biodegradability 1998-01-01 EPA 712-C-98-076 Test Guideline; Fate, Transport and Transformation The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 308
Fate, Transport and Transformation Test Guidelines: Laboratory Biological Transformation Test Guidelines, 835.3180, Sediment/Water Microcosm Biogradation Test 1998-01-01 EPA 712-C-98-083 Test Guideline; Fate, Transport and Transformation The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 311
Fate, Transport and Transformation Test Guidelines: Laboratory Biological Transformation Test Guidelines, 835.3200, Zahn-Wellens/EMPA Test 1998-01-01 EPA 712-C-98-084 Test Guideline; Fate, Transport and Transformation The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 313
Fate, Transport and Transformation Test Guidelines: Laboratory Biological Transformation Test Guidelines, 835.3210, Modified SCAS Test 1998-01-01 EPA 712-C-98-085 Test Guideline; Fate, Transport and Transformation The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 314
Fate, Transport and Transformation Test Guidelines: Laboratory Biological Transformation Test Guidelines, 835.3300, Soil Biodegradation 1998-01-01 EPA 712-C-98-088 Test Guideline; Fate, Transport and Transformation The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 320
Fate, Transport and Transformation Test Guidelines: Laboratory Biological Transformation Test Guidelines, 835.3400, Anaerobic Biodegradability of Organic Chemicals 1998-01-01 EPA 712-C-98-090 Test Guideline; Fate, Transport and Transformation The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 321
Fate, Transport and Transformation Test Guidelines: Transformation Chemical-Specific Test Guidelines, 835.5045, Modified SCAS Test for Insoluble and Volatile Chemicals 1998-01-01 EPA 712-C-98-097 Test Guideline; Fate, Transport and Transformation The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 329
Fate, Transport and Transformation Test Guidelines: Transformation Chemical-Specific Test Guidelines, 835.5154, Anaerobic Biodegradation in the Subsurface 1998-01-01 EPA 712-C-98-098 Test Guideline; Fate, Transport and Transformation The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 330
Fate, Transport and Transformation Test Guidelines: Transformation Chemical-Specific Test Guidelines, 835.5270, Indirect Photolysis Screening Test: Sunlight Photolysis in Waters Containing Dissolved Humic Substances 1998-01-01 EPA 712-C-98-099 Test Guideline; Fate, Transport and Transformation The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 331
Fate, Transport and Transformation Test Guidelines: Laboratory Biological Transformation Test Guidelines, 835.3170, Shake Flask Die-Away Test 1998-01-01 EPA 712-C-98-297 Test Guideline; Fate, Transport and Transformation The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 310
Fate, Transport and Transformation Test Guidelines: Laboratory Transport Test Guidelines, 835.1110, Activated Sludge Sorption Isotherm 1998-01-01 EPA 712-C-98-298 Test Guideline; Fate, Transport and Transformation The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 323
Fate, Transport and Transformation Test Guidelines: Laboratory Biological Transformation Test Guidelines, 835.3220, Porous Pot Test 1998-01-01 EPA 712-C-98-301 Test Guideline; Fate, Transport and Transformation The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 316
Web-Distributed Labeling for Pesticide Products: Pesticide Registration Notice 2014-01-01 EPA 705-G-2020-0614 Pesticide Registration This Notice presents the Agency's guidance on optional participation in web-distributed labeling for pesticide products. The Agency believes that voluntary adoption of these recommendations by pesticide registrants will help pesticide users to better understand and comply with pesticide labeling. In addition, the Agency believes that web-distributed labeling could allow addition of new uses, modification of existing labeling, and implementation of labeling-based risk mitigation measures more quickly. 513
PRN 2013-2: Peroxy Compounds Task Force 2013-11-13 EPA 705-G-2020-0615 Pesticide Registration This PR Notice announces the establishment of the Peroxy Compounds Task Force (PCTF). The PCTF is open to all registrants and applicants with products containing peroxy compounds created to jointly develop data to support registration review under FIFRA. 429
PRN 2013-1: Silver Task Force North America 2013-05-01 EPA 705-G-2020-0616 Pesticide Registration This PR Notice announces the establishment of the Silver Task Force North America (STFNA), which was created to jointly develop data to support registration review. 428
PRN 2012-1: Material Safety Data Sheets as Pesticide Labeling 2012-01-01 EPA 705-G-2020-0617 Pesticide Registration This Notice updates and clarifies EPA’s determination in PRN 92-4 that a Material Safety Data Sheet that accompanies a pesticide product is considered part of the pesticide’s labeling but does not need EPA approval if it is consistent with 40CFR Part 156. 426
PRN 2011-3: Standard Format for Data Submitted Under FIFRA and Certain Provisions of FFDCA 2011-11-30 EPA 705-G-2020-0618 Pesticide Registration This PR Notice updates and replaces Pesticide Registration Notice 86-5 and discusses both the recommended and the required procedures for submitting FIFRA and FFDCA data. 425
PRN 2011-2: Non-Dietary Exposure Task Force 2011-11-23 EPA 705-G-2020-0619 Pesticide Registration This PR Notice includes information about an industry-wide task force, the Non-Dietary Exposure Task Force (NDEFT), including how registrants can participate or use data developed by the task force. 424
PRN 2011-1: Residential Exposure Joint Venture 2011-01-03 EPA 705-G-2020-0620 Pesticide Registration This PR Notice is to advise registrants of an industry-wide joint venture, titled the Residential Exposure Joint Venture (REJV), which has developed a national survey regarding residential consumer use/usage data for pesticides. 423
PRN 2009-1: Establishment of Antimicrobial Exposure Assessment Task Force II 2009-09-30 EPA 705-G-2020-0621 Pesticide Registration This PR notice announces the establishment of the Antimicrobial Exposure Assessment Task Force II, an industry-wide task force to develop mixer, loader, applicator and post-application exposure data for antimicrobial pesticides used in various settings. 421
PRN 2007-4: Labeling Revisions Required by the Final Rule “Pesticide Management and Disposal; Standards for Pesticide Containers and Containment 2008-04-29 EPA 705-G-2020-0622 Pesticide Registration This notice provides instructions for implementing the new pesticide product label language required by the new regulations in 40 CFR part 156 established by the Final Rule “Pesticide Management and Disposal; Standards for Pesticide Containers and Containment” (71 FR 47330, August 16, 2006). This notice provides guidance to pesticide registrants on revising their product labels in order to implement the new requirements. Most registrants may be able to make the necessary label amendments by notification; however, in some cases an application for amendment and EPA approval may be required. As specified in the final rule, by August 17, 2009, all pesticide products distributed or sold by a registrant must have labels that comply with the new requirements (40 CFR § 156.159). 418
PRN 2005-1: Labeling Statements on Products Used for Adult Mosquito Control 2005-04-15 EPA 705-G-2020-0624 Pesticide Registration This Notice presents the Agency’s guidance on appropriate label language for pesticide products intended for wide-area application to control adult mosquitoes. 415
PRN 2003-3: Procedural Guidance for EPA's Office of Pesticide Programs Procedures Concerning the Development, Modification, and Implementation of Policy Guidance Documents 2003-01-01 EPA 705-G-2020-0625 Pesticide Registration EPA’s Office of Pesticide Programs (OPP) will use the procedures in this document for developing, modifying, and implementing its pesticide program policy guidance documents. 414
PRN 2002-1: Lists of Pests of Significant Public Health Importance 2002-01-01 EPA 705-G-2020-0628 Pesticide Registration This notice identifies pests of significant public health importance. This list does not, by itself, determine whether a pesticide product might be considered a "public health pesticide“ as that term is used in FIFRA. See Appendix A for the list. 413
PRN 2001-4: Elimination of Phenol Resistance Testing for Antimicrobial Disinfectant and Sanitizer Pesticides 2001-01-01 EPA 705-G-2020-0630 Pesticide Registration This Pesticide Registration notice announces the discontinuation of phenol resistance testing as a part of efficacy testing for antimicrobial disinfectants and sanitizers. 412
PRN 2001-2: Acute Toxicity Data Requirements For Granular Pesticide Products, Including Those With Granular Fertilizers in the Product. 2001-01-01 EPA 705-G-2020-0632 Pesticide Registration This PR Notice announces guidance intended to streamline the acute toxicity review and classification process for certain granular pesticide products, including those products that contain granular fertilizers. 411
PRN 2001-1: First Aid Statements on Pesticide Product Labels 2001-01-01 EPA 705-G-2020-0633 Pesticide Registration This PR notice is intended to provide guidance for what the Agency believes is the most updated appropriate first aid language for pesticide product labels to ensure that they continue to adequately protect the public. 410
PRN 2000-10: Changes to "Effective Date and Procedures", "Applicability of the Treated Articles Exemption to Antimicrobial Pesticides" 2000-01-01 EPA 705-G-2020-0634 Pesticide Registration This PR notice addresses the compliance date and other issues related to PR Notice 2000-1, Applicability of the Treated Articles Exemption to Antimicrobial Pesticides. 405
PRN 2000-8: Reportability of Attorneys’ Opinions and Conclusions Under 40 CFR Part 159 and FIFRA Section 6(a)(2) 2000-01-01 EPA 705-G-2020-0635 Pesticide Registration EPA is issuing this pesticide registration notice to inform registrants of EPA’s opinion that an attorney’s professional legal judgment is not an opinion or conclusion that is reportable under 40 CFR part 159. 409
PRN 2000-7: Non-Dietary Exposure Task Force 2000-01-01 EPA 705-G-2020-0636 Pesticide Registration This PR Notice announces an industry-wide task force to jointly develop residential indoor exposure data for pesticides containing one or more of the active ingredients synthetic pyrethroids, pyrethrum and synergists. 408
PRN 2000-2: The FIFRA Endangered Species Task Force 2002-01-01 EPA 705-G-2020-0655 Pesticide Registration This PR Notice announces an industry-wide Task Force that has been formed in response to EPA data requirements related to the potential impact of pesticides on threatened and endangered species. 406
PRN 98-10: Notifications, Non-Notifications and Minor Formulation Amendments 1998-01-01 EPA 705-G-2020-0658 Pesticide Registration This Pesticide Registration notice expands the changes to registration that may be made by notification and non-notification, maintains the expedited review of minor formulation changes, and modifies procedures for notifications of antimicrobial products. 490
PRN 98-9: Modification of Respirator Statements for Pesticide Product Labels 1998-01-01 EPA 705-G-2020-0659 Pesticide Registration This Pesticide Registration Notice informs registrants of technology improvements for respirators and designation changes for certain respirator filters required in pesticide labeling statements. 497
PRN 98-6: Flammability Labeling Requirements for Total Release Fogger Pesticides 1998-01-01 EPA 705-G-2020-0660 Pesticide Registration This notice describes new labeling requirements for total release foggers and provides the procedures and time frame for compliance. It ONLY affects total release foggers containing a propellant with a flash point at or below 20 degrees Fahrenheit. 495
PRN 98-5: New Forms for the Certification with Respect to Citation of Data 1998-01-01 EPA 705-G-2020-0661 Pesticide Registration In 1998, EPA established new forms for citation of data to support the registration or reregistration of pesticide products. These forms are EPA Form 8570-34 (“Certification with Respect to Citation of Data”) and 8570-35 (“Data Matrix”). 494
PRN 98-4: Additional Guidance on Final FIFRA Section 6(a)(2) Regulations for Pesticide Product Registrants w/Attachment 1998-01-01 EPA 705-G-2020-0662 Pesticide Registration This Pesticide Registration Notice provides guidance on reporting information concerning unreasonable adverse effects of their products to EPA under the regulations promulgated in 1997. 493
PRN 98-3: Guidance on Final FIFRA 6(a)(2) Regulations for Pesticide Product Registrants 1998-01-01 EPA 705-G-2020-0663 Pesticide Registration This notice provides registrants comprehensive guidance on implementing the adverse effects reporting regulations that were published in 1997. 492
Worker Protection Standard Relabeling Process for Retailers and Wholesalers 1995-10-23 EPA 705-G-2020-0667 Pesticide Registration This is Attachment 1 for Pesticide Registration Notice 95-5, Labeling Revisions Required By The Worker Protection Standard (WPS) for Sale or Distribution of Certain Agricultural Pesticides after October 23, 1995. 520
PRN 93-1: Statement of Restricted Use Classification 1993-01-01 EPA 705-G-2020-0668 Pesticide Registration This notice explains EPA's policy on the content and placement of the statement required on the front panel of labeling of pesticides classified for restricted use (RU). 460
PRN 93-2: Waiver of Crop Field Trial Data for Aerial Applications 1993-01-01 EPA 705-G-2020-0673 Pesticide Registration This notice is to inform all pesticide registrants that the requirement for crop field trials reflecting aerial applications may be waived under certain circumstances provided adequate data are available on the same crop with use of ground equipment. 461
PRN 93-3: Labeling Statement Prohibiting Application to Water 1993-01-01 EPA 705-G-2020-0674 Pesticide Registration This notice explaining the policy on label statement prohibiting pesticide application to water pertains only to the labeling statement on pesticide products. It does not address the term "wetlands" as defined with respect to the Clean Water Act. 462
PRN 93-4: Ban on Aerosol Products Containing CFCs and HCFCs under the Clean Air Act 1994-01-01 EPA 705-G-2020-0675 Pesticide Registration This notice alerts pesticide registrants to a rule under the Clean Air Act banning distribution and sale of aerosol and pressurized products, including pesticide products, that contain chlorofluorocarbons (CFCs). 463
PRN 93-5: Labeling Requirements of the Clean Air Act 1993-01-01 EPA 705-G-2020-0676 Pesticide Registration A regulation under the Clean Air Act requires a warning statement on products (including pesticide products) manufactured with or containing Class I ozone-depleting substances, including chlorofluorocarbons, methyl chloroform and carbon tetrachloride. 464
PRN 93-6: False or Misleading Statements Related to Efficacy; Revision of PR Notice 91-7 1993-01-01 EPA 705-G-2020-0677 Pesticide Registration This notice clarifies EPA's policy with respect to certain claims of heightened efficacy for pesticide products and supersedes PR Notice 91-7. 465
PRN 93-7: Labeling Revisions Required by the Worker Protection Standard (WPS) 1993-01-01 EPA 705-G-2020-0678 Pesticide Registration The Worker Protection Standard (WPS) for agricultural pesticides, issued in August 1992, requires labeling changes for many pesticide end-use products. See guidance to determine what products are affected. 466
PRN 93-8: Labeling Statement Prohibiting Application to Water; Amendment to PR Notice 93-3 1993-01-01 EPA 705-G-2020-0680 Pesticide Registration This notice adds one paragraph to P.R. Notice 93-3, which requested registrants to amend product labeling to include a new labeling statement prohibiting application of a pesticide to water for certain products. 467
PRN 93-9: Voluntary Reduced-Risk Pesticides Initiative 1993-01-01 EPA 705-G-2020-0681 Pesticide Registration This PR Notice provides guidance on EPA's voluntary, interim process for identifying pesticides which may be eligible for priority treatment as lower risk products (1993). 468
PRN 93-10: Effluent Discharge Labeling Statements 1993-01-01 EPA 705-G-2020-0682 Pesticide Registration This notice describes revised effluent discharge labeling statements required on all manufacturing use products and end use products that may be discharged to waters of the United States or municipal sewer systems. 458
PRN 93-11: Supplemental Guidance for PR Notice 93-7 - Labeling Revisions Required by the WPS 1993-01-01 EPA 705-G-2020-0684 Pesticide Registration This pesticide registration notice augments the guidance provided by PR notice 97-3 to provide options that you may choose to allow efficient production and distribution of products that comply with PR Notice 93-7. 459
PRN 92-1: Requirement to submit and identify adverse effects information 1992-01-01 EPA 705-G-2020-0687 Pesticide Registration This notice clarifies the Office of Pesticide Program's policy with regard to submission and identification of adverse effects information under FIFRA Section 6(a)(2). 455
PRN 92-2: Permissible label claims regarding ozone depleting substances 1992-01-01 EPA 705-G-2020-0688 Pesticide Registration This notice describes EPA's policy for certain chlorofluorocarbon-related labeling claims on pesticide aerosol products. Under this policy, true claims that a product does not contain CFCs or other ozone-depleting substances are permitted on labels. 456
PRN 92-4: Material Safety Data Sheets as Pesticide Labeling 1992-01-01 EPA 705-G-2020-0689 Pesticide Registration This notice describes EPA's interpretation that a material safety data sheet may accompany a pesticide or device without approval from EPA as long as it does not conflict with the approved pesticide labeling. 457
PRN 88-6: Change in Registration Procedures; Agency Approval not Required for Certain Amendments 1988-01-01 EPA 705-G-2020-0691 Pesticide Registration This notice describes certain modifications to pesticide registrations that no longer require an application to or approval by EPA, based on amendments to 40 CFR 152.44 in May 1988. 450
PRN 85-6: Clarification of Label Improvement Program for Fumigants. Revision of PR Notice 84-5 1985-01-01 EPA 705-G-2020-0692 Pesticide Registration This Pesticide Registration Notice revises and clarifies PR Notice 84-5, related to label changes for fumigant products. 446
PRN 84-5: Label Improvement Program for Fumigants 1984-01-01 EPA 705-G-2020-0693 Pesticide Registration This notice required registrants of fumigant products to revise the labeling of products registered under FIFRA section 3 or 24(c) to include additional precautionary statements and other statements described in the notice. 445
PRN 81-4: Label Improvement Program - Label Revisions to Accommodate New AOAC Methods of Chemical Analysis 1981-01-01 EPA 705-G-2020-0694 Pesticide Registration This notice describes procedures EPA will use to ensure that pesticide label ingredient statements reflect percentages of ingredients determined by the most specific analytical techniques approved by the Association of Official Analytical Chemists (AOCA). 441
PRN 80-2: Label Improvement Program: Deletion of Salt Water Emesis Statements 1980-01-01 EPA 705-G-2020-0695 Pesticide Registration As of 1980, pesticide registrants had to remove salt-water emesis statements from product labels. 439
PRN 73-4: Residual Insecticides in Food Handling Establishments 1973-07-06 EPA 705-G-2020-0696 Pesticide Registration This notice provides a copy of a Federal Register notice published July 6, 1973, regarding certain insecticides used in food-handling establishments. It establishes certain definitions and requirements related to approval for crack and crevice treatment. 437
PRN 70-16: Requirements for Additional Labeling on Products Containing Sodium Hypochlorite 1970-01-01 EPA 705-G-2020-0697 Pesticide Registration This PR Notice describes additional labeling for pesticide products containing sodium hypochlorite, due to the rapid degradation of the products, to ensure that product effectiveness is maintained. 435
Improving Labels to Reduce Pesticide Drift 2014-08-01 EPA 705-G-2020-0903 Reducing Pesticide Drift We encourage pesticide manufacturers to state on their product labels that applicators should use DRT-rated technologies in applying pesticide products. The page includes information on how to obtain approval to add these instructions. 382
Who Needs to Apply for Pesticide Applicator Certification in Indian Country under the EPA Plan 2018-09-11 EPA 705-G-2020-0957 Pesticide Applicator Certification in Indian Country Any person who applies restricted use pesticides in an area of Indian country covered by the EPA plan will need a federal certificate from EPA. 515
Definition of Indian Country 2018-12-19 EPA 705-G-2020-0959 Pesticide Applicator Certification in Indian Country Definition of Indian Country 360
PRN 2008-2: Antimicrobial Pesticide Products With Anthrax-Related Claims 2008-08-26 EPA 705-G-2020-0960 Pesticide Registration This notice provides guidance to prospective applicants of antimicrobial products that make labeling claims to “inactivate Bacillus anthracis (anthrax) spores” (hereafter referred to as “anthrax-related products”). This guidance should help the United States be prepared to respond to incidents involving anthrax spores by assuring that anthrax-related products are registered, that they bear appropriate labeling, and that they are effective when used as directed. In addition, this guidance will help protect public health from the potential risks of anthrax spores by employing terms and conditions of registration that limit the use of anthrax-related products to those who are properly trained and determined to be competent in their use. 420
PRN 2008-1: Notice to Manufacturers, Producers, Formulators, and Registrants of Pesticide Products 2008-05-01 EPA 705-G-2020-0961 Pesticide Registration This Notice presents EPA's guidance on optional environmental hazard label language for certain non-restricted use pesticide products intended for outdoor residential use. It clarifies language on how the user can avoid environmental contamination. 419
PRN 2007-3: The Agricultural Handlers Exposure Task Force, L.L.C 2007-09-20 EPA 705-G-2020-0962 Pesticide Registration This PR Notice discusses the Agricultural Handlers Exposure Task Force, an industry-wide task force formed to develop mixer, loader, and applicator exposure data for pesticides used in agricultural settings. It includes contacts for more information. 417
PRN 2007-1: Disposal Instructions on Non-Antimicrobial Residential or Household Use Pesticide Product Labels 2007-01-01 EPA 705-G-2020-0970 Pesticide Registration This notice is being issued to update and revise PR Notice 2001-6 to clarify that the use of a toll-free number in the disposal instructions on non-antimicrobial residential or household use pesticide product labels is optional. If registrants choose to change or remove a toll-free number from the disposal instructions on their label, this notice provides guidance on making such changes. This notice supersedes PR Notice 2001-6. in its entirety and PR Notices 83-3 and 84-1 in part. See unit VI. 416
Draft PRN 2006-A: Use of Antimicrobial Pesticide Products in Heating, Ventilation, Air Conditioning and Refrigeration Systems (HVAC&R) 2006-01-01 EPA 705-G-2020-0972 Pesticide Registration This notice provides guidance to registrants of EPA-registered sanitizer, disinfectant and other antimicrobial products whose labels bear general directions for use on or incorporation within hard, non-porous or porous surfaces, but which are not specifically registered for treatment of Heating, Ventilation, Air Conditioning and Refrigeration Systems (HVAC&R also referred to as HVAC. Some labels currently use the term HVAC but for reference purposes of this PR Notice, HVAC&R will be used) 362
PRN 98-8: Waiver of Fees Associated with Tolerance Objections 1998-01-01 EPA 705-G-2020-0988 Pesticide Registration EPA's regulations require that tolerance objections be accompanied by a filing fee of $3,275. This fee can be waived. This notice clarifies EPA's interpretation of the regulation. 496
PRN 98-2: Liquid Chemical Sterilant Products 1998-01-01 EPA 705-G-2020-0989 Pesticide Registration Liquid chemical sterilant products are no longer regulated as "pesticides" by the Environmental Protection Agency (EPA), but as "medical devices" under the regulatory authority of the Food and Drug Administration (FDA). 491
PRN 97-9: Electronic Submission Of Child-Resistant Packaging Test Data For All Pesticides 1997-01-01 EPA 705-G-2020-0990 Pesticide Registration This pesticide registration notice addresses four issues related to child-resistant packaging. 489
PRN 97-7: Existing Stocks for Labeling Changes in PR Notices 1997-01-01 EPA 705-G-2020-0992 Pesticide Registration EPA intends to establish October 1 as the annual compliance date for most EPA-initiated label changes specified by a PR Notice, FR Notice or similar mechanism. We will allow at least one year for an action to become effective. Other dates may apply. 488
PRN 1997-01-01 EPA 705-G-2020-0997 Pesticide Registration This is a list of common names for use on pesticide Labels approved by The American National Standards Institute. 500
PRN 97-5 Appendix B 1997-01-01 EPA 705-G-2020-0999 Pesticide Registration Appendix B lists other names, not established by ANSI, which may also be used alone in the ingredients statement without an accompanying chemical name. 487
PRN 97-4: Consumer Access Numbers on Pesticide Labels 1997-01-01 EPA 705-G-2020-1015 Pesticide Registration This notice describes EPA policy on including telephone numbers and other access numbers or internet addresses, on pesticide product labeling. It also explains how the telephone number of the National Pesticide Information Center hotline may be used. 486
PRN 97-3: Guidelines for Expedited Review of Conventional Pesticides under the Reduced-Risk Initiative and for Biological Pesticides 1997-01-01 EPA 705-G-2020-1017 Pesticide Registration EPA encourages the development, registration and use of lower-risk pesticide products which would result in reduced risks to human health and the environment. This Pesticide Registration notice and the related web page explain the process and criteria. 485
PRN 97-1: Agency Actions under the Requirements of the Food Quality Protection Act 1997-01-01 EPA 705-G-2020-1018 Pesticide Registration This pesticide registration notice describes EPA's implementation of the Food Quality Protection Act, including the risk cup and risk management strategies under the new safety standard. 484
PRN 96-7: Termiticide Labeling 1996-01-01 EPA 705-G-2020-1021 Pesticide Registration This notice sets forth the Agency's policy with respect to certain labeling statements and minimum product performance (5 year period) for soil treatment termiticide products. 483
PRN Notice 96-6: Pet Pesticide Product Label Statements 1996-01-01 EPA 705-G-2020-1022 Pesticide Registration This notice specifies statements that should be added to the labels of pesticide products registered for use on dogs and/or cats. These label statements will help to ensure that products bear labeling to reduce the potential for misuse of pet products. 499
PRN 96-4: Label Statements Involving Product Efficacy and Potential for Harm to Property 1996-01-01 EPA 705-G-2020-1023 Pesticide Registration This notice explains EPA procedures in approving pesticide labels that include claims relating to the efficacy of agricultural pesticides and provides a warning to growers regarding reliance on label statements regarding pesticide efficacy. 482
PRN 96-3: Pesticide Products Used to Disinsect Aircraft 1996-01-01 EPA 705-G-2020-1024 Pesticide Registration This Notice specifies labeling changes for any pesticide product (insecticide) used for disinsecting aircraft. EPA required these changes based on incident information associated with the use of insecticide spray products occupied aircraft cabins. 481
PRN 96-2: Changes to Child-Resistant Packaging (CRP) Testing Requirements 1996-01-01 EPA 705-G-2020-1025 Pesticide Registration This pesticide registration notice announced revisions to the effectiveness standards applicable to child-resistant packaging (CRP). 480
PRN 96-1: Tolerance Enforcement Methods - Independent Laboratory Validation by Petitioner 1996-01-01 EPA 705-G-2020-1026 Pesticide Registration This notice is intended to clarify the requirements for submission of an Independent Laboratory Validation to accompany new pesticide analytical methods and does not contain additional data requirements. This notice supersedes PR Notice 88-5. 479
PRN 95-5: Labeling Revisions Required By The Worker Protection Standard (WPS) For Sale Or Distribution Of Certain Agricultural Pesticides After October 23,1995 1995-01-01 EPA 705-G-2020-1027 Pesticide Registration This notice provides guidance to people who sell or distribute pesticides on meeting requirements for labeling under the worker protection standard (1992 version). 478
PRN 95-3: Reduction of Worker protection Standard (WPS) Interim Restricted Entry Intervals (REIS) for Certain Low Risk Pesticides 1995-05-03 EPA 705-G-2020-1028 Pesticide Registration On January 11, 1995, EPA published a draft policy on "Reduced Restricted Entry Intervals for Certain Pesticides," in the Federal Register. The final policy was published in the Federal Register on May 3, 1995. This Notice contains the final policy. 477
PRN 95-1: Effluent Discharge Labeling Statements 1995-01-01 EPA 705-G-2020-1029 Pesticide Registration This notice exempts certain pesticide products from bearing effluent discharge labeling statements specified by P.R. Notice 93-10 for manufacturing use products and end use products that may be discharged to waters of the U.S. or municipal sewer systems. 476
PRN 94-9: Announcing the Formation of Two Industry-Wide Task Forces: Agricultural Reentry Task Force and Outdoor Residential Exposure Task Force 1994-01-01 EPA 705-G-2020-1030 Pesticide Registration This Notice announces two industry-wide Task Forces being formed in response to generic exposure data requirements. It contains EPA's policy on a registrant's options for, and responsibilities when joining Task Force as a way to satisfy data requirements. 475
PRN 94-8: Water Soluble Packaging (WSP) 1994-01-01 EPA 705-G-2020-1031 Pesticide Registration This notice describes the registration requirements for pesticide products containing water soluble packaging (WSP). 474
PRN 94-7: Label Improvement Program for the Revision of Use Directions for Commensal Rodenticides and Statement of the Agency's Policies on the Use of Rodenticide Bait Stations 1994-01-01 EPA 705-G-2020-1032 Pesticide Registration This Notice requires registrants of certain pesticide products claimed to control commensal rodents and registered under FIFRA to revise the labeling of such products to bear certain statements concerning "tamper-resistant bait stations." 473
PRN 94-6: Pesticide Products Registered for Use on Humans to Control Lice (Pediculicides) 1994-01-01 EPA 705-G-2020-1034 Pesticide Registration This notice alerts pesticide registrants to a rule issued by Food and Drug Administration (FDA) under the Federal Food, Drug and Cosmetic Act (FFDCA) establishing conditions for safe and effective use of pediculicide drug products. 472
PRN 94-5: Requests for Re-considerations of Carcinogenicity Peer Review Decisions Based on Changes in Pathology Diagnoses 1994-01-01 EPA 705-G-2020-1036 Pesticide Registration This notice sets forth a procedure to be followed for submission of pathology re-reads to the Agency. 471
PRN Notice 94-4: Interim Measures for the Registration of Antimicrobial Products/Liquid Chemical Germicides with Medical Device Use Claims Under the Memorandum of Understanding Between EPA and FDA 1994-01-01 EPA 705-G-2020-1037 Pesticide Registration This Notice is intended to provide the regulated community with detailed guidance on the interim EPA registration procedures for antimicrobial products affected by the June 4, 1993, Memorandum of Understanding (MOU) between EPA and FDA. 498
PR Notice 94-4 MOU on Regulation of Liquid Chemical Germicides Intended for Use on Medical Devices 1994-01-01 EPA 705-G-2020-1039 Pesticide Registration This MOU between EPA and FDA establishes roles for regulation of liquid chemical germicides intended for use on medical devices. An amendment revises the disclaimer statement for labels of all liquid chemical germicides, other than FDA-approved sterilants. 399
PRN 94-2: Recycling Empty Aerosol Pesticide Containers 1994-01-01 EPA 705-G-2020-1040 Pesticide Registration This notice offers registrants use of an optional label statement permitting recycling as an alternative to instructions to dispose of aerosol pesticide containers. Registrants may add a label reference to recycling the empty aerosol pesticide container. 470
PRN 94-1: Withdrawal of PR Notice 91-8 1994-01-01 EPA 705-G-2020-1041 Pesticide Registration EPA withdrew PR Notice 91-8, entitled "Revised Policy To Provide Applicants Other Than Basic Manufacturers An Opportunity To Submit Generic Data and Receive Data Compensation For It." 469
PRN 91-1: Procedures for Voluntarily Requesting Deletion of Approved Uses from Registered Labels 1991-01-01 EPA 705-G-2020-1042 Pesticide Registration This pesticide registration notice defines procedures for registrants to use when they want to request an amendment to delete one or more uses from an approved registration, and it summarizes the actions the Agency will take in response to such requests. 453
PRN 91-2: Accuracy of Stated Percentages for Ingredients Statement 1991-01-01 EPA 705-G-2020-1043 Pesticide Registration The purpose of this notice is to clarify the Office of Pesticide Program's policy with respect to the statement of percentages in a pesticide's label's ingredient statement. 454
PRN 90-3: Announcing the Formation of an Industry-Wide Spray Drift Task Force 1990-01-01 EPA 705-G-2020-1044 Pesticide Registration "A Spray Drift Task Force has been organized pursuant to provisions of FIFRA section 3 (c)(2)(B)(ii) to share the cost of developing a generic spray drift data base capable of satisfying spray drift data requirements for pesticide product registrations. 452
PRN 90-1: Inert Ingredients in Pesticide Products; Revised Policy Statement 1990-01-01 EPA 705-G-2020-1045 Pesticide Registration This notice discusses compliance with Federal Register Notice (54 FR 58314; November 22, 1989). 451
PRN 87-6: Inert Ingredients in Pesticide Products; Policy Statement 1987-01-01 EPA 705-G-2020-1047 Pesticide Registration This PR notice announces certain policies regarding inert ingredients in pesticide products, including amendments required for products containing inert ingredients of toxicological concern. 448
PRN 87-1: Label Improvement Program for Pesticides Applied through Irrigation Systems (Chemigation) 1987-01-01 EPA 705-G-2020-1048 Pesticide Registration This Notice requires registrants of pesticide products registered under FIFRA and applied through irrigation systems to revise the labeling for such products to include additional use directions and other statements described in this Notice. 447
Pesticide Registration (PR) Notice 87-1 MOU 1987-01-01 EPA 705-G-2020-1053 Pesticide Registration These documents provide more information related to implementation of Pesticide Registration Notice 87-1, which addresses label improvement for pesticides applied through irrigation systems. 388
PRN 84-1: Clarification of Label Improvement Program for Farmworker Safety and Pesticide Storage and Disposal Instructions 1984-01-01 EPA 705-G-2020-1054 Pesticide Registration This PR notice clarifies EPA's intentions regarding the Pesticide Label Improvement Program for Farmworker Safety (PR Notice 83-2) and Pesticide Storage and Disposal Instructions (PR Notice 83-3) issued on March 26, 1983. 444
PRN 83-3: Label Improvement Program - Storage and Disposal Label Statements 1983-01-01 EPA 705-G-2020-1058 Pesticide Registration This Notice is to inform all registrants that the label of all pesticide products must include updated storage and disposal statements. No application for amended registration is required if you use the exact wording contained in this Notice. 443
PR Notice 83-3 Appendix B 1983-01-01 EPA 705-G-2020-1059 Pesticide Registration This appendix to PR Notice 83-3 lists pesticides that are hazardous waste under 40 CFR 261, 33(e) and (f) when discarded. 398
PRN 82-1: Revised Policy on Label Claims for Tank Mixing 1982-01-01 EPA 705-G-2020-1061 Pesticide Registration This notice sets out EPA's policy related to claims for tank mixing a pesticide product with another pesticide product. 442
Pesticide Containers 2019-12-03 EPA 705-G-2020-1276 Pesticide Worker Safety The pesticide container regulations establish standards for pesticide containers, repackaging, label instructions and to ensure safe use, reuse and disposal and adequate cleaning of the containers. 386
Rinsing Procedures for Dilutable Pesticide Products in Rigid Containers 2008-06-25 EPA 705-G-2020-1277 Pesticide Worker Safety The pesticide container regulations establish standards for pesticide containers, repackaging, label instructions and to ensure safe use, reuse and disposal and adequate cleaning of the containers. 503
Frequently Asked Questions on the Container and Containment Labeling Requirements 2019-08-27 EPA 705-G-2020-1278 Pesticide Worker Safety Frequently Asked Questions on the Container and Containment Labeling Requirements 375
Buoyant Force Calculations 2016-08-24 EPA 705-G-2020-1279 Pesticide Worker Safety Find out how buoyant force calculations are used to determine if a secondary containment unit complies with the pesticide containment regulations. 356
Interim Policy for Repair of Pesticide Containers 2009-10-09 EPA 705-G-2020-1280 Pesticide Worker Safety EPA will consider on a case-by-case basis whether to allow repair of minor damage to pesticide containers in the retail environment. Find out more about how EPA is implementing this policy. 383
Pesticide Containment Structures 2019-11-12 EPA 705-G-2020-1282 Pesticide Worker Safety Learn about federal and state requirements for pesticide containment structures. 387
Scope of the Federal Pesticide Containment Regulations 2009-12-01 EPA 705-G-2020-1283 Pesticide Worker Safety The purpose of this document is to help you determine whether the federal containment regulations require you to have a secondary containment unit and/or a containment pad. 504
Clarification of PR Notice 2003-1 2015-06-11 EPA 705-G-2020-1287 Pesticide Registration This document clarifies when and how the National Organic Program logo may be used on pesticide products and how to obtain approval to add it. 358
Scope of the Non-refillable Container, Refillable Container, and Repackaging Regulations for Pesticide Containers 2016-08-24 EPA 705-G-2020-1291 Pesticide Worker Safety Two flow charts: Scope of container and repackaging regulations and determining whether Antimicrobial products are exempt from or subject to regulations. 505
EPA Pesticide Container and Repackaging Regulations - Flow Chart 1 2012-04-27 EPA 705-G-2020-1292 Pesticide Worker Safety Flow Chart 1: Is this container a service container or a portable refillable container? 364
EPA Pesticide Container and Repackaging Regulations - Flow Chart 2 2012-04-27 EPA 705-G-2020-1293 Pesticide Worker Safety A flowchart which diagrams the question "Can I fill this large portable refillable container (greater than 119 gallons)? 365
EPA Pesticide Container and Repackaging Regulations - Flow Chart 3 2012-04-27 EPA 705-G-2020-1294 Pesticide Worker Safety Flow Chart 3: Can I fill this small portable refillable container 366
Generic Verification Protocol for Testing Pesticide Application Spray Drift Reduction Technologies for Row and Field Crops 2017-01-01 EPA 705-G-2020-1361 Reducing Pesticide Drift This generic verification protocol provides a detailed method to conduct and report results from a verification test of pesticide application technologies that can be used to evaluate these technologies for their potential to reduce spray drift. 376
PRN 88-2: Clustering of Quaternary Ammonium Compounds 1988-02-26 EPA 705-G-2020-1420 Pesticide Registration This Notice announces that EPA has clustered the Quaternary Ammonium Compounds into four groups for the purpose of testing chemicals to build a database that will support continued registration of the entire family of quaternary ammonium compounds 449
PRN 75-5: Unacceptable Use of the Word "Chlorine" in the Name and Labeling of Pesticides 1975-01-01 EPA 705-G-2020-1423 Pesticide Registration Use of the word "Chlorine" on labels other than in products containing liquefied chlorine under pressure has been determined to be in violation of Section 2(q)(l)(A) of the Federal Insecticide, Fungicide, and Rodenticide Act. 438
PRN 67-5 Economic Poisons Containing Sodium Hypochlorite 1967-09-26 EPA 705-G-2020-1424 Pesticide Registration Products containing sodium hypochlorite at various concentrations have been accepted for registration under the Federal Insecticide, Fungicide, and Rodenticide Act. 434
PRN 66 Federal Registration of Economic Poisons 1966-11-16 EPA 705-G-2020-1425 Pesticide Registration The Federal Insecticide, Fungicide, and Rodenticide Act, and the regulations promulgated thereunder, provide that an economic poison is misbranded if its labeling bears any statement, graphic representation, or design which is false or misleading. 433
Guidance on Basic Elements of an EPA-Funded Tribal Pesticide Program 2017-03-25 EPA 705-G-2020-1475 Pesticide Advisory Committees and Regulatory Partners This guidance document describes basic elements for an EPA-funded tribal pesticide program. 377
NAFTA Guidance on Data Requirements for Pesticide Import Tolerances: Questions & Answers 2018-01-01 EPA 705-G-2020-1476 Pesticide Tolerances These Q&A's provide details of implementation related to a guidance document describing the data requirements for establishing pesticide import tolerances in Canada and the United States: NAFTA Guidance on Data Requirements for Pesticide Import Tolerances. 384
PRN 1982-2 Change in Procedures for Approval of Applications 1982-06-18 EPA 705-G-2020-1506 Pesticide Registration This Notice revises EPA procedures with respect to submission of final printed labeling and agreement to conditions of registration. 404
Worker Protection Standard Application Exclusion Zone 2023-02-16 EPA 705-G-2020-1521 Pesticide Worker Safety These documents provide general guidance to help you comply with the requirements of the Federal Worker Protection Standard (WPS) for agricultural pesticides, 40 CFR part 170, as amended in 2015. 517
Worker Protection Standard Train-the-Trainer Programs, Approval Process and Criteria 2017-08-01 EPA 705-G-2020-1573 Pesticide Worker Safety EPA has prepared guidance material to facilitate the development of Train-the-Trainer programs that meet EPA requirements. 521
PRN 2017-2: Guidance for Herbicide-Resistance Management, Labeling, Education, Training, and Stewardship 2017-01-01 EPA 705-G-2020-1711 Pesticide Registration Provides 11 elements focused on labeling, education, training and stewardship strategies. 431
Pesticide Worker Protection Standard “How to Comply” Manual 2016-09-30 EPA 705-G-2020-1750 Pesticide Worker Safety The “How to Comply” manual provides information for employers on complying with the worker protection standard for agricultural workers. It has been updated to cover the 2015 revisions to the WPS. 389
FIFRA Pesticides Export Policy: Questions & Answers 2019-05-21 EPA 705-G-2020-2509 FIFRA exports questions and answers are intended to assist in compliance with the Environmental Protection Agency's February 18, 1993 rule (58 FR 9062) regarding the exportation of pesticides. 373
FIFRA Pesticides Export Policy: Questions & Answers Issue: Research and Development Pesticides; Active Ingredient Concentrations 2017-02-28 EPA 705-G-2020-2510 FIFRA exports questions and answers are intended to assist in compliance with the Environmental Protection Agency's February 18, 1993 rule (58 FR 9062) regarding the exportation of pesticides. 374
Web-distributed Labeling for Pesticides 2014-01-01 EPA 705-G-2020-2511 Pesticide Labeling Additional information on PR Notice 2014-1 including history of development, examples, and Q&As 514
Worker Protection Standard Frequently Asked Questions 40 CFR Part 170 2016-04-14 EPA 705-G-2020-2523 Pesticide Worker Safety Frequently asked questions and answers related to the WPS rule change in 2015 - published in April 2016. 519
Worker Protection Standard Application Exclusion Zone Requirements Updated Question and Answers 2018-02-15 EPA 705-G-2020-2524 Pesticide Worker Safety This fact sheet contains further explanation of the Application Exclusion Zone (AEZ) requirement in the Agricultural Worker Protection Standard WPS. 518
Revising Certification Plans to Meet the Requirements of the 2017 Certification of Pesticide Applicators Final Rule Questions & Answers 2019-08-23 EPA 705-G-2020-2525 Certification of Pesticide Applicators This document is intended for pesticide State Lead Agencies (SLAs), Tribes and Federal Agencies (“certifying authorities”) to answer their questions on the 2017 Certification of Pesticide Applicators regulation and the requirement to submit to EPA revised certification plans by March 4, 2020. 502
State Certification Plan Outline 2019-04-29 EPA 705-G-2020-2526 Certification of Pesticide Applicators This document serves as a model outline for the order and contents of state certification plans. 508
Qs and As from Federal Agencies on Federal Agency Certification Plans 2019-08-28 EPA 705-G-2020-2527 Certification of Pesticide Applicators This document is intended to answer Federal agency questions on the 2017 Certification of Pesticide Applicators regulation. 501
Federal Agency Certification Plan Outline 2019-08-28 EPA 705-G-2020-2528 Certification of Pesticide Applicators This document is intended to answer Federal agency questions on the 2017 Certification of Pesticide Applicators regulation. 370
Tribal Certification Plan Outline 2019-09-18 EPA 705-G-2020-2529 Certification of Pesticide Applicators This document serves as a model outline for the order and contents of a tribal certification plan for those tribes that choose to develop their own certification plan under 40 CFR § 171.307(b). 512
Certification of Pesticide Applicators in Indian Country: Fact Sheet on Certification Options Available to Federally Recognized Tribes 2019-02-05 EPA 705-G-2020-2531 Certification of Pesticide Applicators The purpose of this document is to inform federally recognized tribal governments and pesticide regulatory agencies of new requirements for tribal certified applicator plans and EPA’s intent to propose revisions to the EPA Plan for the Federal Certification of Applicators of Restricted Use Pesticides within Indian Country (i.e., EPA Plan) and associated options. 357
PRN 2012-X; Draft; Guidance for Antimicrobial Pesticide Products with Mold-Related Label Claims. Docket ID EPA-HQ-OPP-2010-0539 2012-12-12 EPA 705-G-2020-2661 Pesticide Registration Guidance for Antimicrobial Pesticide Products with Mold-Related Label Claims. Docket ID EPA-HQ-OPP-2010-0539 427
PRN 2010-X; Draft; Proposed Guidance on False or Misleading Pesticide Product Brand Names 2010-01-01 EPA 705-G-2020-2662 Draft; PRN; Draft PRN; PRN 2010-x; 2010 Proposed Guidance on False or Misleading Pesticide Product Brand Names. 422
PRN 81-3; Label Improvement Program: Change in Test Methods for and Categorization of Eye Irritation 1981-01-01 EPA 705-G-2020-2670 PRN Label Improvement Program: Change in Test Methods for and Categorization of Eye Irritation 440
PRN 72-6; Changes in standard for expressing potency of products containing Bacillus Truringiensis Berliner 1972-01-01 EPA 705-G-2020-2671 EPA Archive Changes in standard for expressing potency of products containing Bacillus Truringiensis Berliner 436
PRN 2000-6; Minimum Risk Pesticides Exempted under FIFRA Section 25(b) Clarification of Issues 2000-01-01 EPA 705-G-2020-2672 Pesticide Registration Minimum Risk Pesticides Exempted under FIFRA Section 25(b) Clarification of Issues Web information posted in January 2015: Minimum Risk Pesticides Exempted from FIFRA Registration supersedes this PR notice 407
FIFRA Pesticides Export Policy Interpretative Guidance Issue: Multilingual Labeling 1993-04-08 EPA 705-G-2020-2769 FIFRA Pesticides Export Policy This document addresses the requirement that certain labeling statements appear in English and in the languages of destination countries if known or reasonably ascertainable by the exporter. 372
Secondary Containers and Service Containers for Pesticides 2015-10-26 EPA 705-G-2020-2886 container; labels Explains what secondary containers and service containers are; EPA does not require labels on them; and, provides EPA recommendations for them. 506
Table 4: Refillable container Requirements (40 CFR Part 165 Subpart C) 2008-10-01 EPA 705-G-2020-2908 Refillable Container refillable container requirements 510
Pesticide Container and Repackaging Standards 2015-06-01 EPA 705-G-2020-2910 Container/Repackaging Scope of the Non-refillable Container, Refillable Container, and Repackaging Regulations for Pesticide Containers 385
Simple Comparison of the Major 2016 Revisions to the Existing Rule 2017-01-12 EPA 705-G-2020-2912 Certification of Pesticide Applicators Comparison tables of the 2016 revisions to the Certification of Pesticide Applicator Rule to the existing rule. 507
Detailed Comparison of the 2016 Revisions to the Existing Rule 2016-12-30 EPA 705-G-2020-2913 Certification of Pesticide Applicators Comparison tables of the 2016 revisions to the Certification of Pesticide Applicator Rule to the existing rule. 361
How to Get Certified as a Pesticide Applicator 2018-11-15 EPA 705-G-2020-2990 Certification of Pesticide Applicators Information on what someone needs to do to get certified as a pesticide applicator. 381
Federal Certification Standards for Pesticide Applicators 2018-04-02 EPA 705-G-2020-2991 Certification of Pesticide Applicators Information on the standards for applicators. 371
Exporting Unregistered Pesticides: Foreign Purchaser Acknowledgement Statements 2020-01-01 EPA 705-G-2020-3590 FIFRA Export Policy This website provides guidance to companies intending to export unregistered pesticides to promote compliance assistance with FIFRA Sec. 17(a) and related regulations at 40 CFR 168.75) 369
Guidance to Submit A Pesticide Petition 2018-03-01 EPA 705-G-2020-3591 Pesticide Petition EPA offers a number of ways for the public to participate in and comment on regulatory actions that the agency proposes to take regarding the registration and review of pesticides. This webpage identifies those opportunities, including guidance on how to submit a pesticide petition. 380
Worker Protection Standard (WPS) Comparison Chart: Comparison of the Revised Protections to the Previous Protections 2017-01-01 EPA 705-G-2020-3594 Pesticide Worker Safety This table summarizes key provisions in the EPA’s previous WPS regulation and the 2015 revisions. 516
CPARD USER GUIDE: For State Lead Agency (SLA) and Tribal Representatives with Certification Plans (CPs) 2019-11-01 EPA 705-G-2020-3686 Certification of Pesticide Applicators The Certification Plan and Reporting Database (CPARD) is a compilation of EPA?approved pesticide applicator certification plans and reporting as required by the Federal Insecticide, Fungicide and Rodenticide Act (FIFRA) and the federal Certification of Pesticide Applicators regulations at 40 CFR Part 171. In 2019, EPA added a section (Certification 2020) on the review and approval of modified certification plans due to EPA by March 4, 2020. This guide describes how to register and use CPARD. 359
Statement Regarding Respiratory Protection Shortages and Reduced Availability of Respirator Fit Testing Related to Pesticide Uses Covered by the Agricultural Worker Protection Standard during the COVID-19 Public Health Emergency 2020-06-01 EPA 705-G-2020-3699 Pesticides, FIFRA, worker protection The EPA has developed this document with the goal of continuing to protect the health of pesticide handlers while acknowledging the challenges that handler employers and pesticide handlers may face with respect to personal protective equipment (PPE) 509
Guidance on Satisfying the Annual Pesticide Safety Training Requirement under the Agricultural Worker Protection Standard during the COVID-19 Emergency 2020-06-18 EPA 705-G-2020-3700 FIFRA, pesticides, worker protection This temporary guidance addresses pesticide safety training of farmworkers and pesticide handlers in agriculture as required by the Agricultural Worker Protection Standard (WPS) (40 CFR 170). EPA is clarifying that pesticide safety training may be presented remotely, provided all of the WPS training requirements are met. 378
Guidance regarding the Certification of Pesticide Applicators during the COVID-19 Public Health Emergency 2020-07-27 EPA 705-G-2020-3719 FIFRA, Certification of Pesticide Applicators To help states, tribes, and federal certifying authorities meet both the needs of applicators and the requirements of the Certification of Pesticide Applicators (CPA) rule (40 CFR Part 171) during this COVID-19 PHE, EPA has developed this guidance based on certifying authorities’ input. ​​​​​ 379
Pesticide Submission Portal - Quick Reference Guide - Foreign Purchasers Acknowledgement Statements (FPAS) 2021-08-17 EPA 705-G-2021-3738 FIFRA; CDX CDX user guide for submitting Foreign Purchasers Acknowledgement Statements. 1013
PR Notice 2000-1; Applicability of the Treated Articles Exemption to Antimicrobial Pesticides 2000-03-06 PR Notice 2000-1 Pesticide Registration Notices by Year This notice clarifies EPA policy with respect to the scope of the "treated articles exemption" in 40 CFR 152.25(a). This exemption covers qualifying treated articles and substances bearing claims to protect the article or substance itself. EPA does not regard this exemption as including articles or substances bearing implied or explicit public health claims against human pathogens. 391
PR Notice 2000-5; Guidance for Mandatory and Advisory Labeling Statements 2000-05-10 PR Notice 2000-5 Pesticide Registration Notices by Year This notice provides guidance to the registrant for improving the clarity of labeling statements in order to avoid confusing directions and precautions, and to prevent the misuse of pesticides. 392
PR Notice 2001-3; Insect Repellents: Labeling Restrictions for Use on Infants and Children and Restrictions on Food Fragrances and Colors 2001-01-16 PR Notice 2001-3 Pesticide Registration Notices by Year This notice announces EPA's approach to insect repellents bearing claims for use specifically on infants and children. EPA believes that the label changes and policy clarification set forth in this PR Notice will reduce risks associated with the improper use of insect repellents and will improve consumer understanding. Additionally, this PR Notice states EPA's current position on insect repellents formulated to contain colors and fragrances predominantly associated with food (e.g., grape, watermelon, or orange). 393
PR Notice 2001-5; Guidance for Pesticide Registrants on Pesticide Resistance Management Labeling 2001-06-19 PR Notice 2001-5 Pesticide Registration Notices by Year This archived PRN provided guidance for pesticide registrants on pesticide resistance management labeling that has since been superseded. 394
PR Notice 2002-2; Guidance for Submitting Requests for Threshold of Regulation Decisions to OPP 2002-08-20 PR Notice 2002-2 Pesticide Registration Notices by Year In the Federal Register of October 27, 1999 (64 FR 57881), the Environmental Protection Agency (EPA) announced the availability of a document entitled “Threshold of Regulation Policy - Deciding Whether a Pesticide with a Food Use Pattern Needs a Tolerance.” The Threshold of Regulation (TOR) Policy describes criteria and procedures to be considered in determining whether a use of a pesticide in a location and manner that has the possibility of resulting in residues in food is below the threshold of regulation. 395
PR Notice 2003-1; Labeling of Pesticide Products under the National Organic Program 2003-01-31 PR Notice 2003-1 Pesticide Registration Notices by Year This notice describes how registrants can obtain EPA approval of label language indicating that all ingredients (active and inert) in a pesticide product and all uses of that pesticide meet the criteria defined in the United States Department of Agriculture’s National Organic Program Rule. This Pesticide Registration Notice provides an example of acceptable label language and the procedures for adding such identification to product labels. The information on the pesticide label will assist organic growers and those persons certifying organic production methods in knowing which pesticide products meet the requirements of the NOP Rule for use in organic agriculture. 396
PR Notice 2007-2: Guidance on Small-Scale Field Testing and Low-level Presence in Food of Plant-Incorporated Protectants (PIPs 2007-04-30 PR Notice 2007-2 Pesticide Registration Notices by Year This PR Notice provides clarification on the process by which EPA reviews and ensures the safety of residues of plant-incorporated protectants (PIPs) potentially present at low levels in food or feed, and the conditions under which a tolerance or exemption from the requirement of a tolerance would be required for field tests for biotechnology-derived food and feed crop plants containing plant-incorporated protectants. 397
PR (Pesticide Registration) Notice 96-8; Toxicologically Significant Levels of Pesticide Active Ingredients 1996-10-31 PR Notice 96-8 Pesticide Registration Notices by Year This notice sets out EPA's interpretation of the term "toxicologically significant" as it applies to contaminants in pesticide products that are also pesticide active ingredients. This notice provides risk-based concentration levels of such contaminants that will generally be considered toxicologically significant. These concentrations are defined according to the type of pesticide that is contaminated and the pesticide category of the contaminant. 390
PR Notice 97-5; Use of Common Names for Active Ingredients on Pesticide Labeling 1997-09-11 PR Notice 97-5 Pesticide Registration Notices by Year This notice announces EPA policy to expand the use of common names on pesticide labeling. EPA will permit the use of common names approved by the American National Standards Institute (ANSI) in the label ingredients statement without the accompanying scientific chemical names, and will permit the use of other common names listed in this notice without the accompanying scientific chemical name. EPA also recommends the inclusion on labels of Chemical Abstracts Service (CAS) numbers to identify ingredients definitively. 400
PR Notice 97-6; Use of Term "Inert" in the Label Ingredients Statement 1997-09-11 PR Notice 97-6 Pesticide Registration Notices by Year This notice announces a change in EPA policy regarding the label ingredients statement. Effective immediately, the phrase "Inert ingredients," may be replaced by the term "Other ingredients." Although no registrant is required to make this change, EPA encourages registrants to do so. Provided the term "Other ingredients" is used, the change may be made at any time without notification to the Agency. 401
PR Notice 98-1; Self-Certification of Product Chemistry Data 1998-01-12 PR Notice 98-1 Pesticide Registration Notices by Year The Office of Pesticide Programs has established a self-certification program for certain product chemistry data of manufacturing-use products and end-use products produced by a non-integrated formulation system. This program is voluntary and is intended to simplify and accelerate the processing of applications for registration and reregistration while maintaining protection of public health and the environment. To be eligible for self-certification, a product must be formulated from registered source(s). 402
PR Notice 99-1; Import of Unregistered Pesticides Intended for Export 1999-03-01 PR Notice 99-1 Pesticide Registration Notices by Year This Pesticide Registration (PR) notice clarifies EPA's interpretation of the scope of the Federal Insecticide, Fungicide and Rodenticide Act (FIFRA) Section 17 (a)(1), as it relates to the import of unregistered pesticides, devices or active ingredients used in producing a pesticide when the importation is solely for the purpose of formulation or packaging for subsequent export. 403
PRN 2017-1 Guidance for Pesticide Registrants on Pesticide Resistance Management Labeling 2017-08-24 PRN 2017-1 PRN; Guidance; PRN 2017-1; 2017-1 PRN 2017-1, Guidance for Pesticide Registrants on Pesticide Resistance Management Labeling, revises and updates PRN 2001-5. PRN 2017-1 applies to all conventional, agricultural pesticides (i.e., herbicides, fungicides, bactericides, insecticides, and acaricides). 430
PRN 2018-1 Pesticides: Guidance for Registrants on the Determination of Minor Use 2018-03-22 PRN 2018-1 PRN 2018-1; Pesticide Registration Notice; OPP; OCSPP This PRN describes the revised approach to interpreting economic minor use based on the concept of the registration of a pesticide as an investment. 432
Assigning Values to Nondetected/ Nonquantified Pesticide Residues in Human Health Dietary Exposure Assessments 2000-03-23 EPA 705-G-2020-0007 Dietary Exposure; Human Health Risk Assessment; Pesticide Residues; Non-Detected Residues; Limit of Quantification OPP’s policy for assigning values for use in human health exposure and risk assessment to non-detected/non-quantified pesticide residues in food. In general, EPA recommends use of a value of ½ the analytical Limit of Detection (LOD), ½ the Limit of Quantitation (LOQ), the (full) Lower Limit of Method Validation (LLMV), or true zero for these non-detected residues. 528
Available EPA Information on Assessing Exposure to Pesticides in Food- A User's Guide 2000-06-21 EPA 705-G-2020-0008 Dietary Exposure; Pesticide Residues in Food; Human Health Risk Assessment Provides a simple overview of EPA's approach to estimating risk and exposure from pesticide residues in food, provides specifics on how to obtain or generate the data and/or information EPA uses in its assessments of exposure and risk from pesticides in food; and provides a list of helpful resources by topic area. 529
Choosing a Percentile of Acute Dietary Exposure as a Threshold of Regulatory Concern 2000-03-16 EPA 705-G-2020-0009 Acute Dietary Exposure; Pesticide Residues in Food; Human Health Risk Assessment EPA is responsible for regulating the nature and amount of pesticide residues in food under the Federal Food, Drug and Cosmetic Act (FFDCA). The Agency performs various types of risk assessments to evaluate the safety of pesticides in food, including analyses to determine the nature and the amounts of pesticides that people might be exposed to over a single day. This paper discusses how EPA generally applies the statutory safety standard to acute dietary risk assessments as to pesticide residues in foods. 543
Data for Refining Anticipated Residue Estimates Used in Acute Dietary Probabilistic Risk Assessments 2000-06-15 EPA 705-G-2020-0011 Pesticide Data; Anticipated Residues; Dietary Exposure; Human Health Risk Assessment The purpose of this document is to outline the types of data EPA's Office of Pesticide Programs can use to refine residue estimates for pesticides and explain when and how these data may be used. Specifically, this document is intended to provide additional guidance to registrants, other test sponsors, interested parties, and data reviewers on the extent and quality of pesticide residue and ancillary data needed to support the use of more refined “anticipated residues” in dietary exposure assessments. 549
Determination of the Appropriate FQPA Safety Factor(s) in Tolerance Assessment 2002-02-28 EPA 705-G-2020-0012 Food Quality Protection Act; FQPA Safety Factor; Pesticide Exposure; Human Health Risk Assessment This document describes how the Office of Pesticide Programs (OPP) determines the appropriate FQPA safety factor(s) when developing aggregate risk assessments and regulatory decisions for single active and "other" (i.e., inert) ingredients of pesticide products. The guidance is specifically addressed to OPP risk assessors but also serves as an important source of information for the public and the regulated community. 553
General Principles for Performing Aggregate Exposure and Risk Assessments 2001-11-28 EPA 705-G-2020-0014 Human Health Risk Assessment; Aggregate exposure; Pesticides; Exposure Pathways This document describes OPP's overall framework and the general principles for performing an aggregate exposure and risk assessment. Aggregate exposure and risk assessment involve the analysis of exposure to a single chemical by multiple pathways (e.g., food, drinking water, and residential uses) and routes (ingestion, dermal, and inhalation). 564
Guidance for Identifying Pesticide Chemicals and Other Substances That Have a Common Mechanism of Toxicity 1999-01-29 EPA 705-G-2020-0015 Pesticide Chemicals; Common Mechanism of Toxicity; Cumulative Risk Assessment The purpose of this document is to describe the approach that EPA will use for identifying and categorizing pesticides and other substances that cause common toxic effects from common mechanisms of toxicity. 566
Guidance on Cumulative Risk Assessment of Pesticide Chemicals That Have a Common Mechanism of Toxicity 2002-01-14 EPA 705-G-2020-0016 Cumulative Risk Assessment; Pesticide Exposure; Common Mechanism of Toxicity This document describes OPP's process for assembling and evaluating information that will constitute a cumulative risk assessment involving food, water, residential, and other nonoccupational exposures to multiple pesticides that share a common mechanism of toxicity. 569
The Use of Data on Cholinesterase Inhibition for Risk Assessments of Organophosphorous and Carbamate Pesticides 2000-08-18 EPA 705-G-2020-0045 Human Health Risk Assessment; Cholinesterase inhibition; Organophosphate; Carbamate; Pesticides This science policy document describes the approaches that the Office of Pesticide Programs (OPP) employs when evaluating data on cholinesterase inhibition and other cholinergic effects related to nervous system function that are the consequences of acetycholinesterase inhibition (i.e., physiological or behavioral 2007changes) in assessing the potential hazard following exposure to organophosphorous or carbamate pesticides that inhibit cholinesterase. 682
Residue Chemistry Test Guidelines: 860.1000 Supplement, Guidance on Constructing Maximum Reasonably Balanced Diets (MRBD) 2008-06-30 EPA 705-G-2020-0273 Test Guideline; Residue Chemistry; Feedstuffs Revision The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 655
Determining Toxicology Data Requirements 2013-05-01 EPA 705-G-2020-0594 Pesticide Registration Provide guidance on the weight of the evidence-based (WOE) determination of data needs for neurotoxicity, subchronic inhalation, subchronic, dermal and immunotoxicity studies and provide guidance on how to consider the data needs determination in risk assessment. Evaluation of waiver requests and development of registration review cases are typical situations in which OPP reviewers will make data need determinations. 556
Guidance for Thyroid Assays in Pregnant Animals, Fetuses and Postnatal Animals, and Adult Animals 2005-10-24 EPA 705-G-2020-1286 Pesticide Registration This study may be done in place of a rat DNT study for thyroid disrupting chemicals. This special study is intended to provide LOAEL or NOAEL to derive RfDs to be protective of thyroid development in pregnant women, fetuses or newborns. 568
(Quantitative) Structure Activity Relationship [(Q)SAR] Guidance Document (NAFTA) 2012-11-01 EPA 705-G-2020-1496 Pesticide Registration Guidance Document developed by the NAFTA Technical Working Group on the Quantitative Structure Activity Relationship. (Q)SAR represents a variety of techniques for predicting activities and properties of untested chemicals based on their structural similarity to chemicals with known activities and properties. 522
Pesticide Cumulative Risk Assessment: Framework for Screening Analysis 2015-06-23 EPA 705-G-2020-1561 Pesticide Science; Assessing Pesticide Risks; Cumulative Risk Assessment; Screening Approach This document provides guidance on how to screen groups of pesticides for cumulative evaluation using a two-step approach: beginning with the evaluation of available toxicological information and, if necessary, followed by a risk-based screening approach. This framework supplements the existing guidance documents for establishing common mechanism groups (CMGs) and conducting cumulative risk assessments (CRA). 647
Developmental Neurotoxicity Study Guidance (NAFTA) 2016-12-01 EPA 705-G-2020-1655 Pesticide Science and Assessing Pesticide Risks This guidance covers review and interpretation of DNT data and was developed collaboratively by EPA and Health Canada, with the goal of more consistent reviews of DNT data. 559
Thyroid Disrupting Pesticides:  Use of Rat Thyroid Data and Application of Uncertainty Factors for RfD Derivation 2005-11-01 EPA 705-G-2020-2341 Uncertainty Factors The objective of this paper is to provide guidance on the use of toxicokinetic or dynamic information to replace the current standard default 10X uncertainty factors which are applied to address interspecies and interindividual (human) differences in the dose–response assessment for pesticides that have been shown to disrupt thyroid function in rats. 683
Preferred Vocabulary for Establishing Pesticide Tolerances 2017-09-27 EPA 705-G-2020-2344 Pesticide Tolerances; Vocabulary This document presents stakeholders who propose pesticide tolerances and regulatory staff charged with reviewing those proposals with the preferred vocabulary terms both for individual commodities and crop groups and subgroups 648
NAFTA Guidance Document on Data Requirements for Tolerances on Imported Commodities in the United States and Canada 2005-12-01 EPA 705-G-2020-2422 data requirement; tolerance; MRL; NAFTA Provides detailed guidance on data requirements that meet the North American Free Trade Agreement (NAFTA) standards for the establishment of pesticide import tolerances or maximum residue levels (MRL) in Canada and the United States. 628
Determining the Number of Field Trials Required to Register Seed-Treatment Uses 2018-02-01 EPA 705-G-2020-2425 seed treatment This page includes the guidance memo, decision trees and additional reference documents to help a manufacturer determine how many field trials are necessary to register seed-treatment uses. 555
Reduced Residue Chemistry Data Requirements for Seed-Treatment Uses 2018-01-26 EPA 705-G-2020-2426 seed treatment This document provides a tiered approach for determining if current crop-specific field trial data are required to support new seed treatment uses or if a reduction in number of field trials is appropriate. 652
Decision Tree for the Residue Data Requirements of Potato Seed-Piece (PSP) Treatments 2018-01-26 EPA 705-G-2020-2427 seed treatment; PSP; decision tree Diagrammatic representation of a decision Tree for the Residue Data Requirements of Potato Seed-Piece (PSP) Treatments. 551
Decision Tree for Seed Treatment (Excluding Potato Seed-Piece Treatment) 2018-01-26 EPA 705-G-2020-2428 seed treatment; decision tree Diagrammatic representation of a decision Tree for the Residue Data Requirements excluding Potato Seed-Piece (PSP) Treatments. 550
Classification of Seed Treatments as Food or Nonfood Uses 1999-10-28 EPA 705-G-2020-2429 seed treatment; food; nonfood Chem SAC determination of seed treatment uses as food versus nonfood based on the results of radiolabeled studies 546
Guidance for Reduced Residue Field Trial Requirements to Support Joint Projects Between Canada and the United States 2018-08-23 EPA 705-G-2020-2539 Crop Field Trials The purpose of this document is to communicate to industry and other interested parties, the revised crop trial requirements for trials that are conducted to support simultaneous domestic registration applications in both Canada and the United States. 567
Conclusions and Recommendations Regarding the Requirement for Inclusion of Adjuvants in Crop Field Trials 2012-08-13 EPA 705-G-2020-2643 Pesticide Crop Field Trials Conclusions and Recommendations Regarding the Requirement for Inclusion of Adjuvants in Crop Field Trials. 548
Developing a Tiered Framework for Extrapolation Modeling 2017-03-14 EPA 705-G-2020-2808 Pesticide Registration This is a web page describing how EPA extrapolates from animals to humans in its risk assessments 557
Proposed Approach to Efficiently Develop Physiologically Based Pharmacokinetic (PBPK) & Physiologically Based Pharmacokinetic-Pharmacodynamic (PBPK-PD) Models for Pesticides 2017-03-14 EPA 705-G-2020-2813 Computational Modelling; PBPK; PBPK-PD Models This document describes OPP's tiered framework for extrapolation modeling for animal >> human testing data. 651
Interim Science Policy: Use of Alternative Approaches for Skin Sensitization as a Replacement for Laboratory Animal Testing Draft for Public Comment 2018-04-04 EPA 705-G-2020-3111 Alternative Approaches; Testing Methods; Skin Sensitization This document describes the science supporting an interim science policy on the acceptance of alternative (in vitro, in silico, in chemico) approaches for identifying skin sensitization hazard. These approaches will be accepted in lieu of laboratory animal studies, most often the local lymph node assay (LLNA) in the mouse (OECD TG 429; OECD 2010a), and Buehler or maximization tests in the guinea pig (OECD TG 406, OECD 2010a). Although this document is a draft for public comment, given the substantial scientific evidence and international activities supporting NAMs for skin sensitization, OPP and OPPT will begin accepting these approaches immediately under the conditions described within. 625
E-Submission Chronic Toxicology Study Supplemental Files 2002-07-01 EPA 705-G-2020-3131 Electronic Submission; Toxicology Data; Pesticide Registration The formats and instructions in these documents are designed to be used as an example or guide for registrants to format electronic files for submission of animal toxicology data to the EPA's Office of Pesticide Programs for review in support of registration and reevaluation of pesticides. 562
Standard Format for Electronic Submission of Supplemental Data Files in Support of Chronic/Sub-Chronic Studies. 2002-07-31 EPA 705-G-2020-3132 Electronic Submission; Toxicology Data; Pesticide Registration The following formats and instructions are designed to be used as an example or guide for registrants to format electronic files for submission of animal toxicology data to the USEPA Office of Pesticide Programs for review in support of registration and re-registration of pesticides. 676
Standard Format for Electronic Submission of Supplemental Data Files in Support of Developmental Neurotoxicity (DNT) Studies. 2002-07-31 EPA 705-G-2020-3133 Electronic Submission; Toxicology Data; Pesticide Registration The following formats and instructions are designed to be used as an example or guide for registrants to format electronic files for submission of animal toxicology data to the USEPA Office of Pesticide Programs for review in support of registration and re-registration of pesticides. 677
Standard Format for Electronic Submission of Supplemental Data Files in Support of Prenatal Developmental Toxicity Data. 2002-07-31 EPA 705-G-2020-3134 Electronic Submission; Toxicology Data; Pesticide Registration registrants to format electronic files for submission of animal toxicology data to the USEPA Office of Pesticide Programs for review in support of registration and re-registration of pesticides. 679
Standard Format for Electronic Submission of Supplemental Data Files in Support of Multi-Generation Reproduction Studies. 2002-07-31 EPA 705-G-2020-3135 Electronic Submission; Toxicology Data; Pesticide Registration The following formats and instructions are designed to be used as an example or guide for registrants to format electronic files for submission of animal toxicology data to the USEPA Office of Pesticide Programs for review in support of registration and re-registration of pesticides. 678
B.7 Residue Data 2016-02-01 EPA 705-G-2020-3318 Study Profile Template Study profile templates serve as a guide for the preparation of study documents. Applicants may include additional information beyond that prescribed in a particular study profile; however, it should be done without affecting or changing the format and content of the template. 531
B.7.1 Plant Metabolism 2016-02-01 EPA 705-G-2020-3319 Study Profile Template Study profile templates serve as a guide for the preparation of study documents. Applicants may include additional information beyond that prescribed in a particular study profile; however, it should be done without affecting or changing the format and content of the template. 532
B.7.2 Livestock Metabolism 2016-02-01 EPA 705-G-2020-3320 Study Profile Template Study profile templates serve as a guide for the preparation of study documents. Applicants may include additional information beyond that prescribed in a particular study profile; however, it should be done without affecting or changing the format and content of the template. 533
B.5.2 Residue Analytical Methods 2016-02-01 EPA 705-G-2020-3321 Study Profile Template Study profile templates serve as a guide for the preparation of study documents. Applicants may include additional information beyond that prescribed in a particular study profile; however, it should be done without affecting or changing the format and content of the template. 530
B.7.6.2 Freezer Storage Stability in Plants 2016-02-01 EPA 705-G-2020-3322 Study Profile Template Study profile templates serve as a guide for the preparation of study documents. Applicants may include additional information beyond that prescribed in a particular study profile; however, it should be done without affecting or changing the format and content of the template. 535
B.7.8.3 Freezer Storage Stability in Livestock 2016-02-01 EPA 705-G-2020-3323 Study Profile Template Study profile templates serve as a guide for the preparation of study documents. Applicants may include additional information beyond that prescribed in a particular study profile; however, it should be done without affecting or changing the format and content of the template. 538
B.7.8 Livestock Feeding 2016-02-01 EPA 705-G-2020-3324 Study Profile Template Study profile templates serve as a guide for the preparation of study documents. Applicants may include additional information beyond that prescribed in a particular study profile; however, it should be done without affecting or changing the format and content of the template. 537
B.7.6 Crop Residue Trials 2016-02-01 EPA 705-G-2020-3325 Study Profile Template Study profile templates serve as a guide for the preparation of study documents. Applicants may include additional information beyond that prescribed in a particular study profile; however, it should be done without affecting or changing the format and content of the template. 534
B.7.7 Processing 2016-02-01 EPA 705-G-2020-3326 Study Profile Template Study profile templates serve as a guide for the preparation of study documents. Applicants may include additional information beyond that prescribed in a particular study profile; however, it should be done without affecting or changing the format and content of the template. 536
B.7.9 Confined Crop Rotation 2016-02-01 EPA 705-G-2020-3327 Study Profile Template Study profile templates serve as a guide for the preparation of study documents. Applicants may include additional information beyond that prescribed in a particular study profile; however, it should be done without affecting or changing the format and content of the template. 539
B.7.9.2 Field Accumulation 2016-02-01 EPA 705-G-2020-3328 Study Profile Template Study profile templates serve as a guide for the preparation of study documents. Applicants may include additional information beyond that prescribed in a particular study profile; however, it should be done without affecting or changing the format and content of the template. 540
90-Day Oral Toxicity [dietary, gavage or drinking water] - [rodent species] 2010-07-01 EPA 705-G-2020-3335 Study Profile Template Study profile templates serve as a guide for the preparation of study documents. Applicants may include additional information beyond that prescribed in a particular study profile; however, it should be done without affecting or changing the format and content of the template. 526
90-Day Oral Toxicity [dietary, gavage or drinking water] - [non-rodent species] 2010-07-01 EPA 705-G-2020-3336 Study Profile Template Study profile templates serve as a guide for the preparation of study documents. Applicants may include additional information beyond that prescribed in a particular study profile; however, it should be done without affecting or changing the format and content of the template. 525
28-Day Dermal Toxicity - [species] 2010-07-01 EPA 705-G-2020-3337 Study Profile Template Study profile templates serve as a guide for the preparation of study documents. Applicants may include additional information beyond that prescribed in a particular study profile; however, it should be done without affecting or changing the format and content of the template. 523
90-Day Dermal Toxicity - [species] 2010-07-01 EPA 705-G-2020-3338 Study Profile Template Study profile templates serve as a guide for the preparation of study documents. Applicants may include additional information beyond that prescribed in a particular study profile; however, it should be done without affecting or changing the format and content of the template. 524
Subchronic Inhalation Toxicity - [species] 2010-07-01 EPA 705-G-2020-3339 Study Profile Template Study profile templates serve as a guide for the preparation of study documents. Applicants may include additional information beyond that prescribed in a particular study profile; however, it should be done without affecting or changing the format and content of the template. 680
Prenatal Developmental Toxicity Study - [rodent species] 2010-07-01 EPA 705-G-2020-3340 Study Profile Template Study profile templates serve as a guide for the preparation of study documents. Applicants may include additional information beyond that prescribed in a particular study profile; however, it should be done without affecting or changing the format and content of the template. 650
Prenatal Developmental Toxicity Study - [non-rodent species] 2010-07-01 EPA 705-G-2020-3341 Study Profile Template Study profile templates serve as a guide for the preparation of study documents. Applicants may include additional information beyond that prescribed in a particular study profile; however, it should be done without affecting or changing the format and content of the template. 649
Reproduction and Fertility Effects Study - [species] 2010-07-01 EPA 705-G-2020-3342 Study Profile Template Study profile templates serve as a guide for the preparation of study documents. Applicants may include additional information beyond that prescribed in a particular study profile; however, it should be done without affecting or changing the format and content of the template. 653
Chronic Toxicity [dietary, gavage, drinking water, dermal or inhalation] - [rodent species] 2010-07-01 EPA 705-G-2020-3343 Study Profile Template Study profile templates serve as a guide for the preparation of study documents. Applicants may include additional information beyond that prescribed in a particular study profile; however, it should be done without affecting or changing the format and content of the template. 544
Chronic Toxicity [feeding, water, dermal or inhalation] - [non-rodent species] 2010-07-01 EPA 705-G-2020-3344 Study Profile Template Study profile templates serve as a guide for the preparation of study documents. Applicants may include additional information beyond that prescribed in a particular study profile; however, it should be done without affecting or changing the format and content of the template. 545
Supplementary Tumor Data Spreadsheet for Toxicology 870.4200 and 870.4300 2012-02-01 EPA 705-G-2020-3345 Study Profile Template Study profile templates serve as a guide for the preparation of study documents. Applicants may include additional information beyond that prescribed in a particular study profile; however, it should be done without affecting or changing the format and content of the template. 681
Guidance and Examples for Supplementary Tumor Data Spreadsheet for Toxicology 870.4200 and 870.4300 2012-02-01 EPA 705-G-2020-3346 Study Profile Template Study profile templates serve as a guide for the preparation of study documents. Applicants may include additional information beyond that prescribed in a particular study profile; however, it should be done without affecting or changing the format and content of the template. 565
Carcinogenicity [dietary, gavage, drinking water, dermal or inhalation] - Mouse 2010-07-01 EPA 705-G-2020-3347 Study Profile Template Study profile templates serve as a guide for the preparation of study documents. Applicants may include additional information beyond that prescribed in a particular study profile; however, it should be done without affecting or changing the format and content of the template. 541
Carcinogenicity [dietary, gavage, drinking water, dermal or inhalation] - Rat 2010-07-01 EPA 705-G-2020-3348 Study Profile Template Study profile templates serve as a guide for the preparation of study documents. Applicants may include additional information beyond that prescribed in a particular study profile; however, it should be done without affecting or changing the format and content of the template. 542
Combined Chronic Toxicity/Carcinogenicity [dietary, gavage, drinking water, dermal or inhalation] - [species] 2010-07-01 EPA 705-G-2020-3349 Study Profile Template Study profile templates serve as a guide for the preparation of study documents. Applicants may include additional information beyond that prescribed in a particular study profile; however, it should be done without affecting or changing the format and content of the template. 547
In Vitro Microbial Gene Mutation 2010-07-01 EPA 705-G-2020-3350 Study Profile Template Study profile templates serve as a guide for the preparation of study documents. Applicants may include additional information beyond that prescribed in a particular study profile; however, it should be done without affecting or changing the format and content of the template. 623
In Vitro Mammalian Cells in Culture Gene Mutation Assay in [name cell type used] cells 2010-07-01 EPA 705-G-2020-3351 Study Profile Template Study profile templates serve as a guide for the preparation of study documents. Applicants may include additional information beyond that prescribed in a particular study profile; however, it should be done without affecting or changing the format and content of the template. 621
In Vitro Mammalian Cytogenetics (specify assay) or In Vitro Sister Chromatid Exchange Assay in (name species/cell type) 2010-07-01 EPA 705-G-2020-3352 Study Profile Template Study profile templates serve as a guide for the preparation of study documents. Applicants may include additional information beyond that prescribed in a particular study profile; however, it should be done without affecting or changing the format and content of the template. 622
In Vivo Mammalian Cytogenetics - Erythrocyte Micronucleus Assay in [name species] 2010-07-01 EPA 705-G-2020-3353 Study Profile Template Study profile templates serve as a guide for the preparation of study documents. Applicants may include additional information beyond that prescribed in a particular study profile; however, it should be done without affecting or changing the format and content of the template. 624
Other Genotoxicity: Unscheduled DNA Synthesis in Primary Rat Hepatocytes / Mammalian Cell Culture 2010-07-01 EPA 705-G-2020-3354 Study Profile Template Study profile templates serve as a guide for the preparation of study documents. Applicants may include additional information beyond that prescribed in a particular study profile; however, it should be done without affecting or changing the format and content of the template. 646
Neurotoxicity Screening Battery - Rat (Acute) 2010-07-01 EPA 705-G-2020-3355 Study Profile Template Study profile templates serve as a guide for the preparation of study documents. Applicants may include additional information beyond that prescribed in a particular study profile; however, it should be done without affecting or changing the format and content of the template. 629
Neurotoxicity Screening Battery - Rat (Subchronic) 2010-07-01 EPA 705-G-2020-3356 Study Profile Template Study profile templates serve as a guide for the preparation of study documents. Applicants may include additional information beyond that prescribed in a particular study profile; however, it should be done without affecting or changing the format and content of the template. 630
Developmental Neurotoxicity Study - Rat 2010-07-01 EPA 705-G-2020-3357 Study Profile Template Study profile templates serve as a guide for the preparation of study documents. Applicants may include additional information beyond that prescribed in a particular study profile; however, it should be done without affecting or changing the format and content of the template. 558
Metabolism Study - Rat 2010-07-01 EPA 705-G-2020-3358 Study Profile Template Study profile templates serve as a guide for the preparation of study documents. Applicants may include additional information beyond that prescribed in a particular study profile; however, it should be done without affecting or changing the format and content of the template. 626
Dermal Penetration 2010-07-01 EPA 705-G-2020-3359 Study Profile Template Study profile templates serve as a guide for the preparation of study documents. Applicants may include additional information beyond that prescribed in a particular study profile; however, it should be done without affecting or changing the format and content of the template. 552
Immunotoxicity 2010-07-01 EPA 705-G-2020-3360 Study Profile Template Study profile templates serve as a guide for the preparation of study documents. Applicants may include additional information beyond that prescribed in a particular study profile; however, it should be done without affecting or changing the format and content of the template. 620
Use Pattern/Exposure Scenarios 2010-07-01 EPA 705-G-2020-3361 Study Profile Template Study profile templates serve as a guide for the preparation of study documents. Applicants may include additional information beyond that prescribed in a particular study profile; however, it should be done without affecting or changing the format and content of the template. 684
Residential Post Application Passive Dosimetry 2010-07-01 EPA 705-G-2020-3362 Study Profile Template Study profile templates serve as a guide for the preparation of study documents. Applicants may include additional information beyond that prescribed in a particular study profile; however, it should be done without affecting or changing the format and content of the template. 654
Mixer/Loader/Applicator Passive Dosimetry 2010-07-01 EPA 705-G-2020-3363 Study Profile Template Study profile templates serve as a guide for the preparation of study documents. Applicants may include additional information beyond that prescribed in a particular study profile; however, it should be done without affecting or changing the format and content of the template. 627
Agricultural Post Application Passive Dosimetry 2010-07-01 EPA 705-G-2020-3364 Study Profile Template Study profile templates serve as a guide for the preparation of study documents. Applicants may include additional information beyond that prescribed in a particular study profile; however, it should be done without affecting or changing the format and content of the template. 527
Dislodgeable Turf Residues 2010-07-01 EPA 705-G-2020-3365 Study Profile Template Study profile templates serve as a guide for the preparation of study documents. Applicants may include additional information beyond that prescribed in a particular study profile; however, it should be done without affecting or changing the format and content of the template. 561
Dislodgeable Foliar Residue 2010-07-01 EPA 705-G-2020-3366 Study Profile Template Study profile templates serve as a guide for the preparation of study documents. Applicants may include additional information beyond that prescribed in a particular study profile; however, it should be done without affecting or changing the format and content of the template. 560
Determination of Transferable Residue on Indoor Treated Surfaces 2010-07-01 EPA 705-G-2020-3367 Study Profile Template Study profile templates serve as a guide for the preparation of study documents. Applicants may include additional information beyond that prescribed in a particular study profile; however, it should be done without affecting or changing the format and content of the template. 554
Hand Press Residues 2010-07-01 EPA 705-G-2020-3368 Study Profile Template Study profile templates serve as a guide for the preparation of study documents. Applicants may include additional information beyond that prescribed in a particular study profile; however, it should be done without affecting or changing the format and content of the template. 570
Health Effects Test Guidelines: Subchronic Toxicity Test Guidelines, 870.3050, Repeated Dose 28-day Oral Toxicity Study in Rodents 2000-07-01 EPA 712-C-00-366 Test Guideline; Health Effects The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 610
Health Effects Test Guidelines: Subchronic Toxicity Test Guidelines, 870.3550, Reproduction/Development Toxicity Screening Test 2000-07-01 EPA 712-C-00-367 Test Guideline; Health Effects The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 616
Health Effects Test Guidelines: Subchronic Toxicity Test Guidelines, 870.3650, Combined Repeated Dose Toxicity with the Reproduction/Development Toxicity Screening Test 2000-07-01 EPA 712-C-00-368 Test Guideline; Health Effects The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 617
Health Effects Test Guidelines: Health Effects Chemical-Specific Test Guidelines, 870.8355, Combined Chronic Toxicity/Carcinogenicity Testing of Respirable Fibrous Particles 2001-07-01 EPA 712-C-01-352 Test Guidelines; Health Effects The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 599
Health Effects Test Guidelines: Acute Toxicity Test Guidelines, 870.1000, Acute Toxicity Testing-Background 2002-12-01 EPA 712-C-02-189 Test Guideline; Health Effects The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 571
Health Effects Test Guidelines: Acute Toxicity Test Guidelines, 870.1100, Acute Oral Toxicity (AOT) 2002-12-01 EPA 712-C-02-190 Test Guideline; Health Effects The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review 572
Health Effects Test Guidelines: Acute Toxicity Test Guidelines, 870.2600, Skin Sensitization 2003-03-01 EPA 712-C-03-197 Test Guideline; Health Effects The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 577
Health Effects Test Guidelines: Special Studies Test Guidelines, 870.7485, Metabolism and Pharmacokinetics 1998-08-01 EPA 712-C-95-244 Test Guideline; Health Effects The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 607
Residue Chemistry Test Guidelines: 860.1000, Background 1996-08-01 EPA 712-C-96-169 Test Guideline; Residue Chemistry The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 656
Residue Chemistry Test Guidelines: 860.1100, Chemical Identity 1996-08-01 EPA 712-C-96-170 Test Guideline; Residue Chemistry The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 657
Residue Chemistry Test Guidelines: 860.1200, Directions for Use 1996-08-01 EPA 712-C-96-171 Test Guideline; Residue Chemistry The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 658
Residue Chemistry Test Guidelines: 860.1300, Nature of the Residue—Plants, Livestock 1996-08-01 EPA 712-C-96-172 Test Guideline; Residue Chemistry The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 659
Residue Chemistry Test Guidelines: 860.1340, Residue Analytical Method 1996-08-01 EPA 712-C-96-174 Test Guideline; Residue Chemistry The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 660
Residue Chemistry Test Guidelines: 860.1360, Multiresidue method 1996-08-01 EPA 712-C-96-176 Test Guideline; Residue Chemistry The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 661
Residue Chemistry Test Guidelines: 860.1380, Storage Stability Data 1996-08-01 EPA 712-C-96-177 Test Guideline; Residue Chemistry The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 662
Residue Chemistry Test Guidelines: 860.1400, Water, Fish, and Irrigated Crops 1996-08-01 EPA 712-C-96-178 Test Guideline; Residue Chemistry The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 663
Residue Chemistry Test Guidelines: 860.1460, Food Handling 1996-08-01 EPA 712-C-96-181 Test Guideline; Residue Chemistry The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 664
Residue Chemistry Test Guidelines: 860.1480, Meat/Milk/Poultry/Eggs 1996-08-01 EPA 712-C-96-182 Test Guideline; Residue Chemistry The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 665
Residue Chemistry Test Guidelines: 860.1500, Crop Field Trials 1996-08-01 EPA 712-C-96-183 Test Guideline; Residue Chemistry The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 666
Residue Chemistry Test Guidelines: 860.1520, Processed Food/Feed 1996-08-01 EPA 712-C-96-184 Test Guideline; Residue Chemistry The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 667
Residue Chemistry Test Guidelines: 860.1550, Proposed Tolerances 1996-08-01 EPA 712-C-96-186 Test Guideline; Residue Chemistry The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 668
Residue Chemistry Test Guidelines: 860.1560, Reasonable Grounds in Support of the Petition 1996-08-01 EPA 712-C-96-187 Test Guideline; Residue Chemistry The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 669
Residue Chemistry Test Guidelines: 860.1850, Confined Accumulation in Rotational Crops 1996-08-01 EPA 712-C-96-188 Test Guideline; Residue Chemistry The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 671
Residue Chemistry Test Guidelines: 860.1900, Field Accumulation in Rotational Crops 1996-08-01 EPA 712-C-96-189 Test Guideline; Residue Chemistry The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 672
Occupational and Residential Exposure Test Guidelines: Applicator Exposure Monitoring Test Guidelines, 875.1200, Dermal Exposure—Indoor 1996-02-01 EPA 712-C-96-209 Test Guideline; Occupational and Residential Exposure The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 633
Occupational and Residential Exposure Test Guidelines: Applicator Exposure Monitoring Test Guidelines, 875.1400, Inhalation Exposure—Indoor 1996-02-01 EPA 712-C-96-213 Test Guideline; Occupational and Residential Exposure The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 635
Occupational and Residential Exposure Test Guidelines: Postapplication Exposure Monitoring Test Guidelines, 875.2200, Soil Residue Dissipation 1996-02-01 EPA 712-C-96-243 Test Guideline; Occupational and Residential Exposure The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 640
Occupational and Residential Exposure Test Guidelines: Applicator Exposure Monitoring Test Guidelines, 875.1000, Background for Application Exposure Monitoring Test Guidelines 1996-02-01 EPA 712-C-96-261 Test Guideline; Occupational and Residential Exposure The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 631
Occupational and Residential Exposure Test Guidelines: Applicator Exposure Monitoring Test Guidelines, 875.1100, Dermal Exposure—Outdoor 1996-02-01 EPA 712-C-96-262 Test Guideline; Occupational and Residential Exposure The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 632
Occupational and Residential Exposure Test Guidelines: Applicator Exposure Monitoring Test Guidelines, 875.1300, Inhalation Exposure—Outdoor 1996-02-01 EPA 712-C-96-263 Test Guideline; Occupational and Residential Exposure The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 634
Occupational and Residential Exposure Test Guidelines: Applicator Exposure Monitoring Test Guidelines, 875.1500, Biological Monitoring 1996-02-01 EPA 712-C-96-264 Test Guideline; Occupational and Residential Exposure The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 636
Occupational and Residential Exposure Test Guidelines: Applicator Exposure Monitoring Test Guidelines, 875.1600, Application Exposure Monitoring Data Reporting 1996-02-01 EPA 712-C-96-265 Test Guideline; Occupational and Residential Exposure The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 637
Occupational and Residential Exposure Test Guidelines: Postapplication Exposure Monitoring Test Guidelines, 875.2000, Background for Postapplication Exposure Monitoring Test Guidelines 1996-02-01 EPA 712-C-96-266 Test Guideline; Occupational and Residential Exposure The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 638
Occupational and Residential Exposure Test Guidelines: Postapplication Exposure Monitoring Test Guidelines, 875.2100, Foliar Dislodgeable Residue Dissipation 1996-02-01 EPA 712-C-96-267 Test Guideline; Occupational and Residential Exposure The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 639
Occupational and Residential Exposure Test Guidelines: Postapplication Exposure Monitoring Test Guidelines, 875.2400, Dermal Exposure 1996-02-01 EPA 712-C-96-269 Test Guideline; Occupational and Residential Exposure The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 641
Occupational and Residential Exposure Test Guidelines: Postapplication Exposure Monitoring Test Guidelines, 875.2500, Inhalation Exposure 1996-02-01 EPA 712-C-96-270 Test Guideline; Occupational and Residential Exposure The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 642
Occupational and Residential Exposure Test Guidelines: Postapplication Exposure Monitoring Test Guidelines, 875.2600, Biological Monitoring 1996-02-01 EPA 712-C-96-271 Test Guideline; Occupational and Residential Exposure The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 643
Occupational and Residential Exposure Test Guidelines: Postapplication Exposure Monitoring Test Guidelines, 875.2900, Data Reporting and Calculations 1996-02-01 EPA 712-C-96-272 Test Guideline; Occupational and Residential Exposure The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 645
Occupational and Residential Exposure Test Guidelines: Postapplication Exposure Monitoring Test Guidelines, 875.2800, Descriptions of Human Activity 1996-02-01 EPA 712-C-96-283 Test Guideline; Occupational and Residential Exposure The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 644
Spray Drift Test Guidelines: , 840.1100, Spray Droplet Size Spectrum 1998-03-01 EPA 712-C-98-055 Test Guidelines; Spray Drift The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 674
Spray Drift Test Guidelines: , 840.1200, Spray Drift Field Deposition 1998-03-01 EPA 712-C-98-112 Test Guideline; Spray Drift The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 675
Health Effects Test Guidelines: Acute Toxicity Test Guidelines, 870.1200, Acute Dermal Toxicity 1998-08-01 EPA 712-C-98-192 Test Guideline; Health Effects The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 573
Health Effects Test Guidelines: Acute Toxicity Test Guidelines, 870.1300, Acute Inhalation Toxicity 1998-08-01 EPA 712-C-98-193 Test Guideline; Health Effects The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 574
Health Effects Test Guidelines: Acute Toxicity Test Guidelines, 870.2400, Acute Eye Irritation 1998-08-01 EPA 712-C-98-195 Test Guideline; Health Effects The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 575
Health Effects Test Guidelines: Acute Toxicity Test Guidelines, 870.2500, Acute Dermal Irritation 1998-08-01 EPA 712-C-98-196 Test Guideline; Health Effects The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 576
Health Effects Test Guidelines: Subchronic Toxicity Test Guidelines, 870.3100, 90-Day Oral Toxicity in Rodents 1998-08-01 EPA 712-C-98-199 Test Guideline; Health Effects The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 611
Health Effects Test Guidelines: Subchronic Toxicity Test Guidelines, 870.3150, 90-Day Oral Toxicity in Nonrodents 1998-08-01 EPA 712-C-98-200 Test Guideline; Health Effects The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 612
Health Effects Test Guidelines: Subchronic Toxicity Test Guidelines, 870.3200, 21/28-Day Dermal Toxicity 1998-08-01 EPA 712-C-98-201 Test Guideline; Health Effects The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 613
Health Effects Test Guidelines: Subchronic Toxicity Test Guidelines, 870.3250, 90-Day Dermal Toxicity 1998-08-01 EPA 712-C-98-202 Test Guideline; Health Effects The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 614
Health Effects Test Guidelines: Subchronic Toxicity Test Guidelines, 870.3465, 90-Day Inhalation Toxicity 1998-08-01 EPA 712-C-98-204 Test Guideline; Health Effects The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 615
Health Effects Test Guidelines: Subchronic Toxicity Test Guidelines, 870.3700, Prenatal Developmental Toxicity Study 1998-08-01 EPA 712-C-98-207 Test Guideline; Health Effects The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 618
Health Effects Test Guidelines: Subchronic Toxicity Test Guidelines, 870.3800, Reproduction and Fertility Effects 1998-08-01 EPA 712-C-98-208 Test Guideline; Health Effects The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 619
Health Effects Test Guidelines: Chronic Toxicity Test Guidelines, 870.4100, Chronic Toxicity 1998-08-01 EPA 712-C-98-210 Test Guideline; Health Effects The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 578
Health Effects Test Guidelines: Chronic Toxicity Test Guidelines, 870.4200, Carcinogenicity 1998-08-01 EPA 712-C-98-211 Test Guideline; Health Effects The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 579
Health Effects Test Guidelines: Chronic Toxicity Test Guidelines, 870.4300, Combined Chronic Toxicity/Carcinogenicity 1998-08-01 EPA 712-C-98-212 Test Guideline; Health Effects The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 580
Health Effects Test Guidelines: Genetic Toxicity Test Guidelines, 870.5140, Gene Mutation in Aspergillus nidulans 1998-08-01 EPA 712-C-98-215 Test Guideline; Health Effects The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 582
Health Effects Test Guidelines: Genetic Toxicity Test Guidelines, 870.5195, Mouse Biochemical Specific Locus Test 1998-08-01 EPA 712-C-98-216 Test Guideline; Health Effects The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 583
Health Effects Test Guidelines: Genetic Toxicity Test Guidelines, 870.5200, Mouse Visible Specific Locus Test 1998-08-01 EPA 712-C-98-217 Test Guideline; Health Effects The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 584
Health Effects Test Guidelines: Genetic Toxicity Test Guidelines, 870.5250, Gene Mutation in Neurospora crassa 1998-08-01 EPA 712-C-98-218 Test Guideline; Health Effects The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 585
Health Effects Test Guidelines: Genetic Toxicity Test Guidelines, 870.5275, Sex-linked Recessive Lethal Test in Drosophila melanogaster 1998-08-01 EPA 712-C-98-220 Test Guideline; Health Effects The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 586
Health Effects Test Guidelines: Genetic Toxicity Test Guidelines, 870.5300, In vitro Mammalian Cell Gene Mutation Test 1998-08-01 EPA 712-C-98-221 Test Guideline; Health Effects The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 587
Health Effects Test Guidelines: Genetic Toxicity Test Guidelines, 870.5375, In Vitro Mammalian Chromosome Aberration Test 1998-08-01 EPA 712-C-98-223 Test Guidelines; Health Effects The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 588
Health Effects Test Guidelines: Genetic Toxicity Test Guidelines, 870.5380, Mammalian Spermatogonial Chromosomal Aberration Test 1998-08-01 EPA 712-C-98-224 Test Guideline; Health Effects The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 589
Health Effects Test Guidelines: Genetic Toxicity Test Guidelines, 870.5385, Mammalian Bone Marrow Chromosomal Aberration Test 1998-08-01 EPA 712-C-98-225 Test Guideline; Health Effects The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 590
Health Effects Test Guidelines: Genetic Toxicity Test Guidelines, 870.5395, Mammalian Erythrocyte Micronucleus Test 1998-08-01 EPA 712-C-98-226 Test Guideline; Health Effects The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 591
Health Effects Test Guidelines: Genetic Toxicity Test Guidelines, 870.5450, Rodent Dominant Lethal Assay 1998-08-01 EPA 712-C-98-227 Test Guideline; Health Effects The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 592
Health Effects Test Guidelines: Genetic Toxicity Test Guidelines, 870.5460, Rodent Heritable Translocation Assays 1998-08-01 EPA 712-C-98-228 Test Guideline; Health Effects The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 593
Health Effects Test Guidelines: Genetic Toxicity Test Guidelines, 870.5500, Bacterial DNA Damage or Repair Tests 1998-08-01 EPA 712-C-98-229 Test Guideline; Health Effects The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 594
Health Effects Test Guidelines: Genetic Toxicity Test Guidelines, 870.5550, Unscheduled DNA Synthesis in Mammalian Cells in Culture 1998-08-01 EPA 712-C-98-230 Test Guideline; Health Effects The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 595
Health Effects Test Guidelines: Genetic Toxicity Test Guidelines, 870.5575, Mitotic Gene Conversion in Saccharomyces cerevisiae 1998-08-01 EPA 712-C-98-232 Test Guideline; Health Effects The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 596
Health Effects Test Guidelines: Genetic Toxicity Test Guidelines, 870.5900, In Vitro Sister Chromatid Exchange Assay 1998-08-01 EPA 712-C-98-234 Test Guideline; Health Effects The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 597
Health Effects Test Guidelines: Genetic Toxicity Test Guidelines, 870.5915, In Vitro Sister Chromatid Exchange Assay 1998-08-01 EPA 712-C-98-235 Test Guideline; Health Effects The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 598
Health Effects Test Guidelines: Neurotoxicity Test Guidelines, 870.6100, Acute and 28-day Delayed Neurotoxicity of Organophosphorus Substances 1998-08-01 EPA 712-C-98-237 Test Guideline; Health Effects The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 600
Health Effects Test Guidelines: Neurotoxicity Test Guidelines, 870.6200, Neurotoxicity Screening Battery 1998-08-01 EPA 712-C-98-238 Test Guideline; Health Effects The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 601
Health Effects Test Guidelines: Neurotoxicity Test Guidelines, 870.6300, Developmental Neurotoxicity Study 1998-08-01 EPA 712-C-98-239 Test Guideline; Health Effects The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 602
Health Effects Test Guidelines: Neurotoxicity Test Guidelines, 870.6500, Schedule-Controlled Operant Behavior 1998-08-01 EPA 712-C-98-240 Test Guideline; Health Effects The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 603
Health Effects Test Guidelines: Neurotoxicity Test Guidelines, 870.6850, Peripheral Nerve Function 1998-08-01 EPA 712-C-98-241 Test Guideline; Health Effects The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 604
Health Effects Test Guidelines: Neurotoxicity Test Guidelines, 870.6855, Neurophysiology: Sensory Evoked Potentials 1998-08-01 EPA 712-C-98-242 Test Guideline; Health Effects The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 605
Health Effects Test Guidelines: Genetic Toxicity Test Guidelines, 870.5100, Bacterial Reverse Mutation Test 1998-08-01 EPA 712-C-98-247 Test Guideline; Health Effects The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 581
Spray Drift Test Guidelines: , 840.1000, Background for Pesticide Aerial Drift Evaluation 1998-03-01 EPA 712-C-98-319 Test Guideline; Spray Drift The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 673
Health Effects Test Guidelines: Special Studies Test Guidelines, 870.7200, Companion Animal Safety 1998-08-01 EPA 712-C-98-349 Test Guideline; Health Effects The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 606
Health Effects Test Guidelines: Special Studies Test Guidelines, 870.7600, Dermal Penetration 1998-08-01 EPA 712-C-98-350 Test Guideline; Health Effects The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 608
Fate, Transport and Transformation Test Guidelines: Laboratory Biological Transformation Test Guidelines, 835.3160, Biodegradability in Sea Water 1998-01-01 EPA 712-C-98-351 Test Guideline; Fate, Transport and Transformation The following test guideline is part of a series that has been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 563
Health Effects Test Guidelines: Special Studies Test Guidelines, 870.7800, Immunotoxicity 1998-08-01 EPA 712-C-98-351 Test Guideline; Health Effects The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 609
Residue Chemistry Test Guidelines: 860.1650, Submittal of Analytical Reference Standards 2008-11-01 EPA 712-F-08-001 Test Guideline; Residue Chemistry The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 670
Small Business Certification Examples 2018-01-01 EPA 705-G-2020-0598 PRIA Fees An example of a certification for small business. 699
Data Requirements Checklists for PRIA Fee Categories 2014-03-10 EPA 705-G-2020-0601 PRIA Fees Data requirements checklists for PRIA fee categories 687
Paying PRIA Application Fees 2018-01-01 EPA 705-G-2020-0602 PRIA Fees Describes how to the Agency review of a fee payment, how to submit payment for PRIA application, different methods of payment. 697
Appeals of Fee and Waiver Decisions 2019-01-01 EPA 705-G-2020-0603 PRIA Fees Describes how an applicant can appeal a fee or waiver determination by the EPA. 685
Checklists for 45/90 Preliminary Technical Screen 2018-01-01 EPA 705-G-2020-0605 PRIA Fees Applicant may use checklists to ensure that their application is complete and ready for in-depth review, as required by FIFRA. Applicants may submit the checklists with their application. 686
Fee Reduction Tables 2023-03-02 EPA 705-G-2020-0607 PRIA Fees Under PRIA, refunds for a portion of the registration service fee are provided following the withdrawal of a PRIA covered application and at the request of an applicant. These tables provide the information for each registering division. 691
Interpretations of PRIA 3 Fee Categories 2015-07-17 EPA 705-G-2020-0608 PRIA Fees This document includes the expanded information about PRIA fee categories. 692
Templates and Instructions for PRIA Fee Payments 2016-01-01 EPA 705-G-2020-1284 PRIA Fees The documents on this page provide templates and instructions for bank transfer and wire payments of PRIA fees. 702
Exemptions for Federal and State Governments under PRIA 2016-01-01 EPA 705-G-2020-2512 PRIA Information on how an agency of the federal government or a state government shall be exempt from covered registration service fees. 689
PRIA Fee Waivers for Small Businesses 2014-03-04 EPA 705-G-2020-2513 PRIA Information on PRIA fee waivers for small businesses 698
Overview of PRIA Fee Reduction and Refund Formula 2019-01-01 EPA 705-G-2020-2515 PRIA Information on how the Agency calculates registration service fee reductions and refunds under PRIA. 696
Factors for IR-4 Public Interest Finding 2019-01-01 EPA 705-G-2020-2516 PRIA Information on the factors the Agency considers to make an IR-4 public interest finding for a PRIA registration service fee exemption 690
Interpretations of PRIA Fee Categories 2019-01-01 EPA 705-G-2020-2649 PRIA Fees These 19 documents provides interpretations associated with each PRIA fee category. 693
Office of Pesticide Program Electronic Label (OPPEL) Pilot 2018-01-01 EPA 705-G-2020-3596 OPPEL In an effort to make pesticide label information easier to find and the approval of pesticide labels more efficient, EPA is working with pesticide registrants to pilot an electronic label system. As part of the OPPEL pilot, nine pesticide registrants will be developing and submitting pesticide labels to EPA through a fully electronic system, instead of as paper or PDF files. 694
Structured Product Labeling (SPL) User Guide (unabridged) 2018-02-05 EPA 705-G-2020-3597 OPPEL The purpose of this document is to provide instructions on how to use the OPPEL Product Label (SPL) Builder. This document provides guidance on how to properly prepare a Product Label and/or Use Index document for submission to EPA. 701
EPA CDX SmartLabel Builder User Guide Version 2 2018-04-18 EPA 705-G-2020-3598 OPPEL This document provides information on EPA's OPPEL Builder is a Structured Product Label (SPL) document builder, located within the EPA’s Central Data Exchange (CDX). The  SPL Builder is the Agency’s publicly offered tool to build, validate, and submit structured xml files to the EPA for review and registration. 688
Structured Product Labeling (SPL) Draft Implementation Guide with Validation Procedures and User Guide 2018-01-01 EPA 705-G-2020-3599 FIFRA; Labeling This document provides an introduction to the OPPEL Model, as well as guidance on how to extract pesticide information into the Structured Product Label (SPL) model for submission to EPA. 700
OPPEL Pilot Document Guides, including Vocabulary Guide Version 3 2018-09-29 EPA 705-G-2020-3600 OPPEL These documents are being used to pilot the OPPEL process, in particular the model for constructing an OPPEL label. 695
Assembly of Electronic Packages and Discs 2013-05-03 EPA 705-G-2020-0479 Pesticide Registration Methods for assembling electronic packages and creating submission discs 704
Study Formatting and Supplemental Information 2019-09-17 EPA 705-G-2020-0481 Pesticide Registration; Study Formatting; Supplemental Information Information and guidance on e-submission study formatting and supplemental files and review aids. 722
E-submission Resource Documents for Assembly of Electronic Packages and Discs 2018-03-30 EPA 705-G-2020-0487 Pesticide Registration; E-submission; Electronic Packages Learn more about submitting pesticide applications via the Pesticide Submission Portal. 711
Full Specifications for Text PDF Label Submissions 2008-01-17 EPA 705-G-2020-0492 Pesticide Registration; Specifications Label Submissions The following guidance is provided for creating and submitting product labels in electronic format to EPA. Submission of electronic labels to EPA is voluntary, but if done then two specifications are mandatory. 714
E-Submission Guidance Updates 2019-02-15 EPA 705-G-2020-0493 Pesticide Registration; E-submission Guidance; Dossier-Formatted E-submission guidance updates for all e-submissions and Dossier formatted submissions. 710
Critical PDF Label Specifications for Electronic Submission 2017-02-23 EPA 705-G-2020-0498 Pesticide Registration; Electronic Submission Label Specifications Guidance information about electronic submission for critical PDF label specifications. 707
Frequent Questions about Electronic Submission of Labels 2017-04-14 EPA 705-G-2020-0499 Pesticide Registration; Electronic Label Submission FAQs Find information to help you with e-submission of labels. 713
Creating a PDF Version of Study Reports - General Specifications 2008-06-25 EPA 705-G-2020-0563 Pesticide Registration This document lists software, layout, and other specifications for creating PDF versions of study reports for electronic submission for pesticide registration. 706
How to Search for Information about Pesticide Ingredients and Labels 2014-01-06 EPA 705-G-2020-0574 Ingredients Used in Pesticide Products How to use the databases Pesticide Chemical Search, Pesticide Product Label System (PPLS), and InertFinder to find information such as Chemical Abstract Service (CAS) numbers, active and inert ingredients, and regulatory actions. 715
2020 Annual Pesticide Registration Maintenance Fees 2019-11-26 EPA 705-G-2020-1098 Pesticide Registration All section 3 and section 24(c) registrations are subject to an annual maintenance fee described in FIFRA Section 4(i)(5). The amount of this fee varies from year to year depending on the authorizing legislation. Affected applicants will be contacted by mail with instructions for submitting the fee. The deadline for responding to the maintenance fee notification is Wednesday, January 15, 2020. The fee per product will vary from year to year as the fee is dependent upon the projected number of products for which registrants will pay this fee. The fee for 2020 is $4,000. Please note that checks, bank drafts and money orders are no longer an acceptable form of payment. 703
Pesticide Submissions Portal (PSP) Frequently Asked Questions 2015-09-18 EPA 705-G-2020-1448 Pesticide Registration Pesticide Submissions Portal (PSP) Frequently Asked Questions 720
Disclosure of Reviews of Pesticide Test Data 1985-11-27 EPA 705-G-2020-1484 Pesticide Registration This document describes a class determination that certain EPA-prepared reviews of data submitted under the Federal insecticide, Fungicide, and Rodenticide Act are not entitled to confidential treatment. 709
Data Compensation Documents 1984-08-01 EPA 705-G-2020-1494 Pesticide Registration EPA does not have specific forms to use related to data compensation for inert ingredients. These documents will help the registrant with the process. 708
Pesticide Product Label System (PPLS) Application Program Interface (API) 2016-06-20 EPA 705-G-2020-1564 Pesticide Labels Pesticide Product Label System (PPLS) provides a single point of access to U.S. EPA environmental data contained in the U.S. EPA databases. 719
Voluntary Incident Reporting Forms and Instructions 1998-08-04 EPA 705-G-2020-1747 Reporting Pesticide Incidents Reporting forms that can be used by Registrants to report 6(a)(2) related incidents to the EPA. 724
Electronic Submissions of Pesticide Applications 2019-08-19 EPA 705-G-2020-2411 electronic submission; portal; PSP; application materials General Information about Electronic Submission of Pesticide Applications, application materials required and tools for developing an electronic submission. 712
National List of Active EPA-Registered Foreign and Domestic Pesticide and/or Device-Producing Establishments 2019-10-21 EPA 705-G-2020-2456 Pesticide Registration; establishment This website contains guidance on updating establishments and includes a CSV file lists the most current non-Confidential Business Information (CBI) of active EPA-registered foreign and domestic pesticide-producing and device-producing establishments based on data from the Section Seven Tracking System (SSTS). 716
Pesticide Submissions Portal (PSP) User Guide 2018-03-28 EPA 705-G-2020-2822 Pesticide Registration, CDX, PSP, pesticide submissions portal The purpose of this PDF document is to provide instructions on how to use the PSP application. This document provides guidance on how to properly prepare a package for submission to EPA. 721
CDX Pesticide Submissions Portal (PSP) Registration User Guide 2016-02-12 EPA 705-G-2020-2823 Pesticide Registration, CDX, PSP, pesticide submissions portal; central data exchange The purpose of this PDF document is to walk through the registration and user profile management processes in CDX, specifically for Pesticide Submission Portal (PSP) workflow submissions. 705
Office of Pesticide Programs eDossier Builder User Guide 2015-08-27 EPA 705-G-2020-2824 eSubmission; XML; eDossier; eDossier Builder The eDossier Builder system, developed by the Environmental Protection Agency (EPA) Office of Pesticide Programs (OPP), allows registrants to create packages for electronic submission in a user-friendly manner and presents packages to EPA systems in a specified format. 717
Office of Pesticide Programs eSubmission XML Guidance Document 2015-08-26 EPA 705-G-2020-2825 Pesticide Registration, eSubmission, XML The purpose of this PDF document is to provide registrants instructions for constructing an XML file for inclusion in an electronic submission package and submitting the documents to the Environmental Protection Agency (EPA) Office of Pesticide Programs (OPP) electronically on CD/DVD. 718
Submitting EPA Form 3540-16 Through the SSTS CDX Application 2016-10-12 EPA 705-G-2020-2836 3540-16 PDF for Submitting EPA Form 3540-16 Through the SSTS CDX Application 723
Tarp Testing Guidance 2019-06-06 EPA 705-G-2020-0561 Soil Fumigants Since the reactivity, stability, and other chemical properties are different for each soil fumigant pesticide, the permeability of each fumigant through a film will be different. Certain tarps that qualify for buffer zone reduction credits are listed. 730
Soil Fumigant Buffer Zone Calculator 2018-07-01 EPA 705-G-2020-3052 Soil Fumigants Buffer zone calculator tool for applicators, growers, and enforcement personnel applying/monitoring soil fumigant applications. 728
Methyl Bromide Commodity Fumigation Buffer Zone Lookup Tables 2017-03-13 EPA 705-G-2020-3054 Fumigants The labels of the products listed require that all applications must have a specified buffer zone around treatment and aeration areas. Buffer zone distances must be determined according to the tables and instructions listed. The applicable buffer zone is part of the directions for use of these products. 726
Enhancing Stakeholder Input in the Pesticide Registration Review and ESA Consultation Processes and Development of Economically and Technologically Feasible Reasonable and Prudent Alternatives 2013-03-19 EPA 705-G-2020-3071 Endangered Species; Pesticides This document, which was developed jointly by the EPA, the U.S. Department of Agriculture (USDA), the National Marine Fisheries Service (NMFS) in the U.S. Department of Commerce and the Fish and Wildlife Service (USFWS) in the U.S. Department of Interior, provides guidance to staff and managers participating in the associated processes. 725
Opportunities to Participate in Pesticide Reevaluation 2019-05-02 EPA 705-G-2020-3075 Pesticides Web page providing information about the public participation process during registration review. 727
Soil Fumigant Toolbox 2018-07-10 EPA 705-G-2020-3610 Soil Fumigants This website provides soil fumigant information on training, fumigant management plans, buffer zones, and other safety measures to ensure protections for agricultural workers and bystanders. 729
Pesticide Registration 2019-12-19 EPA 705-G-2020-0411 Pesticide Registration This site provides resources for an individual or company wanting to register a pesticide active ingredient or pesticide product in the United States. Features: a manual (blue book), other guidance, and coordinated lists of requirements by pesticide type. 811
Pesticide Registration Manual 2017-04-20 EPA 705-G-2020-0412 Pesticide Registration Manual; Describes the pesticide registration process for companies and individuals wanting to register their pesticide product. 812
Conventional Pesticide Registration 2017-03-20 EPA 705-G-2020-0413 Pesticide Registration; Conventional Conventional pesticides are all active ingredients other than biological pesticides and antimicrobial pesticides. Learn about the requirements and process for registering a conventional pesticide. 742
Study Profile Templates 2017-04-25 EPA 705-G-2020-0432 Pesticide Registration; Study Profile Templates Listing of study profile templates and brief description about each to include downloadable file in Word and/or PDF formats. 947
Conventional Reduced Risk Pesticide Program 2019-09-14 EPA 705-G-2020-0434 Pesticide Registration; Reduced Risk Find out about the Conventional Reduced Risk Pesticide Program, which expedites the review and regulatory decision-making process of conventional pesticides that pose less risk to human health and the environment than existing conventional alternatives. 743
Inert Ingredients Overview and Guidance 2020-01-30 EPA 705-G-2020-0444 Pesticide Registration; FIFRA; Pesticides; Antimicrobial; This Web page provides information on inert ingredients approved for use in pesticide products and the guidance documents that are available to assist in obtaining approval for a new inert ingredient. 771
Registration Requirements and Guidance 2017-04-18 EPA 705-G-2020-0467 Pesticide Registration; Requirements; Guidance; Forms; Data Requirements This page lists the categories of requirements that all applicants for all categories of pesticides must complete to help you navigate the process. 909
Label Review Manual 2019-05-09 EPA 705-G-2020-0470 Pesticide Registration; Label Review Manual Table of Contents for Label Review Manual 775
Pesticide Registration Manual: Introduction 2018-04-02 EPA 705-G-2020-0483 Pesticide Registration Manual This manual is intended as a resource for companies and individuals who wish to have their pesticide products registered by EPA. This introduction gives an overview of the contents of the manual. 844
Pesticide Registration Manual: Chapter 1 - Overview of Requirements for Pesticide Registration and Registrant Obligations 2019-11-21 EPA 705-G-2020-0484 Pesticide Registration Manual; Overview of Requirements; Registrant Obligations This chapter provides an overview of the federal laws under the authority of which EPA oversees pesticide use in the U.S. 818
Pesticide Registration Manual: Chapter 2 - Registering a Pesticide Product 2017-12-20 EPA 705-G-2020-0491 Pesticide Registration Manual; Guidance Registering Pesticide Product; Examples This chapter discusses what information is required to be submitted to EPA when applying for a pesticide product registration and the process for reviewing the applications. 829
Suggested Format for Acute Toxicity Studies 2008-06-01 EPA 705-G-2020-0503 Pesticide Registration; Format Acute Toxicity Studies This document suggests the format for final reports on pesticide studies (right column of the tables in the document) and provides instructions for the creation of PDF Version 1.3 electronic submission documents (left column of the tables). 948
Pesticide Registration Manual: Chapter 5 - Registration Fees 2018-04-02 EPA 705-G-2020-0504 Pesticide Registration Manual; Registration Fees Information about pesticide registration fees according to the Pesticide Registration Improvement Extension Act (PRIA 3) 832
Pesticide Registration Manual: Chapter 6 - Amending a Registered Pesticide Product 2017-08-30 EPA 705-G-2020-0505 Pesticide Registration Manual; Amending Product Registration This chapter covers all aspects of amending a registered product including label changes, formulation changes, associated data requirements, and the forms that need to be submitted. 833
Pesticide Registration Manual: Chapter 7 - Notifications and Minor Formulation Amendments 2017-08-02 EPA 705-G-2020-0506 Pesticide Registration Manual; Notifications; Minor Formulation Amendments This chapter provides information about preparing and submitting a notification for a pesticide product 834
Pesticide Registration Manual: Chapter 8 - Inert Ingredients 2017-05-24 EPA 705-G-2020-0507 Pesticide Registration Manual; Inert Ingredients This chapter describes how EPA reviews inert ingredients as part of the pesticide product review process. 835
Pesticide Registration Manual: Chapter 9 - Supplemental Distribution of a Registered Pesticide 2017-07-13 EPA 705-G-2020-0508 Pesticide Registration Manual; Supplemental Distribution This chapter provides information about the supplemental distribution of a registered pesticide or product. 837
Pesticide Registration Manual: Chapter 10 - Data Compensation Requirements 2017-05-24 EPA 705-G-2020-0509 Pesticide Registration Manual; Data Compensation; Requirements This chapter provides information about data compensation requirements, procedures, and obligations when submitting an application for registration, amended registration, reregistration or registration review. 819
Pesticide Registration Manual: Chapter 11 - Tolerance Petitions 2018-04-02 EPA 705-G-2020-0510 Pesticide Registration Manual; Tolerance Petitions This Chapter provides information on definitions, interpretative regulations and procedures for filing a petition for establishment of a tolerance or an exemption from the requirement of a tolerance. 820
Pesticide Registration Manual: Chapter 12 - Applying for an Experimental Use Permit 2017-05-23 EPA 705-G-2020-0511 Pesticide Registration Manual; Experimental Use Permit This chapter of the pesticide registration manual describes the all requirements for Experimental Use Permits (EUP), and includes how to apply for an EUP, labeling requirements, application format, and data reporting requirements. 821
Pesticide Registration Manual: Chapter 13 - Devices 2017-05-24 EPA 705-G-2020-0512 Pesticide Registration Manual; Devices This chapter describes how EPA regulates pesticidal devices. 822
Bridging or Waiving Data Requirements 2019-09-17 EPA 705-G-2020-0513 Pesticide Registration; Bridging Data Requirements Pesticide registrants can request a waiver of data requirements or seek to bridge data from one data set to another. The documents below explain our approach to data waivers. 739
Pesticide Registration Manual: Chapter 14 - How to Obtain an EPA Company or Establishment Number or Change Address or Contact Information 2019-10-03 EPA 705-G-2020-0514 Pesticide Registration; Manual; EPA Company or Establishment Number This chapter provides information on how to get an establishment number for pesticide registration applicants 823
Pesticide Registration Manual: Chapter 15 - Submitting Data and Confidential Business Information 2017-05-24 EPA 705-G-2020-0515 Pesticide Registration Manual; Submitting; Confidential Business Information This chapter includes information on how to submit data as well as special considerations concerning what data and information can be considered to be confidential business information. 824
Pesticide Registration Manual: Chapter 16 - Transfer of Product Registrations and Data Rights 2020-01-15 EPA 705-G-2020-0518 Pesticide Registration Manual; Transfer of Products; Data Rights This chapter discusses specific information to be submitted to EPA for the transfer of product registration and/or data rights from one person or company to another. 825
Pesticide Registration Manual: Chapter 17 - State Regulatory Authority 2019-07-29 EPA 705-G-2020-0519 Pesticide Registration Manual; State Authority FIFRA authorizes states to issue Experimental Use Permits, Special Local Needs registrations, and to apply for Emergency Exemptions under specific conditions. This chapter provides detailed information relevant to state actions under FIFRA. 826
Pesticide Registration Manual: Chapter 18 - Other Federal or State Agency Requirements 2019-07-29 EPA 705-G-2020-0520 Pesticide Registration Manual; Other Federal Requirements; State Agency Requirements This chapter provides information that a pesticide registrant may need know in order to meet other federal, state, or local requirements after the registrant has obtained a federal registration. 827
Pesticide Registration Manual: Chapter 19 - How to Obtain Publications 2018-12-18 EPA 705-G-2020-0521 Pesticide Registration Manual; Obtaining Publications This chapter provides information on how and where to obtain publications. 828
Pesticide Registration Manual: Chapter 20 - Forms and How to Obtain Them 2017-02-28 EPA 705-G-2020-0522 Pesticide Registration Manual; Forms This chapter provides listings of the forms that are required when applying for a pesticide product, experimental use permit, and distributor registrations. 830
Pesticide Registration Manual: Chapter 21 - Directions for Submitting Applications and Contacting EPA 2018-04-02 EPA 705-G-2020-0523 Pesticide Registration Manual; Submitting Applications This chapter provides directions for submitting application information to the EPA pesticide program. 831
Pesticide Registration Manual: Appendix B - Examples of Registrant Documents 2017-08-31 EPA 705-G-2020-0524 Pesticide Registration Manual Examples of Registrant Documents 814
Pesticide Registration Manual: Appendix C - Pesticide Forms Overview Table 2016-11-05 EPA 705-G-2020-0525 Pesticide Registration Manual; Pesticide Forms This chapter provides listings of the forms that are required when applying for a pesticide product, experimental use permit, and distributor registrations 815
Pesticide Registration Manual: Appendix A - Guidance Documents 2017-03-13 EPA 705-G-2020-0526 Pesticide Registration Manual Find links to EPA guidance documents supporting the pesticide registration process. 813
Pesticide Registration Manual: Appendix D - Examples of Completed Forms 2020-01-07 EPA 705-G-2020-0529 Pesticide Registration Manual; Examples View examples of completed pesticide registration forms. 816
Pesticide Registration Manual: Registrant Summary of Pesticide Petitions for EPA's Notice of Filing 2011-10-01 EPA 705-G-2020-0530 Pesticide Registration Manual; Electronic Submission Provides a company with information to electronically prepare and submit a pesticide tolerance petition to EPA. 847
Pesticide Registration Manual: Blank Forms 2020-01-07 EPA 705-G-2020-0542 Pesticide Registration Manual; Forms These forms are to be used by applicants for pesticide registration. 817
Pesticide Registration Manual: Confidential Statement of Formula Documents 2012-09-11 EPA 705-G-2020-0545 Pesticide Registration; Confidential Statement of Formula; Attachment These documents will help you complete the confidential statement of formula for pesticides registrations. 838
Pesticide Registration Manual: Product Chemistry 2017-02-21 EPA 705-G-2020-0546 Pesticide Registration; Product Chemistry These documents will help you avoid common mistakes in completing the product chemistry aspect of the pesticide registration form. 846
Pesticide Registration Manual: How to Obtain a Company Number and Register an Official Address 2019-03-19 EPA 705-G-2020-0547 Pesticide Registration; Company Number; Company Address Registrants must obtain a company number before registering their first product with the Agency. Registrants or others who plan to “produce” pesticides or devices must obtain the company number first, then submit EPA Form 3540-8. Find out how to do this. 842
Pesticide Registration Manual: List of Data Submitters Sent Offer to Pay Letters 2016-11-05 EPA 705-G-2020-0548 Pesticide Registration Manual; Data Submitter's List Sample format for providing the list of data submitters to whom you sent offer to pay letters. 845
Pesticide Registration Manual: Example Transmittal Document 2016-11-05 EPA 705-G-2020-0549 Pesticide Registration Manual; Transmittal Document This example can be used in setting up a transmittal document for a pesticide registration package. 841
Pesticide Registration Manual: Title Page For a Newly Submitted Study 2017-07-03 EPA 705-G-2020-0550 Pesticide Registration Manual; Title Page Certain information should be included on the title page of a study submitted to EPA in support of pesticide registration. See a template for these elements. 849
Pesticide Registration Manual: Example Good Laboratory Practice Statements 2016-11-05 EPA 705-G-2020-0551 Pesticide Registration Manual; GLP Example statements related to the GLP standard. 839
Pesticide Registration Manual: Stickers For Submitted Studies - Example 2016-11-04 EPA 705-G-2020-0552 Pesticide Registration Manual; Submitted Studies Information to provide on pesticide studies submitted to EPA. 848
Pesticide Registration Manual: How to Report Changes to Company Name or Address 2019-03-27 EPA 705-G-2020-0554 Pesticide Registration Manual; Report Changes Address and Company Name Any changes to the official address, withdrawal of an existing agent, appointment of a new agent or changes to any of the contact information for the company or its agent must be reported to EPA. Find out more about how to do this. 843
Pesticide Use Site Index 2016-12-06 EPA 705-G-2020-0595 Pesticide Registration; Pesticide Use Site; Index This Pesticide Use Site Index will help a company (or other applicant) identify which data requirements are needed to register a pesticide product. 851
Child-Resistant Packaging for Pesticides 2019-12-18 EPA 705-G-2020-0596 Pesticide Registration; CRP To protect children from poisonings around the home, pesticide law requires that certain household pesticides be in child-resistant packaging. 740
Guidance on IR-4 Exemptions 2019-03-29 EPA 705-G-2020-0597 PRIA Fees; IR-4 Exemptions Information and guidance about inter-regional project 4 (IR-4) registration fee exemptions. 764
Policy on Existing Stocks of Pesticide Products 1991-06-26 EPA 705-G-2020-1259 Pesticide Labels; Existing Stocks This statement establishes general principles the Agency generally will apply in determining whether and under what conditions to allow the sale and use of existing stocks of pesticides for which the registration has been amended, canceled, or suspended. 853
Pesticide Labeling Questions & Answers 2019-10-21 EPA 705-G-2020-1260 Pesticide Labels; Q & A Pesticide manufacturers, applicators, state regulatory agencies, and other stakeholders raise questions or issues about pesticide labels. The questions on this page are those that apply to multiple products or address inconsistencies among product labels. 809
Pest Control Devices and Device Producers: 1976 Federal Register Notice 1976-11-19 EPA 705-G-2020-1295 Pesticide Registration Consolidation and clarification of requirements for pesticide devices. 806
Process for Evaluating & Implementing Alternative Approaches to Traditional in Vivo Acute Toxicity Studies for FIFRA Regulatory Use 2016-02-04 EPA 705-G-2020-1393 Pesticide Science and Assessing Pesticide Risks; Alternative Approaches in Vivo Acute Toxicity EPA’s Office of Pesticide Programs (OPP) has developed a strategic vision1 for implementing the 2007 NRC report on Toxicity Testing in the 21st Century. 856
Test Guidelines for Pesticide Data Requirements 2017-05-23 EPA 705-G-2020-1395 Pesticide Science and Assessing Pesticide Risks In evaluating a pesticide registration application, EPA assesses a wide variety of potential human health and environmental effects associated with use of the product. 950
Accelerated Storage Stability and Corrosion Characteristics Study Protocol 2012-11-16 EPA 705-G-2020-1490 Pesticide Registration; Accelerated Storage Stability Corrosion Characteristics EPA has determined that studies using this protocol will, in certain circumstances, provide the Agency with all the information it needs to make a determination on the storage stability of pesticides. 733
Protection of Proprietary Data Rights for Data Used to Support Tolerance Exemptions for Inert Ingredients 2017-03-13 EPA 705-G-2020-1493 Pesticide Registration; Protection Data Rights; Inert Ingredients; Tolerance Exemptions The FFDCA provides both exclusive use and data compensation protections for data that inert ingredient manufacturers submit to EPA to establish or maintain tolerances or tolerance exemptions for these ingredients. Find information about these protections. 905
Guidance on Efficacy Testing for Pesticides Targeting Certain Invertebrate Pests 2019-12-13 EPA 705-G-2020-1507 Pesticide Registration; Efficacy Testing; Claims; Invertebrate Pests This page is intended to help pesticide registrants complete the efficacy requirements related to invertebrate pests that may damage structures or pose significant risks to public health. 762
Pesticide Registration Manual: Example Letter for Registration or Amendment Applications Document 2016-11-07 EPA 705-G-2020-1620 Pesticide Registration Manual; Examples Letter for Registration This example letter can be used in submitting pesticide registration or amendment applications. 840
Label Review Manual Chapter 10; Revised Respirator Descriptions for Public Comment 2018-04-12 EPA 705-G-2020-1734 Pesticide Registration; Label Review Manual Revised Respirator Descriptions for Public Comment Documents 776
Spanish Translation Guide for Pesticide Labeling 2019-10-10 EPA 705-G-2020-2066 Pesticide Labels Spanish translations of health and safety information for use on pesticide product labels. 916
Inert Use Information | InertFinder | Pesticides | US EPA 2020-01-21 EPA 705-G-2020-2412 inert; CAS; food; nonfood; fragrance; InertFinder is an online database for searching substances used as inert ingredients in pesticide products. 772
Acute Oral Toxicity Up-And-Down-Procedure 2017-03-29 EPA 705-G-2020-2416 acute oral toxicity; up and down; 870.1100 Provides information on the program and associated documentation for conducting the Up-and-Down Procedure, an alternative acute toxicity test that provides a way to determine the toxicity of chemicals with fewer test animals by using sequential dosing steps. 737
Guidance on Placement of First Aid Statements on Pesticide Labels 2018-03-08 EPA 705-G-2020-2419 first aid; label In response to comments from states and pesticide registrants, EPA is releasing final guidance clarifying where first aid statements should appear on the label of pesticide products. 765
Guidance on FIFRA 24(c) Registrations 2019-06-07 EPA 705-G-2020-2424 24(c); state registration EPA guidance (including Q&A) on registering 24(c) (Special Local Needs) registrations. 763
Suggestions for Applicants on Information Considered when Evaluating Benefits of New Conventional Active Ingredients/Significant New Use Site Requests 2018-09-01 EPA 705-G-2020-2432 benefits; new active ingredient In order to assist registrants of conventional pesticides, through this webpage, EPA is providing some suggestions on the types of information applicants could provide that would help BEAD review the benefits that accrue to potential users of the pesticide as part of the registration process. 949
Implementation Guidance for Enhanced Reporting for Registrants of Pet Spot-on Products 2019-08-07 EPA 705-G-2020-2435 pet spot-on; incident reporting template Links to the documents that provide background and summary information on the pet spot-on enhanced reporting pilot and guidance for implementing the use of standardized incident reporting templates. 768
EPA Evaluation of Pet Spot-on Products: Analysis and Plans for Reducing Harmful Effects 2019-08-08 EPA 705-G-2020-2436 pet spot-on; analysis Provides information on the EPA Evaluation of Pet Spot-on Products, the Analysis and Plans for Reducing Harmful Effects. It also includes links to enhanced reporting templates. 751
Label Guidance for Specific Types of Pesticides 2017-10-23 EPA 705-G-2020-2444 warranty; repellents; antimicrobials; Guidance on label contents as needed to clarify issues or implement program changes 774
Logos and Graphics on Pesticide Product Labels 2019-05-21 EPA 705-G-2020-2445 logo; label Guidance for applying to add a logo to a product label. 796
Pesticide Labels: Guidance on Warranty Statements 2016-10-16 EPA 705-G-2020-2453 warranty; label This guidance includes examples of improper warranty statements that go beyond what the agency considers acceptable and examples of how to fix these statements, in addition to examples of statements that are acceptable under FIFRA, and that could be incorporated into FIFRA labels. 810
Use of the Local Lymph Node Assay and Reduced Dose Protocol for LLNA in Assessing Pesticide Products 2019-08-08 EPA 705-G-2020-2458 Pesticide Registration; LLNA; Reduced protocol This policy is intended to expand the usefulness the traditional (or radiolabeled) LLNA protocol for assessment of dermal sensitization potential to single component pesticide products (i.e., technical grade active ingredients) and to pesticides with multiple components (i.e., end use products). 955
Voluntary Cancellation of a Pesticide Product or Use 2019-12-03 EPA 705-G-2020-2463 Pesticide Registration; voluntary cancellation This site provides guidance on voluntarily cancelling a pesticide use or registration. 957
Method for testing ready-to-use consumer bait stations with dogs 2009-05-20 EPA 705-G-2020-2468 Pesticide Registration; bait This protocol is designed to test the abilities of ready-to-use bait stations to isolate bait from dogs. 800
Method for testing ready-to-use bait stations with adults for facility of opening, reclosing, and securing 1987-10-29 EPA 705-G-2020-2469 Pesticide Registration; bait This protocol is designed to test the reliability with which untrained adults can perform tasks necessary for proper use of ready-to-use bait stations. 798
Method for testing ready-to-use bait stations with young children 1987-10-29 EPA 705-G-2020-2470 Pesticide Registration; bait This protocol is designed to test the abilities of ready-to-use bait stations to isolate bait from children of pre-school age. 799
Standard norway rat/roof rat anticoagulant technical and concentrated dry bait laboratory test method 1976-05-06 EPA 705-G-2020-2471 Pesticide Registration; bait This method is designed to determine the effectiveness of dry bait anticoagulant technical and concentrated rodenticide products for standard Norway and roof rats. 939
Standard mouse acute placepack dry bait laboratory test method 1976-09-01 EPA 705-G-2020-2472 Pesticide Registration; bait This method is designed to determine the effectiveness of acute dry bait rodenticide products used in placepacks for control of house mice. 929
Standard norway rat and roof rat acute placepack dry bait laboratory test method 1976-09-01 EPA 705-G-2020-2473 Pesticide Registration; bait This method is designed to determine the effectiveness of acute dry bait rodenticide products used in placepacks for control of Norway and roof rats. 930
Standard house mouse anticoagulant placepack penetration laboratory test method 1975-01-01 EPA 705-G-2020-2474 Pesticide Registration; bait This method is designed to determine the effectiveness of anticoagulant dry bait rodenticide products used in placepacks for house mouse control. 925
Standard norway rat and roof rat anticoagulant placepack dry bait laboratory test method 1975-01-01 EPA 705-G-2020-2475 Pesticide Registration; bait This method is designed to determine the effectiveness of anticoagulant dry bait rodenticide products used in placepacks for rat control. 932
Standard peromyscus species anticoagulant dry bait laboratory test method 1975-01-01 EPA 705-G-2020-2476 Pesticide Registration; bait This method is designed to determine the effectiveness of ready-to-use dry bait anticoagulant rodenticide products used for control of Peromyscus spp. 943
Standard peromyscus species acute dry bait laboratory test method 1975-01-01 EPA 705-G-2020-2477 Pesticide Registration; bait This method is designed to determine the effectiveness of acute dry bait rodenticide products used for control of Peromyscus spp. 941
Standard house mouse anticoagulant wax block and wax pellet laboratory test method 1975-01-01 EPA 705-G-2020-2478 Pesticide Registration; wax block and pellet This method is designed to determine the effectiveness anticoagulant rodenticide products claimed to be suitable to use for house mouse control in wet or damp environments. 928
Standard norway rat anticoagulant wax block and wax pellet laboratory test method 1990-12-02 EPA 705-G-2020-2479 Pesticide Registration; wax block and pellet This method is designed to determine the effectiveness anticoagulant rodenticide products claimed to be suitable to use for rat control in wet or damp environments. 933
Standard house mouse anticoagulant tracking powder efficacy laboratory test method 1991-09-27 EPA 705-G-2020-2480 Pesticide Registration; powder This method is designed to determine the effectiveness of anticoagulant tracking powder rodenticide products for house mice. 927
Standard norway rat/roof rat acute tracking powder efficacy laboratory test method 1992-12-17 EPA 705-G-2020-2481 Pesticide Registration; powder This method is designed to determine the effectiveness of acute tracking powder used for control of Norway or roof rats. 937
Standard house mouse acute dry bait laboratory test method 1991-10-08 EPA 705-G-2020-2482 Pesticide Registration; bait This method is designed to determine the effectiveness of ready-to-use acute dry bait rodenticide products used for house mouse control. 919
Standard norway rat/roof rat acute dry bait laboratory test method 1991-10-08 EPA 705-G-2020-2483 Pesticide Registration; bait This method is designed to determine the effectiveness of ready-to-use acute dry bait rodenticide products used for rat control. 934
Standard house mouse acute liquid bait laboratory test method 1991-09-27 EPA 705-G-2020-2484 Pesticide Registration; bait This method is designed to determine the effectiveness of acute rodenticide products used to make liquid baits for controlling house mice. 920
Standard norway rat/roof rat acute liquid bait laboratory test method 1991-06-19 EPA 705-G-2020-2485 Pesticide Registration; bait This method is designed to determine the effectiveness of products used in acute liquid bait rodenticides used to control Norway and roof rats 935
Standard norway rat/roof rat anticoagulant tracking powder efficacy laboratory test method 1991-06-19 EPA 705-G-2020-2486 Pesticide Registration; powder This method is designed to determine the effectiveness of anticoagulant tracking powder rodenticide products for rats. 940
Standard house mouse anticoagulant dry bait laboratory test method 1991-06-18 EPA 705-G-2020-2487 Pesticide Registration; bait This method is designed to determine the effectiveness of dry bait anticoagulant rodenticide products used for control of house mice. 923
Standard norway rat/roof rat anticoagulant dry bait laboratory test method 1991-06-18 EPA 705-G-2020-2488 Pesticide Registration; bait This method is designed to determine the effectiveness of ready-to-use dry bait anticoagulant rodenticide products used for control of rats. 938
Standard house mouse anticoagulant liquid bait laboratory test method 1991-06-17 EPA 705-G-2020-2489 Pesticide Registration; bait This method is designed to determine the effectiveness of anticoagulant rodenticide products used to make liquid baits for controlling house mice. 924
Standard norway rat and roof rat anticoagulant liquid bait laboratory test method 1991-06-16 EPA 705-G-2020-2490 Pesticide Registration; bait This method is designed to determine the effectiveness of anticoagulant rodenticide products used to make liquid baits for controlling commensal rats. 931
Standard house mouse acute tracking powder efficacy laboratory test method 1992-12-15 EPA 705-G-2020-2491 Pesticide Registration; powder This method is designed to determine the effectiveness of acute tracking powder for house mice. 922
Standard house mouse acute technical and concentrated dry bait laboratory test method 1992-12-14 EPA 705-G-2020-2492 Pesticide Registration; bait This method is designed to determine the effectiveness of dry bait technical and concentrated acute rodenticide products for house mice. 921
Standard house mouse anticoagulant technical and concentrated dry bait laboratory test method 1992-12-13 EPA 705-G-2020-2493 Pesticide Registration; bait This method is designed to determine the effectiveness of dry bait anticoagulant technical and concentrated rodenticide products for standard house mice. 926
Standard peromyscus species acute technical and concentrated dry bait laboratory test method 1992-12-15 EPA 705-G-2020-2494 Pesticide Registration; bait This method is designed to determine the effectiveness of ready-to-use dry bait technical and concentrated acute rodenticide products for Peromyscus spp. 942
Standard peromyscus species anticoagulant technical and concentrated dry bait laboratory test method 1992-12-15 EPA 705-G-2020-2495 Pesticide Registration; bait This method is designed to determine the effectiveness of ready-to-use dry bait anticoagulant technical and concentrated rodenticide products used for control of Peromyscus spp. 944
Standard norway rat/roof rat acute technical and concentrated dry bait laboratory test method 1992-12-13 EPA 705-G-2020-2496 Pesticide Registration; bait This method is designed to determine the effectiveness of dry bait technical and concentrated acute rodenticide products for standard Norway and roof rats. 936
EPA Response to letter dated August 31, 2018, regarding disruptions in availability of 1,2-benzisothiazolin-3-one (BIT) and the self-certification process. 2018-10-18 EPA 705-G-2020-2498 Pesticide Registration; BIT self-certification This letter is in response to a registrant letter requesting the incorporation of further clarifications and additions to EPA’s August 23, 2018, letter addressing disruptions in availability of 1,2 benzisothiazolin-3-one (BIT) and providing for a streamlined self-certification process. 752
Response to letter dated November 8, 2018, requesting that the Agency expand the expedited process for minor formulation amendments (MFAs) described in our October 18, 2018, letter 2018-12-21 EPA 705-G-2020-2499 Pesticide Registration; MFA This letter contains the Agency's response to a registrant letter regarding expanding the expedited process for minor formulation amendments 914
Response to letter dated July 27, 3018, concerning a situation where an unforeseen foreign production site closure has led to disruption in availability of 1,2-benzisothiazolin-3-one (BIT) (CAS Reg. No. 2634-33-5) 2018-08-23 EPA 705-G-2020-2500 Pesticide Registration; BIT self-certification This letter contains the Agency's response to a registrant letter regarding a request for self-certification when an unforeseen foreign production site closure has led to a disruption in availability of BIT. 913
State FIFRA Issues, Research, and Evaluation Group Final Guidance for State Lead Agencies for the Development and Implementation of Managed Pollinator Protection Plans 2015-04-03 EPA 705-G-2020-2504 Pollinator Protection This document contains guidance for states on the development and implementation of managed pollinator protection plans. 945
EPA Actions to Protect Pollinators 2017-10-23 EPA 705-G-2020-2507 Pollinator Protection This page contains a summary of EPA's actions to protect pollinators from pesticide exposure. 750
U.S. Environmental Protection Agency's Policy to Mitigate the Acute Risk to Bees from Pesticide Products 2017-01-12 EPA 705-G-2020-2770 Pollinator Protections; bees Policy document describing the EPA's approach to mitigate acute risk from pesticides to bees. 953
Regulation of Pesticide Residues on Food 2019-04-30 EPA 705-G-2020-2787 Pesticide Registration; tolerances This page provides links to guidance about tolerances. 910
Notifying the Public about Pesticide Tolerances 2017-02-09 EPA 705-G-2020-2789 Pesticide Registration; tolerances; notice to public This page includes summary information about a notice of filing of a petition to establish a tolerance, emergency exemptions, establishing tolerances and exemptions, revoking tolerances, and tolerance objections. 804
Pesticide Cancellation Under EPA's Own Initiative 2018-11-07 EPA 705-G-2020-2790 Pesticide Registration; tolerances; cancellation Cancellation of a pesticide registration may be initiated by EPA after the Agency has evaluated the potential risks and benefits associated with registered uses of a pesticide.  This page describes steps leading to cancellation. 807
How to Search for Tolerances for Pesticide Ingredients in the Code of Federal Regulations 2018-04-02 EPA 705-G-2020-2794 Pesticide Registration; tolerances; MRLs This page provides instructions and links to searching for tolerances. 767
Strategic Vision for Adopting 21st Century Science Methodologies 2018-04-10 EPA 705-G-2020-2801 Pesticide Registration; Risk Assessment; integrated approaches to testing and assessment (IATA) This guidance relates to the use of new technologies in molecular, cellular, computational sciences to supplement or replace traditional methods of toxicity testing and risk assessment. 946
Guiding Principles for Data Requirements 2013-05-31 EPA 705-G-2020-2803 Pesticide Registration; data requirements PDF that summarizes how/why EPA exercises its authority to require certain data it deems necessary to support regulatory decisions 766
Non-Animal Testing Approach to EPA Labeling for Eye Irritation 2017-05-03 EPA 705-G-2020-2806 Pesticide Registration; non-animal testing; eye irritation This is a webpage describing alternative in vitro/ex vivo assays for the eye irritation test 803
Guidance for Identifying, Selecting and Evaluating Open Literature Studies 2017-10-03 EPA 705-G-2020-2815 Pesticide Registration; literature evaluation; risk assessment This is a web page providing guidance on how to evaluate open literature data to support pesticide applications, and also how EPA itself evaluates open literature for use in the risk assessment process. 760
Controlling Rodents and Regulating Rodenticides 2018-07-10 EPA 705-G-2020-2837 Rodents, Rodenticides, regulating Site with multiple links. 741
Spot-On Enhanced Reporting Pilot Template Development Synopsis 2018-01-23 EPA 705-G-2020-2839 pets, spot-on Products; reporting sales and incident Spot-On Enhanced Reporting Pilot Template Development Synopsis PDF. 918
About Pesticide Registration - Pesticide Registration 2019-06-26 EPA 705-G-2020-2843 Pesticide Registration Describes the process for evaluating pesticide registration applications - human health and environmental risk considerations. 731
Pesticide Emergency Exemptions 2019-11-07 EPA 705-G-2020-2845 Pesticide Registration; evaluation criteria; emergency exemptions Provides details on types and evaluation criteria for emergency exemptions. 808
Minor Uses and Grower Resources 2019-08-02 EPA 705-G-2020-2848 exclusive use; minor use Provides information on Minor Use Crops and Pesticides, International MRLs, NAFTA Minor Use Joint Reviews, Crop Grouping, Exclusive Use Periods, Definition of a Minor Use, Establishing or Extending Exclusive Use Periods. 802
Pesticide Registration Policy and Guidance 2018-04-10 EPA 705-G-2020-2849 Pesticide Registration; toxicity testing; human; human studies This page lists toxicity testing topics and guidance, protection of human test subjects, additional guidance and policy information. 850
Draft Waiver Guidance on Dermal Toxicity Testing: Retrospective Analysis and Guidance for Waiving Acute Dermal Toxicity Tests for Pesticide Formulations 2016-03-11 EPA 705-G-2020-2854 Pesticide Registration; toxicity testing; waiving This page provides a link to guidance for waiving dermal toxicity data. 747
User Documentation for the AOT425StatPgm Program 2003-06-01 EPA 705-G-2020-2859 acute oral toxicity; up and down; 870.1100; OECD 425 Guidance for how to use the AOT425StatPgm Program. 956
OECD Guideline for Testing of Chemicals 2001-12-17 EPA 705-G-2020-2860 acute oral toxicity; up and down; 870.1100; OECD 425 Guidance providing information and descriptions on the OECD Test Guideline 425, how to perform the studies and what data needs to be submitted. 805
QA Testing for the AOT425StatPgm Program 2001-06-01 EPA 705-G-2020-2861 acute oral toxicity; up and down; 870.1100; OECD 425 Guidance for how to use the AOT425StatPgm Program; description of the model, how to use, how to construct data sets and compare. 906
Toxicology Guidance: Performance of the Up-and-Down Procedure 2017-03-29 EPA 705-G-2020-2862 acute oral toxicity; up and down; 870.1100; OECD 425 This summary is intended to accompany the Up-and-Down Procedure (UDP) test guideline and the AOT425StatPgm program and assist the user in interpreting its output. The UDP guideline uses the maximum likelihood estimation method for calculation of the LD50 and profile likelihood (PL) methods for estimation of most confidence intervals. This summary addresses choice of dose progression and initial dose level for the UDP and describes the performance of the test under a variety of circumstances. 951
Crosswalk of Paragraphs: OPPTS 870.1100 versus OECD 425 Acute Oral Toxicity: Up-and-Down Procedure 2017-03-29 EPA 705-G-2020-2863 acute oral toxicity; up and down; 870.1100; OECD 425 Guidance on relationship and cross-walk between OPPTS 870.1100 guideline and OECD 425 guideline. 744
Elements of an Offer to Pay for the Use of Inert Ingredient Data 2019-10-17 EPA 705-G-2020-2865 Data Compensation Inert Ingredient This link offers guidance on elements that should be included in an Offer to Pay for the use of Inert ingredient data. 748
Pet Spot-on Enhanced Reporting Implementation Guidance (PDF) 2018-02-01 EPA 705-G-2020-2870 Standardized Templates, Enhanced Reporting, Incident, Sales, Mitigation, Implementation; Conditions of Registration, expiration PDF of Guidance to use EPA's Standardized Incident and Sales Templates for enhanced reporting of adverse incidents and requesting changes to conditions of registration (Quarterly to Annual submission of enhanced reporting; Removal of 2-year expiration date); Webinar took place 5/10/2018; PDF first dated February 2018 and updated August 2019 852
Spot-on Enhanced Reporting Pilot Concluding Webinar and Implementation (PDF) 2018-05-10 EPA 705-G-2020-2871 Standardized Templates, Enhanced Reporting, Incident, Sales, Mitigation, Implementation; Conditions of Registration, expiration PDF of Webinar PowerPoint presentation. 917
Enhanced Incident Reporting Template (XLSX) 2017-03-01 EPA 705-G-2020-2872 Enhanced reporting, adverse incident, pet spot-on EPA's standardized template for submission of enhanced reporting for adverse incidents 749
Sales Reporting Template (XLSX) 2017-03-01 EPA 705-G-2020-2873 Enhanced reporting, adverse incident, pet spot-on, sales EPA's standardized template for submission of corresponding enhanced reporting sales data 915
Meetings with Manufacturers of Pet Spot-on Products 2009-01-01 EPA 705-G-2020-2874 Pet spot-on, mitigation, adverse effect, adverse incident, dog, cat Web page includes sections: Summary of Meetings we held with the Product Registrants; Generic mitigation table provided to product registrants; next steps. 797
Data Requirements for Pesticide Registration 2019-06-26 EPA 705-G-2020-2894 Pesticide Registration - data Data Requirements to Register a Pesticide 745
Understanding the Science behind EPA’s Pesticide Decisions 2019-08-02 EPA 705-G-2020-2898 Pesticide Registration Understanding the Science behind EPA’s Pesticide Decisions 954
Repellency Awareness Graphic 2016-01-01 EPA 705-G-2020-2902 Pesticide Registration Overview of the repellency awareness graphic 911
Formulation / End-use Product - Product Chemistry Evaluation (based on OECD Dossier Numbering) Identity, Physical and Chemical Properties, Analytical Methods, Confidential Information 2016-05-01 EPA 705-G-2020-2916 Pesticide registration, product chemistry The study profile template describes the layout and scope of information that should be contained within a study profile and can serve as a guide for the preparation of the study document. 756
General Guidance for Petitioning the Agency for the Establishment of a New/Amended Food Use Inert Ingredient Tolerance or Tolerance Exemption under PRIA 3 2013-01-08 EPA 705-G-2020-2923 Pesticide Registration Guidance for new/amended food use inert ingredient tolerance or tolerance exemption 757
General Guidance for Requesting the Establishment of a Tolerance Exemption for a Low Risk Polymer or Nonfood Use Approval of a Low Risk Polymer under PRIA 3 2013-01-23 EPA 705-G-2020-2924 Pesticide Registration Guidance for establishing tolerance exemption for low risk polymer or nonfood use approval of low risk polymers 759
General Guidance for Requesting the Approval of a New Nonfood Use Inert Ingredient1 or Amending a Currently Approved Nonfood Use Inert Ingredient under PRIA 3 2013-01-23 EPA 705-G-2020-2925 Pesticide Registration Guidance for requesting the approval of a new nonfood use inert ingredient or amending a currently approved nonfood use inert ingredient 758
List of Trade Name Inert Ingredients 2014-02-05 EPA 705-G-2020-2927 Pesticide Registration EPA’s Office of Pesticide Programs (OPP) has developed a list of trade names for inert ingredients used pesticide products registered under FIFRA. 795
Trade Name Database 2020-02-14 EPA 705-G-2020-2934 Pesticide registration, inerts The List of Trade Names of Inert Ingredients database is intended solely to enhance public access to information related to the EPA approval status of trade name inert ingredients used in pesticide products. 952
Inert Ingredient Frequently Asked Questions 2015-12-01 EPA 705-G-2020-2937 Pesticide registration, inerts This document answers frequently asked questions about inert ingredients 770
Pesticide Registration Manual: Chapter 8 - Inert Ingredients 2017-05-24 EPA 705-G-2020-2940 Pesticide Registration This chapter describes how EPA reviews inert ingredients as part of the pesticide product review process. 836
Label Review Manual, Chapter 1: Purpose of the Manual 2016-12-01 EPA 705-G-2020-2941 Pesticide Registration This chapter describes the purpose of the Label Review Manual. 786
Label Review Manual, Chapter 2: What is a Pesticide? 2021-01-19 EPA 705-G-2020-2942 Pesticide Registration This chapter describes what a pesticide is. 787
Label Review Manual, Chapter 3: General Labeling Requirements 2018-03-01 EPA 705-G-2020-2943 Pesticide Registration This chapter describes general labeling requirements. 788
Label Review Manual, Chapter 4: Types of Label Reviews 2011-12-01 EPA 705-G-2020-2944 Pesticide Registration This chapter describes types of label reviews. 789
Label Review Manual, Chapter 5: Ingredient Statements 2012-03-01 EPA 705-G-2020-2945 Pesticide Registration This chapter describes the ingredient statement on the pesticide label. 790
Label Review Manual, Chapter 6: Use Classification 2012-01-01 EPA 705-G-2020-2946 Pesticide Registration This chapter describes the use classifications on the label. 791
Label Review Manual, Chapter 7: Precautionary Statements 2018-03-01 EPA 705-G-2020-2947 Pesticide Registration This chapter describes the precautionary statements on the label. 792
Label Review Manual, Chapter 8: Environmental Hazards 2012-09-01 EPA 705-G-2020-2948 Pesticide Registration This chapter describes the environmental hazards section on the label. 793
Label Review Manual, Chapter 9: Physical or Chemical Hazards 2012-09-01 EPA 705-G-2020-2949 Pesticide Registration; Pesticide Labeling This chapter describes the physical or chemical hazards section on the label. 794
Label Review Manual, Chapter 10: Worker Protection Label 2016-02-01 EPA 705-G-2020-2950 Pesticide Registration; Pesticide Labeling This chapter describes worker protection labeling. 777
Label Review Manual, Chapter 11: Directions for Use 2014-12-01 EPA 705-G-2020-2951 Pesticide Registration; Pesticide Labeling This chapter describes the directions for use section of the label. 778
Label Review Manual, Chapter 12: Labeling Claims 2013-11-01 EPA 705-G-2020-2952 Pesticide Registration; Pesticide Labeling This chapter discusses claims made on labels. 779
Label Review Manual, Chapter 13: Storage and Disposal 2013-07-01 EPA 705-G-2020-2953 Pesticide Registration; Pesticide Labeling This chapter describes the storage and disposal section of the label. 780
Label Review Manual, Chapter 14: Identification Numbers 2012-11-01 EPA 705-G-2020-2954 Pesticide Registration; Pesticide Labeling This chapter describes identification numbers on labels. 781
Label Review Manual, Chapter 15: Company Name and Address 2017-08-01 EPA 705-G-2020-2955 Pesticide Registration; Pesticide Labeling This chapter describes listing the company name and number on the label. 782
Label Review Manual, Chapter 16: Graphics and Symbols 2017-08-01 EPA 705-G-2020-2956 Pesticide Registration; Pesticide Labeling This chapter describes graphics and logos listed on labels. 783
Label Review Manual, Chapter 17: Net Contents/Net Weight 2018-02-01 EPA 705-G-2020-2957 Pesticide Registration; Pesticide Labeling This chapter describes the net contents and net weight located on the label. 784
Label Review Manual, Chapter 18: Unique Product Labeling 2013-09-01 EPA 705-G-2020-2958 Pesticide Registration; Pesticide Labeling This chapter describes unique product labeling. 785
Guidance for Pesticide Registrants on Location of the First Aid Statement and Clarification on Definition of Label "Panel" per 40 CFR 156.68 2016-12-07 EPA 705-G-2020-2961 First Aid Statement; Pesticide Labeling Clarification memo on the Agency's interpretation of the word "panel" in the context of 40 CFR 156.68 including where First Aid statements must appear on a product's label based on the product's toxicity category. 761
First Aid Guidance Document – EPA’s Guidance for Pesticide Registrants on Location of the First Aid Statement per 40 CFR 156.68. (Docket ID: EPA-HQ-OPP-2016-0545) 2018-03-07 EPA 705-G-2020-2963 First Aid Statements; Pesticide Labeling This document summarizes the EPA's decision regarding the interpretation of the term “panel” in the context of 40 CFR 156.68 and includes a clarification regarding where first aid statements must appear on pesticide labels based on the product’s Toxicity Category. 753
First Aid Guidance: Response to Public Comments on EPA’s Guidance for Pesticide Registrants on Location of the First Aid Statement and Clarification on Definition of Label “Panel” per 40 CFR 156.68. (Docket ID: EPA-HQ-OPP-2016-0545) 2018-03-07 EPA 705-G-2020-2964 First Aid Statements; Pesticide Labeling This document summarizes the EPA's response to public comments on its memorandum to clarify the interpretation of the term “panel” in the context of 40 CFR 156.68 and to clarify where first aid statements must appear on pesticide labels based on the product’s Toxicity Category. 754
Minor revisions to “First Aid Guidance Document – EPA’s Guidance for Pesticide Registrants on Location of the First Aid Statement per 40 CFR 156.68” and Response to Public Comments 2018-03-07 EPA 705-G-2020-2965 First Aid Statement; Pesticide Labeling The purpose of this note is to clarify minor changes made to the documents titled “First Aid Guidance Document – EPA’s Guidance for Pesticide Registrants on Location of the First Aid Statement per 40 CFR 156.68” and “First Aid Guidance: Response to Public Comments on EPA’s Guidance for Pesticide Registrants on Location of the First Aid Statement and Clarification on Definition of Label “Panel” per 40 CFR 156.68” located in docket EPA-HQ-OPP-2016-0545 on www.regulations.gov. 801
Questions and Answers - Exclusive Use Data Protection for Minor Use Registrations 2018-02-01 EPA 705-G-2020-2970 Exclusive Use; Minor Use; Pesticide Registration This document contains guidance on Exclusive Use Data Protection for Minor Use Registrations. 907
Questions and Answers - Extension of Exclusive Data and Minor Use Designation, Suggestions to Applicants for Agronomic Information 2016-11-01 EPA 705-G-2020-2971 Exclusive Use; Minor Use; Pesticide Registration This document contains guidance for extending exclusive data and requesting minor use designation. 908
About Risk Assessment 2020-01-06 EPA 705-G-2020-2975 Pesticide Risk Assessment Webpage containing information regarding risk assessment basics. 732
Indexes to Part 180 Tolerance Information for Pesticide Chemicals in Food and Feed Commodities 2017-05-23 EPA 705-G-2020-2976 Pesticide Tolerances Webpage describing information that may be helpful in finding specific pesticide tolerance information available in the CFR at Part 180. 769
Application Submission and Screening 2016-08-22 EPA 705-G-2020-2979 Pesticide Registration High-level overview page with links to various component checklists for pesticide registration application submissions. 738
Ingredients Used in Pesticide Products 2019-04-30 EPA 705-G-2020-2986 Pesticide Registration Links to pesticide information, groups, inerts, and databases. 773
Repellents: Protection against Mosquitoes, Ticks and Other Arthropods 2019-04-30 EPA 705-G-2020-2987 Pesticide Regulation This page offers information about preventing bites and insect repellents and includes links to related guidance. 912
Protecting Pets from Fleas and Ticks 2018-10-17 EPA 705-G-2020-2988 Pesticide Registration Links to information about controlling fleas, ticks and other related guidance. 904
Food and Pesticides 2019-03-06 EPA 705-G-2020-2994 Pesticide Registration Page includes information about pesticides on food and how this is regulated; it includes links to related guidance. 755
Product Chemistry for Technical Grade of the Active Ingredient or Manufacturing Use Products (Group A and B data) 2016-05-01 EPA 705-G-2020-3292 Study Profile Template Study profile template for product chemistry evaluation 858
Product Chemistry for End Use Products 2006-05-01 EPA 705-G-2020-3293 product chemistry Template for product chemistry of end use products 857
Acute Oral Toxicity - [species] 2004-05-01 EPA 705-G-2020-3329 Study Profile Template Study profile template for acute oral toxicity study 736
Acute Dermal Toxicity - [species] 2004-05-01 EPA 705-G-2020-3330 Study Profile Template Study profile template for acute dermal toxicity study 734
Acute Inhalation Toxicity - [species] 2004-05-01 EPA 705-G-2020-3331 Study Profile Template Study profile template for acute inhalation toxicity study 735
Primary Eye Irritation - [species] 2004-05-01 EPA 705-G-2020-3332 Study Profile Template Study profile template for primary eye irritation study 855
Primary Dermal Irritation - [species] 2004-05-01 EPA 705-G-2020-3333 Study Profile Template Study profile template for primary dermal irritation study 854
Dermal Sensitization - [species] 2004-05-01 EPA 705-G-2020-3334 Study Profile Template Study profile template for dermal sensitization study 746
Pesticide Submissions Portal (PSP) - CDX User Guide 2021-08-13 EPA 705-G-2021-3739   CDX user guide for the submission of pesticides including registration, notifications, petitions, data call-ins, and acknowledgements. 1014
Product Performance Test Guidelines: Invertebrate Control Agent Product Performance Test Guidelines, 810.3800, Methods for Efficacy Testing of Termite Baits 2004-08-01 EPA 712-C-04-371 Test Guideline; Product Performance This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 865
Product Performance Test Guidelines: Invertebrate Control Agent Product Performance Test Guidelines, 810.3700, Insect Repellents to be Applied to Human Skin 2010-07-07 EPA 712-C-10-001 Test Guideline; Product Performance This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 864
Product Performance Test Guidelines: Invertebrate Control Agent Product Performance Test Guidelines, 810.3900, Laboratory Product Performance Testing Methods for Bed Bug Pesticide Products 2017-06-01 EPA 712-C-17-001 Test Guideline; Product Performance This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 866
Product Performance Test Guidelines: Invertebrate Control Agent Product Performance Test Guidelines, 810.3500, Premises Treatments 2019-08-28 EPA 712-C-19-001 Test Guideline; Product Performance This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 862
Product Properties Test Guidelines: Product Identity, Composition, and Analysis Test Guidelines, 830.1550, Product Identity and Composition 1996-08-01 EPA 712-C-96-006 Test Guideline; Product Properties This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 895
Product Properties Test Guidelines: Product Identity, Composition, and Analysis Test Guidelines, 830.1600, Description of Materials Used to Produce the Product 1996-08-01 EPA 712-C-96-007 Test Guideline; Product Properties This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 896
Product Properties Test Guidelines: Product Identity, Composition, and Analysis Test Guidelines, 830.1620, Description of Production Process 1996-08-01 EPA 712-C-96-008 Test Guideline; Product Properties This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 897
Product Properties Test Guidelines: Product Identity, Composition, and Analysis Test Guidelines, 830.1650, Description of Formulation Process 1996-08-01 EPA 712-C-96-009 Test Guideline; Product Properties This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 898
Product Properties Test Guidelines: Product Identity, Composition, and Analysis Test Guidelines, 830.1670, Discussion of Formation of Impurities 1996-08-01 EPA 712-C-96-010 Test Guideline; Product Properties This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 899
Product Properties Test Guidelines: Product Identity, Composition, and Analysis Test Guidelines, 830.1700, Preliminary Analysis 1996-08-01 EPA 712-C-96-011 Test Guideline; Product Properties This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 900
Product Properties Test Guidelines: Product Identity, Composition, and Analysis Test Guidelines, 830.1750, Certified Limits 1996-08-01 EPA 712-C-96-012 Test Guideline; Product Properties This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 901
Product Properties Test Guidelines: Product Identity, Composition, and Analysis Test Guidelines, 830.1800, Enforcement Analytical Method 1996-08-01 EPA 712-C-96-013 Test Guideline; Product Properties This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 902
Product Properties Test Guidelines: Physical/Chemical Properties Test Guidelines, 830.6302, Color 1996-08-01 EPA 712-C-96-019 Test Guideline; Product Properties This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 870
Product Properties Test Guidelines: Physical/Chemical Properties Test Guidelines, 830.6303, Physical State 1996-08-01 EPA 712-C-96-020 Test Guideline; Product Properties This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 871
Product Properties Test Guidelines: Physical/Chemical Properties Test Guidelines, 830.6304, Odor 1996-08-01 EPA 712-C-96-021 Test Guideline; Product Properties This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 872
Product Properties Test Guidelines: Physical/Chemical Properties Test Guidelines, 830.6313, Stability to Normal and Elevated Temperatures, Metals, and Metal Ions 1996-08-01 EPA 712-C-96-022 Test Guideline; Product Properties This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 873
Product Properties Test Guidelines: Physical/Chemical Properties Test Guidelines, 830.6314, Oxidation/Reduction: Chemical Incompatibility 1996-08-01 EPA 712-C-96-023 Test Guideline; Product Properties This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 874
Product Properties Test Guidelines: Physical/Chemical Properties Test Guidelines, 830.6315, Flammability 1996-08-01 EPA 712-C-96-024 Test Guideline; Product Properties This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 875
Product Properties Test Guidelines: Physical/Chemical Properties Test Guidelines, 830.6316, Explodability 1996-08-01 EPA 712-C-96-025 Test Guideline; Product Properties This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 876
Product Properties Test Guidelines: Physical/Chemical Properties Test Guidelines, 830.6317, Storage Stability 2002-06-01 EPA 712-C-96-026 Test Guideline; Product Properties This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 877
Product Properties Test Guidelines: Physical/Chemical Properties Test Guidelines, 830.6319, Miscibility 1996-08-01 EPA 712-C-96-027 Test Guideline; Product Properties This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 878
Product Properties Test Guidelines: Physical/Chemical Properties Test Guidelines, 830.6320, Corrosion Characteristics 1996-08-01 EPA 712-C-96-028 Test Guideline; Product Properties This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 879
Product Properties Test Guidelines: Physical/Chemical Properties Test Guidelines, 830.6321, Dielectric Breakdown Voltage 1996-08-01 EPA 712-C-96-029 Test Guideline; Product Properties This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 880
Product Properties Test Guidelines: Physical/Chemical Properties Test Guidelines, 830.7000, pH 1996-08-01 EPA 712-C-96-030 Test Guideline; Product Properties This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 881
Product Properties Test Guidelines: Physical/Chemical Properties Test Guidelines, 830.7050, UV/Visible Absorption 1996-08-01 EPA 712-C-96-031 Test Guideline; Product Properties This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 882
Product Properties Test Guidelines: Physical/Chemical Properties Test Guidelines, 830.7100, Viscosity 1996-08-01 EPA 712-C-96-032 Test Guideline; Product Properties This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 883
Product Properties Test Guidelines: Physical/Chemical Properties Test Guidelines, 830.7200, Melting Point/Melting Range 1998-03-01 EPA 712-C-96-033 Test Guideline; Product Properties This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 884
Product Properties Test Guidelines: Physical/Chemical Properties Test Guidelines, 830.7220, Boiling Point/Boiling Range 1996-08-01 EPA 712-C-96-034 Test Guideline; Product Properties This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 885
Product Properties Test Guidelines: Physical/Chemical Properties Test Guidelines, 830.7300, Density/Relative Density/Bulk Density 2002-06-01 EPA 712-C-96-035 Test Guideline; Product Properties This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 886
Product Properties Test Guidelines: Physical/Chemical Properties Test Guidelines, 830.7370, Dissociation Constants in Water 1996-08-01 EPA 712-C-96-036 Test Guideline; Product Properties This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 887
Product Properties Test Guidelines: Physical/Chemical Properties Test Guidelines, 830.7520, Particle Size, Fiber Length, and Diameter Distribution 1996-08-01 EPA 712-C-96-037 Test Guideline; Product Properties This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 888
Product Properties Test Guidelines: Physical/Chemical Properties Test Guidelines, 830.7550, Partition Coefficient (n-octanol/water), Shake Flask Method 1996-08-01 EPA 712-C-96-038 Test Guideline; Product Properties This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 889
Product Properties Test Guidelines: Physical/Chemical Properties Test Guidelines, 830.7560, Partition Coefficient (n-octanol/water), Generator Column Method 1996-08-01 EPA 712-C-96-039 Test Guideline; Product Properties This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 890
Product Properties Test Guidelines: Physical/Chemical Properties Test Guidelines, 830.7570, Partition Coefficient (n-octanol/water), Estimation by Liquid Chromatography 1996-08-01 EPA 712-C-96-040 Test Guideline; Product Properties; Partition Coefficient This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 891
Product Properties Test Guidelines: Physical/Chemical Properties Test Guidelines, 830.7840, Water Solubility: Column Elution Method; Shake Flask Method 1998-03-01 EPA 712-C-96-041 Test Guideline; Product Properties; Water Solubility This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 892
Product Properties Test Guidelines: Physical/Chemical Properties Test Guidelines, 830.7860, Water Solubility, Generator Column Method 1998-03-01 EPA 712-C-96-042 Test Guideline; Product Properties; Water Solubility This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 893
Product Properties Test Guidelines: Physical/Chemical Properties Test Guidelines, 830.7950, Vapor Pressure 1996-08-01 EPA 712-C-96-043 Test Guideline; Product Properties; Vapor Pressure This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 894
Product Properties Test Guidelines: 830.1000, Background for Product Properties Test Guidelines 1998-03-01 EPA 712-C-96-310 Test Guideline; Product Properties; Background This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 869
Product Performance Test Guidelines: Invertebrate Control Agent Product Performance Test Guidelines, 810.3000, General Considerations for Efficacy of Invertebrate Control Agents 1998-03-01 EPA 712-C-98-409 Test Guideline; Product Performance This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 859
Product Performance Test Guidelines: Invertebrate Control Agent Product Performance Test Guidelines, OCSPP 810.3100, Treatments for Imported Fire Ants 2021-01-19 EPA 712-C-98-410 Test Guideline; Product Performance This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 867
Product Performance Test Guidelines: Invertebrate Control Agent Product Performance Test Guidelines, OCSPP 810.3300, The Efficacy of Topically Applied Pet Products Against Certain Invertebrate Pests 2021-01-19 EPA 712-C-98-411 Test Guideline; Product Performance This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 868
Product Performance Test Guidelines: Invertebrate Control Agent Product Performance Test Guidelines, 810.3200, Livestock, Poultry, Fur- and Wool-bearing Animal Treatments 1998-03-01 EPA 712-C-98-414 Test Guideline; Product Performance This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 860
Product Performance Test Guidelines: Invertebrate Control Agent Product Performance Test Guidelines, 810.3400, Mosquito, Black Fly, and Biting Midge (Sand Fly) Treatments 1998-03-01 EPA 712-C-98-419 Test Guideline; Product Performance This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 861
Product Performance Test Guidelines: Invertebrate Control Agent Product Performance Test Guidelines, 810.3600, Structural Treatments 1998-03-01 EPA 712-C-98-424 Test Guideline; Product Performance This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 863
Product Properties Test Guidelines: Product Identity, Composition, and Analysis Test Guidelines, 830.1900, Submittal of Samples 2008-11-01 EPA 712-F-08-002 Test Guideline; Product Properties This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 903
Amphibian Metamorphosis Assay 2011-09-01 EPA 705-G-2020-3369 Endocrine Disruptor Testing, test guideline, AMA, Amphibian Metamorphosis Assay, study profile template, SPT Amphibian Metamorphosis Assay, 890.1100, Study Profile Template. 959
Androgen Receptor Binding (Rat Prostate) 2011-10-01 EPA 705-G-2020-3370 Endocrine Disruptor Testing, test guideline, Androgen Receptor Binding (Rat Prostate), 890.1150, Study Profile Template, SPT Androgen Receptor Binding (Rat Prostate), 890.1150, Study Profile Template. 960
Aromatase (Human Recombinant) 2011-07-01 EPA 705-G-2020-3371 Endocrine Disruptor Testing, test guideline, AMA, Amphibian Metamorphosis Assay, study profile template, SPT Aromatase (Human Recombinant), 890.1200, Study Profile Template 963
Estrogen Receptor Binding 2011-10-01 EPA 705-G-2020-3372 Endocrine Disruptor Testing, test guideline, AMA, Amphibian Metamorphosis Assay, study profile template, SPT Estrogen Receptor Binding, 890.1250, Study Profile Template 992
Estrogen Receptor Transcriptional Activation (Human Cell Line HeLa-9903) 2011-08-01 EPA 705-G-2020-3373 Endocrine Disruptor Testing, test guideline, AMA, Amphibian Metamorphosis Assay, study profile template, SPT Estrogen Receptor Transcriptional Activation (Human Cell Line HeLa-9903), 890.1300, Study Profile Template 995
Fish Short-Term Reproduction 2011-10-01 EPA 705-G-2020-3374 Endocrine Disruptor Testing, test guideline, AMA, Amphibian Metamorphosis Assay, study profile template, SPT Fish Short-Term Reproduction 890.1350, Study Profile Template 999
Hershberger (Rat) 2011-10-01 EPA 705-G-2020-3375 Endocrine Disruptor Testing, test guideline, AMA, Amphibian Metamorphosis Assay, study profile template, SPT Hershberger, 890.1400, Study Profile Template 1001
Female Pubertal (Rat) 2011-08-01 EPA 705-G-2020-3376 Endocrine Disruptor Testing, test guideline, AMA, Amphibian Metamorphosis Assay, study profile template, SPT Female Pubertal (Rat), 890.1450, Study Profile Template 997
Male Pubertal (Rat) 2011-08-01 EPA 705-G-2020-3377 Endocrine Disruptor Testing, test guideline, AMA, Amphibian Metamorphosis Assay, study profile template, SPT Male Pubertal (Rat), 890.1500, Study Profile Template. 1004
Steroidogenesis (Human Cell Line – H295R) 2011-07-01 EPA 705-G-2020-3378 Endocrine Disruptor Testing, test guideline, AMA, Amphibian Metamorphosis Assay, study profile template, SPT Steroidogenesis (Human Cell Line - H295R), 890.1550, Study Profile Template 1006
Uterotrophic (Rat) 2011-09-01 EPA 705-G-2020-3379 Endocrine Disruptor Testing, test guideline, AMA, Amphibian Metamorphosis Assay, study profile template, SPT Uterotrophic (Rat), 890.1600, Study Profile Template 1008
Endocrine Disruptor Screening Program Tier 1 Assays: Considerations for Use in Human Health and Ecological Risk Assessments 2013-06-01 EPA 705-G-2020-3553 Endocrine Disruptor Screening Program, EDSP, Tier 1, testing Guidance for the conduct of Tier 1 screening assays for endocrine disruption effects. 982
Endocrine Disruptor Screening Program 1998-08-11 EPA 705-G-2020-3563 Endocrine Disruptor Screening Program; EDSP; Policy; EDSTAC Policy Notice; EPA's Initial outline of the Endocrine Disruptor Screening Program (EDSP) 965
Endocrine Disruptor Screening Program; Proposed Statement of Policy 1998-12-28 EPA 705-G-2020-3564 Endocrine Disruptor Screening Program; EDSP; Policy; EDSTAC Policy Notice; Further additional details of the Endocrine Disruptor Screening Program (EDSP) 991
Endocrine Disruptor Screening Program Universe of Chemicals and General Validation Principles 2012-11-01 EPA 705-G-2020-3569 Endocrine Disruptor Screening Program; EDSP; EDSP Universe of Chemicals; EDSP General Validation Principles U.S. Environmental Protection Agency Endocrine Disruptor Screening Program Universe of Chemicals and General Validation Principles. A Guidance document jointly developed by the Office of Chemical Safety & Pollution Prevention, the Office of Water and the Office of Research and Development. 984
Endocrine Disruptor Screening Program; Final Second List of Chemicals and Substances for Tier 1 Screening 2013-06-14 EPA 705-G-2020-3570 Endocrine Disruptor Screening Program; EDSP; EDSP Policy; EDSP List 2; Chemical Selection Policy Notice; Description of Final EDSP List 2. This document announces the final second list of 109 chemicals identified for Tier 1 screening under the Endocrine Disruptor Screening Program (EDSP). The EDSP is established under section 408(p) of the Federal Food, Drug, and Cosmetic Act (FFDCA), which requires EPA to develop a chemical screening program using appropriate validated test systems and other scientifically relevant information to determine whether certain substances may have hormonal effects. The second group of chemicals to be tested consists of chemicals that section 408(p) of the FFDCA  requires be screened, i.e., pesticide active ingredients and chemicals used as pesticide inert ingredients (also known as other ingredients) and section 1457 of the 1996 amendment to the SDWA. 989
Endocrine Disruptor Screening Program; Final Policies and Procedures for Screening Safe Drinking Water Act Chemicals 2013-06-14 EPA 705-G-2020-3571 Endocrine Disruptor Screening Program; EDSP;  Safe Drinking Water Act; SDWA; Policy Policy Notice. This document describes EPA's final policies and procedures for requiring Tier 1 screening under the Endocrine Disruptor Screening Program (EDSP) of chemicals for which EPA may issue EDSP test orders pursuant to section 1457 of the Safe Drinking Water Act (SDWA) and section 408(p) of the Federal Food, Drug, and Cosmetic Act (FFDCA). Section 408(p) of the FFDCA directed EPA to develop a chemical screening program using appropriate validated test systems and other scientifically relevant information (OSRI) to determine whether certain chemicals may have hormonal effects. These final policies and procedures supplement the EDSP policies and procedures that were published in the Federal Register on April 15, 2009. 988
Final Second List of Chemicals for Tier 1 Screening 2014-06-26 EPA 705-G-2020-3572 Endocrine Disruptor Screening Program; EDSP; Policy; Final EDSP List 2; Chemical Selection; Modification Modification of Final EDSP List 2 noting removal of 2 chemicals. A revised list is provided. On May 22, 2014, EPA removed hydrazine and hydrochlorofluorocarbon (HCFC-22) from the Second List of Chemicals for Screening to allow for further consideration of their physical/chemical properties and/or occurrence in regards to whether these substances are appropriate candidates for testing in the EDSP under Safe Drinking Water Act authority at this time. The U.S. Court of Appeals for the Third Circuit granted EPA’s motion for voluntary partial vacatur and remand regarding these two chemicals. 998
Endocrine Disruptor Screening Program: Use of High Throughput Assays and Computational Tools 2015-06-15 EPA 705-G-2020-3573 Endocrine Disruptor Screening Program; EDSP; EDSP Policy; High Throughput Assays; HT; Computational Toxicology; Comp Tox Policy Notice; This document describes how EPA is planning to incorporate an alternative scientific approach to screen chemicals for their ability to interact with the endocrine system. This will improve the Agency's ability to fulfill its statutory mandate to screen pesticide chemicals and other substances for their ability to cause adverse effects by their interaction with the endocrine system. The approach incorporates validated high throughput assays and a computational model and, based on current research, can serve as an alternative for some of the current assays in the Endocrine Disruptor Screening Program (EDSP) Tier 1 battery. EPA has partial screening results for over 1800 chemicals that have been evaluated using high throughput assays and a computational model for the estrogen receptor pathway. In the future, EPA anticipates that additional alternative methods will be available for EDSP chemical screening based on further advancements of high throughput assays and computational models for other endocrine pathways. Use of these alternative methods will accelerate the pace of screening, decrease costs, and reduce animal testing. In addition, this approach advances the goal of providing sensitive, specific, quantitative, and efficient screening using alternative test methods to some assays in the Tier 1 battery to protect human health and the environment. 986
Endocrine Disruptor Screening Program; Policies and Procedures for Initial Screening 2009-04-15 EPA 705-G-2020-3574 Endocrine Disruptor Screening Program; EDSP; Policy; Screening Policy Notice; This document describes the policies and procedures EPA generally intends to adopt for initial screening of chemicals under the Endocrine Disruptor Screening Program (EDSP). The EDSP is established under section 408(p) of the Federal Food, Drug, and Cosmetic Act (FFDCA), which requires endocrine screening of all pesticide chemicals and was established in response to growing scientific evidence that humans, domestic animals, and fish and wildlife species have exhibited adverse health consequences from exposure to environmental chemicals that interact with their endocrine systems. 990
Amphibian Metamorphosis Assay 2011-10-12 EPA 705-G-2020-3575 Endocrine Disruptor Testing, test guideline, AMA, Amphibian Metamorphosis Assay, data evaluation spreadsheet template, DEST Amphibian Metamorphosis Assay, 890.1100, Data Evaluation Spreadsheet Template. 958
Androgen Receptor Binding (Rat Prostate) 2011-09-20 EPA 705-G-2020-3576 Endocrine Disruptor Screening Program, EDSP, Androgen Receptor Binding, data evaluation spreadsheet template, DEST Androgen Receptor Binding, 890.1150, Data Evaluation Spreadsheet Template. 961
Aromatase (Human Recombinant) 2011-09-30 EPA 705-G-2020-3577 Endocrine Disruptor Screening Program, EDSP, Aromatase, data evaluation spreadsheet template, DEST Aromatase (Human Recombinant), 890.1200, Data Evaluation Spreadsheet Template 962
Estrogen Receptor Binding 2011-09-17 EPA 705-G-2020-3578 Endocrine Disruptor Screening Program, EDSP, Estrogen Receptor Binding, data evaluation spreadsheet template, DEST Estrogen Receptor Binding, 890.1250, Data Evaluation Spreadsheet Template 993
Estrogen Receptor Transcriptional Activation (Human Cell Line HeLa-9903) 2011-09-15 EPA 705-G-2020-3579 Endocrine Disruptor Screening Program, EDSP, Estrogen Transcriptional Activation (Human Cell Line HeLa-9903), data evaluation spreadsheet template, DEST Estrogen Receptor Transcriptional Activation (Human Cell Line HeLa-9903), 890.1300, Data Evaluation Spreadsheet Template 994
Fish Short-Term Reproduction 2011-09-09 EPA 705-G-2020-3580 Endocrine Disruptor Screening Program, EDSP, Fish short-term reproduction, data evaluation spreadsheet template, DEST Fish Short-Term Reproduction, 890.1350, Data Evaluation Spreadsheet Template 1000
Hershberger (Rat) 2011-09-07 EPA 705-G-2020-3581 Endocrine Disruptor Screening Program, EDSP, Hershberger (Rat), data evaluation spreadsheet template, DEST Hershberger, 890.1400, Data Evaluation Spreadsheet Template 1002
Female Pubertal (Rat) 2011-09-07 EPA 705-G-2020-3582 Endocrine Disruptor Screening Program, EDSP, Female Pubertal (Rat), data evaluation spreadsheet template, DEST Aromatase (Human Recombinant), 890.1450, Data Evaluation Spreadsheet Template 996
Male Pubertal (Rat) 2011-09-07 EPA 705-G-2020-3583 Endocrine Disruptor Screening Program, EDSP, Male Pubertal (Rat), data evaluation spreadsheet template, DEST Male Pubertal (Rat), 890.1500, Data Evaluation Spreadsheet Template. 1003
Steroidogenesis (Human Cell Line – H295R) 2011-09-03 EPA 705-G-2020-3584 Endocrine Disruptor Screening Program, EDSP, Steroidogenesis (Human Cell Line - H295R), data evaluation spreadsheet template, DEST Steroidogenesis (Human Cell Line - H295R) 890.1550, Data Evaluation Spreadsheet Template 1005
Uterotrophic (Rat) 2011-09-07 EPA 705-G-2020-3585 Endocrine Disruptor Screening Program, EDSP, Uterotrophic (Rat), data evaluation spreadsheet template, DEST Uterotrophic (Rat), 890.1600, Data Evaluation Spreadsheet Template 1007
Corrections and Clarifications on Technical Aspects of the Endocrine Disruptor Screening Program Tier 1 Assays (OCSPP test guideline series 890) 2011-03-04 EPA 705-G-2020-3586 Endocrine Disruptor Screening Program; EDSP; EDSP Tier 1 Assays; Corrections, Clarifications In response to questions raised by Test Order recipients and others, e.g., Endocrine Policy Form, CropLife America, the Agency provided a detailed guidance document correcting and clarifying technical aspects of the conduct of Tier 1 assays for the EDSP. (37 p) 964
Endocrine Disruptor Screening Program Weight-of-Evidence: Evaluating Results of EDSP Tier 1 Screening to Identify the Need for Tier 2 Testing 2011-09-14 EPA 705-G-2020-3587 Weight-of-Evidence, WoE, EDSP, Tier 1 Screening This guidance document provides basic principles and criteria for using a weight-of-evidence (WoE) approach for evaluation and interpretation of EDSP Tier 1 screening, which includes Tier 1 assay results and other information to identify candidate chemicals for Tier 2 testing. 985
Endocrine Disruptor Screening Program Universe of Chemicals 2012-11-01 EPA 705-G-2020-3588 Endocrine Disruptor Screening Program; EDSP; EDSP Universe of Chemicals Guidance on EDSP Universe of Chemicals for potential endocrine disruptor screening and testing 983
Endocrine Disruptor Screening Program Test Guidelines: Three Tier 2 Non-Mammalian Tests 2015-08-25 EPA 705-G-2020-3621 Endocrine Disruptor Screening Program, EDSP, Tier 2, test guidelines, Larval Amphibian Growth and Development Assay,  LAGDA, Medaka Extended One-generation Reproduction Test, MEOGRT, Avian Two-generation Toxicity Test in the Japanese Quail, JQTT Notice of Availability; EPA is announcing the availability of three Office of Chemical Safety and Pollution Prevention (OCSPP) final test guidelines: Medaka Extended One-generation Reproduction Test (MEOGRT), OCSPP Test Guideline 890.2200; Larval Amphibian Growth and Development Assay (LAGDA), OCSPP Test Guideline 890.2300; and Avian Two-generation Toxicity Test in the Japanese Quail (JQTT), OCSPP Test Guideline 890.2100. These test guidelines are part of a series of test guidelines established by OCSPP for use in testing pesticides and chemical substances. 981
Endocrine Disruptor Screening Program: Weight-of-Evidence Guidance Document; Availability 2011-09-28 EPA 705-G-2020-3622 Endocrine Disruptor Screening Program; EDSP; Policy; EDSP List 1; Weight-of-Evidence Notice of Availability; EPA's Endocrine Disruptor Screening Program (EDSP) is announcing the availability of a final guidance document titled, “Weight-of-Evidence: Evaluating Results of EDSP Tier 1 Screening to Identify the Need for Tier 2 Testing.” This weight-of-evidence (WoE) guidance document was revised based on public and peer review comments and existing peer-reviewed EPA guidelines. This guidance document provides basic principles and criteria for application of a WoE approach to evaluate results from the battery of Tier 1 screening assays along with other scientific and technical information relevant to Tier 1 screening to determine whether or not a chemical has the potential to interact with the estrogen, androgen, or thyroid (E, A, or T) hormonal pathways of the endocrine system. The combined results and information will also be used to identify which tests and information may be needed for Tier 2 testing. 987
Endocrine Disruptor Screening Program (EDSP); Announcing the Availability of the Tier 1 Screening Battery and Related Test Guidelines 2009-10-21 EPA 705-G-2020-3623 Endocrine Disruptor Screening Program, EDSP, Tier 1, test guidelines Notice of Availability; EPA is announcing the availability of the Endocrine Disruptor Screening Program (EDSP) Tier 1 battery of assays and availability of test guidelines (protocols) for conducting the assays included in the battery. The EDSP was established under section 408(p) of the Federal Food, Drug, and Cosmetic Act (FFDCA), which directed EPA “to develop a screening program. . .to determine whether certain substances may have an effect in humans that is similar to an effect produced by a naturally occurring estrogen, or such other endocrine effect as the Administrator may designate.” Coordinated by EPA, several in vitro and in vivo screening assays were developed, standardized, and validated to identify the potential of a chemical substance to interact with the estrogen, androgen or thyroid (E, A, or T) hormonal systems. Test chemicals that were thought to be potentially interactive as well as non-interactive with the E, A, or T hormonal systems were used to evaluate feasibility of the protocols, relevance of endpoints and reliability of results within and among independent contract laboratories. Subsequent independent peer review of individual assays helped to clarify the strengths and limitations of each assay and define their modes of action involving the E, A, or T hormonal systems within the context of the EDSP Tier 1 battery. EPA submitted a proposed battery of assays to the Federal Insecticide, Fungicide, and Rodenticide Act Scientific Advisory Panel (FIFRA SAP) for external peer review in March 2008. Based on the SAP recommendation, which found the proposed battery adequate to begin screening chemicals to detect the potential for interaction with the E, A, or T hormonal systems, 966
Endocrine Disruptor Screening Program Test Guidelines: EDSP Tier 1 Test Guidelines, 890.1100, Amphibian Metamorphosis (Frog) 2009-10-01 EPA 740-C-09-002 Endocrine Disruption Testing; 890.1100; test guideline; Amphibian Metamorphosis (Frog) This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 967
Endocrine Disruptor Screening Program Test Guidelines: EDSP Tier 1 Test Guidelines, 890.1150, Androgen Receptor Binding (Rat Prostate Cytosol) 2009-10-01 EPA 740-C-09-003 Endocrine Disruption Testing; EDSP Tier 1 Test Guidelines, 890.1150, Androgen Receptor Binding (Rat Prostate Cytosol) This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 968
Endocrine Disruptor Screening Program Test Guidelines: EDSP Tier 1 Test Guidelines, 890.1200, Aromatase (Human Recombinant) 2009-10-01 EPA 740-C-09-004 Endocrine Disruption Testing; EDSP Tier 1 Test Guidelines; 890.1200; Aromatase (Human Recombinant) This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 969
Endocrine Disruptor Screening Program Test Guidelines: EDSP Tier 1 Test Guidelines, 890.1250, Estrogen Receptor Binding (Rat Uterine Cytosol) 2009-10-01 EPA 740-C-09-005 Endocrine Disruption Testing;  EDSP Tier 1 Test Guidelines; 890.1250; Estrogen Receptor Binding (Rat Uterine Cytosol) This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 970
Endocrine Disruptor Screening Program Test Guidelines: EDSP Tier 1 Test Guidelines, 890.1300, Estrogen Receptor Transcriptional Activation (Human Cell Line (HeLa-9903)) 2009-10-01 EPA 740-C-09-006 Endocrine Disruption Testing; EDSP Tier 1 Test Guidelines; 890.1300; Estrogen Receptor Transcriptional Activation (Human Cell Line (HeLa-9903)); ERTA This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 971
Endocrine Disruptor Screening Program Test Guidelines: EDSP Tier 1 Test Guidelines, 890.1350, Fish Short-term Reproduction 2009-10-01 EPA 740-C-09-007 Endocrine Disruption Testing; EDSP Tier 1 Test Guidelines: 890.1350:  Fish Short-term Reproduction This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 972
Endocrine Disruptor Screening Program Test Guidelines: EDSP Tier 1 Test Guidelines, 890.1400, Hershberger (Rat) 2009-10-01 EPA 740-C-09-008 Endocrine Disruption Testing;  EDSP Tier 1 Test Guidelines; 890.1400; Hershberger (Rat) This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 973
Endocrine Disruptor Screening Program Test Guidelines: EDSP Tier 1 Test Guidelines, 890.1450, Female Pubertal (Rat) 2009-10-01 EPA 740-C-09-009 Endocrine Disruption Testing;  EDSP Tier 1 Test Guidelines; 890.1450; Female Pubertal (Rat) This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 974
Endocrine Disruptor Screening Program Test Guidelines: EDSP Tier 1 Test Guidelines, 890.1600, Uterotrophic (Rat) 2009-10-01 EPA 740-C-09-010 Endocrine Disruption Testing; EDSP Tier 1 Test Guidelines; 890.1600; Uterotrophic (Rat) The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 977
Endocrine Disruptor Screening Program Test Guidelines: EDSP Tier 1 Test Guidelines, 890.1550, Steroidogenesis (Human Cell Line - H295R) 2009-10-01 EPA 740-C-09-011 Endocrine Disruption Testing; EDSP Tier 1 Test Guidelines; 890.1550; Steroidogenesis (Human Cell Line - H295R) This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 976
Endocrine Disruptor Screening Program Test Guidelines: EDSP Tier 1 Test Guidelines, 890.1500, Male Pubertal (Rat) 2009-10-01 EPA 740-C-09-012 Endocrine Disruption Testing; EDSP Tier 1 Test Guidelines; 890.1500; Male Pubertal (Rat) This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 975
Endocrine Disruptor Screening Program Test Guidelines: EDSP Tier 2 Test Guidelines, 890.2300, Larval Amphibian Growth and Development Assay 2015-08-01 EPA 740-C-15-001 Endocrine Disruption Testing; EDSP Tier 2 Test Guidelines; 890.2300; Larval Amphibian Growth and Development Assay; LAGDA This test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 980
Endocrine Disruptor Screening Program Test Guidelines: EDSP Tier 2 Test Guidelines, 890.2200, Medaka Extended One Generation Reproduction Test 2015-08-01 EPA 740-C-15-002 Endocrine Disruption Testing; EDSP Tier 2 Test Guidelines; 890.2200; Medaka Extended One Generation Reproduction Test The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 979
Endocrine Disruptor Screening Program Test Guidelines: EDSP Tier 2 Test Guidelines, 890.2100, Avian Two-Generation Toxicity Test in the Japanese Quail 2015-08-01 EPA 740-C-15-003 Endocrine Disruption Testing; EDSP Tier 2 Test Guidelines; 890.2100, Avian Two-Generation Toxicity Test in the Japanese Quail; JQTT The following test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review. 978

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